3,133 research outputs found
Nota introduttiva (saggi di Francesco Mora su Simmel)
No full textGeorg Simmel was undoubtedly the author to whom Francesco Mora, throughout his scholarly career, most frequently directed his critical attention. The four essays selected for this volume also testify to the continuity of his work on Simmel, from his debut essay in 1985 to the contributions devoted, more than thirty years later, to "The Meaning of Life and Conflict" (2018) and the expression "Forms of Life" (2018). The Venetian philosopher's hermeneutic objective, which will also be central to the two monographs, and, in particular, to the one on the "Principle of Reciprocity": to trace the apparently eclectic and panoramic nature of Simmelian work back to the common thread of a unitary interpretation
Author response
No full textDetecting pathogens and mounting immune responses upon infection is crucial for animal health. However, these responses come at a high metabolic price (McKean and Lazzaro, 2011, Kominsky et al., 2010), and avoiding pathogens before infection may be advantageous. The bacterial endotoxins lipopolysaccharides (LPS) are important immune system infection cues (Abbas et al., 2014), but it remains unknown whether animals possess sensory mechanisms to detect them prior to infection. Here we show that Drosophila melanogaster display strong aversive responses to LPS and that gustatory neurons expressing Gr66a bitter receptors mediate avoidance of LPS in feeding and egg laying assays. We found the expression of the chemosensory cation channel dTRPA1 in these cells to be necessary and sufficient for LPS avoidance. Furthermore, LPS stimulates Drosophila neurons in a TRPA1-dependent manner and activates exogenous dTRPA1 channels in human cells. Our findings demonstrate that flies detect bacterial endotoxins via a gustatory pathway through TRPA1 activation as conserved molecular mechanism.sponsorship: Vlaams Instituut voor Biotechnologie Alessia Soldano Luis Franco Guangda Liu Natalia Mora Emre Yaksi Bassem A Hassanr Fonds Wetenschappelijk Onderzoek G.0702.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0077.15 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0680.10 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0681.10 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0503.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0654.15 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0761.10N Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0596.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0565.07 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar KU Leuven GOA/14/011 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar European Commission IUAP P7/13 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekensr KU Leuven OT/12/091 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar KU Leuven PF-TRPLe Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talavera (Vlaams Instituut voor Biotechnologie, Fonds Wetenschappelijk Onderzoek|G.0702.12, Fonds Wetenschappelijk Onderzoek|G.0077.15, Fonds Wetenschappelijk Onderzoek|G.0680.10, Fonds Wetenschappelijk Onderzoek|G.0681.10, Fonds Wetenschappelijk Onderzoek|G.0503.12, Fonds Wetenschappelijk Onderzoek|G.0654.15, Fonds Wetenschappelijk Onderzoek|G.0761.10N, Fonds Wetenschappelijk Onderzoek|G.0596.12, KU Leuven|GOA/14/011, KU Leuven|OT/12/091, European Commission|IUAP P7/13, KU Leuven PF-TRPLe)status: Publishe
Carta sobre la necesidad de obtener permiso del gobernador de California antes de despachar barcos desde las misiones, 1774 agosto 24
No full textCarta que discute una situación en la que un barco de las misiones partió sin el conocimiento del gobernador, causando discordia entre el gobernador y Mora. El autor expresa preocupación por la perturbación causada por tales incidentes e instruye al destinatario a no repetir esta acción, haciendo hincapié en la necesidad de obtener permiso del gobernador antes de despachar barcos. —— Letter discussing a situation where a ship from the missions departed without the knowledge of the governor, causing discord between the governor and Mora. The author expresses concern over the disruption caused by such incidents and instructs the recipient not to repeat this action, emphasizing the need to obtain permission from the governor before dispatching ships. 1 f. (2 p.
Informe sobre un despacho de una lancha sin orden del gobernador, 1775 marzo 26
No full textFr. Vicente de Mora afirma que envió un barco para llevarse al Fr. Nicolás Muñoz a San Blas sin el permiso del gobernador Felipe Barri porque no sabía que lo necesitaba. Relata el hecho que motivó la denuncia del gobernador en su contra. Al final del documento, el autor describe los desacuerdos que han tenido con el gobernador Barri, argumentando que deberían estar exentos de sus órdenes. —— Fr. Vicente de Mora affirms that he sent a boat to take Fr. Nicolas Muñoz to San Blas without Governor Felipe Barri's permission because he did not know he needed it. He recounts the event that led to the governor's complaint against him. In the end of the document, the author describes the disagreements they have had with Governor Barri, arguing that they should be exempt from his orders. 6 f. (12 p.
Two-stage index computation for bandits with switching penalties II : switching delays
No full textThis paper addresses the multi-armed bandit problem with switching penalties including both costs and delays, extending results of the companion paper [J. Niño-Mora. "Two-Stage Index Computation for Bandits with Switching Penalties I: Switching Costs". Conditionally accepted at INFORMS J. Comp.], which addressed the no switching delays case. Asawa and Teneketzis (1996) introduced an index for bandits with delays that partly characterizes optimal policies, attaching to each bandit state a "continuation index" (its Gittins index) and a "switching index", yet gave no algorithm for it. This paper presents an efficient, decoupled computation method, which in a first stage computes the continuation index and then, in a second stage, computes the switching index an order of magnitude faster in at most (5/2)+O(n) arithmetic operations for an n -state bandit. The paper exploits the fact that the Asawa and Teneketzis index is the Whittle, or marginal productivity, index of a classic bandit with switching penalties in its semi- Markov restless reformulation, by deploying work-reward analysis and LP-indexability methods introduced by the author. A computational study demonstrates the dramatic runtime savings achieved by the new algorithm, the near-optimality of the index policy, and its substantial gains against a benchmark index policy across a wide instance range.
