1,513 research outputs found
A novel approach to simulate gene-environment interactions in complex diseases
No full textBackground: Complex diseases are multifactorial traits caused by both genetic and environmental factors. They represent the major part of human diseases and include those with largest prevalence and mortality (cancer, heart disease, obesity, etc.). Despite a large amount of information that has been collected about both genetic and environmental risk factors, there are few examples of studies on their interactions in epidemiological literature. One reason can be the incomplete knowledge of the power of statistical methods designed to search for risk factors and their interactions in these data sets. An improvement in this direction would lead to a better understanding and description of gene-environment interactions. To this aim, a possible strategy is to challenge the different statistical methods against data sets where the underlying phenomenon is completely known and fully controllable, for example simulated ones.
Results: We present a mathematical approach that models gene-environment interactions. By this method it is possible to generate simulated populations having gene-environment interactions of any form, involving any number of genetic and environmental factors and also allowing non-linear interactions as epistasis. In particular, we implemented a simple version of this model in a Gene-Environment iNteraction Simulator (GENS), a tool designed to simulate case-control data sets where a one gene-one environment interaction influences the disease risk. The main aim has been to allow the input of population characteristics by using standard epidemiological measures and to implement constraints to make the simulator behaviour biologically meaningful.
Conclusions: By the multi-logistic model implemented in GENS it is possible to simulate case-control samples of complex disease where gene-environment interactions influence the disease risk. The user has full control of the main characteristics of the simulated population and a Monte Carlo process allows random variability. A knowledge-based approach reduces the complexity of the mathematical model by using reasonable biological constraints and makes the simulation more understandable in biological terms. Simulated data sets can be used for the assessment of novel statistical methods or for the evaluation of the statistical power when designing a study
Computerised simulation of fetal heart rate signals
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2017 E-Health and Bioengineering Conference, EHB 2017
28 July 2017, Article number 7995392, Pages 185-188
6th IEEE International Conference on E-Health and Bioengineering, EHB 2017; Grigore T. Popa University of Medicine and PharmacySinaia; Romania; 22 June 2017 through 24 June 2017; Category numberCFP1703P-ART; Code 129704
Computerised simulation of fetal heart rate signals(Conference Paper)
Romano, M.abEmail Author, Iuppariello, L.bcEmail Author, D'Addio, G.bEmail Author, Clemente, F.dEmail Author, Amato, F.aEmail Author, Cesarelli, M.bcEmail Author
aDMSC, University Magna Graecia, Cǎtanzaro, Italy
bFondazione S. Maugeri, Clinica Del Lavoro e della Riabilitazione, Telese Terme (BN), Italy
cDIETI, University Federico II, Napoli, Italy
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Abstract View references (24)
Computerized systems employed for the analysis of cardiotocographic signals have become almost indispensable tools in fetal monitoring, for which evaluation of fetal heart rate signals plays a key role. Consequently to the diffusion of these systems, new software and complex signal processing methodologies are spreading and are gaining more and more interest. For testing the performances of new software and/or techniques, the availability of synthetic signals with a-priori known characteristics can be very helpful. In this paper we describe an updating of a procedure previously published for the computerized simulation of fetal heart rate signals, realized in order to obtain more realistic signals. Obtained results, analyzed by a team of experts, are satisfying, in that new simulated signals appear less regular and more complex, and hence more similar to real signals. Nevertheless, further research is necessary for obtaining very realistic signals. The future research will be initially focused on the study of floatingline and uterine contractions simulation
Mending Termini Station, una utopia per la Città Eterna
No full textMending Termini Station è il titolo di una sperimentazione accademica trattata e approfondita nell’ambito di un Master in finanza immobiliare (LUISS Business School), un workshop internazionale (con Roma Tre, Sapienza, ETSAB/UPC e UFRGS) e di un laboratorio di urbanistica presso l’Università Roma Tre.
