116 research outputs found
Architectural designs attributed to Simon Pitz in the collection of the Jesuit archive in Glatz
No full textSimon Pitz (1592–1625) was a Jesuit architect providing designs for numerous Jesuit
buildings in Czechia, Moravia, Silesia and Poland. His oeuvre was known from several designs
preserved in archives in Czechia, as well as the Jesuit Archive in Cracow (some of which were
published in both Czech and Polish literature). An inventory in this order’s archive in Glatz
(pol.: Kłodzko), drawn in 2018, revealed some previously unknown designs by this architect,
some of which show alternative versions of designs already linked with Pitz, others can be
attributed to him on the basis of distinctive architectural motifs or details. The article presents
some of these previously unknown drawings by the architect, preserved in Polish archives,
among others: alternative designs for the Jesuit church in Jitschin, additional designs of the
college and church in Königgrätz, Jesuit novitiate (seminary) in Böhmisch Krumau and five
versions of designs for the church in Komotau. Some designs may have been developed for
Kuttenberg – they depict a huge complex of buildings (approx. 182 by 104 m), with a church
surrounded by five courtyards. Designs preserved in Glatz indicate also that Pitz was the
author of the Jesuit church in Lutsk, which has been previously linked with Giacomo Briano.
At the present state of knowledge it can be concluded that Pitz’s legacy is among the largest
and most interesting collections of designs by Jesuit architects active in Central Europe in the
seventeenth century
Влияние стабильности основных параметров пучка на измерение размера пучка в PITZ
No full textThe photo injector test facility in Zeuthen (PITZ) is used to develop and characterize electron sources which produce a nominal bunch charge of 1 nC with the lowest possible transverse emittance. Measurements of the beam size provide us with knowledge on important beam characteristics. For example the measurement of the emittance is based on beam size measurements. Therefore, the control of uncertainties of beam size measurements is very important to validate the experimental results. The statistical uncertainty of transverse beam size measurements due to the beam energy and bunch charge jitters is considered in this paper.Стенд випробувань фотоінжекторів PITZ використовується для розробки та вивчення характеристик джерел електронів, що випромінюють пучки з номінальним зарядом в 1 нКл та якомога меншим емітансом. Одним з базових вимірів є вимір поперечного розміру електронного пучка. Наприклад вимірювання емітансу базується на вимірах розміру пучка. Таким чином врахування невизначеності вимірів розміру пучка є важливим для визначення вірогідності експериментальних результатів. В даній роботі розглянута статистична невизначеність виміру поперечного розміру електронного пучка в PITZ.Стенд испытания фотоинжекторов PITZ служит для разработки и характеризации источников электронов, которые способны производить пучки с номинальным зарядом в 1 нКл и малым поперечным эмиттансом. Одним из базисных измерений при характеризации фотоинжектора является измерение поперечного размера электронного пучка. В частности, измерение поперечного эмиттанса основано на измерениях размера пучка. Знание погрешности в измерении размера пучка является очень важным условием для определения достоверности экспериментальных результатов. В данной работе рассмотрена статистическая неопределенность в измерении поперечного размера электронного пучка, вызванная флуктуациями энергии и заряда пучка.This work has partly been supported by the European Community, contract numbers RII3-CT-2004-506008 (IA-SFS) and 011935 (EURO-FEL), and by the ”Impuls- und Vernetzungsfonds” of the Helmholtz Association, contract number VH-FZ-005.
