65 research outputs found
[P2–059]: RATIONAL DESIGN, SYNTHESIS AND BIOLOGICAL SCREENING OF CYANOPYRIDINE‐TRIAZINE HYBRIDS AS LEAD MULTITARGET ANTI‐ALZHEIMER AGENTS
No full textGSK3 Inhibitors in the Therapeutic Development of Diabetes, Cancer and Neurodegeneration: Past, Present and Future
No full textAn overview about Hedychium spicatum: a review
No full textThe Indian Himalayan Region (IHR) serves as tremendous repository of plant biodiversity which is derived from extreme altitudinal gradients and phenomenal geographic provinces and has been proved as the richest reservoir of medicinal plants and aromatic plants. The lavish range of plant biodiversity in IHR is supported by various landscape features that provide myriad of habitats. Hedychium spicatum Buch-Ham (Zingiberaceae), commonly known as spiked ginger lily, is found in the entire Himalayan region. Rhizome contains about 4% of essential oil and its phytochemical investigations have shown the presence of a variety of terpenoids (monoterpenoids, sesquiterpenoids and diterpenoids).Traditionally, the rhizomes are used in the treatment of respiratory disorders, fevers, tranquilizer, hypotensive, antispasmodic, CNS depressant, analgesic, anti-inflammatory, antimicrobial, antioxidant, antifungal, pediculicidal and cytotoxic activities. The family Zingiberaceae well known for its immense medicinal values is distributed widely throughout the tropics, particularly in Southeast Asia. Zingiberaceae family is an important natural resource that provides many useful products for food, spices, medicines, dyes, perfume and aesthetics. Ethnobiologically, H. spicatum is not commonly popular throughout the Indian Himalayan region, but multifarious uses are practised specifically in different regions. In this review, we will briefly explain about the various multi-faceted aspects about Hedychium spicatum.
Keywords: Hedychium spicatum, Chemical composition, Rhizomes, Zingiberaceae
RECENT PROMISING ADVANCES IN DEVELOPMENT OF ANTIMICROBIAL AGENTS: A REVIEW
Get PDFAntimicrobial resistance is a serious global threat. There is a global menace of antibiotic resistant “super bug”, though the extent and the severity of the problem varies. Resistance hampers therapeutic options and drives clinicians to use newer and more expensive drugs. In serious cases, multi-resistance provides no treatment options. To overcome resistance, a continuous supply of new antibiotics offers an obvious way; but the pipeline of agents in development by the Pharmaceutical industry is very limited. There is an ever-evolving need to develop and evaluate newer alternative strategies for countering a worsening clinical situation to overcome resistance and reduce the morbidity and mortality associated with infections caused by antibiotic-resistant bacteria. The widespread distribution of Antimicrobial resistance has not been paralleled by the development of newer antimicrobials. This happens due to the process of drug discovery and clinical trials of new antimicrobials taking longer time and only a fewer new agents been approved for use. In modern era, where obstacles like chemo-resistance and mutations torment medicine, scientists across the world are looking to adapt lateral approaches in encountering diseases.
Keywords: antimicrobial resistance, super bug, antibiotic
Correction: Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C
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Correction|October 06 2021
Correction: Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C
Vishwas Mishra, Avipsa Bose, Shashi Kiran, Sanghita Banerjee, Idrees A. Shah, Pooja Chaukimath, Mudasir M. Reshi, Swarna Srinivas, Anaxee Barman, Sandhya S. Visweswariah
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Author and Article Information
Vishwas Mishra
Avipsa Bose
Shashi Kiran
Sanghita Banerjee
Idrees A. Shah
Pooja Chaukimath
Mudasir M. Reshi
Swarna Srinivas
Anaxee Barman
Sandhya S. Visweswariah
Online ISSN: 1540-9538
Print ISSN: 0022-1007
© 2021 Mishra et al.
This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
J Exp Med (2021) 218 (11): e2021047909292021c.
https://doi.org/10.1084/jem.2021047909292021c
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Corrected article Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C
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Vol. 218, No. 11 | 10.1084/jem.20210479 | September 21, 2021
The authors regret that the legends to Fig. 3 (C, D, and I) and Fig. 4 (B, C, and E) did not originally specify that the values shown are adjusted P values. In addition, the colors used in the bar graph in Fig. 4 B were not correct nor defined. The corrected legends, with new text underlined, and corrected Fig. 4 are shown here.
