204 research outputs found
KAYU PULE SEBAGAI MEDIA PEMBUAT TOPENG BALI
No full textABSTRAK
Masyarakat Bali memiliki aktivitas keagamaan, seni dan budaya yang melibatkan atau menggunakan topeng (tapel). Seiring perkembangannya, topeng-topeng yang di buat dari kayu dengan berbagai ukuran, digunakan dengan tujuan yang berbeda-beda. Selain itu, dinamika budaya topeng di Bali juga diwarnai dengan munculnya topeng-topeng ciptaan baru hasil olah kreativitas para seniman setempat. Hal ini mengisyaratkan bahwa budaya topeng Bali terus hidup dan berdegup sesuai denyut kreativitas senimannya. Penulis pada kesempatan kali ini menggunakan pendekatan secara kualitatif karena metode ini dapat digunakan untuk mengungkapkan dan memahami sesuatu dibalik fenomenayang belum diketahui oleh orang banyak. Topeng atau tapel bali pada umumnya dibuat dari kayu yang dipercaya memiliki unsur magis atau pun memiliki nilai sakral
Kata kunci: Kayu Pule, Media, Topeng Bali
ABSTRACT
Balinese people have religious, artistic and cultural activities that involve or use masks (tapel). As it develops, masks made of wood of various sizes are used for different purposes. Apart from that, the dynamics of mask culture in Bali is also marked by the emergence of new masks created by the creativity of local artists. This indicates that Balinese mask culture continues to live and beat according to the pulse of the artist\u27s creativity. The author on this occasion uses a qualitative approach because this method can be used to reveal and understand something behind a phenomenon that is not known by many people. Balinese masks or tapels are generally made of wood which is believed to have magical elements or has sacred values
Keywords: Pule Wood, Media, Balinese Mas
SUBALTERNITAS PEREMPUAN BALI DALAM KUMPULAN CERPEN AKAR PULE KARYA OKA RUSMINI
No full textDiscussing subaltern in literature means reading and interpreting an author�s
view on the condition that is becoming the identity of the subalterns. In this research,
it focuses on the position of Oka Rusmini as an author who is considered to represent
a group of intellectuals who sought to speak for subaltern groups in her short stories.
Subaltern groups refer to those who experience oppression. These groups are people
who cannot speak up. Subaltern class is a group of non-elite marginal class (East)
suppresses by cultural borders and knowledge producing colonial subjects. The act of
subaltern is oppression subjected to the marginalized because of power and the desire
to maintain power. This occurs between those who have interest with those who are
marginalized.
This study uses the theory of the subaltern proposed by Gayatri Chakravorty
Spivak in her essay Can the Subaltern Speak?. This theory is used as a tool to analyze
the problems arise in a collection of short stories written by Oka Rusmini entitled
Akar Pule.
Oka Rusmini as author, in the collection of short stories Akar Pule, wants to
show women subaltern in Bali. Women subaltern in Bali occurs in various domains
like women subaltern in culture, especially in the caste system, women subaltern in
the institution of marriage, women subaltern due to the myth of maleness, women
subaltern in facing social construction, and women subaltern by fellow women.