The author would like to thank all members of the PITZ group and especially S. Khodyachykh, L. Staykov and M. Krasilnikov for the productive discussions and helpful advices
Влияние стабильности основных параметров пучка на измерение размера пучка в PITZ
No full textThe photo injector test facility in Zeuthen (PITZ) is used to develop and characterize electron sources which produce a nominal bunch charge of 1 nC with the lowest possible transverse emittance. Measurements of the beam size provide us with knowledge on important beam characteristics. For example the measurement of the emittance is based on beam size measurements. Therefore, the control of uncertainties of beam size measurements is very important to validate the experimental results. The statistical uncertainty of transverse beam size measurements due to the beam energy and bunch charge jitters is considered in this paper.Стенд випробувань фотоінжекторів PITZ використовується для розробки та вивчення характеристик джерел електронів, що випромінюють пучки з номінальним зарядом в 1 нКл та якомога меншим емітансом. Одним з базових вимірів є вимір поперечного розміру електронного пучка. Наприклад вимірювання емітансу базується на вимірах розміру пучка. Таким чином врахування невизначеності вимірів розміру пучка є важливим для визначення вірогідності експериментальних результатів. В даній роботі розглянута статистична невизначеність виміру поперечного розміру електронного пучка в PITZ.Стенд испытания фотоинжекторов PITZ служит для разработки и характеризации источников электронов, которые способны производить пучки с номинальным зарядом в 1 нКл и малым поперечным эмиттансом. Одним из базисных измерений при характеризации фотоинжектора является измерение поперечного размера электронного пучка. В частности, измерение поперечного эмиттанса основано на измерениях размера пучка. Знание погрешности в измерении размера пучка является очень важным условием для определения достоверности экспериментальных результатов. В данной работе рассмотрена статистическая неопределенность в измерении поперечного размера электронного пучка, вызванная флуктуациями энергии и заряда пучка.This work has partly been supported by the European Community, contract numbers RII3-CT-2004-506008 (IA-SFS) and 011935 (EURO-FEL), and by the ”Impuls- und Vernetzungsfonds” of the Helmholtz Association, contract number VH-FZ-005.
The author would like to thank all members of the PITZ group and especially S. Khodyachykh, L. Staykov and M. Krasilnikov for the productive discussions and helpful advices
EXercise to prevent Anthracycline-based Cardio-Toxicity (EXACT 2.0) in women with breast cancer
No full textBackground: Cancer and cardiovascular disease are the leading causes of death for Canadian women. Many women will receive anthracyclines (AC) as treatment for breast cancer (BC) which can have cardiotoxic effects. Lifestyle inte1ventions, including aerobic exercise (AE), may offer an opportunity to prevent cardiotoxity when used in combination with, or in replacement of,
pharmacological agents.
Objective: To evaluate whether a 24-week, home-based AE program during AC-based chemotherapy will prevent cardiotoxicity in women with BC.
Methods: Since 2019, women with BC receiving AC-based chemotherapy at St. Boniface Hospital have been recruited and randomized to either the control or AE group. Baseline patient demographics and cardiovascular risk factors were obtained. Cardiac function was assessed using trans thoracic echocardiography to quantify left ventricular ejection fraction (L VEF) and global longitudinal strain (GLS). Quality of life and cancer therapy related fatigue were assessed using the Functional Assessment
for Cancer Therapy-Breast and Functional Assessment of Chronic Illness Therapy-Fatigue scales, respectively.
Results: A total of 19 women were enrolled who were middle-aged and had few cardiac risk factors. The average adherence to AE was 93%. There was no significant difference between the control and AE groups at baseline and no adverse changes were observed between baseline and 6-month follow-up in either group for L VEF, GLS, or quality oflife factors.
Conclusion: This pilot study supports that a 24-week, home-based AE program is feasible with high adherence. Further recruitment and future studies are required to determine whether home-based AE is cardioprotective in the setting of chemotherapy mediated cardiotoxicity
Atomic Oxygen and Heat Release Rate Monitoring in Hydrogen Tubular Flames
No full textEvolving combustion applications require efficient devices whose complexity continues to grow, but they require accurate simulations in turbulent reacting environments that are difficult to validate. Thus, fundamental laminar configurations, such as tubular flames, are an attractive means to independently study turbulent characteristic (stretch and curvature) effects on reaction chemistry. The laminar nature of tubular flames makes them prime candidates for validating full and reduced chemical mechanisms in direct numeric simulations against measurements. This work seeks to provide further insight into tubular flame structure by imaging atomic oxygen profiles; testing the validity of the latest chemical mechanisms in a stretched and curved environment; and re-examining the utility of common heat release tracers in hydrogen-fueled combustion. Quantitative atomic oxygen measurements are conducted in H2-O2 tubular flames via femtosecond, Two-photon Absorption Laser Induced Fluorescence (fs-TALIF) where signal quenching is corrected through Raman scattering measurements of major species. The study finds that temperature-dependent quenching of the fluorescence signal must be considered for accurate quantitative fs-TALIF. Measured atomic oxygen profiles in non-cellular (one-dimensional) tubular flames (diluted with N2 or CO2) are shown to be well-predicted by the latest chemical mechanisms. However, no new mechanism can accurately describe the two-dimensional flame in the presence of cellular instability. Atomic oxygen profiles are reasonably predicted within the cells when N2 is the diluent, but dearth regions and curvature trends are not well-modeled, and temperature is over-predicted. When diluted with CO2 all of the mechanisms over-estimate O-atom number densities by 340% though temperature is more accurately predicted. In addition to these measurements, heat release markers for hydrogen combustion are also explored. Knowledge of heat release in combustion devices is necessary to avoid destructive thermo-acoustic instabilities; however, it cannot be directly measured. Thus, combinations of potential chemical tracers are numerically compared to calculated heat release in tubular flames. The legacy tracer, electronically excited OH, is shown to under-predict heat release in zones of low reactivity while hydrogen atom is determined to more accurately trace heat release through each reaction zone of the flames
Muisca heppneri, nov.sp.
