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Melatonin – the New Multipotential Drug of the Future?
Full text linkBARANOWSKA, Alicja, MATYKA, Kamila, MATYSZEWSKA, Aleksandra, SŁOWIACZEK, Anna, SUTKOWSKI, Jakub, WILCZEWSKA, Ewelina & WOJNAR, Marcin. Melatonin – the New Multipotential Drug of the Future? Journal of Education, Health and Sport. 2023;13(4):330-338. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.13.04.040
https://apcz.umk.pl/JEHS/article/view/42578
https://zenodo.org/record/7699566
The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.
Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).
Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.
Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).
© The Authors 2023;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 14.02.2023. Revised: 22.02.2023. Accepted: 01.03.2023. Published: 05.03.2023.
Melatonin – the New Multipotential Drug of the Future?
Baranowska Alicja, Matyka Kamila, Matuszewska Aleksandra, Słowiaczek Anna, Sutkowski Jakub, Wilczewska Ewelina, Wojnar Marcin
A. Baranowska, Szpital Miejski w Siemianowicach Śląskich, [email protected] ORCID : 0000-0002-0558-4194
K. Matyka, Dolnośląskie Centrum Onkologii, Pulmonologii i Hematologii we Wrocławiu, [email protected], ORCID : 0000-0003-4650-3079,
A. Matyszewska, Dolnośląskie Centrum Onkologii, Pulmonologii i Hematologii we Wrocławiu, [email protected], ORCID : 0000-0003-3608-5803,
A. Słowiaczek, Dolnośląskie Centrum Onkologii, Pulmonologii i Hematologii we Wrocławiu, [email protected], ORCID : 0000-0002-8971-8646,
J. Sutkowski, Dolnośląskie Centrum Onkologii, Pulmonologii i Hematologii we Wrocławiu, [email protected], ORCID : 0000-0001-8970-1716,
E. Wilczewska, Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu, [email protected], ORCID : 0000-0003-3861-1555,
M. Wojnar, Dolnośląski Szpital Specjalistyczny im. T. Marciniaka – Centrum Medycyny Ratunkowej we Wrocławiu, [email protected] ORCID : 0000-0002-4092-8335,
Abstrakt
Wprowadzenie: Melatonina jest powszechnie znanym lekiem i suplementem diety, który cieszy się na rynku farmaceutycznym stale rosnącą popularnością. Ta znana już od ponad 50 lat indoloamina wytwarzana jest przez szyszynkę zależnie od rytmu dobowego. Nazywana również “hormonem ciemności” i wydzielana głównie w godzinach nocnych, kojarzona jest przede wszystkim z leczeniem zaburzeń rytmu snu i czuwania czy zaburzeń związanych z nagłą zmianą strefy czasowej (ang. jet lag). Wiele badań naukowych wykazało jednak, że melatonina charakteryzuje się wielokierunkowym działaniem. Jest używana zarówno jako chronobiotyk, czyli lek regulujący rytm dobowy, jak również posiada właściwości przeciwzapalne, antyoksydacyjne, przeciwnowotworowe, reguluje funkcje mitochondriów, oraz wpływa na wiele układów i narządów utrzymując organizm w stanie homeostazy.
Cel pracy: Artykuł poglądowy ma na celu przybliżenie mechanizmu działania melatoniny, jej obecnych zastosowań w praktyce klinicznej oraz potencjalnych kierunków terapii z jej użyciem w przyszłości.
Materiał i metody: Podsumowanie doniesień dostępnych w publikacjach i badań naukowych zamieszczonych w bazach informacji medycznych Pubmed, CrossRef, Google Scholar oraz pozycjach książkowych.
Wyniki: Plejotropowe działanie melatoniny może zostać wykorzystane jako lek wspomagający w leczeniu zaburzeń snu, schorzeń ośrodkowego układu nerwowego, układu sercowo-naczyniowego, układu pokarmowego, oraz wielu nowotworów.
Wnioski: Pomimo wielu istotnych doniesień na temat pozytywnego wpływu melatoniny w leczeniu schorzeń wielu dziedzin medycyny, konieczne jest pogłębienie badań z jej udziałem oraz powstania rekomendacji jej stosowania celem bezpiecznego wprowadzenia leku do powszechnej praktyki klinicznej.
