1,720,968 research outputs found
The Idea for Production of a Novel Narrow Spectrum Covid-19 Drug
Full text linkMost drugs used in current medication for Covid-19 patient indicate several side effects due to the broad-spectrum drugs that affect the whole cells of human body (infected and healthy cells). Antiviral such as enzyme inhibitors, dideoxy, nucleoside/nucleotide analogs, amino acid analogs, even single chemical compound such as chloroquine phosphate, carboxylic acid type drugs and similar drugs may suppress some key molecules and changed pH not only in reactions which related to virus but also inevitably in the whole cells of human body. Based on all facts, then I designed the less cells destroying method to inhibit specifically SARS-CoV-2 replication in human cells. Since the sequence of single strand positive sense of SARS-CoV-2 has determined, the mechanism of its replication inside human lung cells was also well understood, the transport membrane (endocytosis) of oligonucleotides are well known and the supportive biotechnological methods are adequate to produce this type of drug then I proposed this methods and design respectively: 1) Study the specific sequence of SARS-CoV-2 RNA. 2) Synthesize the oligonucleotide using nucleotides analogs (to produce fake primers) that can specifically attach to the specific sequence of SARS-CoV-2 RNA. 3) Conduct in vitro experiments using the fake primers produced and the infected cells, study the efficiency of endocytosis of fake primers through cell membrane and to know the best dosage that can inhibit the SARS-CoV-2 replication. 4) Conduct clinical tests to the Covid-19 patients based on the in vitro test results (after passing the ethics protocol). So, the proposed novel narrow spectrum drug is the fake primer produced
Studi Produksi Enzim Lipase Toleran Kadar Garam Staphylococcus sp. TL9
Full text linkTelah dilakukan penelitian optimasi untuk menentukan beberapa parameter optimum yang berperan dalam produksi lipase oleh Staphylococcus sp. TL9, strain yang diisolasi dari terasi udang fermentasi terasi. Strain ini dipilih karena memiliki aktivitas lipase yang tinggi serta sifat-sifat teknologi yang lebih baik dibandingkan dengan empat bakteri penghasil lipase lain yang telah diisolasi sebelumnya. Metode one-factor-at-time (OFAT) telah dilakukan untuk memilih parameter yang tepat yang memengaruhi produksi lipasenya. Suhu dan pH awal optimum untuk produksi lipase adalah 37 oC dan 7,0. Selain itu, konsentrasi inokulum 2,0% (b/v) minyak zaitun, 10% (b/v) NaCl, dan 1,5% (v/v) semuanya memberikan produksi lipase tertinggi serta kecepatan agitasi pada 150 rpm. Sementara itu, percobaan time course menggunakan kondisi optimum terpilih menunjukkan bahwa pada waktu inkubasi 48 jam produksi lipase paling tinggi (2,27 U/mL) yang mengindikasikan 3,34 kali lipat dari produksi awal (0,67 U/mL). Lebih jauh, lipase ini juga menunjukkan halotoleran karena aktivitas lipase stabil pada rentang konsentrasi NaCl yang lebih luas (0–20%, b/v).
Kata kunci: Kapi, lipase, Staphylococcus sp. TL9, optimasi
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
The Chemical And Organoleptic Analysis Of The Sago-based Snacks As Additional Food For Diabetes Mellitus Patients
Full text linkSago is one of Indonesia\u27s native food plants that produce sago starch (Metrox-ylon sago Rottb.) which can be processed into food. It also uses as a source of amylose and amylopectin in a snack consumed by people with diabetes mellitus (DM). This is possible because of the glycemic index (GI) value of sago starch. This research was carried out experimentally and divided into two major activities, namely making snacks and characterization. Making snacks following the formulation of A, B, C, and D code, where A and B code are for the snack made from sago, whereas C and D code are for comparison. Characterization was running in terms of proximate analysis and organoleptic tests. The first analysis shows that sago-based snacks have the potential as a meal for people with diabetes mellitus because they have low reduced sugar levels that range from of 0 to 49%. However, the snacks are rich in protein, carbohydrates, and energy. Organoleptic tests also showed that color, taste, texture, and aroma were favored by panelists.Keywords: Sago Starch, Formulations, Snacks, Diabetes Mellitu
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