131 research outputs found
Identità professionali, competenze e relazione di cura: la sfida del multiculturalismo nei contesti educativi e sociosanitari
No full textDossier “The Harmonies and Conflicts of Law, Reason and Emotion: A Literary-Legal Approach. Proceedings of the Special Workshop on ‘Law and Literature’ held at 27th IVR World Conference, Washington, D.C. 27 July – 1 August 2015”
No full textThe topic ‘Law and Emotion’ has prompted a collection of papers previously presented in the Special Workshop that the editors co-convened in 2015 in Washington, D.C., on the occasion of the XXVII World Congress of the International Association for the Philosophy of Law and Social Philosophy. Presented as articles in this volume,they explore (at least one of) the topics suggested above and they do so from a variety of theoretical and cultural-disciplinary backgrounds. They find a common ground in the task of reflection on the relationship between law and emotion through the privileged lens of literature. This Special Workshop has made possible a permanent relationship among the European Network for Law and Literature, here represented by Jeanne Gaakeer; the Italian Society for Law and Literature, coordinated by Carla Faralli and M. Paola Mittica; and the research group rooted in Brazil under the guidance of Marcelo Galuppo
Coworking space as a practised place between welfare working and managerial challenges
No full textPurpose: The paper aims to analyse a specific configuration of coworking space that emphasises the production of social value in the territory (resilient/welfare-oriented coworking). This kind of space represents the current evolution of coworking that recovers the original meaning of coworking space to promote social changes, questions the role of the physical space and brings to the fore its connections between the internal (space) and the external (territory). Design/methodology/approach: The paper presents an action research on a rising network of coworking spaces. The action research was based on qualitative interviews of the founders and main stakeholders of the network and monthly meetings discussions with the steering committee of the coworking spaces. Findings: The paper provides some key elements that highlight different meanings related to the value produced by the coworking spaces and related interpretations of the material and immaterial characteristics of the spaces. The results also highlight different managerial challenges connected with these interpretations. Originality/value: The main results of the study shed light on the fact that it is not enough to focus on material aspects of the coworking space, such as the design and the dispositions of furniture and the curatorship of the relationships among coworkers, if the desired outcome is a reinterpretation of work against the consolidated individualistic paradigm. Rather, the boundary work is the condition that permits to sustain and maintain the evolutionary trajectory of coworking in the most innovative direction. Inside a network of different stakeholders, aimed at integrating individual and collective needs, the constant crossing of boundaries between people, relationships and contexts is the process that permits to generate new meanings and possibilities of action (affordance), holding a transformative potential
Tuscan black kale sprout extract bioactivated with myrosinase: a novel natural product for neuroprotection by inflammatory and oxidative response during cerebral ischemia/reperfusion injury in rat
No full textBackground: Cerebral ischemia and reperfusion (CIR) is a pathological condition characterized by a first blood supply restriction to brain followed by the consequent restoration of blood flow and simultaneous reoxygenation.The aim of this study was to evaluate the neuroprotective effects of Tuscan black kale sprout extract (TBK-SE) bioactivated with myrosinase enzyme, assessing its capability to preserve blood-brain barrier (BBB), in a rat model of CIR.Methods: CIR was induced in rats according to a classic model of carotid artery occlusion for a time period of 1 h and the reperfusion time was prolonged for seven days.Results: By immunohistochemical evaluation and western blot analysis of brain and cerebellum tissues, our data have clearly shown that administration of bioactive TBK-SE is able to restore alterations of tight junction components (claudin-5 immunolocalization). Also, bioactive TBK-SE reduces some inflammatory key-markers (p-selectin, GFAP, Iba-1, ERK1/2 and TNF-alpha), as well as the triggering of neuronal apoptotic death pathway (data about Bax/Bcl-2 balance, p53 and cleaved-caspase 3) and the generation of radicalic species by oxidative stress (results focused on iNOS, nitrotyrosine and Nrf2).Conclusion: Taken together, our findings lead to believe that bioactive TBK-SE exerts pharmacological properties in protecting BBB integrity through a mechanism of action that involves a modulation of inflammatory and oxidative pathway as well into control of neuronal death
A new formulation of cannabidiol in cream shows therapeutic effects in a mouse model of experimental autoimmune encephalomyelitis
No full textCervantes, Borges and i - who is the author?
No full textLiterature can teach us a lot about what Law is, such as when we apply the concept of author to understand the development of legal statutes. Such concept presents a challenge for the area of Law and Literature: who is the Constitution’s author, and how is it possible that the reader of the constitutional text may identify oneself as its author? This problem, (which opposes originalists and living-constitution authors) can be better understood if we take the Constitution as a looking glass (mise-en-abyme, or Droste effect): although the framers had made it, it actually reflects the one who looks into it. Therefore, we need to understand the Constitution from the standpoint of the tension between sense and reference (or denotation).A literatura pode ensinar-nos muito sobre o direito, quando, por exemplo, utilizamos o conceito de autor para compreender o desenvolvimento de textos normativos. Esse conceito cria uma tarefa para o campo de estudo do Direito e Literatura: determinar quem é o autor da Constituição, e como é possível ao leitor do texto constitucional reconhecer-se no lugar de seu autor. Esse problema, que opõe os autores do originalismo e da living constitution, pode ser melhor compreendido se concebermos o texto constitucional como um espelho (mise-en-abyme): ainda que elaborado pelo poder constituinte originário, o que ele reflete é quem de fato se olha em tal espelho. A partir dessa perspectiva, proponho que a Constituição seja compreendida a partir da tensão entre seu sentido e sua referência (ou denotação)
Is β-catenin neutralization cross-involved in the mechanisms mediated by natalizumab action?
