1,720,974 research outputs found
Escalating dose of adalimumab as monotherapy to treat unusual giant and refractory oral-pharyngeal ulcerations in Crohn's disease
No full textCrohn's disease (CD) is a chronic, autoimmune inflammatory disease which may affect the entire gastrointestinal tract, from the oral cavity to the anus. Oral-pharyngeal ulcerations may be significant and persistent in patients with established CD, and the use of TNF-α inhibitor has demonstrated to be useful. We report a unique case of an unusual manifestation of oral CD characterized only by multiple, giant, long-lasting, relapsing ulcerations successfully treated with an escalating dose of Adalimumab at 40 mg weekly as a monotherapy
Autoimmune mucocutaneous blistering diseases in the south of Italy: a 25‐year retrospective study on 169 patients
No full textAutoimmune muco-cutaneous blistering diseases (AMBDs) represent a heterogeneous group of organ-specific and potentially life-threatening diseases. We sought to determine the relationship between clinical remission and therapeutic regimens with clinical type and phenotype of AMBDs, as well as clinical outcomes achieved based on different therapeutic regimens
Cobblestoning soft palate lesion: case report of a difficult diagnosis
Full text linkOral lesions are often the first sign of an Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and
ulcerative colitis (UC). Oral manifestations are not always accompanied by intestinal inflammation’s symptoms. For this
reason, many times, ENT specialist is the first doctor who receives the patient. Diagnosis and treatment of the patients
affected by IBD associated with several extra-intestinal manifestations requiring a multidisciplinary management. Endoscopic examination allows us to diagnose the disease but non-invasive markers of intestinal inflammation, like fecal
calprotectin, may be used to select which patients need to undergo endoscopic examination; thereby avoiding unneces- sary investigations. The therapeutic choice, currently available, to treat oral lesions associated with IBD includes topical
or systemic corticosteroids, immunosuppressive agents, and biologic drug
Global research trends in complex oral sensitivity disorder: A systematic bibliometric analysis of the structures of knowledge
Full text linkA systematic bibliometric analysis of the structure of knowledge was performed to investigate the co-word analysis, the co-citation analysis, and the social network analysis regarding complex oral sensitivity disorder (COSD)
Global research trends in complex oral sensitivity disorder: A systematic bibliometric analysis of the framework
Full text linkA systematic bibliometric analysis was performed to investigate trends in complex oral sensitivity disorder (COSD) research worldwide and compare the contributions of different countries/institutions, scientific journals, authors, keywords, and citations
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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