7,888 research outputs found
Group living homes for older people with dementia: Concept and effects
Eefsting, J.A. [Promotor]Pot, A.M. [Promotor]Depla, M.F.I.A. [Copromotor]Lange, J. de [Copromotor
Cementbetonnen plaatbekledingen op oevers en dijken, bundeling van artikelen uit de vakpers 1990-1991
CUR; Proefproject: Open colloidaal beton a/s dijkbekleding; PT civiele techniek, april 1990. Burger, A.M., Eversdijk, P.J. en Hendriksma, A.M.; Open cementbeton toegepast a/s bekleding voor dijken; Zeewering Breskens, proefproject voor colloidaal beton; Land + Water, mei 1990. Burger, A.M., Eversdijk, P.J. en Hendriksma, A.M.; Colloidaal beton weerstaat zware storm en hoge golven; De praktijk van open cementbeton a/s Plaatbekleding; Land + Water, juni 1990. CUR; Cementbetonnen plaatbekledingen op dijken; Proefprojecten CUR; Civiele Techniek, No4, 1990. Vrieze, C.G. de; Betonnen dijken, groen a/s gras; Proeven met colloidaal beton voor begroeide rivierdijken; Land + Water No.6, juni 1991. Eversdijk, P.J. en Fase, A.G.; Breuksteen met colloidaal beton pakt rivierdijken goed in; Proefproject Opijnen in Julianakanaal; Land + Water No. 7/8, augustus 1991. Rijke, W.G. de en Burger, A.M.; Cementbetonnen plaatbekledingen op dijken en oevers; Praktische ontwerpmethode (1); Civiele Techniek, jaargang 46, No.3, 1991. Rijke, W.G. de en Burger, A.M.; Cementbetonnen plaatbekledingen op dijken en oevers theoretisch waterdicht; Praktische ontwerpmethode (2); Civiele Techniek, jaargang 46, No.4, 1991. CUR; oemonstratieproject open colloidaal beton Noordoostpolder; Civiele Techniek, No.3, 1991
IoWoman, March/April 2004, Vol.34, no.2
Newsletter for the Iowa Commission on the Status of Wome
IoWoman, March/April 2004, Vol. 34, no. 2
Newsletter for the Iowa Commission on the Status of Wome
Gauge Fields and Strings
Based on his own work, the author synthesizes the most promising approaches and ideals in field theory today. He presents such subjects as statistical mechanics, quantum field theory and their interrelation, continuous global symmetry, non-Abelian gauge fields, instantons and the quantam theory of loops, and quantum strings and random surfaces. This book is aimed at postgraduate students studying field theory and statistical mechanics, and for research workers in continuous global theory
The Sphinx Between the First and Second Pyramids. From a Photograph Taken by the Author about 6 a.m., After Sleeping at the Foot of the Sphinx.
Caption: "The Sphinx Between the First and Second Pyramids.From a photograph taken by the Author about 6 A.M., after sleeping at the foot of the Sphinx."The Great Sphinx with two pyramids behind. Black-and-white photograph
Common Book Author Visit Highlights Spring Programming
Common Book author William Kamkwamba will visit campus on April 3 at 11 a.m. in Richardson Ballroom. All events are free and have cultural event status
Author of \u27The Soloist\u27 to Speak
Steve Lopez, author of The Soloist, will speak at 9:30 a.m., Thursday, November 5, in Polsky Theatre as part of the JCCC scholar in residence program
Cerebral cortex involvement in Machado-Joseph disease
FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOBackground and purpose: Machado-Joseph disease (MJD/SCA3) is the most frequent spinocerebellar ataxia, characterized by brainstem, basal ganglia and cerebellar damage. Few magnetic resonance imaging based studies have investigated damage in the cerebral cortex. The objective was to determine whether patients with MJD/SCA3 have cerebral cortex atrophy, to identify regions more susceptible to damage and to look for the clinical and neuropsychological correlates of such lesions. Methods: Forty-nine patients with MJD/SCA3 (mean age 47.7 ± 13.0 years, 27 men) and 49 matched healthy controls were enrolled. All subjects underwent magnetic resonance imaging scans in a 3 T device, and three-dimensional T1 images were used for volumetric analyses. Measurement of cortical thickness