105 research outputs found
Localizzazione immunoistochimica delle cellule ad ACTH nell’ipofisi di pesce spada (Xiphias gladius L.)
No full textPltuitary ACTH cells were immimohistochemically localized in the teleost fish Xiphias gladius L. using
anti-hACTH polychnal serum. ACTH cells were found bordering the murohypophysis (NH) branches in the
adenohypophysis, scattered in the pars intermedia (PI) and in the PD. Along the NH branches the hACTHimmunoreactive
(ir) cells were elongated (medium size 21,27±4,02 um) and disposed in a palized, whereas in
the PI and in PD they were, small and round-shaped (0 7,5 ±1,32 um). The distribution and density of hACTHir
cells did not show difference related to sex and size of specimens
Alterations of basal lamina of seminiferous epithelium in prenatal carbon monoxide-exposed rats.
No full textresti umani delle discariche e della vasca di epoca romana dello scavo Parco Novi Sad.
No full textI reperti umani oggetto del presente studio sono stati messi in luce durante gli scavi, diretti dalla Soprintendenza archeologica per l’Emilia Romagna, per la realizzazione di un parcheggio sotterraneo subito a N-O del centro storico di Modena, corrispondente alla zona periurbana della città romana di Mutina. Essi provengono da tre discariche
pubbliche (SE, SW e NW) utilizzate prevalentemente nella prima età imperiale, rinvenute ai lati di un tratto della strada che collegava Modena a Mantova, fiancheggiata da un’ampia necropoli databile tra il I e il III sec. d.C., e da una vasca per piscicoltura pertinente ad edifici rustici e trasformata in discarica al termine del suo utilizzo
verso la fine del I sec. d.C.3. Il materiale studiato consiste, nel complesso, in 95 crani,
13 mandibole, 88 ossa lunghe e pochi altri frammenti, nonché in due crani umani rinvenuti, con lo scheletro di un cane, in una buca scavata al fondo della discarica di SE.
L’analisi antropologica dei resti ha fornito informazioni su aspetti significativi quali il numero minimo di individui e la loro distribuzione per età e sesso, i distretti scheletrici
maggiormente rappresentati, l’eventuale presenza di lesioni mortali o di tracce di trattamento del cadavere, il carattere primario o secondario del deposito. Questi dati permettono di affrontare alcuni quesiti: le tre discariche e la vasca costituiscono, dal punto di vista dei resti umani in esse contenuti, contesti simili o presentano qualche differenza?Chi potevano essere gli individui cui appartenevano i resti esaminati e cosa è loro successo? Che significato ha la loro deposizione in quei contesti? Cercheremo di rispondere a queste domande nella consapevolezza che un’interpretazione unitaria dovrà attendere il quadro che emergerà dai risultati di tutte le altre discipline e dovrà avvalersi anche delle fonti documentarie disponibili
Neutrophil gelatinase-associated lipocalin immunoexpression in colorectal carcinoma: A stage-specific prognostic factor?
