196,633 research outputs found
WELZER\u27S MANUSCRIPT FOR LUTHERAN CENTRE AT THE BETNAVA NEAR MARIBOR FROM 1587-1598 1587-1598
No full textV svojem diplomskem delu z naslovom Welzerjev obračun za evangeličansko versko središče na Betnavi pri Mariboru 1587-1598 obravnavam transliteracijo gradiva tajnika protestantske verske občine na Dravskem polju konec 16. stoletja, ki je imela svoj sedež ob Herbersteinovem dvorcu na Betnavi. Delo plemiča Klemna Welzerja pl. Ebersteina je bilo zelo pomembno za malo protestantsko skupnost, ki pa je z leti vedno bolj naraščala. Zanimanje za novo vero je raslo, na Betnavi so začeli graditi nove objekte, kot so molilnica, pokopališče, šola in hiša za predikanta. Seveda so za to potrebovali denar in nekoga, ki bo ta denar upravljal. Nalašč za to delo je bil Welzer, ki se je resno lotil svojih obveznosti. Dan za dnem je v svoj obračun (lahko mu rečemo tudi bilanca stanja) zapisoval vse prihodke (donacije zvestih vernikov in dežele Štajerske) in odhodke. Zraven tega je njegovo delo obsegalo tudi naročila in nadzor vsega materiala, ki je bil potreben za gradnjo želenih objektov. Odziv prebivalstva je bil velik, ljudje so vsak mesec prispevali v občinsko blagajno, svoje je redno dodajala tudi dežela Štajerska. Radodarnost ljudi je obsegala tudi pomoč pri delu in prinašanje materiala na gradbišče.
Mala protestantska skupnost se je srečevala tudi s težavami, kot je na primer uničevanje njihove lastnine (razbita stekla, vrata, svoje umrle so morali pokopavati na svojem pokopališču – zato tudi gradnja pokopališča….) idr. Protestantska verska občina na Betnavi je delovala vse do leta 1600, ko so bili protestanti od tod pregnani, njihove stavbe in pokopališče pa porušeni. Ostal je le dvorec Betnava, saj je bil v lasti graščakov, v tem primeru graščaka Herbersteina.This diploma thesis titled Welzer\u27s Manuscript for Lutheran Centre at the Betnava near Maribor 1587-1598 considers the transliteration of the Protestant religious centre secretary\u27s material from the end of the 16th century in a place, that was located next to Herberstein mansion in Betnava. The work of nobleman Klemen Welzer pl. Eberstein was very important for a small Protestant community that grew with every year. Interest in religion was increasing and new objects were being built in Betnava, among them a small oratory, a graveyard, a school and a preacher\u27s house. Welzer was the right person for the job and took his duties very serious. Day after day he noted all income (donations from loyal believers and land Styria) and expenditure in his financial tally (it might as well be called a balance sheet). Besides this his work also included orders and management of the whole material needed for the construction of the desired objects. The response from the residents was immense and people donated to centre treasury on a monthly basis –land Styria also ordinarily contributed its share. The generosity of the people was also shown in work and bringing material to the construction site.
The small Protestant community also faced problems such as destruction of their property (broken glass, doors, they had to bury their deceased at their own graveyard – hence the construction of a graveyard, etc.). The Protestant religious centre in Betnava existed until 1600 when the Protestants were banished from the site and their buildings and graveyard demolished. Betnava mansion is all that is left – thanks to the ownership of the noblemen, namely nobleman Herberstein
MALEC: a multiple access low energy cache
No full textThis paper addresses the dynamic energy consumption in L1 data cache interfaces of out-of-order superscalar processors. The proposed Multiple Access Low Energy Cache (MALEC) is based on the observation that consecutive memory references tend to access the same page. It exhibits a performance level similar to state of the art caches, but consumes approximately 48% less energy. This is achieved by deliberately restricting accesses to only 1 page per cycle, allowing the utilization of single-ported TLBs and cache banks, and simplified lookup structures of Store and Merge Buffers. To mitigate performance penalties it shares memory address translation results between multiple memory references, and shares data among loads to the same cache line. In addition, it uses a Page-Based Way Determination scheme that holds way information of recently accessed cache lines in small storage structures called way tables that are closely coupled to TLB lookups and are able to simultaneously service all accesses to a particular page. Moreover, it removes the need for redundant tag-array accesses, usually required to confirm way predictions.For the analyzed workloads, MALEC achieves average energy savings of 48% in the L1 data memory subsystem over a high performance cache interface that supports up to 2 loads and 1 store in parallel. Comparing MALEC and the high performance interface against a low power configuration limited to only 1 load or 1 store per cycle reveals 14% and 15% performance gain requiring 22% less and 48% more energy, respectively. Furthermore, Page-Based Way Determination exhibits coverage of 94%, which is a 16% improvement over the originally proposed line-based way determination.<br/
