346 research outputs found
Repetitive current control of two-level and interleaved three-phase PWM utility connected converters
No full textThis thesis is mainly concerned with investigations into digital repetitive current controlof two-level and interleaved utility connected PWM converters. The research ismotivated by the relatively poor performance of classical (PI) controllers when theutility voltage harmonic distortion is high. This is due to the low gain, and poordisturbance rejection of the PI controller at the utility harmonic frequencies. Repetitivefeedback controllers have the ability to track or reject periodic disturbances, such asutility harmonics, as they naturally have high gains at the utility voltage harmonicfrequencies, assuming that these frequencies do not change.Repetitive controllers (RC) are known for being sensitive to variations in systemparameters and disturbance frequency, which in practice renders them either ineffectiveor unstable. Another challenge arises from the memory requirements of RC in case ofthe absence of even harmonics, which can make its practical implementation difficultand expensive. In addition, another problem that has not been investigated extensivelyin the literature is that the effectiveness of RC is severely limited by the limitedbandwidth of the plant (the utility connected converter and its filter). Theoreticalanalysis and simulation results presented in this thesis show that RC could noteffectively reject disturbances at frequencies above the closed loop system bandwidth.The design of the converter's output filter bandwidth and the values of its componentsneed to be selected carefully, to enable RC to be used effectively.The research in this thesis focuses on investigating the practical implementation andperformance limits of two types of repetitive controllers (conventional and oddharmonics),used for current control of two-level utility connected converter with LCLoutput filter. The odd-harmonic repetitive controller halves the memory requirementand offers higher gains only at odd harmonic frequencies of interest. The overall controlscheme consists of the traditional classical tracking controller with a dual loop feedbacksystem and RC. The results indicate that the repetitive controller improves the steadystate error and the total harmonic distortion of the output current, provided that theplant's bandwidth is sufficiently large.Finally, a repetitive controller for an interleaved utility connected converter has beendesigned and investigated in this study. The interleaved converter system has higherbandwidth than the two-level converter, which improves the effectiveness of RC. Itprovides good disturbance rejection compared to classical controllers which results inlow output current THD. The RC was demonstrated to be robust despite uncertainty inutility impedance, while achieving a fast almost zero error convergence. The proposedRC has been experimentally implemented using a DSP and the results indicate that thequality of output current complies with international standards on harmonic limits andmatches simulation results obtained from the Matlab/Simulink model of the system
Optimization of SC-CO2 Extraction OF Alpinia Galangal (L.) Wild and Estimation of Cost of Manufacturing (COM) Via SIMULATION Process
No full textIn this study, the rhizome of a ginger plant, Alpinia galangal (L.) Wild, was subjected to supercritical fluid carbon dioxide (SCCO2) extraction at 150-250 bar and 40-60°C. Influence of the operating parameters; temperature and pressure on the yield extract was investigated as well the evaluation of 1-acetoxy-chavicol acetate (1'ACA) content in the best extraction condition by Gas Chromatograph (GC) and Gas Chromatograph/Mass Spectrum (GC/MS). Density of CO2 (kg/L) was calculated using Bender correlation based on the pressure and temperature, therefore solubility of solute in SC-CO2 (g/L) can be determined. PRO/II® software was used to simulate the extraction process at large scale and to estimate the cost of manufacturing (COM) at the best extraction condition. For simulation process, correlation between solubility of solute in SC CO2 and SC CO2 density was calculated based on Chrastil correlation and Peng Robinson was used as the thermodynamic model. The aim of this work is to determine the best SC-CO2 extraction condition for A.galangal rhizome based on yield extract and perform the economical evaluation of the extraction via simulation process
Dr. Jamil Jalibi: The Fragrence of Personal Relation and Research
No full textDr Jamil Jalibi (1929-2019) is a well-known writer, literary historian and critic. There are over thirty books on these genres, to his credit. He wrote a matchless History of Urdu Literature and edited a legendary literary magazine, Naya Daur, for many years. In this article, the author has remembered him, through his personal reflections. Unpublished letters of Dr Jamil Jalibi, addressed to the author, have also been produced here. These letters not only express his sentiments towards his addressee but also reflect his own personality through the words of affection and literature. Questions raised by the author are also answered by the literary genius. Issues requiring explanations have been expounded on, in the endnotes
Dr. Jamil Jalibi: The Fragrence of Personal Relation and Research
No full textDr Jamil Jalibi (1929-2019) is a well-known writer, literary historian and critic. There are over thirty books on these genres, to his credit. He wrote a matchless History of Urdu Literature and edited a legendary literary magazine, Naya Daur, for many years. In this article, the author has remembered him, through his personal reflections. Unpublished letters of Dr Jamil Jalibi, addressed to the author, have also been produced here. These letters not only express his sentiments towards his addressee but also reflect his own personality through the words of affection and literature. Questions raised by the author are also answered by the literary genius. Issues requiring explanations have been expounded on, in the endnotes
