404 research outputs found
ARIES 2018 : infrastructure, innovation, outreach
No full textThis article has two outreach aims. It concisely summarizes the main research and technical efforts in the EC H2020 ARIES Integrating Activity – Accelerator Research and Innovation for European Science and Society [1] during the period 2017/2018. ARIES is a continuation of CARE, TIARA and EuCARD projects [2-3]. The article also tries to show these results as an encouragement for local physics and engineering, research and technical communities to participate actively in such important European projects. According to the author’s opinion this participation may be much bigger [4-27]. All the needed components to participate – human, material and infrastructural are there [4,7]. So why the results are not satisfying as they should be? The major research subjects of ARIES are: new methods of particles acceleration including laser, plasma and particle beam interactions, new materials and accelerator components, building new generations of accelerators, energy efficiency and management of large accelerator systems, innovative superconducting magnets, high field and ultra-high gradient magnets, cost lowering, system miniaturization, promotion of innovation originating from accelerator research, industrial applications, and societal implications. Two institutions from Poland participate in ARIES – these are Warsaw University of Technology and Institute of Nuclear Chemistry and Technology in Warsaw. There are not present some of the key institutes active in accelerator technology in Poland. Let this article be a small contribution why Poland, a country of such big research potential, contributes so modestly to the European accelerator infrastructural projects? The article bases on public and internal documents of ARIES project, including the EU Grant Agreement and P1 report. The views presented in the paper are only by the author and not necessarily by the ARIES
sj-pdf-1-jcb-10.1177_0271678X211045222 - Supplemental material for Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome
No full textSupplemental material, sj-pdf-1-jcb-10.1177_0271678X211045222 for Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome by Ricardo C Nogueira, Marcel Aries, Jatinder S Minhas, Nils H Petersen, Li Xiong, Jana M Kainerstorfer and Pedro Castro in Journal of Cerebral Blood Flow & Metabolism</p
Perspectives and Challenges of Decentralized Identities in the Blockchain era
No full textopenIl presente documento descrive il lavoro svolto durante il periodo di stage, della durata di circa 276 ore, dal laureando Nicola Lazzarin presso l’azienda Athesys s.r.l, con periodo dal 06/07/2023 al 23/07/2023.
Il paradigma delle identità digitali è fondamentale nell’era digitale, ma spesso sottolinea l’inefficienza dei tradizionali sistemi centralizzati.
L’emergere delle Self-sovereign identity (SSI) offre un nuovo approccio promettente per migliorare la gestione delle identità digitali e delle Verifiable Credentials (VC).
Tuttavia, l’attuazione pratica di soluzioni basate su SSI, in particolare utilizzando il framework Hyperledger Aries, rimane una sfida complessa e impegnativa.
La presente tesi trae ispirazione dalla rilevanza delle identità digitali nella società odierna e dalla crescente necessità di soluzioni SSI.
Tuttavia, essa si concentra su una prospettiva critica basata sull’esperienza personale dell’autore, che, nonostante gli sforzi, non è riuscito a pieno a completare l’implementazione di un sistema di scambio di VC utilizzando il framework Hyperledger Aries JavaScript.
Il principale contributo di questa tesi è rappresentato dalla realizzazione parziale di un Proof of Concept (PoC) per un sistema di scambio di VC basato sul framework Hyperledger Aries JavaScript.
Questo PoC offre una base incompleta per ulteriori sviluppi nel campo delle SSI. Inoltre, questa ricerca fornisce una documentazione dettagliata sul processo di implementazione, comprese le scelte di progettazione e le tecnologie utilizzate, per agevolare ulteriori studi e implementazioni nel settore delle identità digitali decentralizzate.
In conclusione, questo tirocinio ha fornito un’opportunità di apprendimento e applicazione pratica di concetti avanzati nel campo delle identità digitali e delle credenziali verificabili.This paper describes the work done during the internship period, lasting about 276 hours, by graduate student Nicola Lazzarin at the company Athesys s.r.l, with a period from 06/07/2023 to 23/07/2023.
The paradigm of digital identities is crucial in the digital age, but often underscores the inefficiency of traditional centralized systems.
The emergence of Self-sovereign identities (SSI) offers a promising new approach to improve the management of digital identities and Verifiable Credentials (VC).
However, the practical implementation of SSI-based solutions, particularly using the Hyperledger Aries framework, remains a complex and demanding challenge.
This thesis draws inspiration from the relevance of digital identities in today's society and the growing need for SSI solutions.
However, it focuses on a critical perspective based on the personal experience of the author, who, despite his efforts, was not fully successful in completing the implementation of a VC exchange system using the Hyperledger Aries JavaScript framework.
The main contribution of this thesis is the partial implementation of a Proof of Concept (PoC) for a VC exchange system based on the Hyperledger Aries JavaScript framework.
This PoC provides an incomplete basis for further development in the field of SSI. In addition, this research provides detailed documentation of the implementation process, including design choices and technologies used, to facilitate further studies and implementations in the area of decentralized digital identities.