Till frågan om Mora ting : ett arkeologiskt perspektiv
No full textThe phenomenon of the medieval royal election thing of Mora, on the outskirts of Uppsala in central Sweden, is an under-researched topic from an archaeological viewpoint. With the archaeological material in focus, the author reviews the current state of research and offers a new hypothesis about the development of Mora as a non -continuous thing site with three phases: in the 500s, 1300s and 1400s. It connects to long debated questions such as where in Mora the actual thing was located, why Mora was chosen to host this important ceremonial act, and how the semi-mythical "Stone of Mora" is to be understood.</p
Till frågan om Mora ting : ett arkeologiskt perspektiv
No full textThe phenomenon of the medieval royal election thing of Mora, on the outskirts of Uppsala in central Sweden, is an under-researched topic from an archaeological viewpoint. With the archaeological material in focus, the author reviews the current state of research and offers a new hypothesis about the development of Mora as a non-continuous thing site with three phases: in the 500s, 1300s and1400s. It connects to long debated questions such as where in Mora the actual thing was located, why Mora was chosen to host this important ceremonial act, and how the semi-mythical “Stone of Mora” is to be understood
La Mora
No full textThe default has been regulated from a perspective focused on protecting the debtor. Nowadays, this view has become outdated and it is necessary to redesign it.In this article, the author studies the default with the support of the Italian doctrine. In this order, he addresses issues such as the assignation of the amounts to be payed and the onus of cooperation that falls on the creditor.La mora ha venido regulándose desde un paradigma de defensa del deudor. Hoy en día, esta imagen viene a ser desfasada y es necesario actualizarla. A lo largo del presente artículo, el autor estudia la figura de la mora apoyándose principalmente en la doctrina italiana. En este marco, toca temas como la asignación de los montos a indemnizar y la carga de cooperación que recae en el acreedo
Avances recientes en complejos de oro-NHC con propiedades biológicas.
No full textThis tutorial review covers the recent advances made in the study of gold complexes containing N-heterocyclic carbene ligands with biological properties. The great stability, ease of modulation of the electronic properties and excellent σ-donating capacity displayed by NHCs allow gold-NHC derivatives to reach high stability in biological media and relatively good internalization into cells and for that they have emerged as excellent potential chemotherapeutics. The new gold-NHC derivatives show superior anticancer activity compared to other standards such as Cisplatin or Auranofin. In addition, the application of gold-NHC complexes in the treatment of other human diseases as antibacterial, antioxidant and antiparasitic agents is reviewed for the first timeEsta revisión tutorial cubre los avances recientes realizados en el estudio de complejos de oro que contienen ligandos de carbeno N-heterocíclicos con propiedades biológicas. La gran estabilidad, la facilidad de modulación de las propiedades electrónicas y la excelente capacidad de donación σ mostrada por los NHC permiten que los derivados de oro-NHC alcancen una alta estabilidad en medios biológicos y una internalización relativamente buena en las células y, para ello, han resultado ser excelentes agentes quimioterapéuticos potenciales. Los nuevos derivados de oro-NHC muestran una actividad anticancerígena superior en comparación con otros estándares como Cisplatin o Auranofin. Además, se revisa por primera vez la aplicación de complejos de oro-NHC en el tratamiento de otras enfermedades humanas como agentes antibacterianos, antioxidantes y antiparasitarios.Mora, Malka-6a6f03ac-44da-4475-b29f-d25fd4a93266-0Gimeno Concepción, María-eef11866-39a0-4333-84be-a909c56a9efb-0Visbal, Renso-3bc64685-c62d-4286-be88-187fbdb60355-
Characterization and computation of restless bandit marginal productivity indices
No full textThe Whittle index [P. Whittle (1988). Restless bandits: Activity allocation in a changing world. J. Appl. Probab. 25A, 287-298] yields a practical scheduling rule for the versatile yet intractable multi-armed restless bandit problem, involving the optimal dynamic priority allocation to multiple stochastic projects, modeled as restless bandits, i.e., binary-action (active/passive) (semi-) Markov decision processes. A growing body of evidence shows that such a rule is nearly optimal in a wide variety of applications, which raises the need to efficiently compute the Whittle index and more general marginal productivity index (MPI) extensions in large-scale models. For such a purpose, this paper extends to restless bandits the parametric linear programming (LP) approach deployed in [J. Niño-Mora. A (2/3) fast-pivoting algorithm for the Gittins index and optimal stopping of a Markov chain, INFORMS J. Comp., in press], which yielded a fast Gittins-index algorithm. Yet the extension is not straightforward, as the MPI is only defined for the limited range of socalled indexable bandits, which motivates the quest for methods to establish indexability. This paper furnishes algorithmic and analytical tools to realize the potential of MPI policies in largescale applications, presenting the following contributions: (i) a complete algorithmic characterization of indexability, for which two block implementations are given; and (ii) more importantly, new analytical conditions for indexability — termed LP-indexability — that leverage knowledge on the structure of optimal policies in particular models, under which the MPI is computed faster by the adaptive-greedy algorithm previously introduced by the author under the more stringent PCL-indexability conditions, for which a new fast-pivoting block implementation is given. The paper further reports on a computational study, measuring the runtime performance of the algorithms, and assessing by a simulation study the high prevalence of indexability and PCL-indexability.
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