The errors appear only in PDFs downloaded before September 27, 2021
Depression Diagnosis with Artificial Intelligence: A Bibliometric Analysis
No full textBackground: Depression, a severe psychological disorder, exerts profound effects on an individual’s life. It saps energy, pleasures, and motivation leading individuals to helplessness and hopelessness, strained relationships, and increased thoughts of suicide ideation. Artificial intelligence has emerged as a potential tool in predictive analysis. With the analysis of big data, AI can detect patterns and indicators that aid in identifying depression with improved accuracy and efficacy. Since 2012, diagnosing depression with AI tools has become a hot topic of research. This study is a bibliometric analysis of the literature on diagnosing depression with artificial intelligence (AI) tools.
Methods: The authors geared up the four digital libraries: Pub Med, Web of Science, Google Scholar and Science Direct databases and applied filters to select relevant publications from 2014 to 2022. They used Microsoft Excel to analyze the data on publication growth, top contributors, keywords, and citations. VOSviewer was used to visualize collaborative maps between authors, institutions, affiliations, and hot topics related to the field.
Results: A total of 476 publications were used for this Bibliometric analysis. From 2019 to 2022, the growth of publications trend has seen a steady increase. The USA is the leading country in terms of publication count. The most cited author was Perlis, who published seven papers on depression and AI. The most affiliated institution was Harvard Medical School, which produced 28 publications. The most common keyword was “depression”, which appeared in 260 publications. The highly contributed journal was “Frontiers in Psychology” and the most cited paper was by Kessler et al., (2015)
ChemInform Abstract: Pivotal Role of Glycogen Synthase Kinase‐3: A Therapeutic Target for Alzheimer′s Disease
No full textSpecificity and Personalized medicine: a novel approach to Cancer management
Get PDFWith the advent of precision and personalized medicine (PPM), medical care may now be adapted to each patient\u27s unique needs. Among the top causes of death in India is cancer. Maximum chemotherapeutic treatments are utilized for cancer patients, despite the lack of long-term effectiveness and significant side effects from these agents. To improve therapeutic success, a new tool called PPM was developed. Insights into pharmacogenomics have aided in the development of and the possibility for individualized cancer treatment. In modern PPM, genetic or other information on a particular patient is used systematically to select or optimize preventative and therapeutic therapy for that patient. Knowledge of a patient\u27s protein, genetic, and metabolic profile can help doctors give them the best possible care. The development of companion diagnostics, in which molecular assays measuring levels of proteins, genes, or specific mutations are used to stratify disease status, pick the appropriate drug, and tune dosages there, is a central feature of this medical strategy. As a result, recent breakthroughs in oncology have piqued interest in the field as a whole, prompting calls for greater emphasis on the role of the oncology department or health care system in the quest for greater accuracy and individualization. In this article, we will examine the state of the art and discuss potential future developments that could help expedite the creation of PPM medicines for the treatment of cancer that has become resistant to standard therapies in individual patients. The focus will be on the phenotypic (activity-based) rather than the genotypic (mechanism-based) approach to PPM development, and how it can benefit cancer patients. The path to precise and individualized treatment has been opened by the article\u27s perspective, in which focus is placed on the specific modifications of the tumor
Reproductive Health of Women: Implications and attributes
Get PDFComplete access to sexual and reproductive health is a fundamental human right. Women and girls all across the world, particularly those living in poverty, have little or no access to reproductive health and rights information and services. Discrimination, shame, restrictive laws and regulations, and long-held traditions are just a few of the barriers to sexual and reproductive health that exist. Despite evidence that these rights may affect not only individual women but also families, communities, and national economies, progress has been slow. Women\u27s lifestyles have evolved throughout history. In the past, most women\u27s lives were challenging. Many ladies were having unintended pregnancies. Childbirth used to be dangerous, and it often resulted in the mother\u27s death. Because they didn\u27t live long enough, most women didn\u27t have to deal with menopause or old age in the past. Reproductive health is an important aspect of a person\u27s entire development and well-being. It could be the result of a positive upbringing, which is critical during adolescence and sets the tone for excellent health throughout adulthood and beyond reproductive years for both men and women. A woman\u27s reproductive life span does not begin at puberty and end at menopause, and a man\u27s reproductive life span does not stop when he is no longer likely to bear children. It is present and vital at all stages of a person\u27s development and maturation. Reproductive health needs may vary depending on one\u27s age and stage of life. However, there is a long term effect over the course of one\u27s life, and each stage has significant ramifications for one\u27s future well-being
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