Microtus felteni Malec and Storch 1963
No full textMicrotus felteni Malec and Storch, 1963. Senckenberg. Biol., 44:171. TYPE LOCALITY: Yugoslavia, Rep. Makedonija (Macedonia), Pelister Mtns, near Trnovo-Magarevo. DISTRIBUTION: S Yugoslavia and Greece (see Niethammer, 1982/1, 1987b). COMMENTS: Subgenus Terricola, savii species group sensu Chaline et al. (1988). Reviewed by Niethammer (1982/i). Chromosomal data summarized and reviewed by Zima and Krâl (1984a). Biochemical comparisons among M. felteni, M. subterraneus, and other voles are documented by Gill et al. (1987).Published as part of Guy G. Musser & Michael D. Carleton, 1993, Order Rodentia - Family Muridae, pp. 501-755 in Mammal Species of the World (2 nd Edition), Washington and London :Smithsonian Institution Press on page 520, DOI: 10.5281/zenodo.735309
From the Union of Lublin to the Mutual Guarantee of the Two Nations
No full textThe purpose of this study is to show changes in the legal and political nature of the alliance between the Kingdom of Poland and the Grand Duchy of Lithuania over
the centuries, from the Union concluded in Lublin in 1569, through the so-called ‘coequatio iuris’ of 1697, until the regulations adopted in the Constitution of May 3,
and the “Reciprocal Guarantee of Both Nations” crowning the process and passed at the Four-Year Sejm on October 20, 1791. The study uses a wide range of archival
manuscript sources, old prints, parliamentary legislation, and also numerous studies using both old and current literature. The main research goal of the study was to show to what extent the changes in the legal nature of the union of the two countries led to their full unification, which was in the past (and sometimes still is) the interpretation of this process in many studies, and to what extent the federalist character of the Polish-Lithuanian Commonwealth was preserved, which is nowadays the dominant view and which the author of this study is a strong supporter [email protected] Akademia im. Andrzeja Frycza Modrzewskiego (Andrzej Frycz Modrzewski Krakow University, Poland)Archiwum Główne Akt Dawnych, Arch. Publ. Potockich 98, 99, 313/II.Archiwum Główne Akt Dawnych, Archiwum Sejmu Wielkiego 13, 15, 22.B. Czart. Ms. 184, 192, 817.Akta unii Polski z Litwą, 1385–1791, ed. S. Kutrzeba, W. Semkowicz, Kraków 1932.Kołłątaj H., O ustanowieniu i upadku konstytucji polskiej 3 maja 1971, Biblioteka Mrówki, vol. 146-151 (n.d.).Porządek sądzenia spraw w Trybunale Wielkiego Księstwa Litewskiego z Konstitutii Sejmowych z Koaequatiej Praw W.X.L. z Koroną Polską i z Statutu W.X.L. zebrany
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Territorien in Ostmitteleuropa. Historische Beziehungen und politische Herrschaftslegitimation, red. D. Willoweit, H. Lemberg, München 2006.Nowina-Konopka P., Od Unii Jagiellońskiej do Unii Europejskiej, [w:] Europa Środkowa – nowy wymiar dziedzictwa, red. J. Purchla, Kraków 2002.Ochmański J., Historia Litwy, 3rd ed., Warszawa – Wrocław 1990.Petrauskas R., Der litauische Blick auf den polnisch-litauischen Staatsverband – “Verlust der Staatlichkeit” oder Bewahrung der Parität, „Zeitschrift für Ostmitteleuropa – Forschung” 2004, Bd. 53, Nr. 3.Piwarski K., Opozycja litewska pod koniec XVII wieku, [w:] Pamiętnik V Powszechnego Zjazdu Historyków Polskich w Warszawie, Lwów 1930.Radwański Z., Prawa kardynalne w Polsce, Poznań 1952.Sapoka A., Didysis Varsuos reformu lietuviskoji Enciklopedija, t. 4, Kaunas 1937.Schepers S., Le droit fédéral en Europe. Un essai historique, Bruxelles 1991.Sielski M., Unia lubelska jako projekt integracji w Europie, [in:] Europa Środkowa – nowy wymiar dziedzictwa, red. J. Purchla, Kraków 2002.Słowik G.P., Głuszek J., Unia czy państwo unitarne? Dylematy twórców Konstytucji 3 Maja wobec relacji Korony i Wielkiego Księstwa Litewskiego, „Rocznik Stowarzyszenia Naukowców Polaków Litwy” 2021, T. 21A.Smoleński W., Sprawa stosunku Polski do Litwy na Sejmie Wielkim, [w:] Księga Pamiątkowa ku czci Bolesława Orzechowicza, Lwów 1916.Szcząska Z., Ustawa Rządowa z 1791 r., [w:] Konstytucje Polski : studia monograficzne z dziejów polskiego konstytucjonalizmu, red. M. Kallas, t. 1, Warszawa 1990.Unia lubelska i tradycje integracyjne w Europie Środkowo-Wschodniej, red. J. Kłoczowski, P. Kras, H. Łaszkiewicz, Lublin 1999.Unie międzypaństwowe – Parlamentaryzm – Samorządność. Studia