41 research outputs found

    Articulating personal pedagogies through learning ecologies

    No full text
    The digital revolution enabled by social and ubiquitous technologies is constantly transforming macro and micro levels of society including industry, organizations and government as well as ways in which we communicate, we work, and we carry on our daily lives. Education is therefore also being challenged to respond to evolving societal demands by supporting the development of competent and engaged citizens. In this context, individuals¿ capability to get involved and exploit the affordances of networked environments for learning and development may condition their opportunities to cope with societal and labor demands. In this chapter, the metaphor of learning ecologies is proposed to provide a framework from which to analyze interactions between individuals and their environment, and the way their experiences across different contexts throughout life promote and shape learning processes. Learning ecologies allow us to explore frontier pedagogies connecting formal, non-formal and informal educational contexts, acting as personal strategies that may orchestrate life-long, life-wide and life-deep learning. We start by defining and framing learning ecologies, providing the theoretical roots and reviewing some recent studies in the field. Next, we propose constructs and models but also strategies and tools that may be of help to enhance and support personal ecologies for learning. Finally, the concept of personal pedagogies is proposed to refer to a set of autonomy and agency skills and attitudes that can be dynamically integrated by individuals to support an ecology for self-development and personal learning. We articulate from this perspective several trends in the area of self-directed learning located in the technological and pedagogical intersection: MOOCs, current awareness, e-portfolios and social networks.La revolución digital habilitada por las tecnologías sociales y en todas partes transforma constantemente los niveles macro y micro de la sociedad, incluyendo industria, organizaciones y gobierno, así como las formas en que nos comunicamos, trabajamos y vivimos nuestra vida cotidiana. La educación, por tanto, está llamada a responder a las cambiantes demandas de la sociedad mediante el apoyo a la formación de ciudadanos competentes y comprometidos. En este contexto, la capacidad individual para involucrarse y explotar las posibilidades de los entornos de red para el aprendizaje y el desarrollo puede condicionar sus oportunidades para hacer frente a las demandas sociales y laborales. En este capítulo, se propone la metáfora de la ecología de aprendizaje para proporcionar un marco a partir del cual analizar las interacciones entre los individuos y su entorno, y la forma en que sus experiencias en diferentes contextos a lo largo de la vida promueven y dan forma a los procesos de aprendizaje. Las ecologías de aprendizaje nos permiten explorar la pedagogía de frontera que conecta contextos educativos formales, no formales e informales, en calidad de estrategias personales que puedan orquestar el aprendizaje a lo largo de toda la vida. Empezamos por definir y enmarcar las ecologías de aprendizaje, proporcionando las raíces teóricas y la revisión de algunos estudios recientes sobre el tema. A continuación, proponemos constructos y modelos, y también las estrategias y herramientas que pueden ser de ayuda para mejorar y apoyar las ecologías personales para el aprendizaje. Por último, se propone el concepto de pedagogías personales para referirse a un conjunto de autonomía, habilidades y actitudes que pueden integrarse de forma dinámica por los individuos para apoyar una ecología para el desarrollo y el aprendizaje personal. Articulamos desde esta perspectiva varias tendencias en el ámbito del aprendizaje autodirigido ubicadas en la intersección tecnológica y pedagógica: MOOCs, alertas de información permanente, e-portfolios y redes sociales.La revolució digital habilitada per les tecnologies socials i a tot arreu transforma constantment els nivells macro i micro de la societat, incloent indústria, organitzacions i govern, així com les formes en què ens comuniquem, treballem i vivim la nostra vida quotidiana. L'educació, per tant, està cridada a respondre a les canviants demandes de la societat mitjançant el suport a la formació de ciutadans competents i compromesos. En aquest context, la capacitat individual per involucrar-se i explotar les possibilitats dels entorns de xarxa per a l'aprenentatge i el desenvolupament pot condicionar les seves oportunitats per fer front a les demandes socials i laborals. En aquest capítol, es proposa la metàfora de l'ecologia d'aprenentatge per a proporcionar un marc a partir del qual analitzar les interaccions entre els individus i el seu entorn, i la forma com les seves experiències en diferents contextos al llarg de la vida promouen i donen forma als processos d'aprenentatge. Les ecologies d'aprenentatge ens permeten explorar la pedagogia de frontera que connecta contextos educatius formals, no formals i informals, en qualitat d'estratègies personals que puguin orquestrar l'aprenentatge al llarg de tota la vida. Comencem per definir i emmarcar les ecologies d'aprenentatge, proporcionant les arrels teòriques i la revisió d'alguns estudis recents sobre el tema. A continuació, proposem constructes i models, i també les estratègies i eines que poden ser d'ajuda per millorar i donar suport a les ecologies personals per a l'aprenentatge. Finalment, es proposa el concepte de pedagogies personals per referir-se a un conjunt d'autonomia, habilitats i actituds que poden integrar-se de forma dinàmica pels individus per donar suport a una ecologia per al desenvolupament i l'aprenentatge personal. Articulem des d'aquesta perspectiva diverses tendències en l'àmbit de l'aprenentatge autodirigit ubicades a la intersecció tecnològica i pedagògica: MOOCs, alertes d'informació permanent, portafolis digitals i xarxes socials

