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Risk of prostate cancer in patients with Parkinson's disease
Get PDFGóralczyk Wanesa, Borowiecka Monika, Mikos Eryk, Kanon Karol. Risk of prostate cancer in patients with Parkinson’s disease. Journal of Education, Health and Sport. 2021;11(9):691-696. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.09.084
https://apcz.umk.pl/JEHS/article/view/JEHS.2021.11.09.084
https://zenodo.org/record/5533822
The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.
© The Authors 2021;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 15.09.2021. Revised: 20.09.2021. Accepted: 27.09.2021.
Risk of prostate cancer in patients with Parkinson’s disease
Wanesa Góralczyk1*, Monika Borowiecka1, Eryk Mikos1, Karol Kanon1
1Medical University of Lublin
*Corresponding author e-mail: [email protected]
Wanesa Góralczyk; ORCID: 0000-0001-5804-2869
Monika Borowiecka; ORCID: 0000-0003-2612-7838
Eryk Mikos; ORCID: 0000-0003-0507-2882
Karol Kanon; ORCID: 0000-0001-6705-1302
Abstract
Introduction: In recent years, an association between Parkinson’s disease and cancer has been reported with many clinical and epidemiological studies, encouraging the investigation of a potential common pathogenic pathway connected with both diseases. However, association between neurogenesis, medical treatment of Parkinson’s disease and occurence of prostate cancer (PCA) is still being discussed.
Brief description of the state of knowledge: There were carried out population-based case-control researches that checked the connection between Parkinson’s disease and the risk of prostate cancer in Western (Canada, USA, UK, Denmark, Sweden, Israel) and Asian (Taiwan) populations. Studies revealed that Parkinson’s disease had significant association with reduced risk of prostate cancer in most of studied populations (Western) and increased in Asian population.
Conclusions: Most of researches proved that Parkinson’s disease was associated with reduction of risk of prostate cancer, which decreased with increasing duration of Parkinson’s disease. The relationship between those conditions in Asian population needs to be checked in the future.
Key words: Parkinson’s disease, prostate cance
Interferon alpha (IFN-α) in systemic lupus erythematosus (SLE)
No full textMOQBIL, Sara, MIKOS, Eryk, DMOCHOWSKA, Joanna, WÓJCIK, Aleksandra & LEZIAK, Milena. Interferon alpha (IFN-α) in systemic lupus erythematosus (SLE). Journal of Education, Health and Sport. 2023;13(1):56-59. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.13.01.008
https://apcz.umk.pl/JEHS/article/view/40149
https://zenodo.org/record/7356717
The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.
Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).
Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.
Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).
© The Authors 2022;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 22.09.2022. Revised: 20.11.2022. Accepted: 23.11.2022.
Interferon alpha (IFN-α) in systemic lupus erythematosus (SLE)
Sara Moqbil, Eryk Mikos, Joanna Dmochowska, Aleksandra Wójcik, Milena Leziak
Medical University of Lublin
Corresponding author: Sara Moqbil, [email protected]
Sara Moqbil: https://orcid.org/0000-0003-1230-1444, [email protected]
Eryk Mikos: https://orcid.org/0000-0003-0507-2882, [email protected]
Joanna Dmochowska, https://orcid.org/0000-0003-0396-2363, [email protected]
Aleksandra Wójcik, https://orcid.org/0000-0003-1669-7466, [email protected]
Milena Leziak https://orcid.org/0000-0001-9911-5534, [email protected]
Abstract:
Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown etiology. An important role in the pathogenesis of SLE has been attributed to interferon alpha (IFN-α), which stimulates the expression of numerous genes, resulting in an increased autoinflammatory response. Recent studies have demonstrated increased levels of this cytokine in patients with SLE, as well as in relatives, indicating that IFN- α is an inherited risk factor for lupus. Cases of induction of SLE/lupus-like syndrome after IFN- α therapy also point to the involvement of interferon in the pathogenesis of the disease. Interferon being a probable initiator of the disease, as well as a marker to examine its exacerbations, is a potential research target to better understand the etiology and pathogenesis of lupus. More research is needed to determine the feasibility of using INF-blocking agents for new therapies in SLE.
