79 research outputs found
sj-docx-1-sgo-10.1177_21582440221146135 – Supplemental material for Linguistic Analysis of Online Domestic Violence Testimonies in the Context of COVID-19
No full textSupplemental material, sj-docx-1-sgo-10.1177_21582440221146135 for Linguistic Analysis of Online Domestic Violence Testimonies in the Context of COVID-19 by Valentin L. Buchner, Sharina Hamm, Barbara Medenica and Marc L. Molendijk in SAGE Open</p
Exposé Landwinningswerken in 1943
No full textDit exposé bevat meerdere nota's betreffende de landwinningswerken in 1943, die voornamelijk plaatsvonden op een zandbank van de vlakte van Ooltgensplaat bij Tiengemeten, Ventjagersplaat genoemd. De twee nota's betreffen: -Verslag van de Landaanwinningswerken gedurende het jaar 1943 (door opzichter Molendijk) In dit verslag worden achtereenvolgens de resultaten van het jaar 1942 onder de loep genomen alvorens het verslag van de landaanwinningswerken wordt besproken in twee stappen: 1. Het aanleggen van beplantingen en 2. Het maken van dammen. -Verslag 1943 omtrent de plantkundige onderzoekingen (door assistent van Eerde) Dit verslag bevat een beschrijving van het plantkundig onderzoek op het proefveld van Zuid Maartensgat. Uit onderzoek bleek dat de Ronde bies zich goed had ontwikkeld waar de zeebies en het riet zich minder gunstig hadden ontwikkeld.Landwinningswerken 194
Exposé Landwinningsvraagstukken
No full textAls algemeen richtslijn is er aangegeven dat bij de opzet van landwinningswerken rekening gehouden moet worden met een tijdperk van ongeveer 40 jaren. Ten einde een nader inzicht in de voor te bereiden werkzaamheden te bekomen, werd er onderzoek verricht en gedeeltelijk in een viertal nota's vastgelegd. De onderzoeken gaan in specifiek over de 'Beplatingsmethode', waarbij slibvangen en beplanting der slikken een voorname rol spelen en de 'Bekleiingsmethode', waarbij getracht wordt sneller tot het doel te komen door inpoldering van een wadgebied en bekleiing ervan met specie uit de ondergrond. Bij het nagaan der mogelijkheden voor de eerstvolgende 40 jaar wordt gestuit op de volgende 7 hoofdvragen van landbouwkundige aard: 1. Is een proefpolder op de Wadden nodig ten einde te onderzoeken welke mening van slib en wadzand de meest wenselijke is? 2. Kan misschien met goedkopere middelen (proefbakken) worden volstaan? Hoe moeten deze worden ingericht? 3. Is het wadzand geschikt om als weidegrond te kunnen dien? Wat is dan de opbrengst per ha.? 4. Kunnen bossen op het Wadzand worden aangelegd? Welke opbrengst? 5. Wat kan met de zogenaamde woelmachine worden bereikt? Deze machine kan vruchtbare klei tot 4 meter diepte beneden maaiveld ophalen en over de oppervlakte spreiden. Kosten per laag van 4 cm dikte bedragen 300 à 400 gulden. 6. Welke resultaten zijn verkregen bij slibbemseting in Westerwolde en Drente? Een ter plaatse gehouden navraag wees uit dat een laag slib van eenige milimeter dikte na 30 jaar nog steeds opmerkelijk resultaten gaf. 7. Welk kavelgrootte is het meest wenselijk? De viertal nota's betreffen: - Verslag werkzaamheden in 1942 op Hollandsch Diep en Maartensgat (door opzichter Molendijk) - Verslag werkzaamheden in 1942 op de Hellegatplaten (door opzcihter Van Eyk) - Programma van onderzoek betreffende plantenonderzoek (door Dr. L.F. Kamps) - Verslag werkzaamheden proefvelden en plantenonderzoek in 1942 (door assisten Van Eerde)Landwinningswerken 194
Randomness of RCTs investigating effects of vitamine D on depression
No full textFabricated data contaminates the evidence synthesised in meta-analyses. in randomized controlled trials (RCTs), between-group sampling variability in baseline variables should show predictable patterns. Assessment of the patterns of variability can be performed through Monte-Carlo simulations. When the results of these analyses show that patterns deviate from the expected, it is likely the data is not generated by the process of randomisation. Inspired by Carlisle, and based on our previous work (Langeveld et al., under review, preregistration: https://osf.io/8mtg6), we explore non-randomness in baseline variables and unusual patterns drop-out rates in RCTs investigating potential efficacy of vitamine D supplementation on depression.
Carlisle, J. B. (2012). The analysis of 168 randomised controlled trials to test data integrity. Anaesthesia, 67(5), 521-537.