Oka Rusmini as intellectuals in Bali, was only able to present as
\"representative\" of the subaltern through her works. In Akar Pule, Oka Rusmini
shows that as an intellectual, she was actually unable to make the subaltern women
speak. The theme of subaltern women in Balinese society that she always put forward
in her works is a way to uncover discourses that there is violence against women in
Bali
Island Kings:Imperial Masculinity and Climate Fragilities
No full textIn this chapter we interrogate relations between masculinities and climate politics by focusing on global elites. The positionality of elite actors as white, wealthy, cis-gendered men is usually ignored, even by critical scholars of climate politics. We characterise their strategies as expressing “imperial masculinity”: that is, they assume they can use their extreme wealth to insulate themselves from climate insecurities. However, these strategies to make themselves invulnerable to climate disasters are ultimately hubristic. While climate impacts are indeed highly unequal, many of the places elite men use to display their wealth are highly climate-fragile. We use the example of Richard Branson and his Caribbean island to illustrate how hyper-elite men are indeed subject to climate impacts in ways that exceed their attempts to make themselves impregnable to the consequences of climate change
Island Kings:Imperial Masculinity and Climate Fragilities
No full textIn this chapter we interrogate relations between masculinities and climate politics by focusing on global elites. The positionality of elite actors as white, wealthy, cis-gendered men is usually ignored, even by critical scholars of climate politics. We characterise their strategies as expressing “imperial masculinity”: that is, they assume they can use their extreme wealth to insulate themselves from climate insecurities. However, these strategies to make themselves invulnerable to climate disasters are ultimately hubristic. While climate impacts are indeed highly unequal, many of the places elite men use to display their wealth are highly climate-fragile. We use the example of Richard Branson and his Caribbean island to illustrate how hyper-elite men are indeed subject to climate impacts in ways that exceed their attempts to make themselves impregnable to the consequences of climate change
Island Kings:Imperial Masculinity and Climate Fragilities
No full textIn this chapter we interrogate relations between masculinities and climate politics by focusing on global elites. The positionality of elite actors as white, wealthy, cis-gendered men is usually ignored, even by critical scholars of climate politics. We characterise their strategies as expressing “imperial masculinity”: that is, they assume they can use their extreme wealth to insulate themselves from climate insecurities. However, these strategies to make themselves invulnerable to climate disasters are ultimately hubristic. While climate impacts are indeed highly unequal, many of the places elite men use to display their wealth are highly climate-fragile. We use the example of Richard Branson and his Caribbean island to illustrate how hyper-elite men are indeed subject to climate impacts in ways that exceed their attempts to make themselves impregnable to the consequences of climate change
is a direct transcriptional target of MYCN in neuroblastoma
No full textThe MYCN oncogene is the major negative prognostic marker in neuroblastoma with important roles in both the pathogenesis and clinical behavior of this aggressive malignancy. MYC oncogenes activate both proliferative and apoptotic cellular pathways and, accordingly, inhibition of p53-mediated apoptosis is a prerequisite for MYC-driven tumorigenesis. To identify novel transcriptional targets mediating the MYCN-dependent phenotype, we screened a MYCN-amplified neuroblastoma cell line by using chromatin immunoprecipitation (ChIP) cloning. We identified the essential p53 inhibitor and protooncogene MDM2 as a putative target. MDM2 has multiple p53-independent functions modulating cell cycle and transcriptional events. Standard ChIP with MYCN antibodies established the binding of MYCN to a consensus E-box within the human MDM2 promoter. Oligonucleotide pull-down assays further established the capacity of MYCN to bind to this promoter region, confirming the ChIP results. Luciferase reporter assays confirmed the E-box-specific, MYCN-dependent regulation of the MDM2 promoter in MYCN-inducible neuroblastoma cell lines. Real-time quantitative PCR and Western blot analysis demonstrated a rapid increase in endogenous MDM2 mRNA and MDM2 protein upon induction of MYCN. Targeted inhibition of MYCN in a MYCN-amplified neuroblastoma cell line resulted in decreased MDM2 expression levels with concomitant stabilization of p53 and induction of apoptosis. Our finding that MYCN directly modulates baseline MDM2 levels suggests a mechanism contributing to the pathogenesis of neuroblastoma and other MYC-driven malignancies through inhibition of MYC-stimulated apoptosis
