1,363 research outputs found
Also By The Same Author: AKTiveAuthor, a Citation Graph Approach to Name Disambiguation
No full textThe desire for definitive data and the semantic web drive for inference over heterogeneous data sources requires co-reference resolution to be performed on those data. In particular, name disambiguation is required to allow accurate publication lists, citation counts and impact measures to be determined. This paper describes a graph-based approach to author disambiguation on large-scale citation networks. Using self-citation, co-authorship and document source analyses, AKTiveAuthor clusters papers, achieving precision of 0.997 and recall of 0.818 over a test group of eight surname clusters
Ep. #181 - Nigel Clark
No full textThis recording and transcript form part of a collection of podcasts conducted by the Cultures of Energy at Rice University. Cultures of Energy brings writers, artists and scholars together to talk, think and feel their way into the Anthropocene. We cover serious issues like climate change, species extinction and energy transition. But we also try to confront seemingly huge and insurmountable problems with insight, creativity and laughter.Cymene and Dominic discuss a strange effort to police sugar packet play on this week’s podcast. Then (15:52) we are delighted to welcome Nigel Clark to the conversation. Nigel is Chair of Social Sustainability and Human Geography at Lancaster University (https://www.lancaster.ac.uk/lec/about-us/people/nigel-clark ). He is the author of Inhuman Nature: Sociable Life on a Dynamic Planet (2011) and co-editor of Atlas: Geography, Architecture and Change in an Interdependent World (2012), Material Geographies (2008) and Extending Hospitality(2009). We start things off by talking about a new book he is working on called The Anthropocene and Societythat he is working on with Bron Szerszynski and what it means to rethink humanity through planetary strata, flows, and multiplicity. We turn from there to Australian feminism, phosphates, Aotearoa New Zealand as a space of settler grassland experiments, wealth, and geocide. Then we touch on fire and its excess, our brittle life on an earth’s surface caught between solar and geothermal vitalities, metamorphosis, the early connection between gunpowder and combustion engines and European geotrauma. A special birthday week shout-out to our very own eternal Cymene Howe :
Social theory and the sociological imagination: an interview with Nigel Dodd (1 of 2)
No full textPart I of our interview with Nigel Dodd, interviewed by Riad Azar. Nigel Dodd is Professor in the Sociology Department at the LSE. He obtained his PhD from the University of Cambridge in 1991 on the topic of Money in Social Theory, and lectured at the University of Liverpool before joining the LSE in 1995. Nigel’s main interests are in the sociology of money, economic sociology and classical and contemporary social thought. He is author of The Sociology of Money and Social Theory and Modernity (both published by Polity Press). His most recent book, The Social Life of Money, was published by Princeton University Press in September 2014
Maine Interview piece with Nigel Calder of Alna, author of the Boatowners\u27s M
No full textMaine Interview piece with Nigel Calder of Alna, author of the Boatowners\u27s Mechanical and Electrical Manual, which has sold over 90,000 copies, and a number of other books, including The Cruising Guide to the Northwest Caribbean and Cuba: A Cruising Guide
Effect of KRAS and mTOR inhibitors on tissue factor gene expression in two human pancreatic cancer cell lines
No full textTissue factor (TF) is a transmembrane receptor and cofactor of factor (F) VII/VIIa. The TF/FVIIa complex activates the coagulation cascade. It is highly expressed in pancreatic ductal adenocarcinoma (PDAC). Elevated levels of circulating, tumor-derived TF+ extracellular vesicles are associated with venous thromboembolism in pancreatic cancer. Since hemostasis requires TF, systemic inhibition of TF to reduce VTE risk would lead to severe bleeding. Previous studies reported that the Kirsten rat sarcoma viral oncogene homolog (KRAS) and mammalian target of rapamycin (mTOR) pathways regulate TF gene expression in human cancer cells. Therefore, we hypothesized that blocking KRAS and mTOR would reduce TF gene expression in PDAC. We examined the effect of the KRAS inhibitor stabilized alpha helices of son of sevenless 1 (SAH-SOS1A) and the mTOR inhibitor sapanisertib on TF gene expression in two high-TF expressing PDAC cell lines HPAF-II and BxPC-3. We hypothesized that 1) inhibition of KRAS with SAH-SOS1A would reduce TF expression in HPAF-II cells, which