Il progetto MTS attualizza l’ipotesi del Piano Regolatore di Roma del 1931 (Piacentini), con l’eliminazione dell’attuale Stazione Termini, sostituita da un passante ferroviario sotterraneo per i soli treni AV e da una nuova stazione ipogea, il riuso e la valorizzazione del sedime ferroviario liberato dai binari, la chiusura dell’anello ferroviario - previsione confermata anche dal vigente PRG 2008 - e il riordino integrato della mobilità e del trasporto pubblico dell’area centrale di Roma.
Il saggio illustrerà studi preparatori, analisi storiche, modello attuale, valutazioni critiche e gioco di ruolo, dove sono stati rappresentati i tre attori principali della trasformazione: il Comune, RFI (Gruppo Ferrovie dello Stato), e i cittadini stessi, e le soluzioni proposte, caratterizzate per fattibilità urbanistica, trasportistica e socioeconomica
PIANIFICARE NELLA CITTÀ DEI POVERI. L’ESPERIENZA DEL PLAN MAESTRO PER IL RAMAL A DI ZACATECOLUCA (EL SALVADOR)
No full textMemoria y cubanidad, entre pasado y futuro. El proyecto Oriental Cuba Small Historical Centres
No full textThe recovery of the urban, architectural, and cultural memory of small patrimonial centres, suspended between the Spanish colonial heritage of the Leyes de Indias and the symbolic one of the Cuban Revolution, is the main objective of the project “OCSHC - Oriental Cuba Small Historical Centres: an integrated strategy for the intelligent recovery and enhancement of the minor historical centres of the eastern provinces of Cuba”.
The project, funded by the AICS Italian Agency for Development Cooperation, was born from a joint initiative between the Oficina del Conservador de la Ciudad of Santiago de Cuba the Faculty of Construction of the Universidad de Oriente and the Department of Architecture of Roma Tre University.
OCSHC provides for the definition of an integrated strategy for the construction of a network of small patrimonial towns in the provinces of Granma, Santiago de Cuba, Holguín y Guantánamo, within the framework of a sustainable and solidarity development scenario based on the recovery and enhancement of the historical heritage urban and the places of culture and local communities.La recuperación de la memoria urbana, arquitectónica y cultural de pequeños centros patrimoniales, suspendidos entre el legado colonial español de las Leyes de Indias y el simbólico de la Revolución Cubana, es el objetivo del proyecto “OCSHC – Oriental Cuba Small Historical Centres: una estrategia integral para la recuperación y puesta en valor inteligente de los centros históricos menores de las provincias orientales de Cuba”.
El proyecto, financiado por la Agencia Italiana de Cooperación para el Desarrollo AICS, nace de una iniciativa conjunta entre la Oficina del Conservador de la Ciudad de Santiago de Cuba, la Facultad de Construcciones de la Facultad de Oriente y el Departamento de Arquitectura de la Universidad Roma Tre.
OCSHC prevé la definición de una estrategia integral para la construcción de una red de pequeñas ciudades patrimoniales en las provincias de Granma, Santiago de Cuba, Holguín y Guantánamo, en el marco de un escenario de desarrollo sostenible y solidario basado en la recuperación y puesta en valor del patrimonio histórico urbano y de los lugares de la cultura y de las comunidades locales
The pilot experience of the Plan Maestro for the “Ramal A” of Zacatecoluca (El Salvador)
No full textPolicies for the informal city of the America Latina have seen an evolution of approaches. During 50s, the topic of the “City of Invisible” has been faced trying to solve the problem in its effects, not in its causes, through the uprooting, relocation of the inhabitants and the demolition of the settlements.
In 90s the approach changed, facing the need for a simultaneous coordinated action, top-down and bottom-up, ensuring the Right to the City, previously denied, that can be implemented moving from "doing" to "putting-in-able-to-do," through communities’ formation and empowerment.
In this context, we find the Plan Maestro for the recovery and integration of the Ramal “A”, one of 26 most precarious urban settlements in the city of Zacatecoluca, identified in the Map of Urban Poverty and Social Exclusion in El Salvador by the Program for Development of the United Nations.