Abstract 3686: Generation of an off-the-shelf cell-based platform (PDC-vac) for active antitumor immunotherapy
No full textAbstract
The development of efficient vaccines for the treatment of cancers in combination or not with other agents such as checkpoint inhibitors represents a major public health issue but remains a challenge. A dozen of vaccine drug products is expected to be marketed in the next few years. In this context, off-the-shelf and potent platforms are more attractive than individualized vaccines that are tailored to each patient in many aspects. We have recently developed a new cell-based vaccine approach named PDC*vac (formerly GeniusVac). This cell-based vaccine was developed thanks to the establishment, from leukemic PDC, of unique human PDC line (PDC*line). We have previously shown the potential of peptide-loaded PDC*line to induce strong and fully functional HLA-A*02:01-restricted anti-tumor immunity in vitro and in vivo (Aspord et al, 2010, 2012). PDC*mel (GenusVac-Mel4), our first product is currently developed for the treatment of melanoma patients (NCT01863108). The high efficiency of PDC*vac renders the strategy very attractive for further clinical developments in active immunotherapy field. Our aim is to optimize PDC*vac technology by passing use peptides and render the vaccine easier to manufacture. We engineered our PDC*line using retrovirus to force the endogenous expression of one or more tumor or viral antigenic peptides or whole tumor/viral proteins (gp100, tyrosinase, Melan-A, Mage-A3, CMVpp65, flu, EBV) that broaden the panel of antigens presented. Data obtaining with different polypeptide and protein gene coding constructions and the expansion of multi-specific antigen-specific T-cells at the same time will be presented. Moreover, we will present how we succeed to obtain 100% of efficacy in antigen presentation by the PDC*line engineered to express tumor proteins or polyepitopes. We have validated the use of retrovirus constructs to create a new generation of an “off-the-shelf” cancer vaccines highly potent to stimulate antitumor-specific T-cells.
Citation Format: Joel Plumas, Kevin Lenogue, Alexandre Walencik, Jean-Paul Molens, Laurence Chaperot, Martin Pule. Generation of an off-the-shelf cell-based platform (PDC-vac) for active antitumor immunotherapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3686. doi:10.1158/1538-7445.AM2017-3686</jats:p
A educação física do Sistema Único de Saúde (SUS): efetividade de uma intervenção de base comunitária para promoção da atividade e saúde
No full textTese [doutorado] - Universidade Federal de Santa Catarina, Centro de Desportos. Programa de Pós-graduação em Educação Física, Florianópolis, 2013A expansão e consolidação da Estratégia Saúde da Família por todo o país têm garantido importantes conquistas, que possibilitaram a ampliação de suas ações com a inserção de outros profissionais envolvidos na promoção da saúde. Apesar de reconhecida como uma das profissões da área da saúde desde 1998, só após dez anos a educação física foi convidada a participar das políticas de saúde do SUS. Como novo espaço de atuação para a educação física, torna-se necessária a construção de um novo fazer, considerando os métodos, as técnicas e os procedimentos sistematicamente e historicamente adotados pelos profissionais pioneiros no SUS, e as mudanças constantes do perfil de doença da população. Neste sentido, esta pesquisa investigou sobre o processo de formação continuada e de intervenção da educação física para promoção da saúde na atenção básica, buscando implementar, desenvolver e avaliar a efetividade de um programa de intervenção, de base comunitária, com a população atendida pela Estratégia Saúde da Família quanto aos indicadores de saúde, barreiras para a prática de atividade física, percepção do programa, comportamento e nível da atividade física, além de outros indicadores. Mesmo com a adesão baixa às atividades práticas nas unidades básicas de saúde e da pouca visibilidade do Programa Ação e Saúde por parte da população, observou-se que os resultados comprovaram a efetividade para mudança de comportamento para atividade física e saúde em adultos na atenção primária, com resultados mais efetivos nos homens, e com uma maior redução do comportamento inativo nas mulheres. Quanto às barreiras para atividade física, as estratégias utilizadas pelo Pro Ação e Saúde demonstraram ser efetivas, onde os adultos apresentaram mudanças significativas para a maioria das barreiras entre o survey pré e pós, com a redução significativa para maioria das barreiras entre as mulheres quando comparadas aos homens. Apesar da efetividade comprovada da estratégia utilizada, em curto prazo (12 meses), sobre os indicadores de saúde, e os comportamentos e barreiras para atividade física em adultos e a percepção do programa, nota-se