1,720,982 research outputs found
Metachronous cardiac and cerebral sarcomas: case report with focus on molecular findings and review of the literature
No full textAlthough multiple primary malignancies are relatively rare, they have increased in frequency over the last decades, partly because of advances in diagnosis and therapy. This report describes for the first time the case of a patient with past occupational exposure to asbestos and no family history of cancer who developed 2 rare primary malignancies: a cardiac sarcoma and a gliosarcoma 11 months later. Molecular-cytogenetic studies did not identify common lesions to these 2 rare metachronous sarcomas. The gliosarcoma was associated with monosomy 10 and underlying PTEN monoallelic loss, which has been recurrently observed. In the cardiac sarcoma, MDM2 amplification and CDKN2AB/9p21 biallelic deletion suggested intimal sarcoma. No causal relationship was found between cardiac sarcoma and asbestos exposure, although MDM2 abnormalities were linked to malignant mesothelioma
Radiotherapy for early-stage prostate cancer in men under 70 years of age
No full textAims: To demonstrate that radiotherapy (RT) is a valid alternative to surgery in men ≤70 years old with localized prostate cancer. Methods: From 1988 to 2009, 214 patients with T1-2 N0 M0 prostate cancer were treated with RT. The effects of patient- and treatment-related risk factors on toxicity were investigated. Results: Median follow-up was 105 months (range 14.2-180). The 5-, 10-, and 15-year biochemical relapse-free survival for all 214 patients was 80%, 61.9%, and 57.5%, respectively. In bivariate analysis, age (≤65 vs 65-70 years) was not a significant factor for biochemical relapse, while radiation dose was (p = 0.05) in multivariate analysis. Cancer-specific survival rates at 5, 10, and 15 years were 98.4%, 93.2%, and 69.7%, respectively. Median overall survival (OS) was 167 months (95% confidence interval 147.3-186.7). The OS rates at 5, 10, and 15 years were 91.8%, 75.8%, and 42.5%, respectively. Acute genitourinary (GU) and gastrointestinal (GI) toxicities occurred in 105 (49%) and 98 patients (45.8%), respectively, with only 2 cases of grade III GI toxicity. Late GU and GI toxicities occurred in 17 (7.9%) and 20 (9.3%) patients, respectively, with 1 grade III GI toxicity and 2 grade III GU toxicities. Risk factors for late toxicity were age and RT dose and technique, which were unrelated to acute toxicity. Conclusions: Age ≤70 years does not consistently confer a negative prognosis for localized prostate cancer. Radiotherapy appears to be a viable alternative to surgery, offering excellent long-term cancer control
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Deep Inspiration Breath Hold (DIBH) Radiotherapy for the treatment of left breast cancer. Technique and dosimeric comparison in a cohort of patients.
No full textopenConfronto Dosimetrico cuore ed IVA nel trattamento del tumore al seno sinistro su coorte di pazienti con e senza utilizzo DIBH
implementation and validation of an auto-segmentation atlas for the contouring of pelvic malignancies
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Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Validation of a surface guided radiotherapy protocol, for breast cancer treatment. Mono-institutional experience of ULSS5 Radiotherapy Unit
No full textopenLa radioterapia ha un ruolo fondamentale nel trattamento adiuvante del tumore della mammella. Lo sviluppo di nuove tecnologie ha consentito la possibilità di erogare trattamenti radianti sempre più precisi ed efficaci. Il corretto posizionamento durante la seduta di radioterapia rimane un punto cruciale dell'intero processo e il TSRM agisce da protagonista in questa fase. La radioterapia guidata dalle immagini (IGRT) fornisce uno strumento prezioso per il controllo della posizione e la correzione degli errori di set-up. Recentemente é stata introdotta la surface guided radiotherapy (SGRT) che consente di confrontare la posizione pretrattamento del paziente con il pianificato senza l'utilizzo di radiazioni ionizzanti ma mediante sistemi ottici che ricostruiscono la superficie del soggetto. Nella UOC di Radioterapia Oncologica dell'ospedale di Rovigo é stato introdotto il sistema di SGRT per il trattamento radiante della mammella. Il sistema é già validato da numerosi lavori in letteratura ma si é resa necessaria una verifica interna. Sono stati confrontati gli spostamenti ottenuti mediante SGRT con il precedente protocollo di IGRT mediante immagini portali dimostrando una buona concordanza tra i due metodi.Radiation therapy plays a primary role in the adjuvant treatment of breast cancer. The development of new technologies increased the precision and effectivness of radio theraphy treatments. The correct positioning during the radiotherapy session remains a crucial point of the whole process and the TSRM acts as a protagonist in this phase. Image Guided Radiation Therapy (IGRT) provide a valuable tool for position control and correction of set-up errors. Surface guided radiotherapy (SGRT) has recently been introduced, which allows to compare the patient's pre-treatment position with the planned one without using ionizing radiation but instead by using optical systems that reconstruct the subject's surface. In the Oncological Radiotherapy Unit of Rovigo this SGRT system was introduced for breast treatment. The system is already validated by numerous literature studies but an internal verification was required. The displacements obtained by SGRT with the previous IGRT protocol by portal images were compared
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