38 research outputs found
Role of sleep duration in the regulation of glucose metabolism and appetite.
No full textSleep curtailment has become a common behavior in modern society. This review summarizes the current laboratory evidence indicating that sleep loss may contribute to the pathophysiology of diabetes mellitus and obesity. Experimentally induced sleep loss in healthy volunteers decreases insulin sensitivity without adequate compensation in beta-cell function, resulting in impaired glucose tolerance and increased diabetes risk. Lack of sleep also down-regulates the satiety hormone leptin, up-regulates the appetite-stimulating hormone ghrelin, and increases hunger and food intake. Taken together with the epidemiologic evidence for an association between short sleep and the prevalence or incidence of diabetes mellitus and/or obesity, these results support a role for reduced sleep duration in the current epidemic of these metabolic disorders. Screening for habitual sleep patterns in patients with "diabesity" is therefore of great importance. Studies are warranted to investigate the putative therapeutic impact of extending sleep in habitual short sleepers with metabolic disorders.Journal ArticleResearch Support, N.I.H. ExtramuralResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Reviewinfo:eu-repo/semantics/publishe
Impact of sleep and its disturbances on hypothalamo-pituitary-adrenal axis activity
No full textinfo:eu-repo/semantics/publishe
Republican Satire in the Dock: Forensic Rhetoric in Lucilius
No full textThis is the author accepted manuscript. The final version is available from OUP via the DOI in this record
Ri-leggere un retore
No full textLa présente étude développe quelques points portant sur la langue de Calpumius Flaccus. Après un bref état de la question, assorti de l’analyse de l’une de ces questions, elle traite des caractéristiques de son lexique, examinées au travers de quelques enquêtes statistiques et de l’étude de quelques cas spécifiques. Les premiers résultats obtenus permettent de discuter la date de l’auteur, qui pourrait être postérieure aux Ier-IIe siècles de notre ère.My paper develops some questions concerning Calpurnius Flaccus’ language. After a brief status quaestionis with the explanation of one of these problems, I will deal with characteristics of his lexicon, through some statistical inquiries realized with the aid of freely available software and the support of some specific case studies. The first results give elements to discuss the date of the author, that could be later than 1st-2nd century AD
La responsabilité vaut-elle la peine?
No full textThe article starts from a questioning that introduces, in relation to the topic of responsibility, an equivocation in the word “worthwhile”. After characterizing law in the present as a fragmented and debilitated body, the author asks what could reestablish the force of law and the dignity of responsible acts. For that purpose, a surprising thesis is advanced: law and responsibility will only recover their force through the anticipation of power and even of extreme violence, viz. the death penalty. However, this doesn’t refer to the executed death penalty, but to the one that could be anticipated, thus determining that responsible acts are worthwhile, which would then indicate the symbolic and actual force of the law. Key words: responsibility, death penalty, law, desire, psychoanalysis.O artigo parte de uma interrogação que introduz, quanto à questão da responsabilidade, uma equivocidade na expressão “vale a pena”. Após caracterizar o direito e a lei na atualidade como um corpo fragmentado e sem forças, o autor se interroga sobre o que poderia restabelecer a força da lei e igualmente a dignidade do ato responsável. Para tal, o autor introduz uma tese surpreendente: o direito, a lei e a responsabilidade somente encontrariam sua força por meio da antecipação da força e até mesmo da violência extrema, ou seja, a pena de morte. Mas não a pena de morte aplicada, e sim aquela que poderia ser antecipada, determinando assim que vale a pena o ato de responsabilidade, que indicaria então a força simbólica e efetiva da lei. Palavras-chave: responsabilidade, pena de morte, lei, direito, desejo, psicanálise
Untitled in english
No full textDesde 1927 diversos pesquisadores buscam modelar as tensões resultantes da combinação de cargas rodoviárias e empenamentos decorrentes de gradientes térmicos em placas de concreto para pavimentação. As tensões resultantes desses estudos revelam que a influência do empenamento térmico é muito significativa quando comparadas com os resultados das tensões causadas apenas pelos eixos rodoviários e tais efeitos tendem a ser agravados quando da utilização de bases cimentadas. Apesar dessas constatações, os métodos tradicionais de dimensionamento de pavimentos em concreto de cimento Portland não consideram o efeito conjunto das cargas e gradientes térmicos. Neste trabalho, o autor modelou numericamente, com o uso do método dos elementos finitos, as tensões principais maiores em pavimentos constituídos de placas de concreto de cimento Portland e bases cimentadas