Abstract
Introduction: Melatonin is a well-known drug and dietary supplement that is steadily growing in popularity on the pharmaceutical market. This indolamine, which has been known for more than 50 years, is produced by the pineal gland depending on the circadian rhythm. Also referred to as the "darkness hormone" and secreted mainly during nighttime hours, it is primarily associated with the treatment of sleep-wake rhythm disorders or disorders associated with sudden shifting time zones (jet lag). However, many scientific studies have shown that melatonin has multidirectional effects. It is used both as a chronobiotic, i.e., a drug that regulates circadian rhythms, as well as having anti-inflammatory, anti-oxidative, and anti-carcinogenic properties, regulating mitochondrial function, and affecting many systems and organs, keeping the organism in a state of homeostasis.
Purpose: This review article aims to provide an overview of the mechanism of action of melatonin, its current indications in clinical practice, and potential future directions for therapy use.
Materials and methods: A summary of reports available in publications and scientific studies posted in medical information databases: Pubmed, CrossRef, Google Scholar, and book positions.
Results: The pleiotropic effect of melatonin can be used as an supportive drug in the treatment of sleep disorders, disorders of the central nervous system, the cardiovascular system, the gastrointestinal system, and many oncological diseases.
Conclusions: Despite a number of important reports on the positive effects of melatonin in the treatment of disorders in many areas of medicine, it is necessary to deepen research with its participation and the emergence of recommendations for its use in order to safely introduce the drug into common clinical practice.
Keywords : melatonin; pineal gland; cancer; circadian rhythm; chronobiotic
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Sudden cardiac death in athletes – can we prevent it?
No full textSŁOWIACZEK, Anna, MATYKA, Kamila, WOJNAR, Marcin, WILCZEWSKA, Ewelina, SUTKOWSKI, Jakub, MATYSZEWSKA, Aleksandra & BARANOWSKA, Alicja. Sudden cardiac death in athletes – can we prevent it? Journal of Education, Health and Sport. 2023;13(5):27-32. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.13.05.003
https://apcz.umk.pl/JEHS/article/view/42583
https://zenodo.org/record/7701616
The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.
Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).
Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.
Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).
© The Authors 2023;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 14.02.2023. Revised: 22.02.2023. Accepted: 01.03.2023. Published: 06.03.2023.
Sudden cardiac death in athletes – can we prevent it?
Anna Słowiaczek
Dolnośląskie Centrum Onkologii, Pulmonologii i Hematologii we Wrocławiu
ORCID: 0000-0002-8971-8646
[email protected]
Kamila Matyka
Dolnośląskie Centrum Onkologii, Pulmonologii i Hematologii we Wrocławiu
ORCID: 0000-0003-4650-3079
[email protected]
Marcin Wojnar
Dolnośląski Szpital Specjalistyczny im. T. Marciniaka - Centrum Medycyny Ratunkowej we Wrocławiu
ORCID: 0000-0002-4092-8335
[email protected]
Ewelina Wilczewska
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu
ORCID: 0000-0003-3861-1555
[email protected]
Jakub Sutkowski
Dolnośląskie Centrum Onkologii, Pulmonologii i Hematologii we Wrocławiu
ORCID: 0000-0001-8970-1716
[email protected]
Aleksandra Matyszewska
Dolnośląskie Centrum Onkologii, Pulmonologii i Hematologii we Wrocławiu
ORCID: 0000-0003-3608-5803
[email protected]
Alicja Baranowska
Szpital Miejski w Siemianowicach Śląskich
ORCID: 0000-0002-0558-4194
[email protected]
Abstract
Introduction and purpose: Sudden cardiac death (SCD) is a rare condition, however it is the leading medical cause of death in population of athletes. This study reviews the epidemiology and common causes of SCD in this group. The literature on the role of pre-participation screening and of the other preventive measures was also reviewed.
Review methods: A review of the available literature on sudden cardiac death in athletes was conducted using PubMed and Google Scholar databases.
Description of the state of knowledge: SCD is the leading cause of death in athletes. However, the incidence is difficult to estimate and varies in different populations. The etiology is age-dependent, in young individuals the most common cause of sudden cardiac death are hypertrophic cardiomyopathy and congenital coronary artery anomalies. In the older athlete population (over 35 years old) atherosclerotic coronary artery disease is the main cause. Screening process varies between countries and besides taking the medical history and physical examination can involve electrocardiogram, echocardiography and other examinations.
Conclusions: A review of the following studies has shown, that pre-participation screening of athletes may help to reduce the incidence of sudden death. Equal focus should be put on the availability of medical facilities during sports events, including experienced medical team and access to automated external defibrillation.
Key words: sudden cardiac death; sport-related death; hypertrophic cardiomyopathy; pre-participation screenin
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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