que, para se constituir o fazer da educação física, faz-se necessária uma maior compreensão do cotidiano da atenção primária e das bases teóricas que sustentam esse espaço chamado Sistema Único de Saúde. Logo, intervir com a educação física (atividade física) na perspectiva da promoção da saúde significa ampliar o conhecimento para além das questões biológicas e focar a atenção no desenvolvimento de habilidades e atitudes, que estimulem a construção do empoderamento. No Brasil, o maior desafio para os profissionais de educação física que desejam atuar na atenção primária, é identificar metodologias eficazes e efetivas para a rotina do SUS, pois, apesar de termos um modelo de atenção à saúde, como a Estratégia Saúde da Família, em constante crescimento e com boa resolubilidade, por outro lado ainda temos a limitação dos profissionais de saúde sobre a compreensão e entendimento do fazer de promoção da saúde In the last years the practices and in health cares has suffered constant changes and / or reformulations. The expansion and consolidation of Health of the Family Strategy n the whole country have been guaranteeing important conquests, which made possible the enlargement of their actions with the insertion of other professionals involved in the promotion of the health. In spite of the been recognized as one of the professions of the health area since 1998, only ten years after the physical education is invited to participate in the politics of health of SUS. As the new space for the performance of physical education, it becomes necessary the construction of a new action, considering the methods, the techniques and the systematically and historically procedures adopted by the pioneering professionals in SUS, and the constant changes of the profile of disease of the population. Therefore, to intervene with the physical education (physical activity) in the perspective of the promotion of the health means to enlarge the knowledge besides the biological subjects and to focus the attention in the development of abilities and attitudes, that stimulate the construction of the empowerment. In this sense, this research Intended to Investigate on the process of continuous formation and Intervention of the physical education for the promotion of health in the basic attention, searching to implement, develop and evaluate the effectiveness of an Intervention program, of community basis, with the population assisted by the Family Health Strategy as for the health indicators: barriers for the practice of physical activity, perception of the program, the behavior and level of physical activity, besides other Indicators. Even with the low adhesion to the practical activities in basic health units and the low visibility of the and Health Action Program by the population, It was observed that the results proved the effectiveness of behavior change for physical activity and health in adults in primary care, with more effective results for men, and with the greater reduction of inactive behavior among women. For the barriers for physical activity, the strategies used by program demonstrated to be effective, where the adults resented significant changes for most of the barriers between the survey pre and pos, with significant reduction for the majority barriers among of the women when compared to the men. Just for perception of the social barriers (extensive day of work, family commitments and domestic chores) and the fear of injuring among the women, and barriers for the behavioral and physics among the men there were not significant changes. In spite of the proven effectiveness of the strategy used, in short period (12 months), on the indicators of health, and the behaviors and barriers for physical activity in adult and perception of program, noticed that it is doing to constitute the physical education, It Is Necessary done the correct understanding of the larger daily of the primary attention of the theoretical bases and which sustain this space called SUS. In Brazil, the largest challenge for the physical education professionals who want to act in the primary attention is to identify effective and affective methodologies for the routine of the SUS, because, in spite of we have a model of attention to health to the Health of the Family Strategy in constant growth and with good resolution, on the other hand we still have the health professionals' limitation on the correct comprehension and correct understanding of the action of promotion of health
CITRA PEREMPUAN DALAM KUMPULAN CERPEN AKAR PULE KARYA OKA RUSMINI
No full textPenelitian ini dilatarbelakangi oleh kuatnya dominasi laki-laki terhadap perempuan dengan mengetengahkan tema budaya patriarki di Bali yang terdapat dalam kumpulan cerpen Akar Pule karya Oka Rusmini. Adapun rumusan masalah adalah (1) bagaimana struktur teks cerpen Sipleg, Sawa, dan Pastu (2) bagaimana citra perempuan, dan (3) bagaimana tinjauan feminisme terhadap citra perempuan.
