453 research outputs found
James Sheen Dowling
No full text<p>James Sheen Dowling was born on 2 December 1819 in London, England. He arrived in Sydney on 24 February 1828 on the 'Hooghly' with his parents, Sir James and Maria Dowling, where his father was to take up a position as puisne judge of the Supreme Court of New South Wales. James Sheen Dowling was educated under John Dunmore Lang, Joseph Docker, William Cape, at the Sydney College, and after returning to England in 1836, at King's College, London (LLB 1841). Admitted to the Middle Temple in 1840, he was called to the Bar on 24 November 1843. He gained experience in common law, equity pleading and conveyancing and worked for his uncle, Alfred Septimus Dowling at the 'Legal Observer and Solicitor's Journal'. Following his father's death, he returned to Sydney in September 1845. (1)<br /><br />He was admitted to the New South Wales Bar on 20 October 1845. In 1846 he was appointed acting Judge-Advocate to the new penal colony to be called 'North Australia', at or near what is now Gladstone, Queensland. After the settlement failed, he returned to Sydney where he continued his practice at the Bar and reported for the Sydney Morning Herald. On 1 January 1851, he was appointed Police Magistrate of the City of Sydney, a position he was to occupy until 11 February 1857. It also included the duties of Visiting Magistrate to Darlinghurst Gaol from 10 November 1856. He was appointed Crown Prosecutor for the Court of Quarter Sessions at Sydney on 12 February 1857. (2)<br /><br />On 1 January 1859 he was appointed District Court Judge for the Western Police District and Chairman of Quarter Sessions, Western District, an area that included Bathurst, Carcoar, Dubbo, Hartley, Molong, Mudgee, and Orange. On 1 October 1861 he was made one of the two District Court Judges for the Metropolitan and Coast Police District and Chairman of Quarter Sessions, Cumberland and Coast District. Metropolitan and Coast District initially included Sydney to Penrith and Windsor, and the South Coast to Eden. In 1866 it expanded to take in the Hunter Region but in 1870 it shed the South Coast area. In 1878 it was renamed the Metropolitan and Hunter District. In 1865, following Alfred Cheeke's rise to the Supreme Court, Dowling became Senior District Court Judge Metropolitan and Coast District. In 1867 he was allowed 12 months leave of absence on half salary from 7 January 1867 to 16 January 1868. Whilst acting for Judge Henry Ralph Francis at Young in 1874, he suffered a serious coach accident near Binalong. He was on leave from 1 February to 30 April and 1 to 30 June. The accident left him with long term impairment. (3) By April 1878 Dowling was occasionally acting as a Supreme Court Judge, a role he appears to have continued in the 1880s. Dowling tendered his resignation in February 1889 due to ill health but was persuaded to take leave from 1 March 1889 to 30 June, when he visited Europe. He eventually retired on 31 July 1889 on a pension and died at his home in Woollahra on 4 May 1902. (4)<br /><br />Endnotes<br />1. A R Dowling, 'Dowling, James Sheen (1819-1902)', Australian Dictionary of Biography, Online edition, <a href="http://www.adb.online.anu.edu/biogs/A040093b.htm%20cited%2011%20January%202008">http://www.adb.online.anu.edu/biogs/A040093b.htm</a> cited 11 January 2008; HTE Holt, 'James Sheen Dowling' in A Court Rises: the lives and times of the Judges of the District Court of New South Wales (1859-1959), North Sydney, Law Foundation of New South Wales, 1976, p.27-33; Fred Johns, Johns's Notable Australians and Who's Who in Australasia, Adelaide, the Author, 1908, p.344; 'Dowling, James Sheen (1819-1902)', Australian Encyclopaedia, Sydney, Angus and Robertson, 1958, p.277; The Jurist, 9 December 1843, p.436, at Google Book Search <a href="http://books.google.com/books?id=G0cwAAAAIAAJ&printsec=titlepage#PPA436,M">http://books.google.com/books?id=G0cwAAAAIAAJ&printsec=titlepage#PPA436,M</a> cited 21 February 2008; Obituary Daily Telegraph 5 May 1902 as cited in 'The Death of ex-Judge Dowling', Forbes Flyer, Winter 2007, Issue 16, p.3 <a href="http://www.forbessociety.org.au/Publications/FFlyer/documents/winter.pdf"><font color="#800080">http://www.forbessociety.org.au/Publications/FFlyer/documents/winter.pdf</font></a> cited 1 February 2008.