196,120 research outputs found
Rules-based vs. principles-based regulation in the UK banking sector. Does Brexit matter?
No full textThis article examines the potential impact of Brexit in the context of the banking sector as it relates to UK credit institutions and the recognition measures for foreign banks. In doing so it seeks to analyse and put light upon the quest for coordinating these measures under practitioner lenses. This in turn is intended to aid reflection on how Brexit changes might best be adapted in UK banking regulation. The first part of this article addresses the regulatory approaches from a theoretical perspective, arguing whether it is still relevant to discuss the distinction between principles-based and outcomes-based regime. The second part of the article explores the effects of Brexit in practice, focussing primarily on investor protection and passporting arrangements. The article argues that the MiFID directive represents the legislative framework to achieve mutual recognition among banks and to avoid the risk of de-regulation in the UK financial markets. The article concludes with some observations on the potential divisive impact of Brexit on UK regions, particularly how Brexit might best be regulated if the UK remains within the European Economic Area
Distribuzione dei consumi idrici durante il ciclo colturale del fagiolo (tipo "Borlotto") misurati con lisimetro a pesata.
No full textL'analisi della complessità per il governo dei processi: un'applicazione della metodologia delle condizioni critiche alla valutazione della sicurezza in ambito urbano
No full textA two-point heuristic to calculate the stepsize in subgradient method with application to a network design problem
No full textWe introduce a heuristic rule for calculating the stepsize in the subgradient method for unconstrained convex nonsmooth optimization which, unlike the classic approach, is based on retaining some information from previous iteration. The rule is inspired by the well known two- point stepsize by Barzilai and Borwein (BB) [6] for smooth optimization and it coincides with (BB) in case the function to be minimised is convex quadratic.
Under the use of appropriate safeguards we demonstrate that the method terminates at a point that satisfies an approximate optimality condition.
The proposed approach is tested in the framework of Lagrangian relaxation for integer linear programming where the Lagrangian dual requires maximization of a concave and nonsmooth (piecewise affine) function. In particular we focus on the relaxation of the Minimum Spanning Tree problem with Conflicting Edge Pairs (MSTC). Comparison with classic subgradient method is presented. The results on some widely used academic test problems are provided too
BRAIN id: SBA2 - pollen dataset
No full textMiglionico (MT, S Italy).
Dataset including pollen counts from sediment samples collected from the castle 'Castello del Malconsiglio' of Miglionico (Matera, S Italy; 40°34'03"N 16°40'51"E, 138 m asl; site chronology: 14th-15th cent AD). The site is included in the BRAIN database (https://brainplants.successoterra.net/; site id: SBA2)
Percutaneous coronary intervention utilizing a new endothelial progenitor cells antibody-coated stent: A prospective single-center registry in high-risk patients
No full textObjective: To prospectively evaluate the outcome with circulating endothelial progenitor cell (EPC) capture stent implantation in a cohort of consecutive patients with high-risk angiographic and/or clinical features. Background: Genous R-stent (TM) is a stainless steel coronary stent covered with antibodies specific to EPC's surface antigens, designed to promote the formation of a confluent functional endothelial layer over the device; conceivably, this may prevent both stent thrombosis and restenosis. Methods: From November 2005 to March 2007, 80 patients received 93 EPC capture stents at Campus Bio-Medico, University of Rome. Patients had two or more of the following high-risk features: diabetes mellitus (33%), unstable coronary syndromes (73%), left ventricular dysfunction (8%), multivessel intervention (9%), B2/C lesions (56%). Results: Acute success was achieved in 79/80 patients (98%), without Q-wave myocardial infarction (MI), in-hospital death or emergency bypass surgery; no patient had acute or subacute stent thrombosis. Follow-up was available in 78 patients (mean 14 +/- 4 months): noncardiac death occurred in one patient, acute MI in one patient; no patient required bypass surgery; 10 patients (13%) underwent percutaneous target lesion revascularization (TLR); three patients (4%) had reintervention on a nontarget vessel. Kaplan-Meyer life-table analysis showed event-free survival of 86% and TLR-free survival of 90% at one and a half year follow-up. Conclusions: The cell capture stent is safe and effective, with satisfactory immediate results and mid-term outcome, without evidence of stent thrombosis. Whether those devices represent a viable alternative to currently available drug-eluting or bare metal stents will need to be evaluated in larger randomized studies. (c) 2008 Wiley-Liss, Inc
Biochemical Characterization and NMR Study of the Region E748-A785 of the Human Protein MRP6/ABCC6
No full textMultidrug-resistance-associated protein 6 (MRP6/ABCC6) is a protein belonging to the ABC transporter family
which couple ATP hydrolysis with the transport of molecules across biological membranes. MRP6 topology presents
three transmembrane domains and two nucleotide-binding domains (NBDs). The protein is structurally and functionally
poorly characterized. Mutations in ABCC6 gene cause Pseudoxanthoma elasticum, a recessive genetic disorder affecting
the elastic tissues. Most mutations have been found in NBDs that are critical for ATP binding and hydrolysis.
With the aim to better characterize MRP6, we have performed a preliminary study on the fragment E748-A785 of MRP6-
NBD1, with the wild type sequence and the R765Q mutation found in PXE affected patients. CD and NMR spectroscopy
show the presence of helical structures in both peptides. Fluorescence experiments demonstrate that peptides bind ATP.
The NMR structure of the mutated peptide is compared with the corresponding region of the MRP6-NBD1 modeled structure
using as a template the X-ray structure of MRP1-NBD1. The finding that both wild type and mutated peptide present
the same structure and similar affinity for ATP suggests that the onset of PXE symptoms is a consequence of the different
type of interactions involving residue 765 R/Q inside the protein
Scarso valore predittivo della ecografia tradizionale nella diagnostica del reflusso vescico-ureterale
No full textnon disponibil
- …
