171,391 research outputs found
SCRaPL: A Bayesian hierarchical framework for detecting technical associates in single cell multiomics data
No full textSingle-cell multi-omics assays offer unprecedented opportunities to explore epigenetic regulation at cellular level. However, high levels of technical noise and data sparsity frequently lead to a lack of statistical power in correlative analyses, identifying very few, if any, significant associations between different molecular layers. Here we propose SCRaPL, a novel computational tool that increases power by carefully modelling noise in the experimental systems. We show on real and simulated multi-omics single-cell data sets that SCRaPL achieves higher sensitivity and better robustness in identifying correlations, while maintaining a similar level of false positives as standard analyses based on Pearson and Spearman correlation
Squarks and gluinos at a TeV collider: testing the identity of Yukawa and gauge couplings in SUSY-QCD
No full textBrandenburg A, Maniatis M, Weber MM, Zerwas PM. Squarks and gluinos at a TeV collider: testing the identity of Yukawa and gauge couplings in SUSY-QCD. European Physical Journal C. 2008;58(2):291-300
Searching for candidate genes for asthma using combined linkage and segregation analysis
No full textSUSY QCD corrections to the polarization and spin correlations of top quarks produced in e(+)e(-) collisions
No full textBrandenburg A, Maniatis M. SUSY QCD corrections to the polarization and spin correlations of top quarks produced in e(+)e(-) collisions. Physics Letters B. 2003;558(1-2):79-91.We compute the supersymmetric QCD corrections to the polarization and the spin correlations of top quarks produced above threshold in e(+) e(-) collisions, taking into account arbitrary longitudinal polarization of the initial beams. (C) 2003 Published by Elsevier Science B.V
The myth of visual depth cues IV: Cue integration
No full text“Visual depth cues” are conventionally invoked to explain the perception of a 3D world. They are also said to be “combined” or “integrated” for even greater effectiveness. The logical and empirical problems (Maniatis 2021a-c) that apply to the various depth cues individually and the depth cue concept generally apply to “cue integration” as well. Evidence in favor of the view is ad hoc, “models” fundamentally incomplete and contradictions never resolved
Impact of SUSY-QCD corrections on top quark decay distributions
No full textBrandenburg A, Maniatis M. Impact of SUSY-QCD corrections on top quark decay distributions. Physics Letters B. 2002;545(1-2):139-146.We compute the supersymmetric QCD corrections to the decay distribution of polarized top quarks for the semileptonic decay mode t(up arrow) --> bl(+)nu(l). As a byproduct, we reinvestigate the SUSY-QCD corrections to the total decay width Gamma(t --> W(+)b) and resolve a discrepancy between two previous results in the literature. (C) 2002 Elsevier Science B.V. rights reserved
On the phenomenology of a two-Higgs-doublet model with maximal CP symmetry at the LHC. Part II: radiative effects
No full textManiatis M, Nachtmann O. On the phenomenology of a two-Higgs-doublet model with maximal CP symmetry at the LHC. Part II: radiative effects. Journal of High Energy Physics. 2010;2010(4): 27.The processes p (p) over bar and pp -> gamma + heavy-flavour jet(s) + X are studied in the framework of a special two-Higgs-doublet model, the MCPM. As distinguishing feature of this model we find that radiative Higgs-boson production and decay lead to heavy flavour c jets but no b jets in the above processes. Thus, the prediction is that b jets should be given by the normal QCD processes whereas for c jets an excess over the QCD expectation should occur. We present results both for Tevatron and LHC energies
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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