Dr. Jamil Jalibi: The Fragrence of Personal Relation and Research
No full textDr Jamil Jalibi (1929-2019) is a well-known writer, literary historian and critic. There are over thirty books on these genres, to his credit. He wrote a matchless History of Urdu Literature and edited a legendary literary magazine, Naya Daur, for many years. In this article, the author has remembered him, through his personal reflections. Unpublished letters of Dr Jamil Jalibi, addressed to the author, have also been produced here. These letters not only express his sentiments towards his addressee but also reflect his own personality through the words of affection and literature. Questions raised by the author are also answered by the literary genius. Issues requiring explanations have been expounded on, in the endnotes
Corrigendum
No full textBoyer TD, Medicis JJ, Pappas SC, Potenziano J, Jamil K. A randomized, placebo-controlled, double-blind study to confirm the reversal of hepatorenal syndrome type 1 with terlipressin: the REVERSE trial design. Open Access Journal of Clinical Trials. 2012;4:39–49.Dr Jamil’s first name was incorrectly spelt as Khuramm Jamil in the author list. The correct spelling is Khurram Jamil.Read the original articl
ڈاکٹرجمیل جالبی کا حاسئہ تحقیق : میرا جی، راشد اور میرکے خصوصی حوالےسے: SENSATION OF RESEARCH OF DR JAMIL JALBI:WITH SPECIAL REFERENCE TO MIRA.G, RASHID & MEER
No full textDr. Jamil Jalbi being an authentic reference of Urdu literature, Research and criticism has no alternative in Reseach specially. He has reviewed critically work of many literary personalites. Critical analysis of Mira.G, Rashid and Meer by Dr Jamil Jalbi are significantly known in Urdu literature. The purpose of this article is to explore Reseach expertise of Dr. Jamil Jalbi regarding Kulyat-e-Meera G, Noon-Meem Rashid-Aik Mutalia, Muhammad Taqi Meer. Author has concluded that criterion and standards of Research established by Dr. Jamil Jalbi are road map for new scholars and Researchers
ترجمےکافن اور ڈاکٹر جمیل جالبی کی ترجمہ نگاری: THE ART OF TRANSLATION AND THE RENDERINGS OF DR. JAMIL JALBI (WITH SPECIAL REFERENCE OF JANWARASTAN)
No full textTranslation and discourse analysis are the best sources of uniformity and conformity among societies and civilizations regarding meanings, ideologies, concepts and beliefs. Dr. Jamil Jalbi transforms from English language to Urdu aphoristically with same sense of meaning and context. The Researcher has critically evaluated translation of George Orwell’s novel “Animal Farm” in Urdu Language entitled “Janwarstan” by Dr. Jamil Jalbi where idioms, phrases, phrasal verbs and slangs have been transformed as Lingua Franca. The reader feels originality that is real sense of Dr. Jamil Jalbi. A sociological system allegorically has been revealed by the author and conveyed the 2nd language with contextual aspect of civilization. Political differences how run among societies are real theme and how the misuse of power handles the situations
MCL-1 localizes to sites of DNA damage and regulates DNA damage response
No full textMCL-1, a pro-survival member of the BCL-2 family, was previously shown to have functions in ATR-dependent Chk1 phosphorylation following DNA damage. To further delineate these functions, we explored possible differences in DNA damage response caused by lack of MCL-1 in mouse embryo fibroblasts (MEFs). As expected, Mcl-1(-/-) MEFs had delayed Chk1 phosphorylation following etoposide treatment, compared to wild type MEFs. However, their response to hydroxyurea, which causes a G(1)/S checkpoint response, was not significantly different. In addition, appearance of gamma-H2AX was delayed in the Mcl-1(-/-) MEFs treated with etoposide. We next investigated whether MCL-1 is present, together with other DNA damage response proteins, at the sites of DNA damage. Immunoprecipitation of etoposide-treated extracts with anti-MCL-1 antibody showed association of MCL-1 with gamma-H2AX as well as NBS1. Immunofluorescent staining for MCL-1 further showed increased co-staining of MCL-1 and NBS1 following DNA damage. By using a system that creates DNA double strand breaks at specific sites in the genome, we demonstrated that MCL-1 is recruited directly adjacent to the sites of damage. Finally, in a direct demonstration of the importance of MCL-1 in allowing proper repair of DNA damage, we found that treatment for two brief exposures to etoposide , followed by periods of recovery, which mimics the clinical situation of etoposide use, resulted in greater accumulation of chromosomal abnormalities in the MEFs that lacked MCL-1. Together, these data indicate an important role for MCL-1 in coordinating DNA damage mediated checkpoint response, and have broad implications for the importance of MCL-1 in maintenance of genome integrity.Peer reviewedfinal article publishedprotein complexchromosomesG2/McheckpointDNA repai
The small molecule 2-phenylethynesulfonamide induces covalent modification of p53
No full textp53 is a tumor suppressor protein which is either lost or inactivated in a large majority of tumors. The small molecule 2-phenylethynesulfonamide (PES) was originally identified as the inhibitor of p53 effects on the mitochondrial death pathway. In this report we demonstrate that p53 protein from PES-treated cells was detected in reduced mobility bands between molecular weights 95–220 kDa. Resolution of p53 aggregates on urea gel was unable to reduce the high molecular weight p53 aggregates, which were shown to be primarily located in the nucleus. Therefore, our data suggest that PES exerts its effects through covalent cross-linking and nuclear retention of p53. [ABSTRACT FROM AUTHOR]Peer reviewedfinal article publishe
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