não-aderidas submetidos a cargas rodoviárias e gradientes térmicos, apresentando modelos de cômputo detensões nessas camadas. Foram estudadas estruturas com espessuras de placa entre 0,15 m e 0,35 m. A base cimentada possuía valores de espessura entre 0,10 m e 0,20 m e contemplava módulos de deformação entre 10 GPa (referente a uma BGTC) e 25GPa (referente a um CCR). Três condições de suporte do subleito foram analisadas: pobre, regular e boa. O comprimento das placas possuía valores de 4,00 m, 5,50 m e 7,50 m. Os valores de gradiente térmico foram obtidos na pista experimental do Laboratório de Mecânica dePavimentos, situada no campus da Universidade de São Paulo na cidade de São Paulo. Essa pista é constituída de 5 seções, com placas de comprimentos e espessuras distintos, base bem como as espessuras da base. É variado também entre as seções o tipo de material de base: BGS ou CCR. Tal pista foi fomentada pela FAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo. Na pista experimental foram efetuadas provas de carga estáticas e dinâmicas. Os ) resultados obtidos na prova de carga estática se mostraram de pouca utilidade. Já os resultados da prova de carga dinâmica foram bastante condizentes com aqueles calculados com o uso do programa ILSL2. Da comparação entre os valores de tensão calculados com os medidos em pista obteve-se um coeficiente de correlação igual a 0,50. Verificou-se, por fim, da análise de um projeto hipotético, que a consideração dos gradientes térmicos quando do projeto das características de um pavimento de concreto de cimento Portland com juntas e barras de transferência se faz necessário. Observou-se, ainda, que quando se considera os efeitos do empenamento térmico no dimensionamento tem-se como resposta espessuras elevadas tanto de placa quanto de base. A busca do consumo da resistência à fadiga da placa de revestimento adequado aos parâmetros de projeto revelou que apenas a placa é sujeita ao fenômeno da fadiga. A base cimentada apresentou consumo muitíssimo menor que o da placa. Tais resultados reforçam a necessidade de ajuste nosmétodos de projeto, buscando limitar o uso de pavimentos de concreto com bases não-aderidas, o que implica no estudo do comportamento dos pavimentos deconcreto compostos, onde placa e base trabalhem aderidas, aumentando a rigidez do conjunto, diminuindo o valor das tensões atuantes pelo aumento da espessura da estrutura e, por fim, utilizando de modo mais eficiente as características de cada um dos materiais.Since 1927 many researchers try to model stresses due to the combination of wheel loads and thermal gradients in concrete slabs for pavements. Stresses given from those studies shown that thermal warping influence is very significant when compared to stresses caused by wheel loads only. These effects tend to get worse when cemented bases are used. Besides those considerations, traditional concrete pavements design methods do not take into account the joint effect of loads and thermal gradients. In this work, the author numerically modeled principal stresses in concrete pavements with unbonded cemented bases subjected to wheel loads and thermal gradients. For modeling the stresses in both slab and base as presents the work the finite element method was used. Studied structures had slabs ranging from 0,15 m and 0,35 m thick. Cemented base thickness ranged from 0,10 m and 0,20 m and its stiffness modulus from 10 GPa (for CTCS) to 25 GPa (for RCC). Three support conditions referring to the subgrade were taken: poor, regular and good. Slabs were 4,00 m, 5,50 m and 7,50 m wide in these analysis. Thermal gradients values were obtained from the Pavement Mechanics Laboratory\'s test track, located at the University of São Paulo campus in São Paulo. The test track is constituted of 5 sections, where slab widths and thicknesses are distinguished, as well as base widths. The kind of base material ranges from section to section: crushed stone or rolled compacted concrete. This test track was build with financial support of the Research Aid Foundation of the State of São Paulo - FAPESP. On the test track were executed static and dynamic load tests. Results form the static test seemed to be of very poor utility. On the other hand, results from the dynamic test were very closed to those computed by ILSL2 program. Comparing the values of computed stresses with those measured at the field, a correlation coefficient of 0,50 was obtained. At last, from the analysis of a hypothetical design, it was inferred that thermal gradient effects must be considered during the design of JPCP with doweled bars and cemented bases. It could be also inferred that high values of slab and base thicknesses are obtained when these effects are taken into account in the design. Analysis showed that only the concrete slab is subjected to the fatigue phenomenon. Cemented base fatigue resistance consumption is very lower than the slab one. These results confirm the necessity of adjustment of the design methods, trying to limit the appliance of concrete pavements with unbonded cemented bases, what implies on the study of composed concrete pavements. This stiffer structure tends to present lower values of stresses and works with materials characteristics in a better way