and volume was performed using the FreeSurfer software. Groups were compared using ancova with age, gender and estimated intracranial volume as covariates, and a general linear model was used to assess correlations between atrophy and clinical variables. Results: Mean CAG expansion, Scale for Assessment and Rating of Ataxia (SARA) score and age at onset were 72.1 ± 4.2, 14.7 ± 7.3 and 37.5 ± 12.5 years, respectively. The main findings were (i) bilateral paracentral cortex atrophy, as well as the caudal middle frontal gyrus, superior and transverse temporal gyri, and lateral occipital cortex in the left hemisphere and supramarginal gyrus in the right hemisphere; (ii) volumetric reduction of basal ganglia and hippocampi; (iii) a significant correlation between SARA and brainstem and precentral gyrus atrophy. Furthermore, some of the affected cortical regions showed significant correlations with neuropsychological data. Conclusions: Patients with MJD/SCA3 have widespread cortical and subcortical atrophy. These structural findings correlate with clinical manifestations of the disease, which support the concept that cognitive/motor impairment and cerebral damage are related in disease.Background and purpose: Machado-Joseph disease (MJD/SCA3) is the most frequent spinocerebellar ataxia, characterized by brainstem, basal ganglia and cerebellar damage. Few magnetic resonance imaging based studies have investigated damage in the cerebral cortex. The objective was to determine whether patients with MJD/SCA3 have cerebral cortex atrophy, to identify regions more susceptible to damage and to look for the clinical and neuropsychological correlates of such lesions. Methods: Forty-nine patients with MJD/SCA3 (mean age 47.7 ± 13.0 years, 27 men) and 49 matched healthy controls were enrolled. All subjects underwent magnetic resonance imaging scans in a 3 T device, and three-dimensional T1 images were used for volumetric analyses. Measurement of cortical thickness and volume was performed using the FreeSurfer software. Groups were compared using ancova with age, gender and estimated intracranial volume as covariates, and a general linear model was used to assess correlations between atrophy and clinical variables. Results: Mean CAG expansion, Scale for Assessment and Rating of Ataxia (SARA) score and age at onset were 72.1 ± 4.2, 14.7 ± 7.3 and 37.5 ± 12.5 years, respectively. The main findings were (i) bilateral paracentral cortex atrophy, as well as the caudal middle frontal gyrus, superior and transverse temporal gyri, and lateral occipital cortex in the left hemisphere and supramarginal gyrus in the right hemisphere(ii) volumetric reduction of basal ganglia and hippocampi(iii) a significant correlation between SARA and brainstem and precentral gyrus atrophy. Furthermore, some of the affected cortical regions showed significant correlations with neuropsychological data. Conclusions: Patients with MJD/SCA3 have widespread cortical and subcortical atrophy. These structural findings correlate with clinical manifestations of the disease, which support the concept that cognitive/motor impairment and cerebral damage are related in disease.222277283FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOSem informaçãoSem informaçãoSem informaçãoD'Abreu, A., França, M.C., Jr., Paulson, H.L., Lopes-Cendes, I., Caring for Machado-Joseph disease: current understanding and how to help patients (2010) Parkinsonism Relat Disord, 16, pp. 2-7D'Abreu, A., França, M.C., Jr., Yasuda, C.L., Souza, M.S., Lopes-Cendes, I., Cendes, F., Thalamic volume and dystonia in Machado-Joseph disease (2011) J Neuroimaging, 21, pp. 91-93Schulz, J.B., Borkert, J., Wolf, S., Visualization, quantification and correlation of brain atrophy with clinical symptoms in spinocerebellar ataxia types 1, 3 and 6 (2010) Neuroimage, 49, pp. 158-168Guimaraes, R.P., D'Abreu, A., Yasuda, C.L., A multimodal evaluation of microstructural white matter damage