<br />2. Supreme Court; NRS 13664, Roll of Barristers and Solicitors, 1824-1876; SR Fiche 852, p.4A; HTE Holt, op.cit, p.29-33; Colonial Secretary; NRS 1286, Returns of the Colony (Blue Books); 1851, p.360; 1856, pp.368, 428; 1857, pp.298, 458; New South Wales Government Gazette No.1, 3 January 1851, p.2; No.170, 11 November 1856, p.2891; No.21, 13 February 1857, p.263.<br />3. HTE Holt, op.cit., Public Service Lists (Blue Books), 1859, p.73; 1861, pp.87, 89; 1865, pp.40, 42; 1866, p.40, 42; 1867, p.40, 48; 1868, p.40, 42; 1870, p.44; 1874, p.42; 1878, p.52; NSW Government Gazette No.214, 22 December 1858, p.2253; No.179, 25 July 1861, p.1593; No.261, 16 December 1865, p.2833; No.296, 25 September, 1878, p.3835.<br />4. HTE Holt, op.cit., NSW Government Gazettes No. 88, 28 March 1878, p.1247; No.342, 23 September 1879, p.4213; No.113, 31 March 1880, p.1509; No.378, 24 September 1880, p.5005; No.112, 25 March 1881, pp.1623-4; No. 144, 8 April 1881, p.2041; No.382, 30 September 1881, p.5000; Public Service Lists (Blue Books), 1889, pp.97, 118.</p>PER-186Acting Judge Advocate North Australia 01/01/1846-31/12/1846<br/>Police Magistrate, Sydney Court of General and Quarter Sessions 01/01/1851-11/02/1857<br/>Crown Prosecutor, Sydney Court of General and Quarter Sessions 12/02/1857-31/12/1858<br/>District Court Judge, Western Police District 01/01/1859-30/09/1861<br/>Chairman, Western Police District Quarter Sessions 01/01/1859-30/09/1861<br/>District Court Judge, Metropolitan and Coast Police District 01/10/1861-31/07/1889<br/>Chairman of Quarter Sessions, Cumberland and Coast District 01/10/1861-31/07/1889<br/>Acting Judge, Supreme Court of New South Wales 01/04/1878-31/12/1881 ?<br/>
Fantasmi a Palazzo Lanfranchi e porcellini d'India a Bagni di Pisa: appunti su Byron, Shelley e il primo "gran commento" di Dante in inglese
No full textAn examination of Shelley and Byron's interest in Dante as a poet and patriot and of their relations with Irish expatriate John Taaffe, author of the first English-language commentary on the Divine Comedy (1821)
P4–195: Missing data and the identification of optimal predictors of conversion to Alzheimer's disease
No full textHuman resource management and economic success: An Australian perspective
No full textIn this paper we examine the case for a link at the national and firm level between human resource management (HRM) and economic success in Australia. A brief history of the industrial development of Australia (and New Zealand) is presented and some differentiating factors noted (Dowling/Boxall 1994). A key factor with regard to Australia is the relatively small size of the population and economy and the disproportionate impact of globalisation and global political and economic events upon the performance of the Australian economy. Recent empirical research in the US which argues that there is evidence that positive employee relations effectively serves as an intangible and enduring asset at the firm level (Fulmer/Gerhart/Scott 2003) is noted, as is the December 2003 special issue of International Journal of Human Resource Management which focuses on Developments in Comparative HRM and concludes that there is evidence both for and against the hypothesis that there are no universal prescriptions for effective HRM. The editors (Wright and Brewster) argue that 'the variety of views about what makes for 'good HRM' and the variety of understandings of which policies and practices lead to success is not only inevitable, but should be welcomed' (Wright/Brewster 2003: 1305). The author is in broad agreement with this conclusion
THE PURE ROTATIONAL SPECTRUM OF NITRIC OXIDE
No full text R. T. Hall, D. Vrabec, J. M. Dowling, Applied Optics in press. J. J. Gallagher and C. M. Johnson, Phys. Rev. 103, 1727 (1956). P. G. Favero, A. M. Mirri, and W. Gordy, Phys. Rev. 114, 1534 (1959).Author Institution: Space Physics Laboratory, The Aerospace CorporationThe pure rotational spectrum of nitric oxide was measured under high resolution using a lamellar grating over the frequency range . The values of the effective rotational constants, , and , were determined by least squares analyses; the values of the effective rotational constants. , are in close agreement with microwave The constants reproduce the observed spectrum to an average deviation of approximately . The unperturbed ground state constants are also given. The spin-orbit coupling constant , is discussed
