1,721,091 research outputs found
Farmacoterapia dell'asma bronchiale
No full textPrincipali aspetti dei farmaci antiasmatici, dal meccanismo d'azione molecolare al razionale d'impiego clinico, si propone di offrire al medio specialista ed all'internista di base un utile strumento di consultazione ed aggiornamento
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Farmacologia clinica dei broncodilatatori e dei glucocorticoidi
No full textAspetti molecolari e clinici dei principali farmaci broncodilatatori e dei glucocorticoidi utilizzati nel trattamento dell'asma bronchiale
HIV-1 matrix protein p17 and its receptors.
No full textThe HIV-1 matrix protein p17 (p17) plays a crucial role in the virus life cycle. It is released in the extracellular space from HIV-1-infected cells and accumulates in the tissues of patients, even in those successfully treated with highly active antiretroviral therapy. Extracellular p17 deregulates the biological activity of many different cells that are directly or indirectly involved in AIDS pathogenesis. All p17 actions depend on interaction between its functional epitope (AT20) located at the protein N-terminal region and different receptors expressed on target cells. This finding corroborates the importance of impeding p17/p17 receptors interaction as a contribution to block AIDS. In this article we review the interaction of p17 with heparan sulfate proteoglycans (HSPGs) and with the chemokine (C-X-C motif) receptor 1 (CXCR1) and 2 (CXCR2). We provide details on how p17 interacts with its receptors and how these interactions are central to the p17 biological activities. Moreover, we highlight the presence of a p17 variant, named S75X, that displays opposite effects on B-cell proliferation, as compared to p17. A two-site model for p17 interaction with G-coupled receptors provides a possible explanation on how mutations naturally occurring within the primary amino acid structure can lead S75X to activate the Akt signaling pathway and promote B-cell growth and transformation. Identifying p17 interaction with HSPGs, CXCR1 and CXCR2 as fundamental events in supporting its activity could help us to find new treatment approaches aimed at blocking all p17/p17 receptors interaction and, consequently, all p17 detrimental activities
Numerical and Experimental Investigation on a Multi-band PIFA for Laptops
No full textA new compact, multiband, single-feed planar inverted-F
antenna (PIFA) for laptop computers is presented. The proposed largebandwidth
radiating system is designed to operate in the IEEE 802.11a
(5.725–5.825 GHz), IEEE 802.11b (2.4 –2.48 GHz), and HIPERLAN2
(5.470 –5.725 GHz) frequency bands. The overall size of the antenna
and its dimensions are suitable for its installation in any position along
the border of the display of a laptop computer. The design procedure is
illustrated and discussed. The antenna behavior has been analyzed by
resorting to both a conformal finite-difference time-domain (CFDTD)
simulation procedure and a finite-element method (FEM) based technique.
The simulation results are shown for the antenna in free space as
well as when it is mounted in the border of a notebook display. A prototype
is realized and the measurement results show good agreement with
the simulation dat
Apporti delle metodiche di analisi multidimensionale alla valutazione statistica dei dati della funzione respiratoria
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