11,113 research outputs found
Genetic Engineering to Investigate Driver Mutations of Gastrointestinal Neuroendocrine Tumors
No full textIn the intestine, rare neuroendocrine epithelial cells secrete hormones that aid the digestive process and modulate the immune response. Gastrointestinal neuroendocrine tumors (GI-NETs) are slow growing and comprised of cells that look similar to neuroendocrine cells. The Magness Lab has found that a subset of transit-amplifying (TA) cells found in the crypts of the small intestine have a gene expression signature with features of both stem and neuroendocrine cells. We hypothesize that oncogenic mutation(s) occurring in intestinal stem cells (ISCs) and/or TA cells keep endocrine progenitor cells derived from ISCs from exiting the cell cycle and fully differentiating. There is currently limited experimental evidence on the specific combination of mutations needed to induce GI-NET formation. However, human GI-NETs have been found to express a loss of function in the tumor suppressor MEN1 (Multiple Endocrine Neoplasia Type I) and high levels of SOX4 (Sry-Box 4), a transcription factor that promotes endocrine differentiation. This thesis investigated whether a MEN1 loss of function mutation alone drove NET phenotypes in human ISCs and progenitor cells. CRISPR-Cas9 gene editing was utilized to introduce the loss of function mutation in the MEN1 gene. MEN1+/- cells were characterized for GI-NET phenotypes, including an increase in endocrine marker ChgA and persistent proliferation despite the progression to a more differentiated enteroendocrine cell phenotype. The results showed that a MEN1+/- mutation is insufficient for increased proliferation or increased incidence of enteroendocrine differentiation. Future studies will involve testing cells with homozygous MEN1 mutations, SOX4 overexpression, and the combination of MEN1 and SOX4 mutations for signs of GI-NET formation. If successful, these studies will provide the first functional evidence for GI-NET driver mutations.Bachelor of Scienc
Letter From William Bell Scott to Mr Chambers
No full textabstract: Concerning Scott's thanks, his writings about his own works, and a manuscript of "The Nightingale Unheard."Seller's Description: Reads "A.L.S. from Author to Mr. Chambers explaining how busy he is... The sonnet is printed in the book. Fredeman: 56.7 £87.50"Handwritten Note: Unknown handwriting at top right reads "June 1st 1877."Publication Details: "The Nightingale Unheard" published in "Poems" by William Bell Scott.Creation Date Details: Undated range is the author's lifespan.Provenance: Removed from:
Poems / by William Bell Scott. Ballads, studies from nature, sonnets, etc. / illustrated by seventeen etchings by the author and L. Alma Tadema. Publisher London : Longmans, Green, 1875. CALL #
HAYDEN SPECIAL COLL SPEC PRB-13
Scott Belsky in Conversation with DesignByThem - Part One.mp4
No full textWatch here as Scott Belsky (CEO/Founder Behance + Author Making Ideas Happen) joins Sydney design duo Sarah Gibson and Nicholas Karlovasitis from DesignByThem to discuss some of the challenges facing creative companies as they try to grow their business. In part one Nick and Sarah get some great advice from Scott about what makes an effective partnership and how to learn from the challenges that can arise. Scott also explains the Behance technique of ?Concepting Teams? with representatives from all areas of the business to brainstorm issues or new ideas
Cardozo AELJ Author Interview Series: Scott Semaya, Class of 2023
No full textThe Cardozo AELJ Author Interview Series seeks to give our readers further insight into the Articles and Notes published in the Cardozo Arts & Entertainment Law Journal. In this interview, Scott Semaya discusses his Note, Name, Image and Likeness: Giving College Athletes the Clearest Guidance to Best Profit off Their NIL, which was published in Volume 41, Issue 2.
This post was originally published on the Cardozo Arts & Entertainment Law Journal website on June 6, 2023. The original post can be accessed via the Archived Link button above
Cardozo AELJ Author Interview Series: Scott Semaya, Class of 2023
No full textThe Cardozo AELJ Author Interview Series seeks to give our readers further insight into the Articles and Notes published in the Cardozo Arts & Entertainment Law Journal. In this interview, Scott Semaya discusses his Note, Name, Image and Likeness: Giving College Athletes the Clearest Guidance to Best Profit off Their NIL, which was published in Volume 41, Issue 2.
This post was originally published on the Cardozo Arts & Entertainment Law Journal website on June 6, 2023. The original post can be accessed via the Archived Link button above
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Cardozo AELJ Author Interview Series: Scott Semaya, Class of 2023
No full textThe Cardozo AELJ Author Interview Series seeks to give our readers further insight into the Articles and Notes published in the Cardozo Arts & Entertainment Law Journal. In this interview, Scott Semaya discusses his Note, Name, Image and Likeness: Giving College Athletes the Clearest Guidance to Best Profit off Their NIL, which was published in Volume 41, Issue 2.
This post was originally published on the Cardozo Arts & Entertainment Law Journal website on June 6, 2023. The original post can be accessed via the Archived Link button above
Scott Belsky in Conversation with DesignByThem - Part Two.mp4
No full textSarah Gibson and Nicholas Karlovasitis from DesignByThem continue their conversation with Scott Belsky (CEO/Founder Behance + Author Making Ideas Happen). They discuss the relationship between taking financial risks in creative enterprise whilst valuing professional standards in their work
Article entitled "Emmett J. Scott, Author and Business Man, Dies"
No full textNewspaper article entitled "Emmett J. Scott, Author and Business Man, Dies." Mr. Scott died on Dec. 12, 1957
Scott Belsky in Conversation with DesignByThem - Part Three.mp4
No full textIn the final part of the conversation Scott Belsky (CEO/Founder Behance + Author: 'Making Ideas Happen') gets an insight into how Sarah Gibson and Nicholas Karlovasitis of DesignByThem use the principals behind Scott's book to inform their process for taking their ideas from concept to delivery
Scott Belsky - Interview Highlights.mp4
No full textWatch here for key insights from the Creative Industries Innovation Centre interview with Scott Belsky on the habits of successful creative professionals
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