z dziejów ustroju Rzeczypospolitej Obojga Narodów, red. W. Uruszczaka, Z. Nogi, M. Zwierzykowskiego, K. Fokta, Warszawa 2020.Uruszczak W., Historia państwa i prawa polskiego, t. 1: 966–1795, 2nd ed., Warszawa 2013.Waga K., Zaręczenie wzajemne obojga narodów, „Przegląd Wileński” 1926, R. IX, nr 8.Wasilewski T., Walka o zrównanie praw szlachty litewskiej z Koroną od unii lubelskiej do początku XVIII wieku, „Zapiski Historyczne” 1986, t. 51, nr 1.Wasilewski T., Wielkie Księstwo Litewskie w dobie Rzeczypospolitej Obojga Narodów (1569–1795). Federacja dwóch państw i narodów czy państwo jednolite?, „Lithuania” 1990, nr 1.Wielka Encyklopedia Powszechna Ilustrowana, Series II, vol. 5-6, Warszawa 1908.Wisner H., Litwa wobec rokoszu (1606–1607), „Kwartalnik Historyczny” 1973, t. 79, nr 2.Woliński J., Koekwacja praw na Litwie 1697 r., [w:] O naprawę Rzeczypospolitej XVII–XVIII w., Warszawa 1965.Zakrzewski A.B., Paradoksy unifikacji prawa i ustroju Wielkiego Księstwa Litewskiego i Korony XVI–XVIII w., „Czasopismo Prawno-Historyczne” 1999, t. 51, nr 1-2.Zakrzewski A.B., Wielkie Księstwo Litewskie (XVI–XVIII w.). Prawo-ustrój-społeczeństwo, Warszawa 2013.22145548
Standardization and application of quantitative PCR methods in patients with hematological malignancies
No full textUsing modem combination chemotherapy regimens, it has been possible to increase the rate of complete remission (CR) in acute lymphoblastic (ALL) and acute myeloid leukemia (AML). The major reason for treatment failure in acute leukemia (AL) is the resistance of leukemic blasts to chemotherapeutic agents, which is accompanied by an inability of the immune system to eradicate residual leukemic cells surviving initial treatment. Such cells are referred to as minimal residual disease (MRD), and are very difficult to detect against the background of regenerating bone marrow (BM).The clinical definition of CR is traditionally based on conventional cytomorphological techniques, which have detection limits of 1-5%. Therefore more sensitive methods are needed for accurate evaluation of the presence of MRD. This thesis has been aimed at the standardization and assessment of molecular techniques for MRD detection in AL. A further goal has been the development of similar methods to gain quantitative information on the mRNA expression of various cytokines in lymph node biopsies from patients with Hodgkin's lymphoma (HL).Experience from the cooperative projects "BIOMED-1 Concerted Action" (CA) and "Europe Against Cancer" (EAC) contributed to MRD evaluation in a standardized way. The collaborative BIOMED-1 study resulted in the standardization of primer sets, and conditions for RT-PCR, firstly for its use in clinical practice for the molecular classification of AL at diagnosis, and secondly for MRD detection during follow-up, in order to evaluate treatment effectiveness. The collaborative efforts of EAC resulted in the development of primers and probes for real-time quantitative (RQ)-PCR analysis for fusion gene (FG) and control gene (CG) transcripts (ABL, GUS, B2M). We applied RQ-PCR to investigate the differences over time in the stabilities of FG and CG transcripts, which may result in over- or under-estimation of MRD levels. The mean stability of most FG transcripts seemed to be comparable to those of the CG; however large differences were observed between patients expressing the same FG transcripts.To compare MRD levels in follow-up BM samples from children with ALL two main methods were used: FC and semi-quantitative ASO-PCR techniques. Comparison between FC and ASOPCR showed significantly consistent results in 78% of the samples. Development of RQ-PCR permitted accurate quantification of PCR products during the exponential phase of the PCR amplification process, in complete contrast to classical PCR end-point quantification. We applied RQ-PCR and FC methods, to compare MRD levels in follow-up samples from 22 ALL patients. When results obtained by RQ-PCR and FC were grouped into positive-negative categories, a significant level of agreement was found in 72% of samples. However, if a cutoff level of 0.01% was applied, the concordance was 89%.Application of RQ-PCR techniques gains quantitative information on DNA and mRNA levels, and so we applied this approach to investigate cytokine mRNA expression in Hodgkin's Lymphoma (HL) samples and HL cell line. Reactive lymphatic tissue and peripheral blood mononuclear cells (PBMCs) from healthy donors were used as controls. The results demonstrated that expression levels of IL-13, IL-10, IL-1beta, IFNgamma, IL-15, and IL-12p35 in HL tissue were higher than those in PBMCs and reactive tissue. The highest mRNA levels for several of the cytokines were found in Epstein-Barr virus-positive samples.In conclusion, this study provides