1,721,050 research outputs found
Glucocorticoid hormone-induced modulation of gene expression and regulation of T-cell death: role of GITR and GILZ, two dexamethasone-induced genes
No full textL'architettura della brevitas nell’Historia di Velleio Patercolo:effetti ideologici e influssi retorici
No full textL'historia di Velleio Patercolo mostra un alto grado di elaborazione che risulta evidente dai passi segnati dai termini "brevitas" e "festinatio", che sono chiari segnali lanciati al lettore e lo invitano a prestare la massima attenzione non solo al singolo passo in cui sono inseriti , ma a tutta la struttura complessiva generata dai riferimenti incrociati intratestualiVelleius Paterculus' "Historia" shows a high degree of elaboration when one focuses on the passages marked by terms like "festinatio" and "brevitas", which are clear signals to the reader and invite him to pay a peculiar attention not only to the single passage they belong to, but also to all the framework that is generated by the intra-textual cross- references
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Susceptibility of murine lymphoma cells treated with 5-(3,3-dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide to NK-mediated cytotoxicity in vitro.
No full textNovel drug-mediated tumor antigens (DMTA) have been detected in chemically induced L5178Y lymphoma of DBA/2 origin, following treatment of tumor-bearing hosts with 5-(3,3-dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide (DTIC). Studies were conducted on the susceptibility of the DTIC-treated subline, maintained in tissue culture, to NK-mediated cytolysis in vitro. The results of the experiments showed that DTIC-treated lymphoma cells are less susceptible to NK cell lysis than the parental line (i.e. L5178Y); the DTIC-treated lymphoma, maintained in vivo as ascitic form, behaved as the corresponding in vitro line, thus suggesting that NK-resistant phenotype was not dependent upon propagation conditions. The intrinsic susceptibility to cell-mediated lysis of the DTIC-treated tumor was unchanged, as demonstrated by lysis produced by alloimmune cytotoxic cells or by natural cytotoxic mesenteric lymph node effectors. "Cold" competition experiments and target binding assay performed with L5178Y/tc and its DTIC-treated subline showed that DTIC-altered cells are less efficient than the parental line as "cold" competitor cells for NK-mediated lysis and bind less efficiently than L5178Y tumor to NK lymphocytes. These data suggested that the NK resistance of the DTIC-treated lymphoma may result from a failure to bind to effector cells, as a consequence of a profound rearrangement of the cell surface produced by DTIC treatment of cancer cells
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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