Human Resource Management and Economic Success: An Australian Perspective
No full textIn this paper we examine the case for a link at the national and firm level between human resource management (HRM) and economic success in Australia. A brief history of the industrial development of Australia (and New Zealand) is presented and some differentiating factors noted (Dowling/Boxall 1994). A key factor with regard to Australia is the relatively small size of the population and economy and the disproportionate impact of globalisation and global political and economic events upon the performance of the Australian economy. Recent empirical research in the US which argues that there is evidence that positive employee relations effectively serves as an intangible and enduring asset at the firm level (Fulmer/Gerhart/Scott 2003) is noted, as is the December 2003 special issue of International Journal of Human Resource Management which focuses on Developments in Comparative HRM and concludes that there is evidence both for and against the hypothesis that there are no universal prescriptions for effective HRM. The editors (Wright and Brewster) argue that "the variety of views about what makes for ?good HRM? and the variety of understandings of which policies and practices lead to success is not only inevitable, but should be welcomed" (Wright/Brewster 2003: 1305). The author is in broad agreement with this conclusion.HRM, Australian Perspective, Firm Performance, Economic Success, German Companies Operating in Australia
Aboriginal Women’s Portraiture: Margaret Olley and Julie Dowling
No full textPortraits of Australian Aboriginal women have historically reflected artistic styles, changing perceptions and the unique characteristics of the individual artist, but it was not until the 1950s that Aboriginal women began to be presented by Australian portraitists in a more humanistic and holistic way. In the 1960s, a shift took place in the way Aboriginal women were portrayed, when the Australian artist Margaret Olley [1923–2011] focused upon Aboriginal women differently. She imaged Aboriginal women in terms of painterly aesthetics, ignoring the societal, racial, and historical meanings that could have been symbolically attached to her imagery if she had chosen to do so. This article focuses firstly on Olley’s contribution and its interpretation by the Gamilaroi art historian, Donna Leslie. It then extends the investigation of Aboriginal women’s portraiture in contemporary Australian art through the exploration of a select group of paintings by the portraitist Julie Dowling (1969– ), of the Badimaya people of Western Australia. This article is written by an Indigenous Australian author
TARGETED TOOL TO MEASURE DEMENTIA LITERACY IN PREVENTION AND TREATMENT AMONG SEXUAL AND GENDER MINORITY OLDER ADULTS
No full textUnderstanding the role of interleukin-8 (IL-8) in canine osteosarcoma metastasis
No full textThe student, Matthew Dowling, accepted the attached license on 2018-06-20 at 22:06.The student, Matthew Dowling, submitted this Thesis for approval on 2018-06-20 at 22:14.This Thesis was approved for publication on 2018-06-22 at 14:38.DSpace SAF Submission Ingestion Package generated from Vireo submission #12656 on 2018-09-27 at 11:16:08Made available in DSpace on 2018-09-27T16:30:14Z (GMT). No. of bitstreams: 2
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Previous issue date: 2018-06-22Embargo set by: Seth Robbins for item 107754
Lift date: 2020-09-27T16:30:34Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 107754
Lift date: 2020-09-27T16:31:43Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 107754
Lift date: 2020-09-27T16:34:29Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemInterleukin-8 (IL-8) is a chemokine whose primary function is to regulate neutrophil chemotaxis and modulate the inflammatory response in normal physiologic conditions. Additionally, IL-8 appears to play an important role in tumorigenesis and metastasis in vitro and in vivo in human solid tumors. There is growing evidence to suggest that IL-8 can serve as a biomarker for patients with cancer, with high IL-8 levels often correlated with advanced stage disease, metastasis, and poorer overall outcome. Though IL-8 appears to be intimately associated with cancer progression and metastasis in human, the role of IL-8 in veterinary oncology is largely unexplored.