Langeveld, D., Sipahioğlu, B., de Kleijn, R., and Molendijk, M.L.. Non-randomness in 224 randomized controlled treatment trials. Under review Lancet Psychiatry (29/03/2025)
Randomness of RCTs investigating effects of omega-3 fatty acid supplementation on symptoms of anxiety
No full textDescription *
Fabricated data contaminates the evidence synthesised in meta-analyses. In randomized controlled trials (RCTs), between-group sampling variability in baseline variables should show predictable patterns. Assessment of the patterns of variability can be performed through Monte-Carlo simulations. When the results of these analyses show that patterns deviate from the expected, it is likely the data is not generated by the process of randomisation. Inspired by Carlisle, and based on our previous work (Langeveld et al., under review, preregistration: https://osf.io/8mtg6), we explore non-randomness in baseline variables and unusual patterns in drop-out rates in RCTs investigating potential efficacy of omega-3 fatty acid supplementation on symptoms of anxiety. In addition, we expect this non-randomness to be associated with a better / more efficacious outcome of the intervention. In an earlier project (Langeveld et al., under review), we found that non-randomness often came with a particular flow of participants through the trial (e.g., equal drop-out rates over treatment arms) and that this too is associated with efficacy of the tested treatment. Such patterns we will investigate too, also in relation to outcome.
The input RCTs will be derived from a recent meta-analysis on this topic, concluding that omega-3 fatty acid supplementation may effectively reduce – in a dose-response fahion - symptoms of anxiety over placebo (Bafkar et al., 2024), although with a low level of evidence. The results from our analyses potentially could add some insight into the validity of some of the input studies and hence the conclusion that comes from the synthesis of this literature.
References
Langeveld, D., Sipahioğlu, B., de Kleijn, R., and Molendijk, M.L.. Non-randomness in 224 randomized controlled treatment trials. Under review Lancet Psychiatry (29/03/2025).
Bafkar, N., Zeraattalab-Motlagh, S., Jayedi, A., & Shab-Bidar, S. (2024). Efficacy and safety of omega-3 fatty acids supplementation for anxiety symptoms: a systematic review and dose-response meta-analysis of randomized controlled trials. BMC psychiatry, 24(1), 455.
References
* Text overlaps with previous OSF project registrations on highly similar project (e.g., projects in which RCTs are tested in which other nutraceuticals are tested than omega-3 fatty acids).
Carlisle, J. B. (2012). The analysis of 168 randomised controlled trials to test data integrity. Anaesthesia, 67(5), 521-537.
Langeveld, D., Sipahioğlu, B., de Kleijn, R., and Molendijk, M.L.. Non-randomness in 224 randomized controlled treatment trials. Under review Lancet Psychiatry (29/03/2025)
Diet quality, dietary patterns and depression: A systematic review and dose-response frequentist and Bayesian meta-analysis of prospective studies II
No full textWe aim to pool, by frequentist and Bayesian meta-analyses, the prospective data on the (putative) dose-response relation between the quality of diet that people adhere to and the incidence of depression/depressive symptoms. Associations between diet and depression (prevention and treatment) from RCTs will also be subjected to meta-analysis. The project is a follow-up and an extension of earlier work from our group (Molendijk et al., 2018).
Molendijk, M., Molero, P., Sánchez-Pedreño, F. O., Van der Does, W., & Martínez-González, M. A. (2018). Diet quality and depression risk: a systematic review and dose-response meta-analysis of prospective studies. Journal of affective disorders, 226, 346-354
The SMILES trial: do undisclosed recruitment practices and a loss of blinding explain the remarkably large effect?
No full textThe SMILES trial showed substantial depressive symptoms improvement following seven consultations on healthy dieting. The very large effect size on depression reduction seems remarkable after 7 sessions of dietary advice. We show that actual participant recruitment of the trial deviated in important aspects from how it is described in the paper and suggest that selectively induced expectancy and a loss of blinding have contributed to the observed effect
A systematic review with meta-analysis on the effects of mental health on SARS-CoV-2 infection risk and COVID-19 outcome
No full textWe want to address the following review questions: Are people with a previous medically-diagnosed mental disorder more likely to become infected with coronavirus disease 2019 (COVID-19)? And is the presence of a mental health disorder a risk factor for worse COVID-19 course, hospital admission, severity, or mortality?
In case we find confirmative answers on the aforementioned questions, we will supplement the systematic review with a narrative review on how mental disorders could affect COVID-19 infection risk and illness course. We aim to present data in the following domains:
1. Stress related to poor mental health and its effect on the immune system and organ functioning.
2. Behavioral and socio-economic correlates of poor mental health (e.g., low quality sleep, substance use, alcohol use, smoking, physical activity, low quality diet, social behavior, institutional psychiatric care, housing) and their effects on the immune system and organ functioning.
3. The effects of antidepressants, antipsychotics, anti-anxiety medication, mood stabilizers, and stimulants) on the immune system and organ functioning. In addition, we will review the evidence for mental health effects of drug types that are used to treat symptoms of COVID-19 (e.g., corticosteroids)
The effect of diet on depression and dementia risk: estimating the reproducibility of scientific observation
No full textThe SMILES trial: do undisclosed recruitment practices and a loss of blinding explain the remarkably large effect?
No full textThe SMILES trial showed substantial depressive symptoms improvement following seven consultations on healthy dieting. The very large effect size on depression reduction seems remarkable after 7 sessions of dietary advice. We show that actual participant recruitment of the trial deviated in important aspects from how it is described in the paper and suggest that selectively induced expectancy and a loss of blinding have contributed to the observed effect
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