    A learning ecologies approach on school leaders' professional development

    No full text
    School leaders are usually provided with administration-led, fully structured programmes for professional development. The research literature identifies some common attributes for leadership that such programmes try to convey. Although this is and will be an important part of school leaders’ professional development, the vast amount of digital open content and open courses available and the accessibility of specialised networks and virtual communities expand opportunities for self-learning and self-development. In this context, the learning ecologies analysis framework proves useful in extending knowledge on what school leaders do for professional development, what they consider the most useful means for continuous updating and what the components of their individual learning ecologies are. This paper presents the more common strategies for professional development that school leaders are used in Catalonia (Spain), their balance between organised professional development activities and self-development, and how they assess the role digital technologies play in their learning ecologies.  A survey with 48 questions was conducted with the aim of gathering information on school leaders’ continuing professional development in Catalan schools. Two hundred twelve school leaders answered the survey. The results focus on learning ecologies, with special emphasis on strategies demonstrating informal learning, forms of privileged training, ICT use and participation in professional networks and communities, and demonstrate that almost half the responders to the survey consider their usual professional development strategy to be self-learning. Results also show that school leaders who stay up to date through self-learning strategies, prefer online learning (resources, activities, courses) and use technology more intensively. Learning ecologies proved to be a useful framework for the analysis of the professional development strategies of school leaders

    Never be silent : publishing & imperialism in Kenya, 1884-1963

    No full text
    Social communications are central to any social struggle. There is a sizable body of literature from other countries on the use of oral medium, newspapers, books and other forms of communications being used as tools for organising against a powerful enemy, as a training ground for cadres and for clarifying and developing revolutionary theory, ideology, organisation and practice. All this ensures a greater unity among those resisting oppression and exploitation. Thus revolutionary and liberation forces of Bolsheviks in the Soviet Union, the Communist Party of China, and in Vietnam had developed theories and practices of revolutionary publishing as part of their revolutionary work. This has also been the case during anti-colonial and anti-imperialist struggles in Africa, but very little of this has been systematically documented as an aspect of revolutionary communications policy and practice. While the colonial communications systems have been reasonably well documented, the resistance communication systems remain largely undocumented and ignored. This book is an initial attempt to document this dynamic communications process in Kenya with its external struggles against colonialism and its complex internal struggles with overlaying divisions of race and class, Kenyan and foreign peoples. The main theme emerging from this experience is that people struggling to change their society always find ways of establishing their own system of communicating with the people they lead and by whom they are led. Their mission of revolution, of change, of peace, of social and economic justice requires that they should never be silent. This was well understood and practised by the liberation forces in Kenya. They were never silent