in spinocerebellar ataxia type 3 (2013) Mov Disord, 28, pp. 1125-1132Tokumaru, A.M., Kamakura, K., Maki, T., Magnetic resonance imaging findings of Machado-Joseph disease: histopathologic correlation (2003) J Comput Assist Tomogr, 27, pp. 241-248Rub, U., Brunt, E.R., Deller, T., New insights into the pathoanatomy of spinocerebellar ataxia type 3 (Machado-Joseph disease) (2008) Curr Opin Neurol, 21, pp. 111-116D'Abreu, A., França, M.C., Jr., Yasuda, C.L., Campos, B.A., Lopes-Cendes, I., Cendes, F., Neocortical atrophy in Machado-Joseph disease: a longitudinal neuroimaging study (2012) J Neuroimaging, 22, pp. 285-291Etchebehere, E.C., Cendes, F., Lopes-Cendes, I., Pereira, J.A., Lima, M.C., Sansana, C.R., Brain single-photon emission computed tomography and magnetic resonance imaging in Machado-Joseph disease (2001) Arch Neurol, 58, pp. 1257-1263Lopes, T.M., D'Abreu, A., França, M.C., Jr., Widespread neuronal damage and cognitive dysfunction in spinocerebellar ataxia type 3 (2013) J Neurol, 260, pp. 2370-2379Kawai, Y., Takeda, A., Abe, Y., Washimi, Y., Tanaka, F., Sobue, G., Cognitive impairments in Machado-Joseph disease (2004) Arch Neurol, 61, pp. 1757-1760Fischl, B., Dale, A.M., Measuring the thickness of the human cerebral cortex from magnetic resonance images (2000) Proc Natl Acad Sci USA, 97, pp. 11050-11055Schmitz-Hubsch, T., du Montcel, S.T., Baliko, L., Scale for the assessment and rating of ataxia: development of a new clinical scale (2006) Neurology, 66, pp. 1717-1720Hutton, C., Draganski, B., Ashburner, J., Weiskopf, N., A comparison between voxel-based cortical thickness and voxel-based morphometry in normal aging (2009) Neuroimage, 48, pp. 371-380Talairach, J., Tournoux, P., (1988) Co-planar Stereotaxic Atlas of the Human Brain, , New York: ThiemeBuckner, R.L., Head, D., Parker, J., A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlas-based head size normalization: reliability and validation against manual measurement of total intracranial volume (2004) Neuroimage, 23, pp. 724-738Fischl, B., Salat, D.H., Busa, E., Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain (2002) Neuron, 33, pp. 341-355Fischl, B., van der Kouwe, A., Destrieux, C., Automatically parcellating the human cerebral cortex (2004) Cereb Cortex, 14, pp. 11-22Desikan, R.S., Segonne, F., Fischl, B., An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest (2006) Neuroimage, 31, pp. 968-980Durr, A., Stevanin, G., Cancel, G., Spinocerebellar ataxia 3 and Machado-Joseph disease: clinical, molecular, and neuropathological features (1996) Ann Neurol, 39, pp. 490-499Seidel, K., Siswanto, S., Brunt, E.R., den Dunnen, W., Korf, H.W., Rub, U., Brain pathology of spinocerebellar ataxias (2012) Acta Neuropathol, 124, pp. 1-21Paulson, H.L., Das, S.S., Crino, P.B., Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain (1997) Ann Neurol, 41, pp. 453-462Costa, M.C., Paulson, H.L., Toward understanding Machado-Joseph disease (2012) Prog Neurobiol, 97, pp. 239-257Rub, U., Gierga, K., Brunt, E.R., Spinocerebellar ataxias types 2 and 3: degeneration of the pre-cerebellar nuclei isolates the three phylogenetically defined regions of the cerebellum (2005) J Neural Transm, 112, pp. 1523-1545Goel, G., Pal, P.K., Ravishankar, S., Gray matter volume deficits in spinocerebellar ataxia: an optimized voxel based morphometric study (2011) Parkinsonism Relat Disord, 17, pp. 521-527Park, H.