717 research outputs found
Sine terra
No full textSine terra raccoglie alcuni progetti e riflessioni che precedono e seguono il workshop omonimo del ciclo Wave che si è tenuto presso l'Università Iuav di Venezia a luglio 2014. Il workshop è stato condotto dai Prof.ri Sara Marini e Benno Albrecht e dai tutors Cristina Baggio, Giovanni Carli, Verdiana Chiesatto, Sara Dotto, Filippo Farronato, Chiara Paone.
Hanno partecipato al workshop gli studenti Roberta Ballico, Chiara Bassan, Tommaso Bisogno, Enrico Bivi, Valentina Braghetto, Herman Buzali, Mirco Cabbia, Federica Caregnato, Davide Castegnaro, Claudia Ceccarello, Fabiana Cortolezzis, Mauro Da Ros, Edoardo Del Conte, Luca Ruggiero D'Elia, Veronica Donà, Alessandro Dona, Giuseppe D'Orsi, Rexhina Fera, Roberto Ferro, Matilde Focchessato, Claudio Franceschetti, Veronica Gaiani, Gaia Carolina Garelli, Filippo Marchiori, Aljoša Marković, Anna Marsella, Claretta Mazzonetto, Laura Moglia, Arianna Mondin, Paolo Nadin, Clelia Nobili, Erica Nonis, Fabio Papandrea, Chiara Pegoraro, Matija Perić, Alberto Petracchin, Giacomo Pincerato, Maria Elena Poloni, Alvise Ritta, Riccardo Rizzetto, Francesca Rocchi, Mary Rosada, Nicola Ruaro, Marco Santoni, Anna Sedino, Michael Silvestri, Luca Soliman, Nicola Stecca, Andrea Stocco, Giulia Tocchet, Isabella Vivaldi, Davide Zaupa
The Influence of Insecure Romantic Attachment on Generativity
No full textExisting research concerning the development of generativity, the capacity to provide care and guidance to future generations, has primarily focused on the role of sociodemographic variables. However, one important feature that might be of importance for the study of generativity is insecure romantic attachment, given its influence on how people establish relationships with others. Still, the role of the two dimensions of insecure romantic attachment (i.e., anxiety and avoidance) on the most studied aspects of generativity (i.e., generative concern and generative acts) remains largely underexplored. Therefore, the present study investigates what contributes to generativity by exploring the role of sociodemographic features (i.e., age, gender, having children, years of education) and above all the two dimensions of insecure romantic attachment on generative concern and acts. A sample of 427 adults (age range: 25–65 years old) completed an online survey including romantic attachment and generativity measures. Afterwards, correlational and regression analyses were conducted to explore the data. Results showed that years of education positively predicted generative concern, whereas both anxiety and avoidance negatively predicted it. Yet, no sociodemographic feature nor dimension of insecure romantic attachment predicted generative acts. Thus, insecure romantic attachment could be a useful key to understanding generative concern. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature
Measurement of sorafenib plasma concentration by high-performance liquid chromatography in patients with advanced hepatocellular carcinoma: is it useful the application in clinical practice? A pilot study
No full textPharmacokinetics and dose-finding studies on sorafenib were conducted on heterogeneous groups of patients with solid tumors. Portal hypertension, gut motility impairment and altered bile enterohepatic circulation may explain different sorafenib toxicological profile in cirrhotic patients. This study evaluated sorafenib plasma concentration in a homogeneous group of cirrhotic patients with hepatocellular carcinoma (HCC). Sorafenib concentrations were determined by liquid chromatography in 12 consecutive patients. Data have been evaluated by the generalized estimating equations method (p value statistical level was set at α = 0.05). (1) There were not significant differences between sorafenib concentrations in patients who tolerate the full dose versus patients with reduced dose due to toxicity; (2) the average sorafenib concentrations measured 3 h after the morning dosing were lower than those measured 12 h after the evening dosing (p = 0.005); (3) sorafenib concentrations decrease overtime (p < 10−4); (4) it has been found an association between the development of severe adverse reactions and sorafenib concentrations (p < 10−5). The relationship between dose and concentration of sorafenib in HCC patients is poor and not clinically predictable, confirming the variability both in the maximum tolerated dose and in plasma concentrations. Several factors may influence the pharmacokinetics in patients with liver disease. This may explain the inter-patient variability of concentrations and the lack of differences in concentration at different dosages. It could be interesting to extend the series of HCC patients to enhance information on the kinetics of the drug; furthermore, to establish a threshold of plasma sorafenib concentrations to predict severe adverse reactions would be clinically usefu