    Draft genome of the filarial nematode parasite Brugia malayi

    No full text
    Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of millions of people in the developing world. We have sequenced the approximately 90 megabase (Mb) genome of the human filarial parasite Brugia malayi and predict approximately 11,500 protein coding genes in 71 Mb of robustly assembled sequence. Comparative analysis with the free-living, model nematode Caenorhabditis elegans revealed that, despite these genes having maintained little conservation of local synteny during approximately 350 million years of evolution, they largely remain in linkage on chromosomal units. More than 100 conserved operons were identified. Analysis of the predicted proteome provides evidence for adaptations of B. malayi to niches in its human and vector hosts and insights into the molecular basis of a mutualistic relationship with its Wolbachia endosymbiont. These findings offer a foundation for rational drug design

    Degenerative lumbar spinal stenosis with neurogenic intermittent claudication and treatment with the Aperius PercLID System: a preliminary report

    No full text
    Object The aim of this study was to evaluate whether clinical improvement is noticeable after a minimally invasive procedure such as that used with the Aperius PercLID System in patients with degenerative lumbar spinal stenosis (DLSS) and neurogenic intermittent claudication (NIC). Methods The patients were treated with the aforementioned system at 3 different centers. The initial requirement to be included in the study was a minimum follow-up of 12 months. The authors studied 40 cases of DLSS in patients with NIC (age 72.7 ± 8.08 years). Symptom severity, physical function, quality of life, and self-rated pain were assessed preoperatively and at the 12-month follow-up using the Zurich Claudication Questionnaire (ZCQ) and a visual analog scale. The procedure was conducted under spinal (35 patients) or local (5 patients) anesthesia, using biplanar fluoroscopy for visualization. Results Single-level treatment was performed in 28 patients and 2-level treatment was performed in 12 patients. Based on time recordings in 24 cases, the mean procedural time was 19.9 ± 5.0 minutes. The mean pain visual analog scale score improved significantly from 8.1 ± 2.19 at baseline to 3.44 ± 2.89 at the 1-year follow-up. The ZCQ score for patient satisfaction showed 90% of the patients being satisfied with the procedure. The mean rates of improvement in ZCQ score for symptom severity and physical function at 1 year were 38.7 ± 33.3% and 33.8 ± 29.7%, respectively, and both proved to be statistically significant. Most improvement was seen in mobility, pain/discomfort, and ability for self-care. Conclusions In this preliminary study, the Aperius system provided clinically significant improvement after 1 year of follow-up in patients older than 65 years with DLSS and NIC.</jats:sec

    Human,climatic and oceanographic influences on the marine environment of Pohnpei, Federated States of Micronesia