No full textMuisca heppneri OPITZ nov.sp. (Figs 30, 60, 95, 112, 142) Holotype: ♀. PANAMÁ: Pmá. Prov., Cerro Campana, 820 m, 8°40'N, 79°56'W. A second label reads: 5 Sept. ’77, H. P. Stockwell (FSCA). Paratypes: 19 specimens. Costa Rica: Provincia de Guanacaste, 9 km S Santa Ceciliam Parque Nacional Guanacaste, 24-VIII-1992, P Rios (WOPC, 1). Panamá: Provincia de Veragua, Santa Fe, Alto Piedra, 11-16-VI- 2010, 850 m, J. B. Heppner (FSCA, 1); Provincia de Panamá, Cerro Campana, 8°40'N, 79°56'W, 850 m, 2-IX-1972, H. Stockwell (WOPC, 2); idem, 5-IX-1977, H. P Stockwell (WOPC, 1); idem, 18-VII-1970, H. P. Stockwell (WOPC, 1); idem, 13-V-1978, 2700', C. W. & L. B. O’Brien & Marshall (WOPC, 5); idem, 18-VI-1976, W. E. Clark (WOPC, 5); idem, 16-VII-1976, W. Clark (WOPC, 1); idem, 6-V- 1973, 454 m, O’Brien & Marshall (WOPC,1); idem, 29-VI- 1974, L. & C. O’Brien, Marshall, & H. Stockwell (WOPC, 1). D i a g n o s i s: Muisca heppneri specimens may be distinguished from those of its sister species, M. lateripunctata, by coloration near the elytral humeral angle. In M. heppneri specimens there are 2 distinct black maculae near the humeral angle. In M. lateripunctata specimens the humeral region is marked by 1 irregularly-shaped brown macula. D e s c r i p t i o n: Size: Length 6.0 mm; width 2.5 mm. Form: As in Fig. 142. Color: Light castaneous, except each elytron with 2 black spots near the humeral angle and a black angular fascia at middle of disc. Head: Funicular antennomeres filiform, capitulum about as long as combined length of funicular antennomeres, capitular antennomeres 9 and 10 oblong triangular (Fig. 30), antennomere 11 obovate; frons wider than width of eye (EW /FW 30/35). Thorax: Pronotum (Fig. 60) oblong (PW /PL 95/115), side margin with well-developed tubercle, disc subglabrous at middle; elytral asetiferous punctation striate to distal 2/3 rd (EL /EW 280/90). Abdomen: Pygidium subquadrate, posterior margin slightly concave; distal margin of 6 th visible sternite broadly concave; aedeagus phallobase wide in basal half, tapered to lobe apices, phallic apex (Fig. 112) triangular. V a r i a t i o n: Size: Length 5.0- 8.5 mm; width 1.5-3.0 mm. Other than body size the available beetles are quite similar in appearance. N a t u r a l h i s t o r y: Specimens were collected during May through September at altitudes ranging from 800 to 850 m; most were taken with a beating sheet. E t y m o l o g y: The specific epithet, heppneri, is a dedicative patronymic. It honors John B. Heppner for his many contributions to taxonomic entomology, among which is his dedication to field taxonomy. D i s t r i b u t i o n (Fig.95): This species is known only from Panamá.Published as part of Opitz, Pitz Pinola Weston, 2018, Classification, Natural History, and Evolution of the Subfamily Peloniinae O (Coleoptera: Cleroidea: Cleridae). Part IX. Taxonomic revision of the New World genus Muisca S, pp. 587-653 in Linzer biologische Beiträge 50 (1) on page 618, DOI: 10.5281/zenodo.400428
Bridging the gap: measuring the impact of cancer patient navigation on time to CancerCare referral and first treatment for lung cancer
No full textBackground: Lung cancer is the leading cause of cancer deaths worldwide, due to advanced stages of disease at presentation. Healthcare systems are increasingly siloed, resulting in a myriad of care transitions that increase the complexity of care, often resulting in poor patient outcomes. Cancer patient navigation (CPN) emerged in Manitoba, as part of the province’s IN SIXTY initiative, with the general aim of guiding patients through the complexities of the healthcare system to reduce barriers to care, streamline services, and promote efficiencies. Since its inception over a decade ago, there has been no formalized evaluation of IN SIXTY and CPN in Manitoba.