Corrigendum: The new Italian registry of infantile thrombosis (RITI): a reflection on its journey, challenges and pitfalls
No full textIn the published article, there was an error in the appendix. An author name was incorrectly written as Foidaelli Thomas. The correct spelling is Foiadelli Thomas. The correct appendix appears below. – Accorsi Patrizia – Aceto Gabriella – Agnoletti Gabriella – Agostini Manuela – Alfarano Angela – Altieri Elena – Amador Carolina – Antonelli Camilla – Arena Vittoria – Asta Francesca – Baggio Laura – Ballardini Elisa – Baracetti Margherita – Baraldi Eugenio – Barberis Laura – Barisone Elena – Basso Anne Letizia – Battajon Nadia – Bersani Iliana – Biddeci Giada – Biffanti Roberta – Bonardi Claudia Maria – Bonaudo Roberto – Boniver Clementina – Boscarol Gianluca – Bottino Roberto – Bravar Giulia – Brizzi Ilaria – Brolatti Noemi – Braguglia Annabella – Guaragni Brunetta – Bugin Samuela – Calvo Pier Luigi – Capasso Antonella – Capodiferro Donatella – Cappelleri Alessia – Cascarano Maria Teresa – Casellato Susanna – Casini Tommaso – Catarzi Serena – Cavaliere Elena – Cavicchiolo Maria Elena – Celestino Silvia – Celle Maria Elena – Centonze Nicola – Cerutti Alessia – Chakrokh Roksana – Offer Chiara – Chiodin Elisabetta – Chirico Gaetano – Chukhlantseva Natalia – Cifarelli Paola – Cinelli Giulia – Coinu Marisa – Colonna Clara – Comito Donatella – Corato Alessandra – Cordelli Duccio Maria – Crichiutti Giovanni – Cursio Ida – Dagri Arianna – De Maria Beatrice – Del Borrello Giovanni – Di Rienzo Francesca – Doglioni Nicoletta – Dolcemascolo Valentina – Dotta Andrea – Drigo Paola – Drimaco Pietro – Ellero Serena – Falcone Alessandra – Fantauzzi Ambra – Farinasso Daniela – Ferilli Michela – Festa Silvia – Fischer Maximilian – Foiadelli Thomas – Fotzi Ilaria – Francavilla Rosa – Freschi Paola – Gaffuri Marcella – Gallo Elena – Gamalero Lisa – Gandioli Claudia – Garuccio Sergio – Gentile Diletta – Ghionzoli Marco – Giliberti Paola – Greco Filippo – Guariento Chiara – Guidotti Isotta – Iodice Alessandro – Janes Augusta – Laghi Elena – Lampugnani Elisabetta – Lassandro Giuseppe – Laverda Anna Maria – Lazzerotti Alessandra – Lo Tartaro Meragliotta Patrizia – Lombardini Martina – Lorenzon Eleonora – Mainini Nicoletta – Massoud Michela – Materia Valeria – Mattera Raffaele – Mauro Isabella – Melani Federico – Meli Mariaclaudia – Messina Giovanni – Monticone Sonia – Moras Marzia – Negro Ilaria – Olzai Giorgio – Pancani Simone – Pandolfi Maria – Passariello Annalisa – Passarini Alice – Passone Eva – Pastorino Myriam – Pegoraro Veronica – Pennoni Serena – Perilongo Giorgio – Pozzessere Anna – Pruna Dario – Pusiol Anna – Putti Maria Caterina – Rabbone Ivana – Radicioni Maurizio – Renna Salvatore – Ricci Maria Luisa – Rimini Alessandro – Rivellini Sara – Rustioni Gianluca – Salvadori Sabrina – Santoiemma Valentina – Santoro Nicola – Schiavulli Michele – Sebellin Sofia – Sesta Michela – Soffiati Massimo – Sorbo Monica – Spanedda Giuseppina – Stangalini Valeria – Stasolla Salvatore – Tanzi Giorgia – Testa Tiziana – Teutonico Federica – Timpani Giuseppina – Toldo Irene – Trapani Sandra – Vaccari Roberto – Vecchi Marilena – Vento Giovanni – Veraldi Daniele – Villa Giovanna – Visintin Gianluca – Zambelloni Cesare – Zellini Francesco – ASST Spedali Civili of Brescia, Brescia – Azienda Ospedaliera Bianchi-Melacrino-Morelli di Reggio Calabria, Reggio Calabria – Azienda Ospedaliera Policlinico Di Bari, Bari – Bambin Gesù Children’s Hospital, Roma – Central Teaching Hospital of Bolzano, Bolzano – Giannina Gaslini Hospital, Genova – Niguarda Hospital, Milano – Ospedale Civile SS. Annunziata, Sassari – San Bortolo Hospital, Vicenza – San Matteo Hospital, Pavia – Santa Chiara Hospital, Trento – ULSS 2 Marca Trevigiana, Treviso – ULSS 8 Berica, Vicenza – University Hospital “Azienda Ospedaliero-Universitaria Meyer”, Firenze – University Hospital Città della Salute e della Scienza, Torino – University Hospital of Modena, Modena – University Hospital of Padova, Padova – University Hospital of Udine, Udine – University Hospital of Verona, Verona – University of Bari, Bari – University of Bologna, Bologna – University of Cagliari, Cagliari – University of Catania, Catania – University of Ferrara, Ferrara – University of Napoli “Federico II”, Napoli – University of Perugia, Perugia The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated
Safety and tolerability of deferasirox in pediatric hematopoietic stem cell transplant recipients: one facility's five years’ experience of chelation treatment
No full textDuodenal-jejunal bypass improves nonalcoholic fatty liver disease independently of weight loss in rodents with diet-induced obesity
No full textNonalcoholic fatty liver disease (NAFLD) is the most common cause of liver-related mortality. NAFLD is associated with obesity, hepatic fat accumulation, and insulin resistance, all of which contribute to its pathophysiology. Weight-loss is the main therapy for NAFLD, and metabolic surgery is the most effective treatment for morbid obesity and its metabolic comorbidities. Although has been reported that Roux-en-Y gastric bypass can reverse NAFLD, it is unclear whether such effects result from reduced weight, from a lower calorie-intake, or from the direct influence of surgery on mechanisms contributing to NAFLD. We aimed to investigate whether gastrointestinal (GI) bypass surgery could induce direct effects on hepatic fat accumulation and insulin resistance, independently of weight reduction. Twenty Wistar rats on a high-fat diet underwent duodenal-jejunal-bypass (DJB) or sham operation and were pair fed (PF) for 15 wk after surgery to obtain a matched weight. Outcome measures include ectopic fat deposition, expression of genes and proteins involved in fat metabolism, insulin-signaling, and gluconeogenesis in liver and muscle. Despite no differences in body weight and calorie intake, DJB showed lower ectopic fat accumulation, improved peripheral and hepatic insulin sensitivity, and enhanced lipid droplet degradation. In both tissues, DJB increased insulin signaling, whereas hepatic key enzymes involved in gluconeogenesis and de novo lipogenesis were decreased. These findings suggest that DJB can reverse, independently of weight loss, ectopic fat deposition and insulin resistance, two features of NAFLD that share a mutual pathway, in which perilipin-2 (PLIN2) seems to be the main player, supporting further investigation into strategies that target the gut to treat metabolic liver diseases.NEW & NOTEWORTHY Our findings suggest that duodenal-jejunal bypass can reverse, independently of weight loss, ectopic fat deposition and insulin resistance, two features of nonalcoholic fatty liver disease that share a mutual pathway, in which perilipin-2 seems to be the main player. Our study supports further investigation into the role of proximal small intestine exclusion in the pathophysiology of nonalcoholic fatty liver disease to uncover less invasive treatments that mimic the effects of metabolic surgery and aims to prevent and treat metabolic liver disease
Using Cone Beam Computed Tomography for Radiological Assessment Beyond Dento-maxillofacial Imaging: A Review of the Clinical Applications in other Anatomical Districts
No full textBackground: Cone Beam Computed Tomography (CBCT) represents the optimal imaging solution for the evaluation of the maxillofacial and dental area when quantitative geometric and volumetric accuracy is necessary (e.g., in implantology and orthodontics). Moreover, in recent years, this technique has given excellent results for the imaging of lower and upper extremities. Therefore, significant interest has been increased in using CBCT to investigate larger and non-traditional anatomical districts. Objective: The purpose of this work is to review the scientific literature in Pubmed and Scopus on CBCT application beyond head districts by paying attention to image quality and radiological doses. Method: The search for keywords was conducted in Pubmed and Scopus databases with no back-date restriction. Papers on applications of CBCT to head were excluded from the present work. From each considered paper, parameters related to image quality and radiological dose were extracted. An overall qualitative evaluation of the results extracted from each issue was done by comparing the conclusive remarks of each author regarding doses and image quality. PRISMA statements were followed during this process. Results: The review retrieved 97 issues from 83 extracted papers; 46 issues presented a comparison between CBCT and Multi-Detector Computed Tomography (MDCT), and 51 reviewed only CBCT. The radiological doses given to the patient with CBCT were considered acceptable in 91% of cases, and the final image quality was found in 99%. Conclusion: CBCT represents a promising technology not only for imaging of the head and upper and lower extremities but for all the orthopedic districts. Moreover, the application of CBCT derived from C-arms (without the possibility of a 360 ° rotation range) during invasive investigations demonstrates the feasibility of this technique for non-standard anatomical areas, from soft tissues to vascular beds, despite the limits due to the incomplete rotation of the tube