-J., Lee, J.D., Kim, E.Y., Morphological alterations in the congenital blind based on the analysis of cortical thickness and surface area (2009) Neuroimage, 47, pp. 98-106Ashburner, J., Computational anatomy with the SPM software (2009) Magn Res Imaging, 27, pp. 1163-1174Ashburner, J., Friston, K.J., Voxel-based morphometry - the methods (2000) Neuroimage, 11, pp. 805-821Dale, A.M., Fischl, B., Sereno, M.I., Cortical surface-based analysis. I. Segmentation and surface reconstruction (1999) Neuroimage, 9, pp. 179-194Fischl, B., Sereno, M.I., Dale, A.M., Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system (1999) Neuroimage, 9, pp. 195-207MacDonald, D., Kabani, N., Avis, D., Evans, A.C., Automated 3-D extraction of inner and outer surfaces of cerebral cortex from MRI (2000) Neuroimage, 12, pp. 340-356Kim, J.S., Singh, V., Lee, J.K., Automated 3-D extraction and evaluation of the inner and outer cortical surfaces using a Laplacian map and partial volume effect classification (2005) Neuroimage, 27, pp. 210-211Pereira, J.B., Ibarretxe-Bilbao, N., Marti, M.J., Assessment of cortical degeneration in patients with Parkinson's disease by voxel-based morphometry, cortical folding, and cortical thickness (2012) Hum Brain Mapp, 33, pp. 2521-2534Voets, N.L., Hough, M.G., Douaud, G., Evidence for abnormalities of cortical development in adolescent-onset schizophrenia (2008) Neuroimage, 43, pp. 665-675Schmitz-Hübsch, T., Coudert, M., Bauer, P., Spinocerebellar ataxia types 1, 2, 3, and 6: disease severity and nonataxia symptoms (2008) Neurology, 71, pp. 982-989Braga-Neto, P., Dutra, L.A., Pedroso, J.L., Cognitive deficits in Machado-Joseph disease correlate with hypoperfusion of visual system areas (2012) Cerebellum, 11, pp. 1037-1044Schmahmann, J.D., Sherman, J.C., The cerebellar cognitive affective syndrome (1998) Brain, 121, pp. 561-579Zamboni, G., de Jager, C.A., Drazich, E., Structural and functional bases of visuospatial associative memory in older adults (2013) Neurobiol Aging, 34, pp. 961-972Porro, C.A., Francescato, M.P., Cettolo, V., Primary motor and sensory cortex activation during motor performance and motor imagery: a functional magnetic resonance imaging study (1996) J Neurosci, 16, pp. 7688-769
Musikstädte as real and imaginary soundscapes: urban musical images as literary motifs in twentieth-century German modernism
PhDThis study examines German literary images of musical life as part of the wider sound identity of the modern German city at the turn of the twentieth century. Focussing on a forty-year period from 1890 to 1930, synonymous with the emergence of the modern German metropolis as an aesthetic object, the project assesses, compares and contrasts how musical life in the Musikstädte was perceived and portrayed by writers in an increasingly noisy urban environment. How does urban musical life influence and condition city writings? What are the differences and similarities between the writings on various musical cities? Can an urban textual sound identity be derived from these differences and similarities? The approach employed to answer these questions is a new, cross-disciplinary one to urban sound in literature, moving beyond reading the key sounds of the urban soundscape using urban musicology, sensorial anthropology and cultural poetics towards a literary contextualisation of the urban aural experience.
The literary motifs of the symphony, the gramophone and urban noise are put under the spotlight through the analysis of a wide range of modernist works by authors who have a special relationship with music. At the centre of this analysis are the Kaffeehausliteratur authors Hermann Bahr, Alfred Polgar and Peter Altenberg, the then Munich-based author Thomas Mann and the lesser known René Schickele. The analysis of these particular works is framed in the music-geographical context of the Musikstadt and literary underpinnings of this topos, ranging from Ingeborg Bachmann to Hans Mayer and, once again, Thomas Mann. In analysing these texts, the methodological approach devised by Strohm, who identifies the blending of a range of urban sounds as a definition of urban space and identity, is applied. His ideas combine historical literary
analysis, musical history and urban sociology. They are rarely used in the analysis of the auditory environment.Arts and Humanities Research Council
Westfield TrustWestfield Trust Studentship
Arts and Humanities Reseach Council (AHRC
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