Purpose: The aim of this thesis was to measure the impact of CPN in Manitoba on supporting patients with primary lung cancer in achieving timely referral to CancerCare Manitoba (CCMB) and first treatment.
Methods: A retrospective, cohort study of Manitoba Cancer Registry and Aria data was completed to compare patients who received care from a nurse navigator as part of CPN to patients who received standard care, on the number of days from lung cancer diagnosis to CCMB referral, and date of first treatment, using multilinear Cox proportional hazards regression analysis.
Findings: Patients who received CPN, actualized by nurse navigators, had a statistically significant reduced number of days from lung cancer diagnosis to referral receipt at CCMB, and to the date of first treatment. The timing of CPN, which was found to occur at different points along the cancer continuum, was also found to affect the degree to which CPN impacted timely lung cancer care. CPN implemented prior to lung cancer diagnosis was found to be the most effective model of care.
Conclusion: CPN is an effective, nurse-led, model of care, that shortens the time to CCMB referral and first treatment for lung cancer. Further research is needed regarding its impact in other disease sites, and during the suspicion-interval of newly suspected cancer.February 202
The Role of TIMP1 in a Pro-Tumor Inflammatory Model of Glioma
No full textGlioblastoma (GB) is the most common, aggressive, and lethal form of adult brain cancer. Treatment of GB is challenged due to the limited efficacy of therapeutic options which leads to inevitable and fatal disease recurrence. A major contributor to the lethality of GB is the unique tumor microenvironment in the brain. This complex environment consists of immune cells, neurons, astrocytes, oligodendrocytes, and the extracellular matrix which together support tumor proliferation, invasion, and therapeutic resistance. One of the primary research objectives in our lab is to further our understanding of how GB tumor cells communicate with the microenvironment to promote tumor progression. Previously, we demonstrated that the tumor derived cytokine IL-33 promotes a pro-tumor inflammatory environment which, in turn, supports aggressive tumor growth. Tumors that express higher levels of interleukin 33 (IL-33) associate with worse overall survival and display increased infiltration of innate immune cells, like microglia and macrophage, which adopt an M2-like pro-tumorigenic phenotype. To extend our characterization of secreted factors that contribute to the establishment of a pro-tumor immune milieu, we profiled tumor interstitial fluid from GB xenografts expressing IL-33 using the high throughput proteomics platform SomaScan temporally through tumor progression. This analysis revealed a significant enrichment of tissue inhibitor of metalloproteinase 1 (TIMP1), a protease inhibitor with emerging roles as a cytokine, in IL-33 expressing xenografts. To investigate the role of TIMP1, we generated a TIMP1 knockout glioma model and determined that these cells have slower proliferation, altered cell morphology, and significant differences in transcriptome and secretome profile. When TIMP1 knockout cells were injected in vivo, only a small percentage of tumor cells established, leading to smaller tumors, dramatic improvement in survival, and the presence of an anti-tumorigenic immune environment. Overall, we have demonstrated that knocking out TIMP1 reduces tumor burden and changes the innate immune infiltration profile. These data indicate that TIMP1 may be a more significant regulator of the tumor microenvironment than previously postulated and may represent a novel drug target in this hard-to-treat cancer
Muisca agma, nov.sp.