No full textAberrant activation of Wnt/β-catenin signaling pathway is commonly associated to cancer development. However, molecular mechanisms controlling Wnt/β-catenin signaling pathway have been clarified only in part. Here, we show that β-catenin is differently modulated in patients with multiple sclerosis (MS), displaying that different pharmacological treatments used for clinical MS management cause different nuclear expression levels of β-catenin. Proteins extracted by peripheral blood mononuclear cells were assessed to evaluate the western blot expression levels of β-catenin. Analyzing our results, we realized that β-catenin is totally inhibited by Natalizumab and could have a role in MS management. This could offer new promising studies focused on the possible therapeutic control of β-catenin translocation
Protective role of (RS)-glucoraphanin bioactivated with myrosinase in an experimental model of multiple sclerosis
No full textThe discovery of new natural compounds with pharmacological properties is a field of interest widely growing. Recent literature shows that Brassica vegetables (Cruciferae) possess therapeutic effects particularly ascribed due to their content in glucosinolates, which upon myrosinase hydrolysis release the corresponding isothiocyanates. This study examines the potential neuroprotective and immunomodulatory effects of (RS)-glucoraphanin from Tuscan black kale (Brassica oleracea L. var. acephala sabellica) bioactivated with myrosinase (bioactive RS-GRA) (10 mg/kg/day intraperitoneally), in an experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis. Methods: EAE was induced by immunization with myelin oligodendroglial glycoprotein peptide (MOG35-55) in mice. After immunization, mice were observed daily for signs of EAE and weight loss. Clinical score was evaluated using a standardized scoring system. Results: By Western blot analysis of spinal cord tissues, we have demonstrated that treatment with bioactive RS-GRA significantly decreased nuclear factor (NF)-kB translocation, pro-inflammatory cytokine production such as interleukin-1Î2 (IL-1Î2), and apoptosis (Bax and caspase 3 expression). Conclusion: Our results clearly demonstrate that bioactive RS-GRA treatment may represent a useful therapeutic perspective in the treatment of this disease. © 2013 John Wiley & Sons Ltd
Anti-inflammatory and anti-apoptotic effects of (RS)- glucoraphanin bioactivated with myrosinase in murine sub-acute and acute MPTP-induced Parkinson's disease
No full textThis study was focused on the possible neuroprotective role of (RS)-glucoraphanin, bioactivated with myrosinase enzyme (bioactive RS-GRA), in an experimental mouse model of Parkinson's disease (PD). RS-GRA is one of the most important glucosinolates, a thiosaccharidic compound found in Brassicaceae, notably in Tuscan black kale seeds. RS-GRA was extracted by one-step anion exchange chromatography, further purified by gel-filtration and analyzed by HPLC. Following, pure RS-GRA was characterized by1H and13C NMR spectrometry and the purity was assayed by HPLC analysis of the desulfo-derivative according to the ISO 9167-1 method. The obtained purity has been of 99%. To evaluate the possible pharmacological efficacy of bioactive RS-GRA (administrated at the dose of 10 mg/kg, ip +5 Î1⁄4l/mouse myrosinase enzyme), C57BL/6 mice were used in two different sets of experiment (in order to evaluate the neuroprotective effects in different phases of the disease), according to an acute (2 injections·40 mg/kg MPTP) and a sub-acute (5 injections·20 mg/kg MPTP) model of PD. Behavioural test, body weight changes measures and immunohistochemical localization of the main PD markers were performed and post-hoc analysis has shown as bioactive RS-GRA is able to reduce dopamine transporter degradation, tyrosine hydroxylase expression, IL-1Î2 release, as well as the triggering of neuronal apoptotic death pathway (data about Bax/Bcl-2 balance and dendrite spines loss) and the generation of radicalic species by oxidative stress (results focused on nitrotyrosine, Nrf2 and GFAP immunolocalization). These effects have been correlated with the release of neurotrophic factors, such as GAP-43, NGF and BDNF, that, probably, play a supporting role in the neuroprotective action of bioactive RS-GRA. Moreover, after PD-induction mice treated with bioactive RS-GRA are appeared more in health than animals that did not received the treatment both for phenotypic behaviour and for general condition (movement coordination, presence of tremors, nutrition). Overall, our results suggest that bioactive RS-GRA can protect neurons against the neurotoxicity involved in PD via an anti-apoptotic/anti-inflammatory action. © 2013 Elsevier Ltd. All rights reserved
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