720 research outputs found
Online_Appendix – Supplemental material for The economic crisis and changes in work–family arrangements in six European countries
No full textSupplemental material, Online_Appendix for The economic crisis and changes in work–family
arrangements in six European countries by Giulia Maria Dotti Sani in Journal of European
Social Policy</p
"Avere credito". Finanze locali, istituzioni e famiglie a Como in antico regime
No full textIl lavoro si occupa dell'uso degli strumenti di credito (compreso il debito pubblico) nelle pratiche sociali e caritative nella Como di antico regime
Update on Several/Certain Adult-Onset Genetic Leukoencephalopathies: Clinical Signs and Molecular Confirmation.
No full textAdult-onset leukoencephalopathies are clinically and pathologically heterogeneous diseases, characterized by overlapping clinical and neuroradiological features and a difficult diagnostic process. Nevertheless, knowledge of the metabolic and genetic basis of leukoencephalopathies is constantly increasing. This article provides an overview of currently known leukoencephalopathies in adulthood, emphasizing, in addition to the classical forms, their atypical clinical presentations. In particular, we review the clinical spectrum and the molecular pathogenesis of certain adult-onset leukoencephalopathies, including cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL), cerebroretinal microangiopathy with calcifications and cysts (CRMCC), hereditary diffuse leukoencephalopathy with spheroids (HDLS), fragile X-associated tremor/ataxia syndrome (FXTAS), vanishing white matter disease (VWM), autosomal dominant leukodystrophy due to lamin B1 duplication (ADLD), and vascular leukoencephalopathy mapping to chromosome 20q13
Time Use in Domestic Settings Throughout the Life Course : The Italian Case
No full textThe volume is the first to take a life-course approach to the study of domestic work in Italy. It provides a coherent and systemic overview of time spent on housework, childcare and adult care over the life course. While most previous research has focused on the time adult women and men spend on housework and the division of domestic chores among partners, this unique contribution studies the amount of time spent on chores by Italians in different phases of the life course. It addresses relevant aspects often neglected in time use studies, such as the socialization to domestic chores among children, teenagers and young adults living in the parental home and the reproduction of gender inequalities in housework at later stages of the life course
Physiology and pathology of notch signalling system.
No full textNotch proteins encode a family of transmembrane receptors that are part of a signalling transduction system known as Notch signalling, an extremely conserved and widely used mechanism regulating programs governing growth, apoptosis and differentiation in metazoans. Notch signalling begins when the Notch receptor binds ligands and ends when the Notch intracellular domain enters the nucleus and activates transcription of target genes. This core pathway is subjected to a wide array of regulatory influences and protein-protein interactions and is correlated with other signalling pathway. This review will summarize recent findings concerning the physiology and pathology of Notch signalling in vascular development and homeostasis. Moreover, the clinical phenotypes of Notch3 signalling system pathology will be described, with particular regard to CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) for which the most recent pathogenetic hypotheses are reported
Cerebrotendinous xanthomatosis.Heterogeneity of clinical phenotype with evidence of previosuly undescribed ophthalmological findings
No full textCerebrontendinous xanthomatosis (CTX) is a rare autosomal recessive neurometabolic disease involving lipid metabolism. The classical phenotype is characterized by neurological dysfunction, tendon xanthomas and juvenile cataracts. Other ophthalmological findings have occasionally been reported. To gain more insight into the type and frequency of ophthalmological alterations in this multisystem metabolic disorder, we examined 13 CTX patients. Besides cataracts, found in all cases, the second most frequent ocular abnormality was paleness of the optic disk, which was found in 6 patients and was probably previously underestimated. Signs of premature retinal senescence were also observed. We discuss the possible relation between these ocular manifestations and the metabolic defect
Caravaggio, Canestro di Frutta
No full textLa scheda fa il punto sul celeberrimo dipinto di Caravaggio caposaldo della Natura morta europea qui presentato in una delle sue rarissime occasioni espositiv
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