1,720,977 research outputs found
In vitro and in silico studies of Syk inhibitors as new antimalarial drugs
Full text linkMalaria remains one of the most devastating infectious diseases and despite the current therapies are efficient, the WHO recommends Artemisinin Combination Therapies (ACTs) as the treatments against P. falciparum malaria to limit the artemisinin resistance. Unfortunately, in the Greater Mekong subregion, their efficacy has recently questioned. A new mechanism of action based on the release of denatured haemoglobin products (haemichromes) bound to erythrocyte membrane through the Band 3 protein has recently characterized. This process, mediated by erythrocytic spleen tyrosine kinase (Syk), entails the Tyr phosphorylation of band 3. The consequent membrane destabilization could be essential for P. falciparum egress, since inhibitors of Syk block these events. The aim of this study was to examine the effects of the Syk inhibitors during parasite growth within the human erythrocyte through in vitro experiments and to explore current molecular docking strategies used in drug discovery and medicinal chemistry. In vitro studies have involved the treatment of parasitized erythrocytes with different concentrations of Syk inhibitors and the Tyr phosphorylation levels in Band 3 residues by proteomic approach was evaluated. In silico studies were based on different approaches of molecular modelling. In presence of Syk inhibitors we observed both in silico and in vitro experiments a marked decrease of band 3 phosphorylation which is proportional to the increase of drug dosage. These studies enabled us to better analyse the structure of different compounds and to possibly discover new Syk inhibitors through virtual screening analysis
Geologia
No full textGeologia e ambiente, Cartografia geologica europea ed extraeuropea, Carte geologiche e carte ad altro contenuto geologico specialistico, Cartografia tematica della Regione Lombardia, Progetto cartografia geoambiental
Tra Adda e Serio Morto: modifiche ambientalie centuriazione al confine tra ager beregomensis e ager cremonensis
No full textpartendo dalla ricostruzione delle variazioni intervenute nella geografia fisica e in particolare nell'idrografia e passando poi ad analizzare le persistenze dell'organizzazione del territorio in età romana, si arriva a ricostruire il rapporto tra gli alvei fluviali attivi in età romana e la centuriazione. in particola5re si vede come un vecchuio alveo del serio fungesse in quel periodo come confine tra i territori di bergamo e cermon
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Psychoanalysts, behavior and cognitive therapists: a comparative analysis of personal constructs.
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