1,720,991 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Association of polymorphisms in genes HOXD1, TNP1, MSX1, TCOF1, FGFR1, COL2A1, WNT3 and TIMP3 with nonsyndromic cleft lip and/or palate in a Brazilian population
No full textOrientadores: Ricardo Della Coletta, Hercilio Martelli JuniorDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de PiracicabaResumo: O desenvolvimento craniofacial envolve uma série de eventos altamente coordenados e variações polimórficas nos genes que controlam estes eventos podem afetar a morfogênese labial e palatina, resultando nas fissuras do lábio e/ou palato não-sindrômicas (FL/PNS). O objetivo do presente estudo foi verificar a associação dos polimorfismos em genes relacionados ao desenvolvimento craniofacial, HOXD1 (rs1374326), TNP1 (rs748044), MSX1 (rs1106514), TCOF1 (rs15251, rs2569062, rs28372960), FGFR1 (rs7829058), COL2A1 (rs1793949), WNT3 (rs11653738) e TIMP3 (rs242082), na susceptibilidade das FL/PNS em uma população brasileira. Para verificar a associação destes polimorfismos, este estudo associou o teste de desequilíbrio de transmissão (TDT) com a análise caso-controle com correção de variações genéticas de ancestralidade em uma amostra composta de 189 trios com fissura labial com ou sem fissura palatina não-sindrômica (FL±PNS), 107 trios com fissura palatina não-sindrômica (FPNS), 318 amostras isoladas de pacientes com FL±PNS, 189 amostras isoladas de pacientes com FPNS e 599 controles. Todos os polimorfismos foram inicialmente analisados por TDT e as associações significantes foram confirmadas na análise caso-controle. Os polimorfismos rs28372960 e rs7829058 foram transmitidos de maneira significante dos genitores para os pacientes com FL±PNS (p=0,04), assim como os polimorfismos rs1374326 e rs11653738 nos trios com FPNS (p=0,04). Contudo, o estudo caso-controle não confirmou tais associações. O haplótipo C-C-T formado pelos polimorfismos rs15251, rs2569062 e rs28372960 no gene TCOF1 foi significantemente mais comum nos pacientes com FL±PNS em comparação com o grupo controle (p=0,01). Frente as modestas associações, nossos resultados não suportam a hipótese de que variantes estudadas nos genes HOXD1, TNP1, MSX1, TCOF1, FGFR1, COL2A1, WNT3 e TIMP3 são fatores de risco para FL/PNS em uma população brasileiraAbstract: The craniofacial development involves a series of highly coordinated events, and polymorphic variations in genes that control these events can affect the morphogenesis of the lip and palate, resulting in the non-syndromic cleft lip and/or palate (NSCL/P). The aim of present study was to verify the association of polymorphisms in genes related to craniofacial development, HOXD1 (rs1374326), TNP1 (rs748044), MSX1 (rs1106514), TCOF1 (rs15251, rs2569062, rs28372960), FGFR1 (rs7829058), COL2A1 (rs1793949), WNT3 (rs11653738) and TIMP3 (rs242082), in the susceptibility of NSCL/P in a Brazilian population. To verify the association of those polymorphisms, the study associated the transmission disequilibrium test (TDT) and a structured case-control analysis based on the individual ancestry proportions in a sample composed of 189 case-parent trios of non-syndromic cleft lip with or without cleft palate (NSCL±P), 107 case-parent trios of non-syndromic cleft palate (NSCP), 318 isolated samples of NSCL±P, 189 isolated samples of NSCP and 599 healthy controls. All polymorphisms were initially evaluated by TDT, and significant associations were valitaded in a case-control analysis. A significant overtransmission of rs28372960 and rs7829058 polymorphisms in NSCL±P trios was observed (p=0.04), as well as the rs1374326 and rs11653738 polymorphisms in NSCP trios (p=0.04). However, the structured case-control analysis did not confirm those associations. The haplotype C-C-T formed by rs15251, rs2569062 and rs28372960 polymorphisms in TCOF1 gene was significantly more frequent in patients with NSCL±P in comparison with the control group (p=0.01). With the modest associations, our results do not support the hypothesis that HOXD1, TNP1, MSX1, TCOF1, FGFR1, COL2A1, WNT3 and TIMP3 variants are risk factors for NSCL/P in a Brazilian populationMestradoPatologiaMestre em Estomatopatologi
Susceptibility of genetic variants and gene-gene and gene-environment factor interactions in the etiology of nonsyndromic oral clefts in the Brazilian population
Get PDFOrientadores: Ricardo Della Coletta, Hercílio Martelli JuniorTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de PiracicabaResumo: A etiologia das fissuras orais não-sindrômicas (FONS) é complexa e fortemente influenciada pelos fatores genéticos e ambientais específicos de cada população. No Brasil, a elevada miscigenação é considerada uma característica que pode influenciar na suscetibilidade das FONS. Para melhor compreender os aspectos genéticos associados as FONS na população brasileira, este estudo compilou resultados de 4 estudos específicos. O primeiro estudo foi uma revisão sistemática e meta-análise de marcadores genéticos avaliados na população brasileira. Este estudo revelou possíveis associações dos polimorfismos de nucleotídeo único (SNP) rs642961 (IRF6), rs987525 e rs1530300 (8q24), rs1801133 (MTHFR) e rs17563 (BMP4) com a etiologia das fissuras labiais com ou sem fissuras palatinas não-sindrômica (FL±PNS). Contudo, frente ao pequeno número de estudos que analisou cada um destes marcadores, mais estudos com amostras robustas e que levem em consideração a elevada miscigenação da população brasileira são necessários. O segundo