Keywords: systemic lupus erythematosus, interferon alpha, IFN-α-induced SL
Non-invasive diagnostic methods for fatal familial insomnia
No full textMikos Eryk, Moqbil Sara, Dmochowska Joanna, Wasyluk Martyna, Góralczyk Wanesa. Non-invasive diagnostic methods for fatal familial insomnia. Journal of Education, Health and Sport. 2022;12(7):616-619. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.07.061
https://apcz.umk.pl/JEHS/article/view/JEHS.2022.12.07.061
https://zenodo.org/record/6892896
The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.
Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).
Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.
Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).
© The Authors 2022;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 10.07.2022. Revised: 17.07.2022. Accepted: 24.07.2022.
Non-invasive diagnostic methods for fatal familial insomnia
Nieinwazyjne metody diagnostyczne śmiertelnej dziedzicznej bezsenności
Eryk Mikos, Sara Moqbil, Joanna Dmochowska, Martyna Wasyluk, Wanesa Góralczyk
Uniwersytet Medyczny w Lublinie
Corresponding author: Eryk Mikos, [email protected]
ORCID ID and e-mail:
Eryk Mikos https://orcid.org/0000-0003-0507-2882, [email protected]
Sara Moqbil https://orcid.org/0000-0003-1230-1444, [email protected]
Joanna Dmochowska https://orcid.org/0000-0003-0396-2363, [email protected]
Martyna Wasyluk https://orcid.org/0000-0001-5897-7568, [email protected]
Wanesa Góralczyk https://orcid.org/0000-0001-5804-2869, [email protected]
Abstract
Fatal familial insomia (FFI) is a dominant autosomal genetic prion disease characterised by progressive sleep impairment, autonomic nervous system disorders and motor symptoms associated with significant loss of nerve cells in the medial thalamic nuclei.
Making a diagnosis of FFI requires the presence of a certain or probable recognised first-degree relative of the patient, together with neuropsychiatric disorders present. In turn, the detection of the PrP mutation allows the diagnosis to be definitively established. In addition, three other tests - polysomnography, brain imaging and cerebrospinal fluid examination - can be helpful.
Fatal familial insomnia is not a fully understood disease. Diagnosis is based on the presence of symptoms of the disease. An important step in diagnosis will be the development of non-invasive diagnostic tests that are reliable in the early and presymptomatic stages of the disease. Polysomnography, imaging studies (PET, SPECT) and cerebrospinal fluid examination should be improved and widely accepted.
Keywords: fatal familial insomnia; diagnostic methods; polysomnography; imaging tests; cerebrospinal fluid biomarkers
Abstrakt
Śmiertelna dziedziczna bezsenność (FFI) jest dominującą autosomalną genetyczną chorobą prionową charakteryzującą się postępującym upośledzeniem snu, zaburzeniami autonomicznego układu nerwowego i objawami ruchowymi związanymi ze znaczną utratą komórek nerwowych w jądrach przyśrodkowych wzgórza.
Postawienie diagnozy FFI wymaga obecności pewnego lub prawdopodobnego rozpoznanego krewnego pierwszego stopnia pacjenta wraz z obecnymi zaburzeniami neuropsychiatrycznymi. Z kolei wykrycie mutacji PrP pozwala na ostateczne ustalenie rozpoznania. Dodatkowo pomocne mogą być trzy inne badania – polisomnografia, obrazowanie mózgu i badanie płynu mózgowo-rdzeniowego.
Śmiertelna dziedziczna bezsenność nie jest w pełni poznaną chorobą. Diagnoza opiera się na obecności objawów choroby. Ważnym krokiem w diagnostyce będzie opracowanie nieinwazyjnych testów diagnostycznych, które są niezawodne we wczesnych i przedobjawowych stadiach choroby. Polisomnografia, badania obrazowe (PET, SPECT) i badanie płynu mózgowo-rdzeniowego powinny zostać ulepszone i powszechnie akceptowane.
Słowa kluczowe: śmiertelna dziedziczna bezsenność; metody diagnostyczne; polisomnografia; badania obrazowe; biomarkery płynu mózgowo-rdzenioweg
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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