    No full text
    File PB200200 could not be included in folder EFR1. Full data available on disc with print copy held at the University of Waikato Library.Coral reefs and marine resources are culturally, as well as economically, vital to Pohnpei, situated in the Federated States of Micronesia (FSM). Farming and fishing are the main sources of livelihood for most Pohnpeian communities. Pohnpei has eleven Marine Protected Areas (MPAs) where nine are situated in the Pohnpei Island Lagoon and two MPAs on the outer low-lying atolls. Like many other Pacific Island countries Pohnpei is on the verge of creating more MPAs. However, the marine environment continues to be significantly threatened by human and natural influences. The recognised threats are yet to be methodically investigated. This thesis used a combination of sediment, coral, fish, climatic, and oceanographic data, and focused on the Pohnpei Lagoon, examining a range of natural and human issues in the marine environment both at the local level (focusing on that within the Pohnpei Lagoon) and regional level (focusing on the western Pacific region). Evidence from historical, archaeological, and modern experience has influenced various marine impacts that have altered the coastline and the marine environment of the Pohnpei Lagoon. Humans have greatly impacted on the coral diversity and fish populations in the Pohnpei Lagoon by over-fishing and contributing to accelerated sediment inputs. My study findings shows that that increased sea surface temperature (SST) caused by El Ni o events is not the only cause of coral bleaching, but also cooling of SST, and other human factors. However, when corals bleach they recover by symbiont shuffling . This is an ingenious way in which corals host one or more varieties of their zooxanthelle (Symbiodinium symbiont clades) that are more tolerant of the stress caused by increased SST and human factors. The recognised natural climatic variability, particularly the El Ni o/Southern Oscillation (ENSO), may pose a significant threat to the Pohnpei Lagoon. El Ni o events are associated with: a change in trade winds and stronger wind gusts attributed to typhoons; lower rainfall causing drought; a decrease in SST attributed to cooling of the marine environment; increase of salinity in marine estuaries affecting development and recruitment of marine species communities; and a steep fall in sea level exposing corals to other elements. The various on-going human threats and El Ni o-like conditions have caused giant clams (Tridacna gigas) to become extinct, have endangered herbivorous fish populations, and caused coral bleaching by cooling of SST. Although high SSTs are normally blamed for coral bleaching, the last major bleaching event in Pohnpei (2002) was likely to be due to a reduction in salinity (freshwater runoff and lower sea level), and there has been strong recovery. However, decreasing water temperatures rather than increases of SSTs may contribute to coral bleaching in the Pohnpei Lagoon and the Micronesian region. The Micronesian region appears to have suffered relatively few episodes of regional coral bleaching events. This is due to the Western Pacific Warm Pool (WPWP) where sea surface temperatures exceed 29 C but also where various feedback mechanisms limit the maximum SSTs. The management aims of Pohnpei's MPAs are to move forward, while still respecting traditional practices. However, a lack of scientific monitoring, technical support and funding restricts our understanding of human and natural influences on the existing MPAs and the Pohnpei Lagoon. With respect to our policy makers the findings of the present research have implications on the future work in Pohnpei's marine environment and for policy makers, to make more-informed decisions before establishing new MPAs. My key recommendations were: 1.) Integrate coral and fish monitoring during and after El Ni o events to understand El Ni o effects on the Pohnpei environment. 2.) Undertake herbivorous fish investigation into their populations inside and outside the MPAs. 3.) Do not cut down vegetation along coastline areas, as it prevents erosion 4.) Investigate Symbiodinium coral clades in Pohnpei Lagoon and the outer low-lying atolls

    How Globalisation Improves Governance

    No full text
    Globalisation, governance and economic performance affect each other in very complex mutual relationships. In this paper, we establish a clear and well-circumscribed hypothesis: “is there an effect of globalisation on governance?” To test this hypothesis or, even more specifically, to test how openness can affect the quality of domestic institutions, we survey available theoretical explanations of causal relationships between globalisation and governance. Microeconomic theory helps us identify trade policy, competition by foreign producers and international investors, and openness-related differences in institution building costs and benefits, as three major transmission mechanisms through which openness affects a country’s corruption levels. Examining a large sample of countries covering a 20-year long period, we found robust empirical support for the fact that increases in import openness do indeed cause reductions in corruption, a crucial aspect of governance. The magnitude of the effect is also quite strong. After controlling for many cross-country differences, openness’ influence on corruption is close to one third of that exercised by the level of development. Some cautious policy conclusions are derived.Corruption, globalisation, governance, international trade.

    BİR ÜNİVERSİTE HASTANESİ’NDE GAMMA-KNIFE RADYOCERRAHİSİ UYGULANAN TEDAVİYE DİRENÇLİ OKB HASTALARINDA NEKROZ HACMİ VE YERLEŞİMİNİN TEDAVİ YANITI, KLİNİK VE SOSYODEMOGRAFİK DEĞİŞKENLER ARASINDAKİ İLİŞKİNİN İNCELENMESİ