Osteosarcoma (OS) is a common, naturally-occurring, highly metastatic cancer in dogs that serves as an excellent model for the disease in people. Recent comparative genomics indicate that IL-8 expression is conserved in both human and canine OS and is a negative prognostic indicator in people with this cancer. Therefore, understanding how IL-8 impacts disease progression, specifically in regards to the development of metastasis, could help us more effectively manage OS in both dogs and people.
In this study, we hypothesized 1) that canine OS cells will express IL-8 and its cognate receptors, CXCR1 and CXCR2, 2) that inhibition of IL-8 signaling will attenuate proliferation and migration, 3) that inhibition of IL-8 signaling will enhance sensitivity to cytotoxic agents, and 4) that IL-8 signaling will influence the expression of genes involved necessary for angiogenesis.
We investigated CXCR1 and CXCR2 gene transcription with qualitative polymerase chain reaction (PCR), and we investigated protein expression for IL-8, CXCR1, and CXCR2 with Western blotting. We evaluated OS cell production of IL-8 with an ELISA. We employed a competitive CXCR1/CXCR2 antagonist (Reparixin), as well as an IL-8 neutralizing monoclonal antibody (mAb), to mitigate IL-8 signaling in cell lines. Fluorescent cellular metabolic assays were used to determine the effects of manipulation of the IL-8 signaling axis on cellular proliferation and on chemosensitization to a platinum chemotherapeutic (carboplatin). Scratch assays were used to assess cellular migration following exposure to one of the IL-8 inhibitory agents. Quantitative PCR was again used to evaluate the gene transcription of VEGF in OS cell lines and a canine endothelial cell line following manipulation of the IL-8 signaling axis.
Gene transcription of the IL-8 receptors was noted in six OS cell lines. Furthermore, we were able to demonstrate protein expression of IL-8 in all cell lines. IL-8 was produced in a cell density-dependent manner in all cell lines examined. We showed that the addition of exogenous IL-8 led to a dose-dependent increase in proliferation in an OS cell line that was a low producer of IL-8. IL-8 receptor blockade appeared to have no impact on proliferation at the doses examined. IL-8 receptor blockade also did not enhance sensitivity to carboplatin in vitro. However, receptor blockade did appear to inhibit migration in a dose-dependent manner in the low-producer of IL-8. IL-8 neutralization with a mAb had not effect on proliferation, migration, or chemosensitization. We were also able to show that addition of IL-8 increased VEGF gene transcription.
These findings suggest that autocrine/paracrine IL-8 signaling may be more important in promoting a more metastatic cellular phenotype in those OS cells that are low-producers of this chemokine. Additionally, our results suggest that IL-8 likely plays a role in cultivating a pro-angiogenic tumor microenvironment.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2020-08-01U of I Only Restriction Lifted for Item 107754 on 2020-09-28T09:15:07Z
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