1,068 research outputs found
Some Remarks on the Recent SRM Related Case-Law of the CJEU with Special Regard to the Meroni Doctrine
No full textThe study elaborates on the development of the Meroni doctrine, derived from the Meroni judgment of the Court of Justice of the European Coal and Steel Community under a different Founding Treaty framework and its applicability to the Banking Union under the current Treaty framework. To fulfil this aim, the author first elaborates on the Advocate General’s opinion and the Judgment of the Court of Justice in the Meroni case and then briefly introduces the evolution and the literature on the issue. After a short introduction of the Banking Union’s institutional order, the author introduces two cases in which issues related to the Meroni doctrine were raised before the General Court, as well as the appellate procedures before the Court of Justice in one of these cases
Artifact-Driven Business Process Monitoring - A Novel Approach to Transparently Monitor Business Processes, Supported by Methods, Tools, and Real-World Applications
No full textThis book proposes a novel technique, named artifact-driven process monitoring, by which multi-party processes, involving non-automated activities, can be continuously and autonomously monitored. This technique exploits the Internet of Things (IoT) paradigm to make the physical objects, participating in a process, smart. Being equipped with sensors, a computing device, and a communication interface, such smart objects can then become self-aware of their own conditions and of the process they participate in, and exchange this information with the other smart objects and the involved organizations. To allow organizations to reuse preexisting process models, a method to instruct smart objects given Business Process Model and Notation (BPMN) collaboration diagrams is also presented. The work constitutes a revised version of the PhD dissertation written by the author at the PhD School of Information Engineering of Politecnico di Milano, Italy. In 2019, the PhD dissertation won the “CAiSE PhD award”, granted to outstanding PhD theses in the field of Information Systems Engineering
Should we increase instruction time in low achieving schools? Evidence from Southern Italy
No full textAbstractThis paper investigates the short term effects of a large scale intervention, funded by the European Social Fund, which provides additional instruction time to selected classes of lower secondary schools in Southern Italy. Selection is addressed using institutional rules that regulate class formation: first year students are divided into groups distinguished by letters, they remain in the same group across grades at the school, and the composition of teachers assigned to groups is stable over time. Using a difference-in-differences strategy, we consider consecutive cohorts of first year students enrolled in the same group. We compare participating groups to non-participating groups within the same school, as well as to groups in non-participating schools. We find that the intervention raised scores in mathematics for students from the least advantaged backgrounds. We also find that targeting the best students with extra activities in language comes at the cost of lowering performance in mathematics. We go beyond average effects, finding that the positive effect for mathematics is driven by larger effects for the best students
Fostering collaboration between start-ups and students for mutually beneficial inspiring learning
No full textThis two-voiced paper is the result of a student-teacher interaction in which the teacher simply paves the floor for a student’s narrative and commentary, from their perspective, of an innovative projectbased studio experience. By partnering with an incubation and start-up program for social innovators in Milan, university faculty considered how to design a studio to stimulate both students and innovators in their different educational and personal trajectories by organising "pairs of teams" with the same design goal(s), conscientious of social innovation, environmental sustainability within a circular economy, and striving for radical solutions. The team for which this student-author is sharing their experience in this paper has been paired with the start-up team “NoLo Ricicla - ilVespaio”, whose innovation idea was based on the question “How could a system of plastic packaging recovery, production and distribution of recycled artefacts be organised on a neighbourhood scale in the neighbourhood of NoLo?
Validazione di modelli macrosismici per la stima del danneggiamento
No full textI metodi macrosismici per la stima del danneggiamento di edifici residenziali sono stati inizialmente sviluppati ed utilizzati per la realizzazione di scenari di rischio all’interno di importanti progetti nazionali per l’area di Vittorio Veneto (Bernardini et al., 2008; Meroni et al., 2008a, 2008b) e la Liguria occidentale (Giovinazzi e Lagomarsino, 2004). Grazie alla loro robustezza e flessibilità hanno successivamente avuto ampia diffusione anche a livello Europeo nei progetti Risk-UE (Mouroux and Le Brun, 2006; Lantada et al., 2010), LessLoss (Spence, 2007), UPStrat-MAFA (2012), Syner-G (2012), Zonno et al. (2010).
Attualmente sono disponibili in letteratura diversi metodi, che si differenziano principalmente nella definizione della vulnerabilità delle strutture, ma la cui formulazione originaria parte dalla definizione del danno macrosismico secondo la scala EMS98 (Grünthal, 1998).