In conclusion, this internship provided an opportunity for learning and practical application of advanced concepts in the field of digital identities and verifiable credentials
Doppler Non-invasive Monitoring of ICP in an Animal Model of Acute Intracranial Hypertension.
No full textBACKGROUND: In many neurological diseases, intracranial pressure (ICP) is elevated and needs to be actively managed. ICP is typically measured with an invasive transducer, which carries risks. Non-invasive techniques for monitoring ICP (nICP) have been developed. The aim of this study was to compare three different methods of transcranial Doppler (TCD) assessment of nICP in an animal model of acute intracranial hypertension. METHODS: In 28 rabbits, ICP was increased to 70-80 mmHg by infusion of Hartmann's solution into the lumbar subarachnoid space. Doppler flow velocity in the basilar artery was recorded. nICP was assessed through three different methods: Gosling's pulsatility index PI (gPI), Aaslid's method (AaICP), and a method based on diastolic blood flow velocity (FVdICP). RESULTS: We found a significant correlation between nICP and ICP when all infusion experiments were combined (FVdICP: r = 0.77, AaICP: r = 0.53, gPI: r = 0.54). The ability to distinguish between raised and 'normal' values of ICP was greatest for FVdICP (AUC 0.90 at ICP >40 mmHg). When infusion experiments were considered independently, FVdICP demonstrated again the strongest correlation between changes in ICP and changes in nICP (mean r = 0.85). CONCLUSIONS: TCD-based methods of nICP monitoring are better at detecting changes of ICP occurring in time, rather than absolute prediction of ICP as a number. Of the studied methods of nICP, the method based on FVd is best to discriminate between raised and 'normal' ICP and to monitor relative changes of ICP
Memoria colectiva, tradición y costumbre. A los 100 años de la reseña de Marc Bloch a Maurice Halbwachs
No full textJusto hace 100 años Maurice Halbwachs publicaba su obra más influyente, Les cadres sociaux de la mémoire, y lo hacía en la colección “Les Travaux de l’Année sociologique” que dirigía Marcel Mauss (Halbwachs, 1925). En la misma colección, ese año se publicaron, entre otros títulos, L´éducation morale (Durkheim, 1925) y, tras haberlo hecho por fascículos en la aludida revista, el Essai sur le don (Mauss, 1925), monografía que, sin ambages, es la referencia fundacional de la Antropología -perdón, Ethnologie- francesa (Ginzburg, 2023) junto con Les formes élémentaires de la vie religieuse (Durkheim, 1912) y alguna de las obras de Lévi-Bruhl. Unos meses después, Marc Bloch, hacía una reseña breve, respetuosa pero también crítica, de la obra de Halbwachs (Bloch, 1925). Este es el texto que presento aquí, en una modesta traducción anotada, a los cien años de su publicación
I.FAST and EURO-LABS Perfect Legacy of ARIES
No full textCERN hosted on May 2-6, 2022, the first annual meeting of the H2020 I.FAST project to support innovation in the field of science and technology of particle accelerators. The project has a completely different character from its predecessors in this area of research. It was approved for implementation a year ago by the EC with the highest marks. It is worth looking at why projects such as ARIES, I.FAST and EURO-LABS are so easily accepted. This alleged ease of acceptance is an appearance. Behind the acceptance, in conditions of extremely tough competition, is the excellent organization of the submitting community that has been developed over the years, as well as the perfect, well-thought-out preparation of the material. The author, a participant in the ARIES and other EC projects in the field of particle accelerator science and technology, presents here, on specific examples, his subjective opinions on how to prepare materials for high-output projects for the EC FP. The author hopes that these remarks may be useful in the process of submitting research projects from Poland in international cooperation to the EC in the best possible way. The science and technology of particle accelerators is an excellent area of showing such examples because it is interdisciplinary and includes the following components: building of research infrastructure, applied physics, mechatronics, materials engineering, automation and robotics, electronics, ICT, innovation, cooperation with industry, and social
Cerebrovascular Pressure Reactivity Monitoring Using Wavelet Analysis in Traumatic Brain Injury Patients: A Retrospective Study
No full textBackground
After traumatic brain injury (TBI), the ability of cerebral vessels to appropriately react to changes in arterial blood pressure (pressure reactivity) is impaired, leaving patients vulnerable to cerebral hypo- or hyper-perfusion. Although, the traditional pressure reactivity index (PRx) has demonstrated that impaired pressure reactivity associates with poor patient outcome, PRx is sometimes erratic and may not be reliable in various clinical circumstances. Here, we introduce a more robust wavelet transform based pressure reactivity index (wPRx) and compare its performance with the widely used traditional PRx across three areas: its stability and reliability in time, its ability to give an optimal cerebral perfusion pressure (CPPopt) recommendation and its relationship with patient outcome.