    No full text
    Obsesifkompulsif bozukluk (OKB), günümüzde nöropsikiyatrik bir hastalık olarak kabuledilmekte olup; etiyolojisinde kortiko-striato-talamo-kortikal (CSTC) döngüdekihiperaktivitenin merkezi bir rol oynadığı, inatçı obsesyonlar vekompulsiyonlarla seyreden, kronik ve ciddi yeti yitimine yol açabilen birbozukluktur ADDIN EN.CITE &lt;EndNote&gt;&lt;Cite&gt;&lt;Author&gt;Goodman&lt;/Author&gt;&lt;Year&gt;2021&lt;/Year&gt;&lt;RecNum&gt;198&lt;/RecNum&gt;&lt;DisplayText&gt;[1]&lt;/DisplayText&gt;&lt;record&gt;&lt;rec-number&gt;198&lt;/rec-number&gt;&lt;foreign-keys&gt;&lt;keyapp=&quot;EN&quot; db-id=&quot;ewd05p50nttxfveat5wv52roarwaxxvwv00a&quot;timestamp=&quot;1757186384&quot;&gt;198&lt;/key&gt;&lt;/foreign-keys&gt;&lt;ref-typename=&quot;JournalArticle&quot;&gt;17&lt;/ref-type&gt;&lt;contributors&gt;&lt;authors&gt;&lt;author&gt;Goodman,Wayne K&lt;/author&gt;&lt;author&gt;Storch, EricA&lt;/author&gt;&lt;author&gt;Sheth, Sameer A&lt;/author&gt;&lt;/authors&gt;&lt;/contributors&gt;&lt;titles&gt;&lt;title&gt;Harmonizingthe neurobiology and treatment of obsessive-compulsivedisorder&lt;/title&gt;&lt;secondary-title&gt;American Journal ofPsychiatry&lt;/secondary-title&gt;&lt;/titles&gt;&lt;periodical&gt;&lt;full-title&gt;AmericanJournal of Psychiatry&lt;/full-title&gt;&lt;/periodical&gt;&lt;pages&gt;17-29&lt;/pages&gt;&lt;volume&gt;178&lt;/volume&gt;&lt;number&gt;1&lt;/number&gt;&lt;dates&gt;&lt;year&gt;2021&lt;/year&gt;&lt;/dates&gt;&lt;isbn&gt;0002-953X&lt;/isbn&gt;&lt;urls&gt;&lt;/urls&gt;&lt;/record&gt;&lt;/Cite&gt;&lt;/EndNote&gt;[1].&nbsp;Farmakoterapi ve bilişsel davranışçı terapi(BDT), OKB yönetiminde ilk basamak tedavi yaklaşımlarını oluşturmaktadır.Selektif serotonin geri alım inhibitörleri (SSRI’lar) ve klomipramin, en sıktercih edilen farmakolojik ajanlar olup ADDIN EN.CITE&lt;EndNote&gt;&lt;Cite&gt;&lt;Author&gt;Association&lt;/Author&gt;&lt;Year&gt;2007&lt;/Year&gt;&lt;RecNum&gt;199&lt;/RecNum&gt;&lt;DisplayText&gt;[2]&lt;/DisplayText&gt;&lt;record&gt;&lt;rec-number&gt;199&lt;/rec-number&gt;&lt;foreign-keys&gt;&lt;keyapp=&quot;EN&quot; db-id=&quot;ewd05p50nttxfveat5wv52roarwaxxvwv00a&quot;timestamp=&quot;1757186806&quot;&gt;199&lt;/key&gt;&lt;/foreign-keys&gt;&lt;ref-typename=&quot;JournalArticle&quot;&gt;17&lt;/ref-type&gt;&lt;contributors&gt;&lt;authors&gt;&lt;author&gt;AmericanPsychiatric Association&lt;/author&gt;&lt;author&gt;Koran, LorrinM&lt;/author&gt;&lt;author&gt;Hanna, GregoryL&lt;/author&gt;&lt;author&gt;Hollander,Eric&lt;/author&gt;&lt;author&gt;Nestadt,Gerald&lt;/author&gt;&lt;author&gt;Simpson, HelenBlair&lt;/author&gt;&lt;/authors&gt;&lt;/contributors&gt;&lt;titles&gt;&lt;title&gt;Practiceguideline for the treatment of patients with