1,721,406 research outputs found
Interview with Constance Magistrelli
Full text linkIn this interview with Julia Stringfellow, Constance Magistrelli, LU class of 1967, discusses her time as a student.https://lux.lawrence.edu/oralhistories/1017/thumbnail.jp
Il Premio P.A.A.L.M.A. Intervista di Giacomo Magistrelli a Gianni Bolongaro
No full textL'intervista è incentrata sulla nascita e sulle prime edizioni del premio P.A.A.L.M.A. Premio Artista+Architetto La Marrana Arteambientale, finalizzato a promuovere azioni di riqualificazione urbana attraverso progetti nati dalla collaborazione tra artisti e architetti
Galleria Vittorio Emanuele II
No full textSchede di catalogo di fotografie appartenenti a un reportage fotografico relativo alla costruzione della Galleria Vittorio Emanuele II a Milano, eseguite tra il 1865 e il 1878 e conservate presso il Civico Archivio Fotografico di Milano
Tra fotografia ed editoria: dalla sperimentazione alla consapevolezza tecnica nella trattatistica fotografica a Milano tra il 1839 e il 1878
No full textThe PROB-PD trial: a pilot, randomised, placebo-controlled study protocol to evaluate the feasibility and potential efficacy of probiotics in modulating peripheral immunity in subjects with Parkinson’s disease
Full text linkAbstract Background Parkinson’s disease (PD) is a common neurodegenerative disease. No disease-modifying treatment is available, and therapy is symptomatic. The histopathologic hallmark is the loss of dopaminergic neurons and accumulation of α-synuclein (α-syn) in surviving neurons, but the underlying pathophysiology is unclear. Inflammatory mechanisms seem to play a prominent role, with an imbalance of immune functions and neurotoxicity caused by reactive oxygen species (ROS). Involvement of peripheral adaptive immunity, with an imbalance in T cell subpopulations and in the expression of transcriptional factors in CD4+ T cells, has also been reported. Although clinical presentation is defined by motor symptoms, patients also report non-motor symptoms, often before the onset of a clinically established disease. Etiopathogenesis of PD is unknown, but an initial aggregation of α-syn in the gut, with subsequent propagation along the vagus nerve to the brain has been hypothesised. Interestingly, in an α-syn overexpressing murine model, the absence of gut microbiota prevented both microglia activation and motor impairment, thus pointing to a fundamental role of microbiota in the development of PD. Magistrelli et al. showed that in peripheral blood mononuclear cells of PD patients, probiotics modulate the in vitro production of cytokines toward an anti-inflammatory profile and reduce the production of ROS. Methods This is a pilot randomised placebo-controlled clinical trial protocol for a 12-week treatment with probiotics. At least 80 patients affected by PD will be recruited and randomly allocated to either the treatment or placebo group in a 1:1 ratio. General inclusion criteria will be the onset of PD 2 to 5 years before the trial and absence of autoimmune comorbidities or immunomodulating therapy. Our primary endpoint is the assessment of changes in extracellular cytokine levels (Interferon (IFN)-γ, tumour necrosis factor (TNF)-α, interleukin (IL)-4, and IL-10) and ROS production. Secondary outcomes include changes in lymphocyte subpopulations and transcriptional factors mRNA levels. Discussion This study is designed to highlight the potential beneficial role of probiotics administration on peripheral immunity through the modulation of gut microbiota. Explorative outcomes will be evaluated to assess variations in motor and non-motor symptoms and the possible correlation with probiotics administration. Trial registration ClinicalTrials.gov ID NCT05173701. Registered 08 November 202
DIFFUSION-WEIGHTED IMAGING IN BREAST LESION EVALUATION Belli P, Costantini M, Bufi E, Magistrelli A, La Torre G, Bonomo L.
No full textPurpose. The purpose of this study was to investigate the ability of diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) in the detection and characterisation of breast lesions.
Materials and methods. From September 2005 to September 2007, 86 patients with breast lesions who underwent magnetic resonance imaging (MRI) in our department were included in our study. MRI was performed with a
1.5-T unit using a standard protocol including DWI sequence. For each breast lesion, the ADC value was calculated and compared with that of normal breast tissue and to the definitive pathological diagnosis. Mann- Whitney U and Kruskal-Wallis tests were used for statistical analysis.