Methods and Findings
515 TBI patients admitted in Addenbrooke’s Hospital, UK (March 23rd, 2003- December 9th, 2014), with continuous monitoring of arterial blood pressure (ABP) and intracranial pressure (ICP) were retrospectively analyzed to calculate the traditional PRx and a novel wavelet transform based wPRx. wPRx was calculated by taking the cosine of the wavelet transform phase-shift between ABP and ICP. A time trend of CPPopt was calculated using an automated curve fitting method that determined the CPP at which the pressure reactivity (PRx or wPRx) was most efficient (CPPopt_PRx and CPPopt_wPRx, respectively).
There was a significantly positive relationship between PRx and wPRx (r = 0.73) and wavelet wPRx was more reliable in time (ratio of between-hour variance to total variance, wPRx 0.957± 0.0032 vs PRx and 0.949 ± 0.047 for PRx, p=0.002). The 2-hour interval standard deviation of wPRx (0.19± 0.07) was smaller than that of PRx (0.30 ± 0.13, p<0.001). wPRx performed better in distinguishing between mortality and survival (AUROC for wPRx was 0.73 vs 0.66 for PRx, p = 0.003). The mean difference between the patients’ CPP and their CPPopt was related to outcome for both calculation methods. There was a good relationship between the two CPPopts (r=0.814, p<0.001). CPPopt_wPRx was more stable than CPPopt_PRx (within patient standard deviation 7.05 ± 3.78 vs 8.45 ± 2.90; p<0.001).
Key limitations include that this study is a retrospective analysis and only compared wPRx with PRx in the cohort of TBI patients. Prospective validation is required prior to better assess clinical utility of this approach.
Conclusions
Wavelet based pressure reactivity index (wPRx) offers several advantages to the traditional PRx: it is more stable in time, it yields a more consistent optimal CPP recommendation, and importantly, it has a stronger relationship with patient outcome. The clinical utility of wPRx should be explored in prospective studies of critically injured neurological patients
SIMULATION-BASED LEARNING IN RELIGIOUS EDUCATION TO DEVELOP STUDENT EMPATHY ON PEACE EDUCATION
No full textSIMULATION-BASED LEARNING IN RELIGIOUS EDUCATION TO DEVELOP STUDENT EMPATHY ON PEACE EDUCATION Aries Musnandar
Abstract This study proposes an effective learning model to increase the quality of students’ empathy through simulation-based learning. The student’s noble behaviour as the objective religious subject in schools can be reached by fostering empathy. But, conservative teaching techniques such as lecturing, presentation and one-way communication are used by most teachers. In contrast, the simulation based-learning model for religious education could involve the affective domain which is appropriate to be used for behaviour change. Peace education in religious education subjects can be elaborated proportionally using simulation based-learning for developing the empathy of student as an important factor to have better peace education results. By using qualitative method, author conducted interview, observation and literature review for further analysis of this study. Research results confirmed that teacher who apply simulation based learning as a suitable method to enhance empathy for elevated tolerant behavior of students which is in line with peace education view. Keywords: Simulation-Based Learning, Empathy, Peace Education, Religious Education
12 22 2020 122 144 http://creativecommons.org/licenses/by-nc/4.0 10.24239/jsi.v17i2.606.122-144 https://www.jurnalhunafa.org/index.php/hunafa/article/view/606 https://www.jurnalhunafa.org/index.php/hunafa/article/download/606/508 https://www.jurnalhunafa.org/index.php/hunafa/article/download/606/50
The Effect of Red Blood Cell Transfusion on Cerebral Autoregulation in Patients with Severe Traumatic Brain Injury
No full textBackground: Red blood cell (RBC) transfusion is associated with inconsistent changes in brain tissue oxygenation (PbO2). Previous studies have failed to consider alterations in cerebral autoregulation. Our objective was to investigate the effect of RBC transfusion on cerebral autoregulation, as measured by pressure reactivity index (PRx). Methods: Retrospective analysis of 28 severe traumatic brain injury (TBI) patients from a prospective registry between 2007 and 2014. We recorded hemoglobin (Hb) concentration, intracranial pressure, PbO2, cerebral perfusion pressure, PRx, and cerebral lactate/pyruvate ratio for 6 h before and after RBC transfusion. We also recorded body temperature, PaO2, PCO2, pH, and fraction of inspired oxygen. Subgroups of normoxia (PbO2 >20 mmHg) and hypoxia (PbO2 2 increased [23.5 mmHg (SD 8) to 25.0 mmHg (SD 9), p = 0.033] following transfusion. PRx increased post-transfusion [0.028 (SD 0.29) to 0.11 (SD 0.24), p = 0.034], indicating worsening cerebrovascular pressure reactivity. In patients with mean PbO2 >20 mmHg pre-transfusion (n = 20), the PRx increased significantly [−0.052 (SD 0.24) to 0.079 (SD 0.22), p = 0.007] but did not change in patients with PbO2 <20 mmHg: PRx [0.22 (SD 0.34) to 0.18 (SD 0.30), p = 0.36]. Conclusion: RBC transfusion in severe TBI patients results in worsening PRx, indicating impaired cerebral autoregulation
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