Nonostante la loro diffusione questi metodi mancano ancora di una esaustiva validazione. La disponibilità di un rilievo macrosismico dettagliato per il centro storico de L’Aquila (Tertulliani et al., 2011, 2012) ha permesso di confrontare i risultati di alcune stime di danneggiamento macrosismico con una situazione reale, pur con alcune limitazioni dettate dalla tipologia dell’edificato in questione e dall’analisi estesa al solo grado di intensità registrato IEMS98 = VIII-IX.PublishedBologna, Italia3T. Pericolosità sismica e contributo alla definizione del rischiorestricte
Preparation of cyclopropylamine derivatives as histone demethylase inhibitors
No full textThe present invention relates to substituted cyclopropylamine derivs. of formula I and pharmaceutical compns. thereof, as KDM1 inhibitors useful in the prevention and/or treatment of cancer, infectious diseases, and aberrant cellular energy metab. disorders such as obesity. I [wherein R1 is heterocyclyl or heterocyclyl substituted by oxo, wherein the heterocyclyl is unsubstituted or substituted by one or more C1-C6 alkyl; R2 is hydrogen, halogen, C1-C6 alkyl, etc.] or stereoisomers or pharmaceutically salts thereof are claimed and exemplified. For example, 3-(benzyloxycarbonylamino)-4-(4-methylpiperazin-1-yl)benzoic acid underwent condensation with tert-Bu N-[trans-2-(4-aminophenyl)cyclopropyl]carbamate followed by BOC deprotection providing trans-II·2HCl. I were evaluated for inhibition for leukemia MV4-11 cell growth using a CellTiter-Flor® fluorescence assay from which II exhibited an IC50 value ≤ 5μM. Synthetic processes for the prepn. of I are also claimed. [on SciFinder(R)
Otorhinolaryngological manifestationsin granulomatosis with polyangiitis (Wegener's)
No full textGranulomatosis with polyangiitis (Wegener's, GPA) is an uncommon disease of unknown etiology classically involves the ELK triad of the ear, nose, throat (E), lungs (L) and kidneys (K) with necrotizing granulomatous inflammation and vasculitis. Most of the initial symptoms begin in the head and neck region with a wide spectrum of involvement of any site ranging from the nasal septum, paranasal sinuses, oral mucosa, larynx and even the external, middle and internal ear. Diagnosis may be delayed because the onset is heterogeneous and sometimes limited to one organ. The pathologic findings of a characteristic inflammatory reaction pattern, and the serum findings of elevated antineutrophil cytoplasmic antibodies can help to establish the diagnosis. The differentiation from other conditions that mimic GPA such as lymphoma and infections is of critical importance to initiate appropriate treatment. Treatment of the underlying disease is medical with the use of immunosuppressive agents and will not be reviewed here. This review focuses on the otorhinolaryngologic manifestation and complication of GPA as well as their surgical management and specifies the role of the otorhinolaryngologist as an integral member of the multidisciplinary care team for patients with GPA
Chlorination of Poly(1-trimethylsilyl)-1-Propyne Membrane
No full textA characterization of poly[( l-trimethylsilyl)-1-propyne] (PTMSP) membranes treated with chlorine water is presented. PTMSP chlorination was carried out by dipping a PTMSP membrane in chlorine water at 25 degrees C. X-ray microanalysis reveals that after treatment the chlorine amount is relevant in the whole section of membranes and that the chlorine concentration increase is balanced by the silicon concentration decrease. Pristine PTMSP and chlorinated PMSTP vibrational spectra allow to suppose that in the macromolecule "special sites" are present which may be preferentially attacked by chlorine. A chlorination reaction scheme is given here
Accelerated Atherosclerosis in Autoimmune Diseases
No full textAtherosclerosis (AS) is a chronic inflammatory disease of arterial vessels, leading to chronic and acute ischemic damage or hemorrhages in virtually any organ. Atherosclerotic plaque formation is the result of inflammatory processes that mediate lymphocyte and macrophage infiltration, lipid intra- and inter-cellular deposition, and eventually smooth muscle cell migration/proliferation and fibrosis. Adaptive and innate immune responses against exogenous as well as self-antigens cooperate in triggering such processes. The atherogenic processes may be magnified and accelerated in patients with autoimmune rheumatic diseases (AIRDs) because of the underlying immune abnormalities, the consequent systemic inflammation and the effects of some concomitant chronic therapies. As a matter of fact, accelerated AS is responsible for increased mortality and morbidity in almost all AIRDs, nowadays. Diagnostic strategies to detect early atherosclerotic lesions and to apply preventive therapeutical approaches have been proposed in order to avoid complications related to accelerated AS in AIRDs. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2008, 2024
Two-step tumour targetting in ovarian cancer patients using biotinylated monoclonal antibodies and radioactive streptavidin
No full textA new method for intraperitoneal tumour targetting in ovarian cancer using biotinylated monoclonal antibodies (MoAb) and radioactive streptavidin is described. Fifteen patients with histologically documented ovarian carcinoma were injected intraperitoneally with 2 mg of biotinylated MoAb MOv18, followed 3-5 days later by 100-150 Î1⁄4g of indium-111 streptavidin, at the specific activity of 280-370 MBq/mg in 500 ml of normal saline. No toxicity was observed. Tumours were imaged from 2 to 48 h after radioactivity injection by recording both planar and single photon emission tomography (SPET) data. All patients underwent surgery 1-8 days later (mean 3 days) after scanning. The resected tumour and normal tissue radioactivity were measured. On the day of surgery, the tumour to normal tissue ratio was 9:1 (range 3:1-30:1) and 45:1 (range 12:1-120:1) for intra- and extraperitoneal samples, respectively. The mean tumor to blood ratio was 14:1 (range 4:1-30:1). The injected dose (i.d.) per gram of tumour was 0.112 (range 0.01-0.3) for recurrences and 0.05 for primary tumour (range 0.005-0.2). Over 24-48 h 14% i.d. (range 8-18% i.d.) was found in the urine, 14% i.d. (range 629% i.d.) in the blood and 63% i.d. (range 56-70% i.d.) was still in the peritoneal cavity. These preliminary clinical data suggest that this two-step strategy may be superior to the conventional approach (radiolabelled antibodies) for intraperitoneal radioimmunolocalization and radioimmunotherapy of ovarian cancer. © 1992 Springer-Verlag
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