No full textMuisca agma OPITZ nov.sp. (Figs 35, 70, 96, 117, 148) Holotype: ♂. Venezuela, Estado de Aragua, Estación Biológica Rancho Grande, 5-V-1973, at black light, G. Ekis (FSCA). Paratypes: 12 specimens. Venezuela: Estado de Lara, Sanare,?- VII- 1964, J. Maldonado (WOPC, 1); Distrito Capital, Caracas (MNHN, 1); idem,?-V-VI-1877, O. Thieme (MNHN, 1); Estado de Miranda, San Antonio de los Altos, 1-VIII-1963, 1800 m, Carlos Bordon (WOPC, 1); Estado de Aragua, Estación Biológica Rancho Grande, 5-V- 1973, at black light, G. Ekis (WOPC, 2); idem, 1500-1900 m, 8-V-1978, O’Brien & Marshall (JNRC, 1); La Tiara, 9-VI-1995, H. & A. Howden (CMNC, 1); Estado de Falcon, 4 km W Curimagua, 16-VIII-1975, M. Murtagh (WOPC, 1); " Venezuela " (MNHN, 1). Colombia: Depatamento de Cauca, Valle del Cauca, Buga, 16-V-1973, G. Ekis (WOPC, 3). D i a g n o s i s: Within the M. testacea -group, each elytron shows an irregular fascia in specimens of M. agma and in those of M. nigrosignata. However, in M. agma specimens, this fascia is fragmented, which is not the case in M. nigrosignata specimens. D e s c r i p t i o n: Size: Length 4.3 mm; width 2.0 mm. Form: As in Fig. 148. Color: Light testaceous, except each elytron with 2 black spots near the humeral angle and a black fragmented angular fascia at middle of disc. Head: Funicular antennomeres subfiliform, progressively more triangular toward capitulum, capitulum about as long as combined length of funicular antennomeres, capitular antennomeres 9 and 10 triangular (Fig. 35), antennomere 11 obovate; frons wider than width of eye (EW /FW 18/33). Thorax: Pronotum (Fig. 70) quadrate (PW /PL 75/75), side margin with well-developed tubercle, disc subglabrous at middle; elytral asetiferous punctation minute, striate to distal 2/3 rd (EL /EW 220/55). Abdomen: Pygidium subquadrate; posterior margin of 6 th visible sternite broadly concave; aedeagus long, phallic plates very narrow, phallic apex (Fig. 117) small, triangular. V a r i a t i o n: Size: Length 4.3-6.0 mm; width 2.0- 2.3 mm. Other than body size, the available specimens are quite homogeneous. N a t u r a l h i s t o r y: Specimens were collected during April and May; those from Colombia at 1700 m; those from Venezuela with a black light set in a montane tropical cloud forest. E t y m o l o g y: The specific epithet, agma, is a Greek noun with a meaning of "fragment". I refer to the fragmentation of the fascia on the elytral disc. D i s t r i b u t i o n (Fig.96): This species is known only from Colombia and Venezuela.Published as part of Opitz, Pitz Pinola Weston, 2018, Classification, Natural History, and Evolution of the Subfamily Peloniinae O (Coleoptera: Cleroidea: Cleridae). Part IX. Taxonomic revision of the New World genus Muisca S, pp. 587-653 in Linzer biologische Beiträge 50 (1) on pages 624-625, DOI: 10.5281/zenodo.400428
Perspectives of advanced thermal management in solar thermochemical syngas production using a counter-flow solid-solid heat exchanger
No full textA modular reactor model is presented for the description of solar thermochemical syngas production involving counter-flow heat exchangers that recuperate heat from the solid phase. The development of the model is described including heat diffusion within the reactive material as it travels through the heat exchanger, which was previously identified to be a possibly limiting factor in heat exchanger design. Heat transfer within the reactive medium is described by conduction and radiation, where the former is modeled with the three-resistor model and the latter with the Rosseland diffusion approximation. The applicability of the model is shown by the analysis of heat exchanger efficiency for different material thicknesses and porosities in a system with 8 chambers and oxidation and reduction temperatures of 1000 K and 1800 K, respectively. Heat exchanger efficiency is found to rise strongly for a reduction of material thickness, as the element mass is reduced and a larger part of the elements takes part in the heat exchange process. An increase of porosity enhances radiation heat exchange but deteriorates conduction. The overall heat exchange in the material is improved for high temperatures in the heat exchanger, as radiation dominates the energy transfer. The model is shown to be a valuable tool for the development and analysis of solar thermochemical reactor concepts involving heat exchange from the solid phase
- …
