1,720,957 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Mesoporous Silica Nanoparticles as a Versatile Drug Delivery Carrier for Biologicals and Small Molecules : A study in Pharmaceutical Sciences
No full textHydrogel-based scaffolds are pivotal in biomedical applications such as tissue engineering and wound healing, due to their structural similarity to the extracellular matrix (ECM). This similarity makes them excellent candidates for supporting tissue formation and delivering bioactive cues. Furthermore, hydrogels are highly adaptable materials, capable of being precisely shaped using semi-solid extrusion 3D printing. Despite these advantages, hydrogels often require reinforcement to enhance their mechanical properties and functionality. A common strategy involves incorporating nanoparticles to form nanocomposite hydrogels, combining the benefits of both hydrogels and nanoparticles. Among the various nanoparticles, mesoporous silica nanoparticles (MSNs) offer exceptional potential in drug delivery due to their tunable particle and pore sizes, large surface area, and modifiable surface chemistry. These attributes facilitate the adsorption and immobilization of a broad range of therapeutic active agents, including small molecules and biomacromolecules.
This thesis aims to fabricate MSN-reinforced naturally derived hydrogels suitable for delivery and immobilization of hydrophobic small-molecule drugs as well as biological proteins. Additionally, it investigates the interactions at three key interfaces within MSN-based nanocomposites and their influence on the therapeutic outcomes: (1) between MSNs and loaded cargo, (2) between MSNs and the hydrogel matrix, and (3) between MSNs and cells cultured within the matrix. Thus, MSNs with varying pore sizes were synthesized to match the molecular sizes of the molecular cargo to be loaded (drugs and proteins). Surface functionalization with neutral, positively and negatively charged functional groups were employed to optimize loading capacity and assess the influence of net surface charge on protein activity, matrix compatibility, and intracellular delivery.
The adsorption of three distinct model proteins (bovine serum albumin, horseradish peroxidase, lysozyme) onto surface-modified MSNs was optimized. Due to their structural sensitivity, the biological activity of immobilized proteins was evaluated for potential applications in nanocomposite hydrogels. MSNs with suitable surface modifications that provide optimal loading capacity and preserve biological activity, were used for fabricating nanocomposite hydrogels. The compatibility, rheological properties, and homogeneity of MSN-incorporated naturally derived hydrogels were thoroughly assessed. Different surface modifications of MSNs significantly influenced their compatibility and homogeneity within the matrix. Protein-loaded MSNs were further evaluated for 3D printability, protein release, and retention of biological activity after release from the 3D scaffolds, with a particular focus on the effect of crosslinking method on the biological activity. For intracellular delivery, hydrophobic drug-loaded MSNs with different surface charges were integrated into cell-laden hydrogel scaffolds. Drug delivery efficacy was evaluated in two biomedical contexts: tissue engineering and in vitro tumor modeling. Surface modified MSNs demonstrated an enhanced biological response compared to plain MSNs.
This thesis provides a basis for a deeper understanding of nano-biointerfaces and their impact on the therapeutic performance of MSN-reinforced hydrogel systems, offering valuable insights into the design of advanced drug delivery platforms.Hydrogelbaserade strukturer är centrala i biomedicinska tillämpningar som vävnadsteknik och sårläkning på grund av deras strukturella likhet med den extracellulära matrisen (ECM). Denna likhet gör dem till utmärkta kandidater för att stödja vävnadsbildning och tillförsel av bioaktiva molekyler. Dessutom är hydrogeler mycket anpassningsbara material, som kan formas exakt med hjälp av halvfast extruderingsbaserad 3D-utskrift. Trots dessa fördelar kräver hydrogeler ofta förstärkning för att förbättra deras mekaniska egenskaper och funktionalitet. En vanlig strategi involverar att inkorporera nanopartiklar för att bilda nanokomposithydrogeler, som kombinerar fördelarna med både hydrogeler och nanopartiklar. Bland de olika nanopartiklarna erbjuder mesoporösa kiseldioxidnanopartiklar (MSN) exceptionell potential för läkemedelstillförsel på grund av deras kontrollerbara partikel- och porstorlekar, stora ytarea och modifierbara ytkemi. Dessa attribut underlättar adsorptionen och immobiliseringen av ett brett spektrum av terapeutiska molekyler, inklusive småmolekylära läkemedel och biomakromolekyler.
Denna avhandling syftar till att tillverka MSN-förstärkta hydrogeler baserade på naturligt utvunna material lämpliga för tillförsel och immobilisering av hydrofoba läkemedel såväl som biologiska proteiner. Dessutom undersöks växelverkningarna vid tre nyckelgränssnitt inom MSN-baserade nanokompositer och deras inverkan på de terapeutiska resultaten: (1) mellan MSN och nyttolasten, (2) mellan MSN och hydrogelmatrisen och (3) mellan MSN och celler odlade i matrisen. Således syntetiserades MSN med varierande porstorlekar för att matcha molekylstorlekarna hos de hydrofoba läkemedel och proteiner som de skulle laddas med. Ytfunktionalisering med neutrala, positivt och negativt laddade grupper användes för att optimera laddningskapaciteten och bedöma påverkan av ytladdning på proteinaktivitet, matriskompatibilitet och intracellulärt upptag och läkemedelstillförsel.
Adsorptionen av tre distinkta modellproteiner på ytmodifierade MSN:er optimerades. På grund av deras strukturella känslighet utvärderades den biologiska aktiviteten hos immobiliserade proteiner för potentiella tillämpningar i nanokomposithydrogeler. MSN med lämpliga ytmodifieringar som ger optimal laddningskapacitet och bevarar biologisk aktivitet användes för att tillverka nanokomposithydrogeler. Kompatibiliteten, reologiska egenskaperna och homogeniteten hos MSN-inkorporerade hydrogeler utvärderades noggrant. Ytmodifieringar av MSN:er påverkade avsevärt deras kompatibilitet och homogenitet inom matrisen. Proteinladdade MSN:er utvärderades ytterligare för 3D-utskrivbarhet, proteinfrisättning och bibehållande av biologisk aktivitet efter frisättning från 3D-strukturerna, med särskilt fokus på effekten av tvärbindningsmetoden på den biologiska aktiviteten. För intracellulär tillförsel integrerades hydrofoba läkemedelsladdade MSN med olika ytladdningar i cellladdade hydrogelstrukturer. Läkemedelstillförseln utvärderades i två biomedicinska sammanhang: vävnadsteknik och in vitro-tumörmodellering. Ytmodifierade MSN:er visade förbättrad biologisk respons jämfört med ofunktionaliserade MSN:er.
Den här avhandlingen bidrar till en djupare förståelse för nano-biogränssnitt och deras inverkan på den terapeutiska prestandan hos MSN-förstärkta hydrogelsystem, och erbjuder värdefulla insikter i designen av avancerade läkemedelstillförselsystei tietoa saavutettavuudest
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
- …