obsessive-compulsivedisorder&lt;/title&gt;&lt;/titles&gt;&lt;dates&gt;&lt;year&gt;2007&lt;/year&gt;&lt;/dates&gt;&lt;urls&gt;&lt;/urls&gt;&lt;/record&gt;&lt;/Cite&gt;&lt;/EndNote&gt;[2],bu ajanlarla gerçekleştirilen tedavi protokollerine rağmen vakaların yaklaşık%40’ı yetersiz yanıt vermekte ve tedaviye dirençli OKB olarak tanımlanmaktadır ADDIN EN.CITE&lt;EndNote&gt;&lt;Cite&gt;&lt;Author&gt;Albert&lt;/Author&gt;&lt;Year&gt;2002&lt;/Year&gt;&lt;RecNum&gt;200&lt;/RecNum&gt;&lt;DisplayText&gt;[3]&lt;/DisplayText&gt;&lt;record&gt;&lt;rec-number&gt;200&lt;/rec-number&gt;&lt;foreign-keys&gt;&lt;keyapp=&quot;EN&quot; db-id=&quot;ewd05p50nttxfveat5wv52roarwaxxvwv00a&quot;timestamp=&quot;1757186927&quot;&gt;200&lt;/key&gt;&lt;/foreign-keys&gt;&lt;ref-typename=&quot;JournalArticle&quot;&gt;17&lt;/ref-type&gt;&lt;contributors&gt;&lt;authors&gt;&lt;author&gt;Albert,Umberto&lt;/author&gt;&lt;author&gt;Bergesio,Chiara&lt;/author&gt;&lt;author&gt;Pessina, Enrico&lt;/author&gt;&lt;author&gt;Maina,Giuseppe&lt;/author&gt;&lt;author&gt;Bogetto,Filippo&lt;/author&gt;&lt;/authors&gt;&lt;/contributors&gt;&lt;titles&gt;&lt;title&gt;Managementof treatment resistant obsessive-compulsive disorder. Algorithms forpharmacotherapy&lt;/title&gt;&lt;secondary-title&gt;PanminervaMedica&lt;/secondary-title&gt;&lt;/titles&gt;&lt;periodical&gt;&lt;full-title&gt;PanminervaMedica&lt;/full-title&gt;&lt;/periodical&gt;&lt;pages&gt;83-91&lt;/pages&gt;&lt;volume&gt;44&lt;/volume&gt;&lt;number&gt;2&lt;/number&gt;&lt;dates&gt;&lt;year&gt;2002&lt;/year&gt;&lt;/dates&gt;&lt;isbn&gt;0031-0808&lt;/isbn&gt;&lt;urls&gt;&lt;/urls&gt;&lt;/record&gt;&lt;/Cite&gt;&lt;/EndNote&gt;[3].&nbsp;Dirençli vakalardainvazif olmayan nöromodülasyon yaklaşımları (örn. transkraniyal manyetik stimülasyon,derin beyin stimülasyonu) ve cerrahi prosedürler giderek daha fazla klinik ilgiodağı haline gelmektedir. Bu bağlamda, anterior kapsülotomi ve singulotomi gibilezyonel cerrahi girişimlere bir alternatif olarak Gamma-Knife Radyocerrahisi(GKRC) ön plana çıkmaktadır.GKRC, stereotaktik çerçeve rehberliğinde belirlenen hedefbeyin bölgelerine yüksek doz iyonizan radyasyon uygulanarak patolojik nöronalhiperaktivitenin modülasyonunu amaçlayan minimal invazif bir nörocerrahiprosedürdür. OKB tedavisinde en yaygın uygulama alanı bilateral anteriorkapsülotomi olup, bu spesifik bölgenin fonksiyonel modülasyonu ile CSTCdöngüsündeki hiperaktivitenin baskılanması hedeflenmektedir. Bununla birlikte,GKRC’nin OKB üzerindeki terapötik etkileri, radyocerrahi sonrası gelişennöronal değişiklikler ve klinik iyileşmeyi belirleyen faktörler tam anlamıylaaydınlatılamamış olup, bu konuda yapılan sistematik çalışmalar sınırlıkalmaktadırADDIN