The construction of gods in the natura deorum of Marco Tulio Cícero
No full textThis dissertation aims to present and discuss the epicurean, stoic and new academy doctrines with the aim of understanding the construction of the gods in the De Natura Deorum by Marco Tulio Cicero. For this work it was not made a history of general, therefore the external elements were not deepened, but it was made a history of the philosophy of Cicero in order to understand the conceptions of the author. The Ciceronian work is a philosophical dialogue written in 45 BC by Marcus Tullius Cicero which was organized in three books and in each of them is discussed the Epicurean, Stoic and New Academy doctrines. Many currents of thought that are used by the author present an attempt to demonstrate that there are many connections and divergences between them. In this work, Cicero uses a clever dialectical style of confrontation of ideas to ensure that each doctrine exposes its philosophy while being confronted by those who are listening to the discussion. Each doctrine exposed is represented by a character: Caio Veleio is the epicurean, Lucílio Balbo is the stoic and Cota is the academic. Considerations were made about the period that the book was written, the Hellenistic, as well as an analysis of Cicero's life, which is essential to understand why, almost at the end of his life, he decided to write about the existence of the gods. In addition, a brief analysis of the doctrines was made based on studies done by other authors, which contributes to understand what remains of Cicero after the Hellenistic doctrines. As it will be possible to see in the conclusion, Cicero is not an effective participant of the dialogue, but his conceptions appear in the voice of the academic Balbo, who is responsible for refuting all the exposed conceptions on the gods.Dissertação (Mestrado)Esta dissertação tem como objetivo apresentar e discutir as doutrinas epicurista, estoica e a nova academia com o intuito de compreender a construção dos deuses na obra intitulada De Natura Deorum de Marco Tulio Cícero. Para a análise da obra não foi feita uma história da filosofia geral, portanto não foram aprofundados os elementos externos, mas uma história da filosofia de Cícero com o intuito de compreender as concepções do autor. A obra ciceroniana em questão é um diálogo filosófico escrito em 45 a.C por Marco Túlio Cícero o qual foi organizado em três livros e em cada um deles são discutidas as doutrinas epicurista, estoica e da nova academia. As variadas correntes de pensamento que são utilizadas pelo autor apresentam uma tentativa de demonstrar que há variadas ligações e divergências entre elas. Na obra em questão, Cicero usa um hábil estilo dialético de confronto de ideias com o intuito de assegurar que cada doutrina faça a exposição da sua filosofia ao mesmo tempo em que são confrontadas por aqueles que estão ouvindo o debate. Cada doutrina exposta é representada por um personagem: Caio Veleio é o epicurista, Lucílio Balbo é o estoico e Cota é o acadêmico. Foram feitas considerações sobre o período no qual fora escrito, o período helenístico, além de uma análise da vida de Cícero, o que é primordial para compreender por que, quase no final da sua vida, ele resolveu escrever sobre a existência dos deuses. Ademais, foi realizada uma breve análise das doutrinas com base em estudos feitos por outros autores, o que contribui para entender o que permanece de Cícero após as doutrinas helenísticas. Como será possível ver na conclusão, Cícero não é um participante efetivo do diálogo, mas suas concepções aparecem na voz do acadêmico Balbo, o qual é o responsável por refutar todas as concepções expostas sobre os deuses
El estilo poético neocatuliano en el Renacimiento: de Pontano a Juan Segundo
No full textThe present research has set as its objective the analysis of the poetic production written in Latin by the first Renaissance imitators of the Roman poet Catullus in 15th century Italy: Leonardo Bruni, Cristoforo Landino and Giovanni Gioviano Pontano, in order to highlight their emulative novelty through the analysis of Catullian intertextuality. Pontano's lyricism especially illustrates the evolution of the so-called neo-Catullian style which inaugurated a new era in neo-Latin poetry, with the Verona poet as its center: in Italy, with the poetry of relevant authors such as Michele Marullo and Jacopo Sannazaro, and in the rest of Europe with outstanding voices such as those of Jean Salmon Macrin and Juan Segundo Everaerts. The first part of the thesis presents the results of a careful analysis of Catullus' style, in order to lay the foundations for the commentary in the second part, which reveals at what point Catullus' legacy surpassed the level of imitatio to become in an authentic aemulatio, as an expression, furthermore, of the mundus significans of each author. The textual interpretation of the humanists focused both on the content and on the lexical and rhetorical aspects: on the "voice" with which