Pengkajian struktur cerpen menggunakan analisis dari Tzevan Todorov, yakni analisis aspek sintaksis berupa analisis terhadap pengaluran dan alur, aspek semantik yang meliputi analisis terhadap tokoh dan latar, lalu aspek verbal yang meliputi analisis terhadap kehadiran pencerita dan tipe pencerita. Pendekatan kritik sastra feminis ideologis digunakan untuk mendapatkan citra perempuan yang terbagi atas citra fisik berupa tanda-tanda jasmaniah, citra psikis berupa rasa dan emosi yang dimiliki perempuan, dan citra sosial berupa bentuk hubungan perempuan dalam masyarakat. Metode penelitian yang digunakan adalah metode deskriptif analisis dengan teknik pengumpulan data berupa studi dokumentasi.
Hasil analisis struktur cerpen memberikan jawaban bahwa pengaluran dan alur mudah dipahami karena didominasi alur linear. Alur kilas balik, sorot balik dan bayangan digunakan untuk menciptakan ketegangan-ketegangan dalam cerita. Tokoh-tokoh perempuan berperan sebagai tokoh utama dan menggerakkan cerita. Latar cerita terjadi di Bali lengkap dengan warna lokal kebudayaan yang khas. Jenis penceritaan dan tipe pencerita hadir memperjelas kedudukan pengarang sebagai pembuat cerita. Citra perempuan yang tercermin adalah perempuan yang mendapatkan penindasan, baik fisik maupun psikis yang dilakukan oleh tokoh laki-laki dalam kehidupannya. Citra sosial yang tercermin adalah citra sosial perempuan yang mendapat pandangan negatif dari masyarakat karena bertindak di luar kelaziman. Berdasarkan tinjauan feminisme, tokoh-tokoh perempuan ditempatkan dalam kurungan budaya patriarki Bali yang mengkontruksi perempuan menjadi makhluk lemah. Terdapat perlawanan perempuan terhadap budaya patriarki yaitu dengan menjadi perempuan yang tidak mau bicara pada siapapun, menjadi istri yang berkhianat pada suami, menjadi perempuan penentang sistem kasta, dan menjadi perempuan yang menolak menikah.
This research is motivated by the strong dominance of men over women with the theme of patriarchal culture in Bali is contained in a collection of short stories Akar Pule by Oka Rusmini. The formulation of the problem is (1) how to structure a short story text Sipleg, Sawa, and Pastu (2) how the image of women, and (3) how the review feminism on the image of women.
Assessment using the analysis of the structure of short stories Tzevan Todorov, the analysis in the form of an analysis of the syntactic aspect describes the plot and how it is arranged, which includes analysis of the semantic aspects of the characters and backgrounds, and verbal aspect which includes an analysis of the presence and type narrator narrator. Feminist literary criticism ideological approach used to obtain the image of women, divided into a physical image signs of physical, mental imagery and emotion in the form of a sense of women-owned, and a form of social image of women in public relations. The method used is descriptive method of analysis with data collection techniques in the form of documentation.
Results of structural analysis of the short story and provide the answers that describes the plot and how is arranged easily understood as predominantly linear flow. Groove flashback, flashback and shadows are used to create tensions in the story. Figures of women as the main character and move the story. Background story happened in Bali culture complete with typical local color. Type of storytelling and storytellers types clarify the present position of the author as the creator of the story. Reflected image of women is women who get oppression, both physically and psychologically by male figures in his life. Social image reflected is the social image of women who received a negative view of society as acting outside prevalence. Based on a review of feminism, female figures are placed in confinement patriarchal culture Balinese women construct a weak creature. There are women's resistance against patriarchy is to be a woman who does not want to talk to anyone, a betrayed wife whose husband, a female opponents of the caste system, and a woman who refused to marry
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