EN.CITE&lt;EndNote&gt;&lt;Cite&gt;&lt;Author&gt;Miguel&lt;/Author&gt;&lt;Year&gt;2019&lt;/Year&gt;&lt;RecNum&gt;111&lt;/RecNum&gt;&lt;DisplayText&gt;[4]&lt;/DisplayText&gt;&lt;record&gt;&lt;rec-number&gt;111&lt;/rec-number&gt;&lt;foreign-keys&gt;&lt;keyapp=&quot;EN&quot; db-id=&quot;ewd05p50nttxfveat5wv52roarwaxxvwv00a&quot;timestamp=&quot;1741937711&quot;&gt;111&lt;/key&gt;&lt;/foreign-keys&gt;&lt;ref-typename=&quot;JournalArticle&quot;&gt;17&lt;/ref-type&gt;&lt;contributors&gt;&lt;authors&gt;&lt;author&gt;Miguel,Euripedes C&lt;/author&gt;&lt;author&gt;Lopes, AntonioC&lt;/author&gt;&lt;author&gt;McLaughlin, NicoleCR&lt;/author&gt;&lt;author&gt;Norén, Georg&lt;/author&gt;&lt;author&gt;Gentil,André F&lt;/author&gt;&lt;author&gt;Hamani,Clement&lt;/author&gt;&lt;author&gt;Shavitt, RoseliG&lt;/author&gt;&lt;author&gt;Batistuzzo, MarceloC&lt;/author&gt;&lt;author&gt;Vattimo, EdoardoFQ&lt;/author&gt;&lt;author&gt;Canteras,Miguel&lt;/author&gt;&lt;/authors&gt;&lt;/contributors&gt;&lt;titles&gt;&lt;title&gt;Evolutionof gamma knife capsulotomy for intractable obsessive-compulsivedisorder&lt;/title&gt;&lt;secondary-title&gt;Molecularpsychiatry&lt;/secondary-title&gt;&lt;/titles&gt;&lt;periodical&gt;&lt;full-title&gt;Molecularpsychiatry&lt;/full-title&gt;&lt;/periodical&gt;&lt;pages&gt;218-240&lt;/pages&gt;&lt;volume&gt;24&lt;/volume&gt;&lt;number&gt;2&lt;/number&gt;&lt;dates&gt;&lt;year&gt;2019&lt;/year&gt;&lt;/dates&gt;&lt;isbn&gt;1359-4184&lt;/isbn&gt;&lt;urls&gt;&lt;/urls&gt;&lt;/record&gt;&lt;/Cite&gt;&lt;/EndNote&gt;[4].Bu çalışmanın temel amacı, bir üniversite hastanesindeGamma-Knife Radyocerrahisi uygulanan tedaviye dirençli OKB hastalarındaradyocerrahi sonrası gelişen nekrotik doku hacmi ve yerleşimunun klinik yanıtile ilişkisini multidisipliner bir perspektifle incelemektir. Özellikle, nekrozhacminin ve hedeflenen beyin bölgesindeki yerleşimunun OKB’nin klinik belirtişiddetindeki değişimler ile ilişkisinin araştırılması planlanmıştır. Ayrıca, Gamma-Knifesonrası hipokampus, amigdala, anterior singulat, posterior singulat, talamus,kaudat ve subtalamik nukleus gibi OKB etiyolojsinde rol oynayan seçilmiş beyinbölgelerinin hacimsel olarak operasyon öncesine göre değişiklik gösteripgöstermedikleri, bu değişikliklerin tedavi yanıtı ile ilişkili olup olmadığınınaraştırması hedeflenmiştir. İkincil amaç olarak da Gamma-Knife cerrrahi sonrası tedaviyanıtı ile ilişkili olabilecek potansiyel sosyodemografik ve klinik değişkenlerin(yaş, cinsiyet, eğitim seviyesi, hastalık süresi, obsesyon temaları gibi) incelenmesiamaçlanmıştır. Böylece, cerrahi müdahalenin obsesif-kompulsif bozukluğunnörobiyolojik temelinde rol oynayan devreler üzerindeki etkileri nesnel olarakdeğerlendirilmesi, elde edilen verilerin klinik prognoz öngörülerine katkısağlaması beklenmektedir.&nbsp;</p
    corecore