Acute pediatric encephalitis: etiology, course, and outcome of a 12-year single-center immunocompetent cohort
No full textBackgroundEncephalitis is an uncommon but severe disorder due to an inflammation of the brain parenchyma, usually diagnosed on clinical, laboratory, electroencephalographic, and neuroradiological features. New causes of encephalitis have been reported in recent years, so diagnostic criteria have changed over time.We report on a single-center experience of a pediatric Hospital, the hub of its region, over 12 years (2008-2021), with the evaluation of all children managed for acute encephalitis.MethodsWe retrospectively reviewed clinical, laboratory, neuroradiological, and EEG data from the acute phase and outcome of all immunocompetent patients diagnosed with acute encephalitis. According to the newly proposed criteria for pediatric autoimmune encephalitis, we divided patients into infectious, definite autoimmune, probable autoimmune, and possible autoimmune, and performed a comparison between the different groups.Results48 patients (26 females, mean age 4.4 years), 19 with infections, and 29 with autoimmune encephalitis, were included. Herpes simplex virus 1 encephalitis was the most frequently identified etiology followed by anti-NMDA receptor encephalitis. Movement disorders at onset and a longer hospital stay were observed more frequently in autoimmune compared to infectious encephalitis (pp < 0.001 and p = 0.001, respectively).Among the autoimmune group, children who started immunomodulatory treatment earlier (within 7 days from onset) had more frequent complete functional recovery (p = 0.002).ConclusionsHerpes virus and anti-NMDAR encephalitis are the most frequent etiologies within our cohort. Clinical onset and course are extremely variable. Since early immunomodulatory treatment was associated with a better functional outcome, our data confirm that a timely diagnostic classification in definite, probable, or possible autoimmune encephalitis can help the clinician in a successful therapeutic approach
Population pharmacokinetics and probability of target attainment of meropenem in critically ill patients
No full textPurpose: Patients admitted to intensive care unit (ICU) with Klebsiella pneumoniae infections are characterized by high mortality. The aims of the present study were to investigate the population pharmacokinetics parameters and to assess the probability of target attainment of meropenem in critically ill patients to provide information for more effective regimens. Methods: Twenty-seven consecutive patients were included in the study. Meropenem was administered as 3-h intravenous (i.v.) infusions at doses of 1–2 g every 8 or 12 h. Meropenem plasma concentrations were measured by a high-performance liquid chromatography (HPLC) method, and a population pharmacokinetics analysis was performed using NONMEM software. Meropenem plasma disposition was simulated for extended (3 h; 5 h) or continuous i.v. infusions, and the following parameters were calculated: time during which free drug concentrations were above minimum inhibitory concentration (MIC) (fT > MIC), free minimum plasma concentrations above 4× MIC (fCmin > 4× MIC), probability of target attainment (PTA), and cumulative fraction of response (CFR). Results: Gender and severity of sepsis affected meropenem clearance, whose typical population values ranged from 6.22 up to 12.04 L/h (mean ± standard deviation (SD) value, 9.38 ± 4.47 L/h). Mean Cmin value was 7.90 ± 7.91 mg/L, suggesting a high interindividual variability. The simulation confirmed that 88 and 97.5 % of patients achieved effective Cmin > 4× MIC values after 3- and 5-h i.v. infusions of meropenem 2 g × 3/day, respectively. On the contrary, the same total daily doses reached the target Cmin > 4× MIC values in 100 % of patients when administered as continuous i.v. infusions. Conclusions: Several factors may influence meropenem pharmacokinetics in ICU patients. Continuous i.v. infusions of meropenem seem to be more effective than standard regimens to achieve optimal therapeutic targets
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