estudo optou por validar 7 SNPs (rs7552 em 2q24.2, rs8049367 em 16p13.3, rs1880646, rs7406226 e rs9891446 em 17p13, rs1588366 em 17q23.2 e rs73039426 em 19q13.11), localizados em regiões associadas com FL±PNS em estudos de larga escala genômica, em 831 pacientes com FL±PNS e 866 controles. A análise de regressão logística levando em consideração as diferenças na ancestralidade genômica e no gênero entre os grupos revelou que o SNP rs7552 é um marcador de risco para o desenvolvimento das FL±PNS. Interações gene-gene (GxG) entre rs7552 com rs8049367, rs1880646, rs9891446, rs1588366 e rs73039426 foram também associadas com risco aumentado para o desenvolvimento das FL±PNS. Embora os SNPs rs1880646 e rs9891446 não foram individualmente associados com FL±PNS, o haplótipo AG (alelo A de rs1880646 e alelo G de rs9891446) foi mais frequente entre os pacientes com FL±PNS em comparação com os controles, exibindo um risco aumentado para o desenvolvimento da fissura. O terceiro estudo avaliou a influência de SNP em genes associados com a neutralização do estresse oxidativo (famílias de genes superóxido dismutase-SOD e paraoxinase-PON) no risco das FL±PNS na população brasileira, considerando interações GxG e gene-fatores ambientais (GxE). Os resultados demonstraram que o alelo C e o genótipo CT do SNP rs2237583 em PON1 evocam efeitos protetores para as FL±PNS, enquanto rs3917490 apresentou significância apenas com amostra composta por pacientes com alta ascendência africana. Várias interações GxG contendo os SNP rs2237583 em PON1 e rs17166879 em PON2 atingiram significância após o ajuste para múltiplos testes. Por fim, o quarto estudo utilizou a estratégia de tag-SNP para verificar a participação de variantes (rs1169, rs7153, rs9968051, rs9819530 e rs6794341) em GOLGB1 na patogênese das fissuras palatinas isoladas não-sindrômicas (FPNS). Neste estudo contendo 270 pacientes com FPNS e 284 controles, nenhuma associação significante foi observada entre as variantes em GOLGB1 e as FPNS. Em conclusão, este estudo revela alguns potenciais marcadores genéticos associados ao desenvolvimento das FONS na população brasileira e reforça a importância de considerar interações GxG na patogênese desta malformação congênitaAbstract: The nonsyndromic oral cleft (NOC) etiology is complex and strongly influenced by specific genetic and environmental factors within each population. In Brazil, the high miscegenation is considered a characteristic that may influence NOC susceptibility. To improve our understanding in the genetic aspects associated with NOC in the Brazilian population, this study compiled results from 4 specific studies. The first study was a systematic review and meta-analysis of genetic markers evaluated in the Brazilian population. This study revealed possible associations of single nucleotide polymorphisms (SNP) rs642961 (IRF6), rs987525 and rs1530300 (8q24), rs1801133 (MTHFR) and rs17563 (BMP4) with the etiology of nonsyndromic cleft lip with or without cleft palate (NSCL±P). However, in the view of the small number of studies that analyzed each of these markers, more studies with robust samples taking into account the high miscegenation of the Brazilian population are necessary. The second study opted to validate 7 SNP (rs7552 in 2q24.2, rs8049367 in 16p13.3, rs1880646, rs7406226 and rs9891446 in 17p13, rs1588366 in 17q23.2 and rs73039426 in 19q13.11), located in regions associated with NSCL±P in large-scale genomic studies, in 831 patients with NSCL±P and 866 controls. Logistic regression analysis adjusted to differences in the genomic ancestry and gender of the groups revealed that the SNP rs7552 is a marker of risk for the development of NSCL±P. Gene-gene (GxG) interactions between rs7552 with rs8049367, rs1880646, rs9891446, rs1588366 and rs73039426 were also associated with increased risk for the development of NSCL±P. Although rs1880646 and rs9891446 were not individually associated with NSCL±P, the A-G haplotype (A allele of rs1880646 and G allele of rs9891446) was more frequent among NSCL±P patients as compared to controls, exhibiting an increased risk to NSCL±P. The third study evaluated the influence of SNP in genes associated with neutralization of stress oxidative (superoxide dismutase-SOD and paraoxonase-PON gene families) in the risk of NSCL±P in the Brazilian population, considering GxG and gene-environment factor (GxE) interactions. The results showed that the C allele and the CC genotype of PON1 rs2237583 evoke significant protective effects against NSCL±P, while rs3917490 showed a significant association only in the sample composed of patients displaying high African ancestry. Some GxG interactions containing PON1 rs2237583 and PON2 rs17166879 reached significance after adjustment for multiple tests. Finally, the fourth study used the tag-SNP strategy to verify the participation of variants (rs1169, rs7153, rs9968051, rs9819530 and rs6794341) in GOLGB1 in the pathogenesis of nonsyndromic cleft palate only (NSCPO). In this study containing 270 patients with NSCPO and 284 controls, no significant associations were observed between variants in GOLGB1 and NSCPO. In conclusion, this study reveals some potential genetic markers associated with the development of NOC in the Brazilian population, and reinforces the importance of considering GxG interactions in the pathogenesis of this congenital malformationDoutoradoPatologiaDoutor em Estomatopatologia2016/02667-0CAPESFAPES
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
- …