Results. A total of 126 breast lesions were detected. Pathology results revealed 100 malignant and 26 benign lesions. Mean diameter of lesions was 26.02 mm (range 4–90 mm), including 52 lesions ≤15 mm in size. Mean ADC value of normal glandular tissue was 1.55×10–3 mm2/s. Mean ADC value of malignant lesions was 0.97×10–3 mm2/s. Mean ADC value for benign lesions was 1.66×10–3 mm2/s. Benign lesions showed ADC values significantly higher than malignant lesions (p<0.0001). Conclusions. DWI provides reliable information to support MRI diagnosis of breast masses. ADC value appears a promising adjunctive parameter in distinguishing malignant from benign breast lesions
Book review: Brewing resistance: Indian Coffee House and the emergency in postcolonial India by Kristin Victoria Magistrelli Plys
No full textIn Brewing Resistance: Indian Coffee House and the Emergency in Postcolonial India, Kristin Victoria Magistrelli Plys explores the Coffee House movement as a space of resistance or ‘autonomous zone’ that emerged to contest the authoritarian turn in India during the Emergency of 1975-77. This book is an important and timely reminder of the history of resistance that underscores the importance of tangible spaces in offering sites of protest against totalitarian regimes, writes Anand Badola. Brewing Resistance: Indian Coffee House and the Emergency in Postcolonial India. Kristin Victoria Magistrelli Plys. Cambridge University Press. 2020
Officina del Gas
No full textSchede di catalogo di una serie di fotografie realizzate dalla studio Spagliardi & Silo tra il 1866 e il 1867 e aventi come soggetto l'Officina del Gas di Milano
Degenerate KAM theory for partial differential equations
No full textThis paper deals with degenerate KAM theory for lower dimensional
elliptic tori of infinite dimensional Hamiltonian systems, depending on one parameter only. We assume that the linear frequencies
are analytic functions of the parameter, satisfy a weak non-degeneracy condition of Rüssmann type and an asymptotic behavior. An application to nonlinear wave equations is given
LA FOTOGRAFIA E I CANTIERI DELLA MILANO POSTUNITARIA 1861-1911
No full textLa tesi considera la varietà di formule espressive e di destinazioni funzionali della fotografia in rapporto alla costruzione di spazi e architetture nella Milano del primo cinquantennio dell’unità d’Italia.
Strumento di lavoro per architetti e ingegneri, la fotografia delle principali operazioni edilizie eseguite nella città lombarda a partire dagli anni sessanta dell’Ottocento rappresenta per la nuova classe dirigente un fondamentale strumento di legittimazione del proprio operato amministrativo e di illustrazione dei progressi compiuti dalla città sulla via della modernizzazione.
Attraverso un itinerario storico della ‘fotografia di cantiere’, costruito anche grazie al confronto con casi italiani e internazionali, lo studio presenta una puntuale analisi del fenomeno in ambito milanese. Tra i progetti affrontati, il piano di riforma del centro cittadino (1865-1878) di Giuseppe Mengoni e i restauri del Castello Sforzesco (1893-1907) di Luca Beltrami, oltre a una serie di interventi minori, documentati da alcuni dei principali fotografi attivi in città e dai redattori della pubblicistica illustrata, tipologia editoriale che tra Otto e Novecento si serve con sempre maggiore consapevolezza del mezzo fotografico. L’evoluzione del linguaggio fotografico viene dunque indagata nel suo contributo alla costruzione di un’iconografia nazionale della modernità, fenomeno che vede la città di Milano porsi in prima fila nel contesto italiano.The study investigates the variety of expressive formulas and functional destinations of the photography production concerning the architectural renovation occurred in the city of Milan between 1861 and 1911.
Design tool for architects and engineers, construction photography reveals itself as a fundamental tool of political legitimation for the new ruling class and illustrates the progress made by the city in terms of modernization.
Through a historical reconstruction of the genre of construction photography, which also considers Italian and international cases, the study presents a detailed analysis of the Milanese phenomenon. Among the projects, the reform plan of the city center (1865-1878) developed by Giuseppe Mengoni and the restoration of the Sforza Castle (1893-1907) led by Luca Beltrami , as well as a number of minor operations. The inquiry considers the production by some of the main photographers working in the city and the iconographic apparatus of the most important illustrated press of the period, which during the late nineteenth century uses with increasing awareness the narrative qualities of the photographic medium.
The evolution of the photographic language is therefore inquired with regard to his contribution to the construction of a national iconography of modernity , a phenomenon that sees the city of Milan in the front line
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