The Plan Maestro is framed in the context of the Project “Strengthening of the Ministry of Culture of the Presidency of El Salvador through the valorization of cultural heritage”, funded by the Italian Agency for Development Cooperation and carried out by the Roma Tre University and Ministry of Culture, with the cooperation of FUNDASAL Salvadoran Foundation for Development and Minimum Housing.
The Plan Maestro sets as main goal the transformation of poverty and exclusion conditions in which the Ramal community lives, through the participatory construction of a strategic and operational plan that provides, on the one hand, the involvement of the experts (planners, architects, technologists, engineers) of Roma Tre and FUNDASAL, together with the experts of the Universidad de El Salvador and the technicians of the Municipality of Zacatecoluca and the Ministry of Public Works of El Salvador, on the other, the Ramal community, and it has been very effective.
The active participation of all these actors, institutional and non-institutional, implemented the metaphor of the “bridge”, by using a top-down and bottom-up approach, which represents an effective modality of intervention in informal contexts of social and urban degradation
Memòria i Cubanitat, entre passat i futur: el projecte Oriental Cuba Small Historical Centres
No full textLa recuperació de la memòria urbana, arquitectònica i cultural de petits centres patrimonials, suspesos entre el llegat colonial espanyol de les Lleis d’Índies i el simbòlic de la Revolució Cubana, és l'objectiu del projecte “OCSHC – Oriental Cuba Small Historical Centres: una estratègia integral per a la recuperació i posada en valor intel·ligent dels centres històrics menors de les províncies orientals de Cuba”. El projecte, finançat per l'Agència Italiana de Cooperació per al Desenvolupament AICS, neix d'una iniciativa conjunta entre l'Oficina del Conservador de la Ciutat de Santiago de Cuba, la Facultat de Construccions de la Facultat d'Orient i el Departament d'Arquitectura de la Universitat Roma Tre. OCSHC preveu la definició d'una estratègia integral per a la construcció d'una xarxa de petites ciutats patrimonials a les províncies de Granma, Santiago de Cuba, Holguín i Guantánamo, en el marc d'un escenari de desenvolupament sostenible i solidari basat en la recuperació i la posada en valor del patrimoni històric urbà i dels llocs de la cultura i de les comunitats localsThe recovery of the urban, architectural, and cultural memory of small patrimonial centres, suspended between the Spanish colonial heritage of the Leyes de Indias and the symbolic one of the Cuban Revolution, is the main objective of the project “OCSHC - Oriental Cuba Small Historical Centres: an integrated strategy for the intelligent recovery and enhancement of the minor historical centres of the eastern provinces of Cuba”. The project, funded by the AICS Italian Agency for Development Cooperation, was born from a joint initiative between the Oficina del Conservador de la Ciudad of Santiago de Cuba the Faculty of Construction of the Universidad de Oriente and the Department of Architecture of Roma Tre University. OCSHC provides for the definition of an integrated strategy for the construction of a network of small patrimonial towns in the provinces of Granma, Santiago de Cuba, Holguín y Guantánamo, within the framework of a sustainable and solidarity development scenario based on the recovery and enhancement of the historical heritage urban and the places of culture and local communities.La recuperación de la memoria urbana, arquitectónica y cultural de pequeños centros patrimoniales, suspendidos entre el legado colonial español de las Leyes de Indias y el simbólico de la Revolución Cubana, es el objetivo del proyecto “OCSHC – Oriental Cuba Small Historical Centres: una estrategia integral para la recuperación y puesta en valor inteligente de los centros históricos menores de las provincias orientales de Cuba”. El proyecto, financiado por la Agencia Italiana de Cooperación para el Desarrollo AICS, nace de una iniciativa conjunta entre la Oficina del Conservador de la Ciudad de Santiago de Cuba, la Facultad de Construcciones de la Facultad de Oriente y el Departamento de Arquitectura de la Universidad Roma Tre. OCSHC prevé la definición de una estrategia integral para la construcción de una red de pequeñas ciudades patrimoniales en las provincias de Granma, Santiago de Cuba, Holguín y Guantánamo, en el marco de un escenario de desarrollo sostenible y solidario basado en la recuperación y puesta en valor del patrimonio histórico urbano y de los lugares de la cultura y de las comunidades locales.Este artículo es parte de las actividades de difusión del proyecto OCSHC, financiado por la Agencia Italiana para la Cooperación al Desarrollo (Ministerio de Relaciones Exteriores, Gobierno italiano).Peer Reviewe
