171 research outputs found
Preface for Marcel Waldinger special issue on premature ejaculation
No full textThe world lost a very dear and brilliant man when Prof Dr Marcel Waldinger passed away this year. I am proud that I got to know him well, and had the chance to learn a lot from him as a scientist. He was passionate about his work related to men and womens sexual dysfunctions, with a special focus on PE, postorgasm illness syndrome, and persistent sexual arousal syndrome
Time Will Tell: Genetic Influences on Ejaculation Time
No full textLifelong premature ejaculation (PE) is a male sexual disorder characterized by persistent short ejaculation times of less than about 1 minute, in more than 90% of intercourses, with nearly every female partner, since the first sexual activities of a man in puberty or adolescence (Waldinger 2007). In about 30% of these men, ejaculation becomes even more faster at the age of 30-35 years (Waldinger 2007). In the 1990s, it has been hypothesised that the short ejaculation time, e.g., the intravaginal ejaculation latency time (IELT) which is the time between intravaginal penetration and the moment of intravaginal ejaculation, is associated with a diminished central serotonin (5-hydroxytryptamine; 5-HT) neurotransmission, a hyperfunction of 5-HT1A receptors, a hypofunction of 5-HT2C receptors and genetic influences (Waldinger et al, 1998) The aim of the thesis was to study the role of serotonergic gene polymorphisms in men with lifelong premature ejaculation (PE) with regard to the duration of their IELT. The duration of the IELT was investigated with a stopwatch that had to be handled by the female partner of the male. After instruction on how to use the stopwatch during intercourse, the IELT was measured at home in a one month baseline period and during a period of daily paroxetine treatment, which is known for its ejaculation delaying effects. In addition, we investigated whether the duration of daily paroxetine treatment-induced ejaculation delay was associated with polymorphism of the 5-HT transporter gene, polymorphisms of the 5-HT1A receptor gene, and the 5-HT2C receptor gene. In addition, it was investigated whether paroxetine-induced ejaculation delay is associated with polymorphism of the 5-HT transporter gene. Another point of investigation was whether in men with lifelong PE response and non-response to paroxetine treatment was associated with paroxetine serum concentration, CYP2D6 genotype, and a number of other factors, such as an intact hypothalamic-pituitary gonadal axis, thyroid function and serum leptin levels. Finally, we analyzed the methodology and design of six studies that were published in recent years on 5-HTTLPR polymorphism and premature ejaculation
La politique au-delà des frontières : la sociologie politique de l’émigration
No full textRoger Waldinger, La politique au-delà des frontières : la sociologie politique de l’émigration, FMSHWP-2012-20, septembre 2012. Télécharger ce document depuis HALSHS (pdf)/Download this Paper (pdf) L’auteur/The author Roger Waldinger is Distinguished Professor of Sociology at UCLA, where he served as Interim Associate Vice-Provost for International Studies from 2010-2012, Chair of the Department of Sociology from 1999 to 2004 and Director of the Lewis Center for Regional Policy from 1995 to..
Peer effects in science : evidence from the dismissal of scientists in Nazi Germany
No full textThis paper analyzes peer e¤ects among university scientists. Specifically, it investigates whether peer quality and the number of peers a¤ect the productivity of researchers in physics, chemistry, and mathematics. The usual endogeneity problems related to estimating peer e¤ects are addressed by using the dismissal of scientists by the Nazi government as a source of exogenous variation in the peer group of scientists staying in Germany. Using a newly constructed panel dataset covering the universe of physicists, chemists, and mathematicians at all German universities from 1925 until 1938 I investigate localized peer e¤ects. There is no evidence for peer e¤ects at the local level. This surprising finding is robust for a large number of specification and robustness checks. In a second part of the analysis, I investigate peer e¤ect among co-authors and find that co-author quality is very important for scientific productivity
Toward Evidence-Based Genetic Research on Lifelong Premature Ejaculation: A Critical Evaluation of Methodology
No full textContribution of Acupuncture to Western Medical Knowledge of Premature Ejaculation: An Intriguing New Development
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