131,888 research outputs found
[Letter from Captain Roy C. McCune to Major Thos. N. Carswell - October 20, 1941]
No full textA letter written to Major Thos. N. Carswell, Commander, Tenth Batttalion, Texas Defense Guard, Abilene, Texas, from Capt. Roy C. McCune, Capt. Inf. Commanding Co. D. 15th Bn. Texas Defense Guard, Dublin, Texas, dated October 20, 1941. McCune acknowledges the invitation from Carswell to attend the Armistice Day Program but declines due to a football game to be played in Dublin
Introductory Statement by Cornelia D. McCune
No full textSource: University Archives Collection 1158, Information files,"Women's Continuing Education Program" -1969, Folder 1 (No Date Listed)Women's Continuing Education Program. (2013). Introductory Statement by Cornelia D. McCune. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/151810
Enfermedad de McCune-Albright
No full textThe diagnosis of McCune-Albright disease is tackled in a female patient of 28 years old, she was admitted in “Mariano Briceño” Integral Diagnostic Center of Health of San Rafael de Carvajal municipality, Trujillo State in Venezuela.Se aborda el diagnóstico de la enfermedad de McCune-Albright en una paciente femenina de 28 años de edad, ingresada en el Centro Diagnóstico Integral de Salud “Mariano Briceño” del Municipio San Rafael de Carvajal, Estado de Trujillo, Venezuela
The McCune Mansion
No full textBlack and White photograph of The McCune Mansion located Main and 1st north in Salt Lake City Near Temple squar
Oral manifestations of McCune-Albright syndrome
No full textMcCune- Albright Syndrome (MAS) is a rare fibrosseous lesion, characterized by a classic triad of polyostotic fibrous dysplasia (PFD), cafι -au-lait macules (CALM) and underlying endocrinopathies. We present the oral findings of an interesting case of MAS with relevant review of literature. A 30-year-old male presented to us with swelling of both jaws over a period of two years. Cutaneous examination revealed cafι - au - lait macule over the back, crossing the midline. Skeletal survey showed expansile, osteolytic, mixed radiolucent- radiopaque lesions in skull and jaw bones. Serum alkaline phosphatase was elevated (388 IU/L), with normal calcium, phosphorus, parathyroid hormone and 25 hydroxy vitamin D levels. Diagnosis of McCune- Albright syndrome was made and he was treated with parenteral bisphosphonates (intravenous Zoledronate 4 mg) and is under follow up for surgical recontouring of the jaws. Early recognition facilitates better treatment and improves prognosis by reducing the morbidity
Sindrom McCune Albright Dengan Manifestasi Fraktur Berulang
No full textAbstrak
Sindrom McCune-Albright (SMA) merupakan kelainan genetik kompleks yang ditandai dengan trias displasia fibrosa poliostotik, café-au-lait, dan hiperfungsi endokrin. Sindrom ini termasuk penyakit langka dengan prevalens sebesar 1 per 100.000 hingga 1.000.000 populasi. Mutasi somatik sporadik gen GNAS (Guanine Nucleotide binding protein Alpha Stimulating) pada kromosom 20q13, yang terjadi pada sindrom ini, mengakibatkan aktivasi G protein α-subunit (Gsα) berkepanjangan yang meningkatkan aktivitas dan fungsi sel terkait. Manifestasi tersering yang ditemukan pada pasien adalah displasia fibrosa (pada 98% kasus). Kasus adalah seorang anak lelaki, 10 tahun, dengan manifestasi fraktur berulang sejak usia 1 tahun dan deformitas tulang. Pemeriksaan bone survey menunjukkan gambaran ground glass dengan lesi litik-sklerotik pada hampir semua tulang yang sesuai dengan displasia fibrosa poliostotik. Pasien ditata laksana dengan pemberian sediaan fosfat, kalsium, serta vitamin D dalam bentuk aktif dan analog. Pemberian bisfosfonat bertujuan untuk mengurangi nyeri tulang dan risiko fraktur pada pasien. Pemantauan berkelanjutan diperlukan untuk mengevaluasi keterlibatan organ endokrin pada pasien dengan SMA.
Kata kunci: displasia fibrosa, fraktur, sindrom McCune Albright
Abstract
McCune-Albright syndrome (MAS) is a rare complex genetic disorder marked by the triad of polyostotic fibrous dysplasia, café-au-lait and endocrine hyperfunction, affecting 1 in 100.000 to 1.000.000 population. The sporadic somatic mutation of Guanine Nucleotide Binding Protein Alpha Stimulating (GNAS) gene at chromosome 20q13 is the proposed cause of this syndrome, triggering the prolonged activation of G protein α-subunit (Gsα), which increases the activity and function of cells. The most common clinical manifestation is fibrous dysplasia, occurring in 98% cases. This case occurred in a 10-year-old boy with recurrent fractures since the age of 1-year-old and skeletal deformities. The bone survey examination shows ground glass appearance with multiple sclerotic-lytic lesions on almost every bone, accordingly to the polyostotic fibrous dysplasia. The pasien has been treated with oral phosphate, calcium and vitamin D. Intravenous bisphosphonates was administered to relieve the associated bone pain and reduce the risk of recurring fractures. Longitudinal observation is necessary for a long term monitoring to evaluate the endocrinopathy associated with MAS.
Keywords: fibrous dysplasia, fractures, McCune-Albright syndrome
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Clinical and Radiographic Gastrointestinal Abnormalities in McCune-Albright Syndrome.
No full textGI abnormalities are common in McCune-Albright syndrome (MAS). MAS-associated pancreatic disease represents an excellent model for studying the pathophysiology of G
α
s
-related GI disease
FAA Safety Seminar (Open to the General Public)
No full textThis seminar will focus on reducing the aviation accident rate through the enhancement of safety culture. Human factors influences on accident and incidents will also be discussed with an emphasis on the prevention of future occurrences.
The keynote speaker is Robert Sumwalt, current member of the National Transportation Safety Board (NTSB). A pilot with more than 30 years of experience including 24 years as an airline pilot, Sumwalt was appointed to a two-year term with the NTSB as Vice Chairman in 2006 by President George W. Bush. He was then reappointed to the Board as a member for an additional five-year term by President Barack Obama in 2011. He has been involved with and led numerous airline safety programs and is co-founder of the Air Line Pilots Association (ALPA) Critical Incident Response Program, which provides guidance to airline personnel involved in traumatic incidents. For more information about Mr. Sumwalt, http://www.ntsb.gov/about/bio_sumwalt.html
Daniel McCune is currently the University Safety Officer for Embry-Riddle Aeronautical University. He is also the Chairman of the Safety committee for the University Aviation Association, and serves on several national Safety advisory committees. Mr. McCune retired from the United States Army after serving 27 years. Mr. McCune\u27s last flying position in the Army was a Citation Jet Captain at Dobbins Air Force Base. He has flown over 6500 accident free hours. He has flown a multitude of aircraft a few are: CE-560, King Air, Queen Air, C-182, UH-1 Helicopter
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