No full textTNM post-surgical staging is considered to be one of the most powerful prognosticators for colorectal carcinoma. Although patient survival mostly decreases concomitantly to stage increase, in a percentage of cases TNM stage appears only to express the anatomic extent of the neoplasia with no correlation with clinical outcome. Thais, the identification of additional prognostic markers for colorectal cancer is required. Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa protein that appears to play an important role in colorectal cancer progression. In order to evaluate whether NGAL expression may be considered as a predictor of colorectal cancer progression, we analyzed its correlation with clinicopathological characteristics, as well as with patient progression-free survival in a series of surgically resected colorectal carcinomas. A variable NGAL immunoexpression was found in 24 out of the 64 analyzed cases. When only the positive cases were considered, a significant association was found between a high NGAL expression and the presence of distant metastases or high tumor stage. In addition, the presence of NGAL was a significant negative prognostic marker correlated with a shorter progression-free survival in stage I colorectal carcinoma, but not in the remaining TNM stages. If our findings are confirmed in more extensive analyses on stage I colorectal carcinoma, NGAL assessment may be used in order to select those patients with a higher progression risk and to submit them to adjuvant therapies useful to prevent adverse outcome
Instabilidade, desregulamentação financeira e a crise do sistema financeiro atual: uma análise a partir de Minsky
No full textTCC (graduação) - Universidade Federal de Santa Catarina. Centro Sócio-Econômico. Economia.Este estudo tem por principal objetivo analisar a desregulamentação do Sistema Financeiro Internacional, relacionando com o Sistema Financeiro Nacional dos Estados Unidos. Para isto, será utilizada a abordagem de Keynes e de Minsky. Após uma análise histórica da evolução do sistema financeiro internacional, será analisado o processo de desregulamentação, desintermediação e securitização, com foco na economia norteamericana. Este trabalho aborda também o processo de desenvolvimento do sistema imobiliário norte americano. Será realizada uma análise das taxas de juros dos Estados Unidos no período de 1980 a 2008 e uma análise do produto interno bruto norte-americano de 1990 a 2009. Por fim, será visto como estes fatores levaram a crise financeira atual
Progetto regionale: sistema per la sorveglianza e il controllo delle infezioni da Legionella in Puglia
No full textSorveglianza e controllo della legionellosi: il Progetto della Regione Puglia
No full textNon previst
PRESTIGIO RING: "A 59-year-old HIV-1 positive, highly treatment-experienced woman failing darunavir/ ritonavir plus raltegravir"
No full textManagement of heavily treatment experienced (HTE) people with HIV remains a challenge. Tailored antiretroviral therapy (ART) is needed in this fragile population who almost invariably harbor viral quasispecies with resistance-associated mutations (RAMs). The reference method for HIV genotypic resistance testing (GRT) has long been Sanger sequencing (SS), but next-generation sequencing (NGS), following recent progress in workflow and cost-effectiveness, is replacing SS because of higher sensitivity. From the PRESTIGIO Registry, we present a case of a 59-year-old HTE woman who failed darunavir/ritonavir plus raltegravir at low-viremia levels due mainly to high pill burden and poor adherence. NGS-GRT was performed on HIV-RNA at failure and the results were compared to all past SS-GRT data available (historical genotype). In this case, NGS-GRT did not detect any minority drug-resistant variants. After discussing several therapeutic options, the treatment was changed to dolutegravir 50 mg twice daily plus doravirine 100 mg once a day, based on clinical history, adherence issues, and pill burden, as well as the historical SS-GRT and the latest NGS-GRT results. At six months follow-up visit, the patient had HIV-RNA below 30 copies/ml and CD4+ T cell count increased from 673 cells/ mm3 to 688 cells/ mm3. Close follow-up of this patient is ongoing
PRESTIGIO RING: "A 59-year-old HIV-1 positive, highly treatment-experienced woman failing darunavir/ ritonavir plus raltegravir"
No full textmanagement of heavily treatment experienced (HTE) people with HIV remains a challenge. tailored antiretroviral therapy (ART) is needed in this fragile population who almost invariably harbor viral quasispecies with resistance-associated mutations (RAMs). the reference method for HIV genotypic resistance testing (GRT) has long been sanger sequencing (SS), but next-generation sequencing (NGS), following recent progress in workflow and cost-effectiveness, is replacing SS because of higher sensitivity. from the PRESTIGIO Registry, we present a case of a 59-year-old HTE woman who failed darunavir/ritonavir plus raltegravir at low-viremia levels due mainly to high pill burden and poor adherence. NGS-GRT was performed on HIV-RNA at failure and the results were compared to all past SS-GRT data available (historical genotype). in this case, NGS-GRT did not detect any minority drug-resistant variants. after discussing several therapeutic options, the treatment was changed to dolutegravir 50 mg twice daily plus doravirine 100 mg once a day, based on clinical history, adherence issues, and pill burden, as well as the historical SS-GRT and the latest NGS-GRT results. at six months follow-up visit, the patient had HIV-RNA below 30 copies/ml and CD4+ T cell count increased from 673 cells/ mm3 to 688 cells/ mm3. close follow-up of this patient is ongoing
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