197,979 research outputs found
Dr. William Maly
No full textFr. Richard Harrington, Dr. William Maly, Fr. Carl M. Reinert. Commencement June 6, 196
RoMEO Studies 4: An analysis of Journal publishers' Copyright Agreements
No full textThis article is the fourth in a series of six emanating from the UK JISC-funded RoMEO Project (Rights Metadata for Open archiving). It describes an analysis of 80 scholarly journal publishers’ copyright agreements with a particular view to their effect on author self-archiving. 90% of agreements asked for copyright transfer and 69% asked for it prior to refereeing the paper. 75% asked authors to warrant that their work had not been previously published although only two explicitly stated that they viewed self-archiving as prior publication. 28.5% of agreements provided authors with no usage rights over their own paper. Although 42.5% allowed self-archiving in some format, there was no consensus on the conditions under which self-archiving could take place. The article concludes that author-publisher copyright agreements should be reconsidered by a working party representing the needs of both partie
A Scalable Architecture for Harvest-Based Digital Libraries - The ODU/Southampton Experiments
No full textThis paper discusses the requirements of current and emerging applications based on the Open Archives Initiative (OAI) and emphasizes the need for a common infrastructure to support them. Inspired by HTTP proxy, cache, gateway and web service concepts, a design for a scalable and reliable infrastructure that aims at satisfying these requirements is presented. Moreover it is shown how various applications can exploit the services included in the proposed infrastructure. The paper concludes by discussing the current status of several prototype implementations
Gentle Harvest of Potatoes in Storage Boxes
No full textRosana G. Moreira, Editor-in-Chief; Texas A&M UniversityThis is a paper from International Commission of Agricultural Engineering (CIGR, Commission Internationale du Genie Rural) E-Journal Volume 7 (2005): Gentle Harvest of Potatoes in Storage Boxes by P. Maly, T. Hoffmann and Ch. Fu
Qualitätsentwicklung und Nutzerorientierung in der Pflege
No full textSchaeffer D. Qualitätsentwicklung und Nutzerorientierung in der Pflege. In: Naegele G, Reichert M, Maly N, eds. 10 Jahre gerontologische Forschung in Dortmund. Bilanzen und Perspektiven. Band 35. Münster: Lit Verlag; 2001: 99-114
Review of \u3cem\u3eVanishing Eden: White Construction of Memory, Meaning, and Identity in a Racially Changing City.\u3c/em\u3eMichael T. Maly and Heather M. Dalmage. Reviewed by Weiyu Mao
No full textMichael T. Maly and Heather M. Dalmage, Vanishing Eden: White Construction of Memory, Meaning, and Identity in a Racially Changing City. Temple University Press (2016), 170 pages, 28.95 (paperback)
Outburst floods of the Maly Yenisei. Part I
No full textThe Yenisei, the largest river flowing to the Arctic Ocean, repeatedly hosted cataclysmic floods during the Pleistocene. The largest of the known floods likely originated from palaeolakes in northern Mongolia, at the headwaters of the Little, or Maly, Yenisei. These ancient floods are among the greatest known globally. They left giant gravel dunes and wide abandoned channels in the Kyzyl basin, and high terraces in the gorges upstream. However, few detailed field studies of the flood deposits and no measurements of their ages have been made thus far. The largest palaeolakes were impounded during major glaciations by outlet glaciers from the East Sayan ice field in southern Siberia. The shorelines suggest four distinct palaeolake depths of 290, 175, 145, and 65 m. The timing and location of the glacier impounding the deepest lakes are uncertain but at its maximum, the Tengis outlet glacier was likely capable of impounding the 175 m lake. The dating of glacial deposits in and around the basin reveals that the maximum late Pleistocene glaciers were during Marine Oxygen Isotope Stage (MIS) 3. The ages for deep-lake sediments exposed in the basin behind the dam’s location support this finding. During MIS 2 the Tengis glacier was large enough to impound at least the 145 m lake. However, the existence of a deep MIS 2 palaeolake in the basin has been challenged, because no evidence has been published of MIS 2 lake sediments from the cutbank outcrops and deep drilling cores. Additionally, the end moraines of the Tengis glacier, separated from the deeply eroded lateral moraines by the Maly Yenisei, remain undated; therefore it is uncertain exactly when this glacier crossed the river. This review is part I of a two-part article; Part II presents new age data to constrain the ages of the glacial dam.</p
