1,798 research outputs found
Whole Cell Therapeutic Vaccine Modified With Hyper-IL6 for Combinational Treatment of Nonresected Advanced Melanoma
No full textActive specific immunotherapy of cancer requires an efficient induction and effector phase. The induction covers potent activation of anti-tumor response, whereas effector breaks the immunosuppression. We report efficacy of therapeutic melanoma vaccine (AGI-101H) used alone in advanced disease as a candidate for further combined treatment. In adjuvant setting in patients with resected metastases AGI-101 Hcombined with surgery of recurring disease demonstrated long-term survival. Seventy-seven patients with nonresectable melanoma (8% IIIB, 21% IIIC, 71% IV) were enrolled. AGI-101H was administered 8 x every 2 weeks, and then every month. At progression, maintenance was continued or induction was repeated and followed by maintenance. Median follow-up was 139.3 months. The median overall survival (OS) was 17.3 months; in patients with WHO 0-1 was 20.3 months. Complete response (CR) and partial response (PR) were observed in 19.4% and 9% of pts. Disease control rate was 54.5% of pts. The median CR+PR duration was 32 months. Reinduction was performed in 36.3% patients following disease progression with 46.6% of CR+PR. No grade 3/4 adverse events were observed. Treatment with AGI-101H of melanoma patients is safe and effective. AGI-101H is a good candidate for combinatorial treatment with immune check-points inhibitors or tumor hypoxia normalizators.Presented work was in part financially supported by The National Centre for Research and Development (Grant number INNOMED/I/6./NCBR/2014) from the Innovative Economy Operational Programme founds, in the framework of the European Regional Development Fund and BioContract Sp. o o. (Poznan, Poland)
Jacek Dehnel – obraz tłumacza
Full text linkThis article attempts to present Jacek Dehnel as a translator. For this purpose, the author refers to selected works discussing Jacek Dehnel as a writer, poet, translator, and artist. In addition, the author uses Jacek Dehnel's statements on translation made in interviews and his critical comments on poetry and prose translations. The author assumes that a discussion on Jacek Dehnel's (or any other translator's) professional activity solely from the perspective of the texts of their translations would be insufficient. In the article, the author suggests that Jacek Dehnel pays particular attention to non-standard varieties of language in his prose, which in turn may influence his translation decisions. The article notes that when it appears impossible to convey the character of the original language in its entirety, Dehnel has been a proponent of departing from the form of the source text to save its exact meaning - also in poetry translation. The article concludes that Jacek Dehnel is familiar with many views on literary translation, he is interested in its theory, willingly participates in discussions in this field, and reviews other translations. Dehnel treats literature as the best source of knowledge about writing and translation. Despite his unquestionable literary, poetic, and translation achievements, Dehnel does not deny that he is still learning how to write and translate from others. The article is also an invitation to further discussion and critical analysis of Jacek Dehnel's translations.Artykuł jest próbą przedstawienia sylwetki Jacka Dehnela jako tłumacza. Autor opiera się na wybranych pracach, omawiających dotychczasowy dorobek Jacka Dehnela jako pisarza, poety, tłumacza oraz artysty. W artykule wykorzystano wypowiedzi Jacka Dehnela na temat tłumaczenia udzielone w wywiadach oraz jego komentarze krytyczne, dotyczące przekładów poezji i prozy. Autor wychodzi z założenia, że omówienie translatorskiej działalności Jacka Dehnela (oraz każdego innego tłumacza) jedynie przez pryzmat tekstów jego przekładów byłoby niewystarczające. Artykuł jest zatem zaproszeniem do dalszej dyskusji i krytycznej analizy tłumaczeń pióra Jacka Dehnela.  
45' Reception, Jacek Bocheński Divine Julius: Episode 10
No full text"Divine Julius" by Jacek Bocheński, the author of the "Roman Trilogy".
Video prepared by Olga Strycharczyk and Marta Pszczolińska.
