1,721,099 research outputs found
Keep neuroinflammation in mind when addressing Alzheimer's disease: A microglia perspective
No full text: This commentary offers a detailed examination of a newly published paper on the effects of small molecule decoys of amyloid-β (Aβ) aggregation on microglial activation. It was discovered that the NSC16224 decoy peptide inhibited proinflammatory cytokines TNFα and IL6 release from microglia in response to Aβ40 and Aβ42 treatment. The research addresses the potential of blocking a sequence of events that lead to the progression of Alzheimer's disease (AD). Here, we discuss the significance of these results in neuroinflammation, highlighting the greater implications for how decoy peptides would be interesting for the research and development of new drugs for AD therapy
Obesity and Protein kinase Cε epsilon expression in peripheral blood cells
No full textThe so-called Metabolic Syndrome is a clustering of metabolic disorders, including insulin resistance, obesity, hyperglycemia, dyslipidemia, and hypertension, mainly caused by overnutrition and sedentary lifestyles particularly in developed countries as well as genetic predisposition. Obesity, insulin resistance and type 2 diabetes are associated and caused by the upregulation of the protein kinase C (PKC)e expression in hepatic, adipose, pancreatic and skeletal tissue. It is well known that PKCe affects insulin receptor (IR) singaling and regulates both insulin secretion and clearance. Here, we have studied the expression levels of PKCe and IR in peripheral blood cells of obese children. Moreover, we have analyzed the correlation between PKCe/IR ratio with the BMI in adult underwent to high caloric food diet. As a final point, the role of PKCe as therapeutic target for management of obesity was discussed
Obesity and Protein kinase Cε epsilon expression in peripheral blood cells
No full textThe so-called Metabolic Syndrome is a clustering of metabolic disorders, including insulin resistance, obesity, hyperglycemia, dyslipidemia, and hypertension, mainly caused by overnutrition and sedentary lifestyles particularly in developed countries as well as genetic predisposition. Obesity, insulin resistance and type 2 diabetes are associated and caused by the upregulation of the protein kinase C (PKC)e expression in hepatic, adipose, pancreatic and skeletal tissue. It is well known that PKCe affects insulin receptor (IR) singaling and regulates both insulin secretion and clearance. Here, we have studied the expression levels of PKCe and IR in peripheral blood cells of obese children. Moreover, we have analyzed the correlation between PKCe/IR ratio with the BMI in adult underwent to high caloric food diet. As a final point, the role of PKCe as therapeutic target for management of obesity was discussed
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Functional and Empirical Knowledge in an Expert System for Fault Diagnosis in Electrical Power Networks
No full textSeeing to learn and learning to see: histology teaching between new technologies, old paradigms and natural cyborgs
No full textHistology is a foundational course in many life science programs. Microscopes have long been the primary instruments used in this discipline, playing a crucial role in histology education for decades. However, with the current significant technological advancements, digital tools are progressively replacing microscopes in university classrooms worldwide. Due to their expense and maintenance requirements, educators are questioning whether the use of traditional microscopes remains a practical approach to teaching this subject. This work aims to present an alternative perspective on the importance and the epistemic peculiarities of microscopes in understanding the microstructure of tissues, moving from internalist approaches to enactive perspectives. Rather than adjudicating a technological contest that many programs have already resolved pragmatically, we offer a philosophical and pedagogical reflection that clarifies what kinds of understanding are cultivated by optical and virtual practices and how those understandings align with contemporary research
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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