Pianificare nella Città dei Poveri. L’esperienza del Plan Maestro per il “Ramal A” di Zacatecoluca (El Salvador) | Planning in the city of the poor. The experience of the Plan Maestro for the Ramal A in Zacatecoluca (El Salvador)
No full textLa crescita rapida degli insediamenti informali, in Africa, in Asia e soprattutto in America Latina, non è ascrivibile solo all’esplosione demografica e a fenomeni globali, ma rappresenta il fallimento di politiche abitative, urbane, economiche e assistenziali a più livelli, nazionali e locali. In queste aree la dicotomia tra formale e informale si
traduce in una netta separazione tra Città dei ricchi e Città dei poveri: le prime dentro mura sorvegliate, le seconde che si insinuano intorno a queste, nei meandri della città frammentata e diffusa. Questa “negazione” della città è la rappresentazione spaziale delle politiche di alimentazione della paura - per il diverso, per il povero - che sviluppano intolleranza e producono diseguaglianza sociale, segregazione e un senso di abbandono e marginalità che si traduce in criminalità, radicalizzazione, scontri interni e esterni. In questo contesto si inserisce il Plan Maestro per il recupero e integrazione di un insediamento precario nella città di Zacatecoluca (El Salvador), il Ramal A, uno dei 26 insediamenti urbani precari, in prevalenza a precarietà estrema e alta, identificati nella “Mapa de Pobreza Urbana y Exclusion Social” del Programma delle Nazioni Unite per lo Sviluppo. Il Plan Maestro vede la luce nell’ambito del Progetto “Fortalecimiento de la Secretaría de Cultura de la Presidencia de El Salvador a través de la valorización del patrimonio cultural” realizzato dall’Università Roma Tre con la collaborazione di FUNDASAL FundaciónSalvadoreña de Desarrollo y Vivienda Mínima, finanziato dall’AICS Agenzia Italiana per la Cooperazione allo Sviluppo. Rappresenta un’esperienza virtuosa nelle attività della cosiddetta Terza Missione dell’Università.The rapid growth of informal settlements, in Africa, Asia and especially in Latin America, cannot be attributed only to the demographic explosion and global phenomena, but represents the failure of housing, urban, economic and welfare at multiple levels, national and local. In these areas the dichotomy between formal and informal exists
translates into a clear separation between the City of the rich and the City of the poor: the former within guarded walls, the latter creeping around them, in the meanders of the fragmented and widespread city. This "denial" of the city is the spatial representation of the policies of fueling fear - for those who are different, for the poor - which develop intolerance and produce social inequality, segregation and a sense of abandonment and marginality which translates into crime, radicalisation, clashes internal and external. The Plan Maestro is inserted in this context for the recovery and integration of a precarious settlement in the city of Zacatecoluca (El Salvador), the "Ramal A", one of the 26 precarious urban settlements, mainly with extreme and high precariousness, identified in the "Map of Urban Poverty and Social Exclusion” of the United Nations Development Programme. The Plan Maestro was born as part of the project "Strengthening the Secretariat of Culture of the Presidency of El Salvador through the valorisation of cultural heritage", carried out by the Roma Tre University with the collaboration of FUNDASAL Salvadorian Foundation for Development and Minimum Living and financed by AICS, the Italian Agency for Development Cooperation. It represents a virtuous experience in the activities of the so-called Third Mission of the University
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