"45 Seconds Reception" series was created as part of the European Research Council (ERC) funded project: Our Mythical Childhood... The Reception of Children's and Young Adults' Culture in Response to Regional and Global Challenges (Grant Agreement 681202; ERC Consolidator Grant led by Prof Katarzyna Marciniak).Information about "Our Mythical Childhood..." is available at http://omc.obta.al.uw.edu.pl
The YouTube channel of the project is available at https://www.youtube.com/channel/UC6zvu9EXsI0gK5rSvgnQse
Jacek Salij's Contemporary Apology of Church
No full textTrudno mówić o Kościele i bronić go we współczesnym świecie. Nie boi się jednak tego zadania polski dominikanin Jacek Salij, który dokonuje swoistej apologii Kościoła. W niniejszym artykule w kilku punktach autor ukazał oryginalność i aktualność eklezjologicznej myśli Jacka Salija. Wielką zaletą teologii o. Salija jest komunikatywność i obrazowość. Apologia Kościoła tego dominikanina bez wątpienia pozwala na nowo spojrzeć na Kościół dzisiejszemu człowiekowi.Nowadays speaking about the Church and defending it is a very big challenge. However a Polish Dominican Jacek Salij is not afraid of this task and he performs a kind of apology for the Church. In this article in several points the author shows originality and timeliness of the ecclesiological thought of Jacek Salij. The great advantage of his theology is communication and imagery. Certainly the apology of Church of the Black Friar gives modern man a new look at the Church
Understanding Reform: The Case of Poland
Full text linkThis report reviews the reform process in Poland in the period 1989-2001, from the formation of the first non-Communist government to the defeat of right-wing forces in the 2001 parliamentary elections and the formation of a governing left-wing coalition of social democrats and the peasants’ party (both of them with roots in the Communist era). It reconstructs the sequence of reforms, assesses their relative successes, and focuses on the problem of the stagnation of the reform process at the end of the 1990s.Poland, reform, transition
„Uroda świata się nie kończy”. Śladem poezji Jacka Łukasiewicza
No full textThe sketch is an attempt to present Jacek Łukasiewicz’s poetry against the background of the poet’s biography divided into three phases, related to the places where Łukasiewicz lived at different times: Sulistrowa, a village located in the Beskid Foothills, where he spent his childhood; Leszno, where he moved with his family in 1945 and graduated from high school, making long lasting friendships with Stanisław Grochowiak or Teodor Krupkowski; and finally Wrocław, where the poet lived continuously since 1951. Adopting a perspective close to geopoetics made it possible to focus attention on the geographical details contained in Jacek Łukasiewicz’s poems and analyze their biographical and cultural references.The sketch is an attempt to present Jacek Łukasiewicz’s poetry against the background of the poet’s biography divided into three phases, related to the places where Łukasiewicz lived at different times: Sulistrowa, a village located in the Beskid Foothills, where he spent his childhood; Leszno, where he moved with his family in 1945 and graduated from high school, making long lasting friendships with Stanisław Grochowiak or Teodor Krupkowski; and finally Wrocław, where the poet lived continuously since 1951. Adopting a perspective close to geopoetics made it possible to focus attention on the geographical details contained in Jacek Łukasiewicz’s poems and analyze their biographical and cultural references
Le mani di Jacek Woszczerowicz, attore “di composizione” [An actor of composition. Jacek Woszczerowicz's hands]
No full text"The article aims to draw attention back to the art of Jacek Woszczerowicz, once a
well-known and beloved Polish actor. It focuses on his peculiar acting style by analyzing two
adaptations of stage dramas and a documentary of a theatrical masterpiece Richard III (1960). In
particular, the author highlights Woszczerowicz’s work on gesture and the role played by hands in
building characters. This brief survey will lead us to re-discover the deep process of cognition and
experience realized dramatically by the artist and to understand why Jan Kott considered him
“the first contemporary Shakespeare”, while Jerzy Grotowski praised him as the greatest “actor of
composition”.
Adequacy of Pedagogical Ideas of Father Jacek Woroniecki
No full textAutorka artykułu przekonuje o potrzebie pamięci o osobie i nauczaniu o. Jacka Woronieckiego. W ogólności przybliża, kim był i poprzez co zasłużył sobie na pamięć potomnych. Wskazuje, na czym polegał wkład Woronieckiego w rozwój pedagogiki jako takiej, a pedagogiki katolickiej w szczególności. W tym celu przywołuje argumenty, za sprawą których poglądy o. Jacka Woronieckiego dotyczące rozumienia kwestii wychowania i roli wychowawcy czy autorytetu w wychowaniu wytrzymują próbę czasu.The publication points at the subject of the need of father Jacek Woroniecki’s person’s and teaching’s memory. In general, it brings closer who he was and through what he deserved posterity’s remembrance. The author of the publication shows the essence of his contribution to the development of pedagogics as such and the Catholic pedagogogics in particular. Therefore she brings up the arguments which make father Jacek Woroniecki’s ideas about understanding the problem of education as well as preceptor’s or role model’s meaning for the education stand the test of time
An actor of composition. Jacek Woszczerowicz’s hands
No full textThe article aims to draw attention back to the art of Jacek Woszczerowicz, once a well-known and beloved Polish actor. It focuses on his peculiar acting style by analyzing two adaptations of stage dramas and a documentary of a theatrical masterpiece Richard III (1960). In particular, the author highlights Woszczerowicz’s work on gesture and the role played by hands in building characters. This brief survey will lead us to re-discover the deep process of cognition and experience realized dramatically by the artist and to understand why Jan Kott considered him “the first contemporary Shakespeare”, while Jerzy Grotowski praised him as the greatest “actor of composition”
Kościół wobec kary śmierci
Full text linkIn the article The Church and the Death Penalty, Fr. Jacek Salij OP, shows the evolution of the attitude towards the death penalty, presented in the Bible and in the contemporary teaching of the Church. The author explains why the Church recognises that nowadays the death penalty should be abolished but at the same time it does not reject it completely.W artykule Kościoł wobec kary śmierci o. Jacek Salij OP ukazuje przemiany, jakie następowały w stosunku do kary śmierci w łonie chrześcijaństwa, jak również we współczesnym nauczaniu Kościoła Katolickiego. Autor wyjaśnia dlaczego Kościół jednocześnie uznaje, iż należy z niej współcześnie zrezygnować, ale jej całkowicie nie odrzuca
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