such creative innovation was expressed. The innovative scope and capacity of the first imitators to revitalize the desacralizing and at the same time pathetic power of Catullian verse is highlighted, while at the same time they used a language, in principle, not native. Furthermore, it is shown how Catullus' model served them not only to compete with the classical world that inspired his poetic creation, especially in his youth, but also to revolutionize a modus poetandi and disrupt a literary tradition of enormous cultural prestige. Finally, the last part outlines the European panorama of the new style inaugurated by Giovanni Pontano, focusing on the ways in which it took shape, that is, how neo-Catullianism was expressed in Italy, France and the Netherlands, through the voices of the best-known poets.La presente investigación se ha fijado como objetivo el análisis de la producción poética escrita en latín por los primeros imitadores renacentistas del poeta romano Catulo en la Italia del siglo XV: Leonardo Bruni, Cristoforo Landino y Giovanni Gioviano Pontano, para poner de relieve su novedad emulativa a través del análisis de la intertextualidad catuliana. El lirismo de Pontano ilustra especialmente la evolución del llamado estilo neocatuliano, que inauguró una nueva época en la poesía neolatina, con el poeta de Verona como centro: en Italia, con la poesía de relevantes autores como Michele Marullo y Jacopo Sannazaro, y en el resto Europa con voces destacadas como las de Jean Salmon Macrin y Juan Segundo Everaerts. La primera parte de la tesis presenta los resultados de un detenido análisis sobre el estilo de Catulo, con el fin de sentar las bases del comentario de la segunda parte, que revela en qué punto el legado de Catulo superó el nivel de la imitatio para convertirse en una auténtica aemulatio, como expresión, además, del mundus significans de cada autor. La interpretación textual de los humanistas se centró tanto en el contenido como en los aspectos léxicos y retóricos: en la «voz» con la que se expresaba tal innovación creativa. Se pone de relieve el alcance innovador y la capacidad de los primeros imitadores para revitalizar el poder desacralizador y a la vez patético del verso catuliano, al tiempo que utilizaban una lengua, en principio, no materna. Además, se muestra cómo el modelo de Catulo les sirvió no sólo para competir con el mundo clásico que inspiró su creación poética, sobre todo en su juventud, sino también para revolucionar un modus poetandi y trastocar una tradición literaria de enorme prestigio cultural. Finalmente, la última parte esboza el panorama europeo del nuevo estilo inaugurado por Giovanni Pontano, centrándose en las formas en que se concretó, es decir, cómo se expresó el neocatulianismo en Italia, Francia y los Países Bajos, a través de las voces de los poetas más conocidos.Escuela de DoctoradoDoctorado en Textos de la Antigüedad Clásica y su Pervivenci
New trends in active filters for improving power quality
No full textSince their basic compensation principles were proposed around 1970, active filters have been studied by many researchers and engineers aiming to put them into practical applications. Shunt active filters for harmonic compensation with or without reactive power compensation, flicker compensation or voltage regulation have been put on a commercial base in Japan, and their rating or capacity has ranged from 50 kVA to 60 MVA at present. In near future, the term of active filters will cover a much wider sense than that of active filters in the 1970s did. The function of active filters will be expanded from voltage flicker compensation or voltage regulation into power quality improvement for power distribution systems as the capacity of active filters becomes larger. This paper describes present states of the active filters based on state-of-the-art power electronics technology, and their future prospects toward the 21st century, including the personal view and expectation of the author</p
Student Journal Club to Improve Cultural Humility with LGBTQ Patients
No full text© The Author(s) 2020. Health degree programs provide opportunities to reduce disparities in care for LGBTQ patients by exposing students to LGBTQ communities and current health issues. However, LGBTQ content is mostly absent from medical school curricula. This mixed method assessment study, conducted during the 2018 to 2019 academic year, examined the feasibility of implementing a medical student journal club focused specifically on LGBTQ health issues as a complementary training tool to support efforts to create an inclusive educational environment. Compared to the pre-test, mean response scores increased for most of the parameters including familiarity with LGBTQ healthcare issues, confidence in the ability to identify harmful medical provider practices, and reading and assessing scientific literature. Qualitative data showed increased confidence, comfort and knowledge about LGBTQ health barriers. This study offers a framework for using a journal club to provide an effective platform for enhancing students’ LGBTQ cultural humility and research literacy
