923 research outputs found
D.H. Lawrence, La Volpe, traduzione e cura di Stefania Michelucci, edizione bilingue
No full textIt is the bilingual and critical edition of D.H. Lawrence's The Fox in the series, Elsinore, Collana di Classici Inglesi, edited and translated by Stefania Michelucci
The volume consists of a long introduction to the text, pp 11-37, of a biographical article on the author and his work (l'autore e l'opera), pp. 39-45), of a note to the text (pp. 47-48) (English and Italian, page to page, pp. 49-227) of explicatory notes (pp. 229-243) and of a biographical section (pp. 245-252)
Ricordo di Stefania Rossi Minutelli
No full textThe author commemorates Stefania Rossi Minutelli – librarian at the Marciana National Library from 1971 to 2005, who died on october 10th, 2008 – remembering her professional career and her role within the Italian Library Association.L'autore ricorda con affetto e stima professionale Stefania Rossi Minutelli – bibliotecaria marciana dal 1971 al 2005, scomparsa nell'ottobre 2008 – ripercorrendo il tratto di strada fatto insieme all'interno dell'Associazione Italiana Biblioteche e del mondo bibliotecario italiano
Research of Prostate Cancer Urinary Diagnostic Biomarkers by Proteomics: The Noteworthy Influence of Inflammation
No full textNowadays, in the case of suspected prostate cancer (PCa), tissue needle biopsy remains the benchmark for diagnosis despite its invasiveness and poor tolerability, as serum prostate-specific antigen (PSA) is limited by low specificity. The aim of this proteomic study was to identify new diagnostic biomarkers in urine, an easily and non-invasively available sample, able to selectively discriminate cancer from benign prostatic hyperplasia (BPH), evaluating whether the presence of inflammation may be a confounding parameter. The analysis was performed by two-dimensional gel electrophoresis (2-DE), mass spectrometry (LC-MS/MS) and Enzyme-Linked Immunosorbent Assay (ELISA) on urine samples from PCa and BPH patients, divided into subgroups based on the presence or absence of inflammation. Significant quantitative and qualitative differences were found in the urinary proteomic profile of PCa and BPH groups. Of the nine differentially expressed proteins, only five can properly be considered potential biomarkers of PCa able to discriminate the two diseases, as they were not affected by the inflammatory process. Therefore, the proteomic research of novel and reliable urinary biomarkers of PCa should be conducted considering the presence of inflammation as a realistic interfering element, as it could hinder the detection of important protein targets
The Global Art Gallery Report with Richard Taittinger, Magnus Resch, Stefania Bortolami, and James Fuentes
No full textModerator: Magnus Resch Book Author and Art Entrepreneur
Panelists:
Stefania Bortolami, Gallery Owner
James Fuentes, Gallery Owner
Richard Taittinger, Gallery Owner
The Global Art Gallery Report is the first and the most wide-ranging report on today\u27s commercial art galleries. Published by Phaidon, it is the first insight of its kind, presenting a detailed and comprehensive portrait of today\u27s gallery scene. In a panel discussion, Magnus Resch will discuss his findings with gallerists Jeffrey Deitch, Stefania Bortolami and James Fuentes. Panelists will shine a light on the future of the art gallery.
Founded in 1969, the Sotheby’s Institute of Art is the first and foremost graduate school for the study of art and its markets. With more than 6,000 alumni working internationally in art fairs, galleries, museums, auction houses, and nonprofits, the Institute’s alumni are shaping the future of the art industry. Past guest speakers at the Institute have included artists, such as: Ulay and Jaša, Dan Graham, Alexandre Singh, Glenn Ligon, Sanford Biggers, Carolee Schneemann, Dara Birnbaum, Alfredo Jaar, Ahmed Alsoudani; and art industry experts from Sotheby’s, Art Basel, Paddle8, Auctionata, Armory Show, Artsy, Whitney Museum, Swiss Institute, MoMA, and others.https://digitalcommons.sia.edu/speaker/1007/thumbnail.jp
A Human Rights Approach to Environmental Health
No full textThis chapter explores the interface between health and the environment through the human rights prism, focusing on the environmental dimension of the right to health and on the now widely recognized right to a healthy, safe and clean environment. To this end, the chapter intends to offers a comprehensive analysis of the relevant provisions contained in human rights treaties and the obligations stemming therefrom. The review of these legal sources is completed by a critical assessment of the case law produced by regional human rights bodies and their evolutive interpretation of individual rights and corresponding State obligations in this field, with a special focus on the case law of the European Court of Human Rights. The aim of this legal analysis is to evaluate the added value of a human rights approach to environmental health litigation, with a view to best achieving the overarching goal of public health protection from environmental harm. The author highlights that human rights can be used in court as effective tools to protect public health against the adverse effects of environmental degradation and severe pollution. She also stresses that the potential of human rights bodies in the field of environmental health is yet fully unexpressed, but further positive developments towards the protection of collective and intergenerational rights related to the environment and human health can be achieved thanks to the dynamic and evolutive approach adopted by these bodies and through the virtuous circle created by judicial cross-fertilization
A Multitude of Women: The Challenges of the Contemporary Italian Novel
No full textA Multitude of Women looks at the ways in which both Italian literary tradition and external influences have assisted Italian women writers in rethinking the theoretical and aesthetic ties between author, text, and readership in the construction of the novel. Stefania Lucamante discusses the valuable contributions that Italian women writers have made to the contemporary novel and illustrates the relevance of the novelistic examples set by their predecessors. She addresses various discursive communities, reading works by Di Lascia, Ferrante, Vinci, and others with reference to intertextuality and the theories of Elsa Morante and Simone de Beauvoir.
