5 research outputs found
Trace amines produced by skin bacteria accelerate wound healing in mice
Full text linkCertain skin bacteria are able to convert aromatic amino acids (AAA) into trace amines (TA) that act as neuromodulators. Since the human skin and sweat contain a comparatively high content of AAA one can expect that such bacteria are able to produce TA on our skin. Here we show that TA-producing Staphylococcus epidermidis strains expressing SadA are predominant on human skin and that TA accelerate wound healing. In wounded skin, keratinocytes produce epinephrine (EPI) that leads to cell motility inhibition by β2-adrenergic receptor (β2-AR) activation thus delay wound healing. As β2-AR antagonists, TA and dopamine (DOP) abrogate the effect of EPI thus accelerating wound healing both in vitro and in a mouse model. In the mouse model, the S. epidermidis wild type strain accelerates wound healing compared to its ΔsadA mutant. Our study demonstrates that TA-producing S. epidermidis strains present on our skin might be beneficial for wound healing.Fil: Luqman, Arif. Eberhard Karls Universität Tübingen.; Alemania. Institut Teknologi Sepuluh Nopember; IndonesiaFil: Muttaqin, Muhammad Zainul. Universitas Muhammadiyah Gresik; IndonesiaFil: Yulaipi, Sumah. Institut Teknologi Sepuluh Nopember; IndonesiaFil: Ebner, Patrick. Eberhard Karls Universität Tübingen.; AlemaniaFil: Matsuo, Miki. Eberhard Karls Universität Tübingen.; AlemaniaFil: Zabel, Susanne. Eberhard Karls Universität Tübingen.; AlemaniaFil: Tribelli, Paula Maria. Eberhard Karls Universität Tübingen.; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Nieselt, Kay. Universitas Muhammadiyah Gresik; IndonesiaFil: Hidayati, Dewi. Institut Teknologi Sepuluh Nopember; IndonesiaFil: Götz, Friedrich. Eberhard Karls Universität Tübingen.; Alemani
Implementasi Widuri Sebagai Media Penyimpanan Laporan Dari Referensi Digital Karya Ilmiah
Full text linkReports of KKP / TA / SKRIPSI is one of the requirements that must be traveled by students to complete the final level of research that has been done. Preparation of reports are currently running manually using paper media . There were identified 5 ( five) subject matter that is formulated to find out the answer. There are also 3 ( three ) benefits , and there are 6 (six) advantages and 1 (one ) shortcomings of the proposed new system. Widuri is a medium for learning, especially Pribadi Raharja in Perguruan Tinggi Raharja. In order to enrich the insights and knowledge, sharing knowledge with others , improve and develop creativity in writing the article. To identify existing problems such as reports on library storage inefficient and writing reports that still use manual design methods ekplotatory author. The author also makes the UML and Literature review on Wiki as a research method. This study aims to allow students to use as a storage facility Widuri report of KKP / TA / SKRIPSI and make references that can be accessed online . By applying widuri as storag Report KPP / TA / SKRIPSI may facilitate students in making a report and look for references. It can be concluded that the WIduri is able to overcome the problems that occur in the collection of the report KKP / TA / SKRIPSI in Perguruan Tinggi Raharja
Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non‐genetic risk factors for Alzheimer's disease among Asian Americans and Canadians
No full textINTRODUCTION: Clinical research in Alzheimer's disease (AD) lacks cohort diversity despite being a global health crisis. The Asian Cohort for Alzheimer's Disease (ACAD) was formed to address underrepresentation of Asians in research, and limited understanding of how genetics and non-genetic/lifestyle factors impact this multi-ethnic population.
METHODS: The ACAD started fully recruiting in October 2021 with one central coordination site, eight recruitment sites, and two analysis sites. We developed a comprehensive study protocol for outreach and recruitment, an extensive data collection packet, and a centralized data management system, in English, Chinese, Korean, and Vietnamese.
RESULTS: ACAD has recruited 606 participants with an additional 900 expressing interest in enrollment since program inception.
DISCUSSION: ACAD's traction indicates the feasibility of recruiting Asians for clinical research to enhance understanding of AD risk factors. ACAD will recruit > 5000 participants to identify genetic and non-genetic/lifestyle AD risk factors, establish blood biomarker levels for AD diagnosis, and facilitate clinical trial readiness.
HIGHLIGHTS: The Asian Cohort for Alzheimer's Disease (ACAD) promotes awareness of under-investment in clinical research for Asians. We are recruiting Asian Americans and Canadians for novel insights into Alzheimer's disease. We describe culturally appropriate recruitment strategies and data collection protocol. ACAD addresses challenges of recruitment from heterogeneous Asian subcommunities. We aim to implement a successful recruitment program that enrolls across three Asian subcommunities
Surgical site infection after gastrointestinal surgery in children: An international, multicentre, prospective cohort study
Full text linkSurgical site infection (SSI) is one of the most common healthcare-associated infections (HAIs). However, there is a lack of data available about SSI in children worldwide, especially from low-income and middle-income countries. This study aimed to estimate the incidence of SSI in children and associations between SSI and morbidity across human development settings
A comprehensive health effects assessment of the use of sanitizers and disinfectants during COVID-19 pandemic: a global survey
No full textCOVID-19 has affected all aspects of human life so far. From the outset of the pandemic, preventing the spread of COVID-19 through the observance of health protocols, especially the use of sanitizers and disinfectants was given more attention. Despite the effectiveness of disinfection chemicals in controlling and preventing COVID-19, there are critical concerns about their adverse effects on human health. This study aims to assess the health effects of sanitizers and disinfectants on a global scale. A total of 91,056 participants from 154 countries participated in this cross-sectional study. Information on the use of sanitizers and disinfectants and health was collected using an electronic questionnaire, which was translated into 26 languages via web-based platforms. The findings of this study suggest that detergents, alcohol-based substances, and chlorinated compounds emerged as the most prevalent chemical agents compared to other sanitizers and disinfectants examined. Most frequently reported health issues include skin effects and respiratory effects. The Chi-square test showed a significant association between chlorinated compounds (sodium hypochlorite and per-chlorine) with all possible health effects under investigation (p-value <0.001). Examination of risk factors based on multivariate logistic regression analysis showed that alcohols and alcohols-based materials were associated with skin effects (OR, 1.98; 95%CI, 1.87–2.09), per-chlorine was associated with eye effects (OR, 1.83; 95%CI, 1.74–1.93), and highly likely with itching and throat irritation (OR, 2.00; 95%CI, 1.90–2.11). Furthermore, formaldehyde was associated with a higher prevalence of neurological effects (OR, 2.17; 95%CI, 1.92–2.44). Furthermore, formaldehyde was associated with a higher prevalence of neurological effects (OR, 2.17; 95%CI, 1.92–2.44). The use of sodium hypochlorite and per-chlorine also had a high chance of having respiratory effects. The findings of the current study suggest that health authorities need to implement more awareness programs about the side effects of using sanitizers and disinfectants during viral epidemics especially when they are used or overused