Outburst floods of the Maly Yenisei. Part I
No full text<div><p>ABSTRACT</p><p>The Yenisei, the largest river flowing to the Arctic Ocean, repeatedly hosted cataclysmic floods during the Pleistocene. The largest of the known floods likely originated from palaeolakes in northern Mongolia, at the headwaters of the Little, or Maly, Yenisei. These ancient floods are among the greatest known globally. They left giant gravel dunes and wide abandoned channels in the Kyzyl basin, and high terraces in the gorges upstream. However, few detailed field studies of the flood deposits and no measurements of their ages have been made thus far. The largest palaeolakes were impounded during major glaciations by outlet glaciers from the East Sayan ice field in southern Siberia. The shorelines suggest four distinct palaeolake depths of 290, 175, 145, and 65 m. The timing and location of the glacier impounding the deepest lakes are uncertain but at its maximum, the Tengis outlet glacier was likely capable of impounding the 175 m lake. The dating of glacial deposits in and around the basin reveals that the maximum late Pleistocene glaciers were during Marine Oxygen Isotope Stage (MIS) 3. The ages for deep-lake sediments exposed in the basin behind the dam’s location support this finding. During MIS 2 the Tengis glacier was large enough to impound at least the 145 m lake. However, the existence of a deep MIS 2 palaeolake in the basin has been challenged, because no evidence has been published of MIS 2 lake sediments from the cutbank outcrops and deep drilling cores. Additionally, the end moraines of the Tengis glacier, separated from the deeply eroded lateral moraines by the Maly Yenisei, remain undated; therefore it is uncertain exactly when this glacier crossed the river. This review is part I of a two-part article; Part II presents new age data to constrain the ages of the glacial dam.</p></div
Folding pathway of the pyridoxal 5'-phosphate C-S lyase MalY from Escherichia coli
No full textMalY from Escherichia coli is a bifunctional dimeric PLP (pyridoxal
5-phosphate) enzyme acting as a β-cystathionase and as
a repressor of the maltose system. The spectroscopic and molecular
properties of the holoenzyme, in the untreated and NaBH4-
treated forms, and of the apoenzyme have been elucidated. A
systematic study of the urea-induced unfolding of MalY has
been monitored by gel filtration, cross-linking, ANS (8-anilino-
1-naphthalenesulphonic acid) binding and by visible, near- and
far-UV CD, fluorescence and NMR spectroscopies under equilibrium
conditions. Unfolding proceeds in at least three stages.
The first transition, occurring between 0 and 1 M urea, gives rise
to a partially active dimeric species that binds PLP. The second
equilibrium transition involving dimer dissociation, release of
PLP and loss of lyase activity leads to the formation of a monomeric
equilibrium intermediate. It is a partially unfolded molecule
that retains most of the native-state secondary structure,
binds significant amounts of ANS (a probe for exposed hydrophobic
surfaces) and tends to self-associate. The self-associated
aggregates predominate at urea concentrations of 2–4 M for
holoMalY. The third step represents the complete unfolding of
the enzyme. These results when compared with the urea-induced
unfolding profiles of apoMalY and NaBH4-reduced holoenzyme
suggest that the coenzyme group attached to the active-site lysine
residue increases the stability of the dimeric enzyme. Both holoand
apo-MalY could be successfully refolded into the active
enzyme with an 85% yield. Further refolding studies suggest
that large misfolded soluble aggregates that cannot be refolded
could be responsible for the incomplete re-activation
Log-ratio magnitude of <i>a</i> and <i>b</i> for each signatures in BRCA (I) and MALY (II).
No full textLog-ratio magnitude of a and b for each signatures in BRCA (I) and MALY (II).</p
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