This study identifies a positive deviation from literary and ideological orthodoxy, a deviation that helps give meaning to the Italian novel and to transform the traditional notion of the canon in Italian literature. Lucamante argues that this is partly due to the merits of women writers and their ability to eschew obsolete patterns in narrative while favoring forms that are more attuned to the ever-changing needs of society. She shows that contemporary novels by women authors mirror a shift from previous trends in which the need for female emancipation interfered with the actual literary and aesthetic significance of the novel. A Multitude of Women offers a new epistemology of the novel and will appeal to those interested in women's writing, readership, Italian studies, and literary studies in general
Knockdown of NANOG Reduces Cell Proliferation and Induces G0/G1 Cell Cycle Arrest in Human Adipose Stem Cells
No full textThe core components of regenerative medicine are stem cells with high self-renewal and tissue regeneration potentials. Adult stem cells can be obtained from many organs and tissues. NANOG, SOX2 and OCT4 represent the core regulatory network that suppresses differentiation-associated genes, maintaining the pluripotency of mesenchymal stem cells. The roles of NANOG in maintaining self-renewal and undifferentiated status of adult stem cells are still not perfectly established. In this study we define the effects of downregulation of NANOG in maintaining self-renewal and undifferentiated state in mesenchymal stem cells (MSCs) derived from subcutaneous adipose tissue (hASCs). hASCs were expanded and transfected in vitro with short hairpin Lentivirus targeting NANOG. Gene suppressions were achieved at both transcript and proteome levels. The effect of NANOG knockdown on proliferation after 10 passages and on the cell cycle was evaluated by proliferation assay, colony forming unit (CFU), qRT-PCR and cell cycle analysis by flow-cytometry. Moreover, NANOG involvement in differentiation ability was evaluated. We report that downregulation of NANOG revealed a decrease in the proliferation and differentiation rate, inducing cell cycle arrest by increasing p27/CDKN1B (Cyclin-dependent kinase inhibitor 1B) and p21/CDKN1A (Cyclin-dependent kinase inhibitor 1A) through p53 and regulate DLK1/PREF1. Furthermore, NANOG induced downregulation of DNMT1, a major DNA methyltransferase responsible for maintaining methylation status during DNA replication probably involved in cell cycle regulation. Our study confirms that NANOG regulates the complex transcription network of plasticity of the cells, inducing cell cycle arrest and reducing differentiation potential
4-cyanopirazoles derivatives as a new class of compounds with potent antifungal activity
No full textIntroduction
We have reported that some 4-nitrosopyrazoles derivatives displayed in
vitro and in vivo potent antifungal activity at no cytotoxic concentration
and some of these compounds were 4 times more potent than
Amphotericine B and Fluconazole respectively against Cryptococcus
Neoformans and C. Krusei.
We reported also that the absence of NO group or its replacement with
NO2 or NH2 groups gave compounds devoid of antimycotical activity.
Aim of the work
To better understand the mechanism of action and with the aim of
identifying the chemical features responsible for the action, we
synthesized and tested a new class of compounds in which the 4-NO group
was replaced with 4-CN group having, these last, similar steric and
electronic features, but different routes by which may be metabolized in
vivo.
Result
The title compounds tested in vitro for antifungal activity against C.
Neoformans and C. Krusei, displayed an interesting antifungal activity,
increased compared to the analogous 4-NO-pyrazole
Stefania Poznanska (1923-2010) : a teacher, nursing tutor
No full textStefania Poznańska, PhD, was one of five managers of the school, which informal name was Cracow School of Nurses. The School was
founded on 5 November 1911 under the name of School of Professional Nursing, also called the "old Cracow school". Its successor i.e. the
University School of Nurses and Health Carers later Hygienists was opened on 10 December 1925. The abovementioned term also refers to
the following nursing schools: University School of Nursing and Midwifery (1946-1951), Public School of Nursing and Midwifery (1949-1951), Public School Of Nursing (1950-1964), Public Medical School of Nursing (1964-1971), Department of Nursing of the Medical Vocational
College No 1 (1971-1981), and Anna Rydlówna Department of Nursing of the Medical Vocational College No 1 (1982-2001). The
school was localised in Cracow, 25 Kopernika St. until 1975, and then was moved to a new location - 12 Michałowskiego St. The aim of the study was the recollection of Stefania Poznańska, PhD, a nurse, teacher, tutor of nursing, author of multiple research studies
and publications, a person dedicated to the development of modern nursing, and last but not least, a great fiend.
The study material is based on a review of personal notes and archive materials gathered by the Institute of Nursing and Midwifery,
Faculty of Health Sciences, Medical Collage, Jagiellonian University in Cracow. Also, personal recollections of multiple encounters
with Stefania Poznańska were taken into account. A biography-historical method as well as the review of documents were applied by
the authors. A significant contribution of Stefania Poznańska to the development of modern nursing must be emphasized. This contribution included her
work for the Programme Committee in Cracow for nursing education curriculum at university level as well as specific detailed programs regarding nursing history and ethical issues in nursing care, and the publication of a series of articles on new concept for teaching nursing
profession. Stefania Poznańska was a person open to another human being
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