contain a constitutively active mutant KRAS, to a greater extent than in BxPC-3, which contains wild-type KRAS, and that 2) mTOR inhibition with sapanisertib would reduce TF expression in both cell lines. HPAF-II and BxPC-3 were treated for 48 hours with either SAH-SOS1A or sapanisertib. Cell viability and growth was measured with a resazurin uptake assay, and total protein concentration was determined using Pierce BCA and DC assays to examine if the inhibitors were toxic. Levels of cellular TF activity were determined using a one-stage coagulation assay. Our study yielded an unexpected result: both inhibitors were toxic to the cells and reduced cell viability, total protein, and TF activity. Taken together, these preliminary studies suggest that the decrease in TF activity in cells treated with either inhibitor is due to cell death rather than a selective inhibition of TF gene expression.Bachelor of Scienc
Modern vacuum practice
No full textModern Vacuum Practice is an easy-to-understand introduction to high vacuum technology suitable for anyone using high vacuum as a tool. The author provides a fundamentally non-mathematical treatment of the subject, assuming little or no prior vacuum knowledge throughout. With its emphasis always on providing practical information, the book gives the reader the knowledge to set up, use, maintain and troubleshoot a vacuum system
Regulation of urokinase plasminogen activator and plasminogen activator inhibitor-1 in murine breast cancer cells
No full textProteases are indispensable for tumor growth, angiogenesis, and metastasis. These proteases are produced by tumor cells, stromal cells, and by the host coagulation cascade. Protease-activated receptor-1 (PAR-1) and PAR-2 are G protein-coupled receptors that serve as the cellular receptors for several of these proteases, including activated coagulation factor VII (FVIIa), activated coagulation factor X (FXa), and thrombin. PAR-1 and PAR-2 have been found to be overexpressed in breast cancer and activation of these receptors contributes to the malignant phenotype of the cells. Activation of PAR-1 or PAR-2 by coagulation proteases increases the expression of urokinase plasminogen activator (uPA) and its inhibitor, plasminogen activator inhibitor-1 (PAI-1). uPA and PAI-1 are overexpressed in breast cancer patients and contribute to tumor angiogenesis, tumor growth, and metastasis. Using the highly metastatic 4T1 murine mammary adenocarcinoma model, I examined the effects of coagulati
The Role of Tissue Factor and Factor VIIa in Hemostasis
No full textTissue factor (TF) is a transmembrane receptor for Factor VII/VIIa (FVII/VIIa). It is constitutively expressed by cells surrounding blood vessels. The endothelium physically separates this potent “activator” from its circulating ligand FVII/FVIIa and prevents inappropriate activation of the clotting cascade. Breakage of the endothelial barrier leads to exposure of extravascular TF and rapid activation of the clotting cascade. TF is also expressed in certain tissues, such as the heart and brain, and provides additional hemostatic protection to these tissues. Small amounts of TF are also present in blood in the form of microparticles, which are small membrane vesicles derived from activated and apoptotic cells. Levels of microparticle TF increase in a variety of diseases, such as sepsis and cancer, and this so-called “blood-borne” TF may contribute to thrombosis associated with these diseases. Recombinant FVIIa has been developed as an effective hemostatic drug for the treatment of hemophilia patients with inhibitory antibodies. In addition, it is used for patients with bleeding that do not respond to conventional therapy. However, the mechanism by which recombinant FVIIa restores hemostasis has not been clearly defined. In conclusion, the TF:FVIIa complex is essential for hemostasis and recombinant FVIIa is an effective hemostatic drug
Triggers, targets and treatments for thrombosis
No full textThrombosis — localized clotting of the blood — can occur in the arterial or the venous circulation and has a major medical impact. Acute arterial thrombosis is the proximal cause of most cases of myocardial infarction (heart attack) and of about 80% of strokes, collectively the most common cause of death in the developed world. Venous thromboembolism is the third leading cause of cardiovascular-associated death. The pathogenic changes that occur in the blood vessel wall and in the blood itself resulting in thrombosis are not fully understood. Understanding these processes is crucial for developing safer and more effective antithrombotic drugs
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