57 research outputs found
Site distribution in resin beads as determined by confocal Raman spectroscopy
No full textScanning confocal Raman spectroscopy was used to study the distribution of reactive sites within a resin bead used for solid-phase synthesis. The distribution of NH2 groups in aminomethylated polystyrene resin (APS) was determined by doping with varying amounts of 4-cyanobenzoic acid. The extent of loading was determined by both elemental analysis and ninhydrin assays. The spatial distribution of the coupled 4-cyanobenzamide within the bead was determined to an in-plane resolution of 1µm and depth resolution of about 4µm, using; the strong Raman CN stretching vibrational transition at 2230 cm(-1). Dry and swollen beads were studied and the distribution was found to be essentially uniform throughout the bead in all cases
Intramolecular free radical cyclisations onto vinyl ethers. A method for the synthesis of β-oxy-γ-butyrolactones
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Convenient Preparation and Use of a New Analytical Construct for the Analysis and Development of Solid-Phase Chemistries
No full textAn expedient and scalable synthesis of a versatile new analytical construct intermediate 1 is
described. The utility of the intermediate 1 is exemplified by the preparation of the construct resin
14 incorporating an acid-labile linker which is used to conveniently develop optimized conditions
leading to the preparation of a small compound array 24{1−3,1−3}. The optimized conditions are
shown to work equally well on both the construct resin 14 and the corresponding base resin 15
The Use of Polymer‐Assisted Solution‐Phase Synthesis and Automation for the High‐Throughput Preparation of Biologically Active Compounds
No full textChemInform Abstract: Synthesis of Cyclic Tetrapeptoid Analogues of the Antiprotozoal Natural Products Apicidin.
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