the basis for rational and efficient molecular quantitative determination of MRD levels. These approaches are conducted whilst the patient is within the first months of treatment, and give information, which allows patient classification into low or high-risk groups. These groups may benefit from the possibility for group-specific treatment modalities, which minimize side effects and optimize treatment outcome. Moreover, the application of these methods can give valuable information on inherent biological variation between different lymphoma samples, and may help to unravel the complex cytokine network contributing to the clinical and biological heterogeneity of these diseases.List of scientific papersI. van Dongen JJ, Macintyre EA, Gabert JA, Delabesse E, Rossi V, Saglio G, Gottardi E, Rambaldi A, Dotti G, Griesinger F, Parreira A, Gameiro P, Diaz MG, Malec M, Langerak AW, San Miguel JF, Biondi A (1999). Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia. Leukemia. 13(12): 1901-28. https://pubmed.ncbi.nlm.nih.gov/10602411II. van der Velden VH, Boeckx N, Gonzalez M, Malec M, Barbany G, Lion T, Gottardi E, Pallisgaard N, Beillard E, Hop WC, Hoogeveen PG, Gabert J, van Dongen JJ; Europe Against Cancer Program (2004). Differential stability of control gene and fusion gene transcripts over time may hamper accurate quantification of minimal residual disease--a study within the Europe Against Cancer Program. Leukemia. 18(4): 884-6. https://pubmed.ncbi.nlm.nih.gov/14961029III. Malec M, Bjorklund E, Soderhall S, Mazur J, Sjogren AM, Pisa P, Bjorkholm M, Porwit-MacDonald A (2001). Flow cytometry and allele-specific oligonucleotide PCR are equally effective in detection of minimal residual disease in ALL. Leukemia. 15(5): 716-27. https://pubmed.ncbi.nlm.nih.gov/11368431IV. Malec M, van der Velden VH, Bjorklund E, Wijkhuijs JM, Soderhall S, Mazur J, Bjorkholm M, Porwit-MacDonald A (2004). Analysis of minimal residual disease in childhood acute lymphoblastic leukemia: comparison between RQ-PCR analysis of Ig/TcR gene rearrangements and multicolor flow cytometric immunophenotyping. Leukemia. 18(10): 1630-6. https://pubmed.ncbi.nlm.nih.gov/15295608V. Malec M, Soderqvist M, Sirsjo A, MacNamara B, Lewin N, Sjoberg J, Bjorkholm M, Porwit-MacDonald A (2004). Real-time polymerase chain reaction determination of cytokine mRNA expression profiles in Hodgkins lymphoma. Haematologica. 89(6): 679-85. https://pubmed.ncbi.nlm.nih.gov/15194535</p
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Dr. Glendon Swarthout
No full textHosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness
Simulation of thermal plant optimization and hydraulic aspects of thermal distribution loops for large campuses
No full textFollowing an introduction, the author describes Texas A&M University and its utilities system. After that, the author presents how to construct simulation models for chilled water and heating hot water distribution systems. The simulation model was used in a $2.3 million Ross Street chilled water pipe replacement project at Texas A&M University. A second project conducted at the University of Texas at San Antonio was used as an example to demonstrate how to identify and design an optimal distribution system by using a simulation model. The author found that the minor losses of these closed loop thermal distribution systems are significantly higher than potable water distribution systems. In the second part of the report, the author presents the latest development of software called the Plant Optimization Program, which can simulate cogeneration plant operation, estimate its operation cost and provide optimized operation suggestions. The author also developed detailed simulation models for a gas turbine and heat recovery steam generator and identified significant potential savings. Finally, the author also used a steam turbine as an example to present a multi-regression method on constructing simulation models by using basic statistics and optimization algorithms. This report presents a survey of the author??s working experience at the Energy Systems Laboratory (ESL) at Texas A&M University during the period of January 2002 through March 2004. The purpose of the above work was to allow the author to become familiar with the practice of engineering. The result is that the author knows how to complete a project from start to finish and understands how both technical and nontechnical aspects of a project need to be considered in order to ensure a quality deliverable and bring a project to successful completion. This report concludes that the objectives of the internship were successfully accomplished and that the requirements for the degree of Degree of Engineering have been satisfied
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