1,721,035 research outputs found
The effect of puberty on insulin resistance in obese children.
No full textJ Endocrinol Invest. 2009 May;32(5):401-5.
The effect of puberty on insulin resistance in obese children.
Pilia S, Casini MR, Foschini ML, Minerba L, Musiu MC, Marras V, Civolani P, Loche
S.
Pediatric Endocrinology Unit, Microcitemico Hospital, ASL Cagliari, Cagliari,
Italy.
OBJECTIVE: Insulin resistance (IR) increases during puberty in normal children.
IR is the first adverse metabolic event of obesity, and the marker of the
metabolic syndrome. We aimed to study the effect of puberty on IR in obese and
normal-weight children.
DESIGN: Cross-sectional evaluation of fasting glucose, insulin concentrations,
and homeostasis model assessment of IR (HOMA-IR) in obese and control children
throughout puberty.
PATIENTS AND METHODS: We recruited 424 obese children (207 pre-pubertal and 217
pubertal divided in Tanner stages 2-3, 4, and 5) and estimated IR using the
HOMA-IR index. Data were compared to those obtained in 123 healthy normal-weight
children (40 pre-pubertal and 83 pubertal divided in Tanner stages 2-3, 4, and
5).
RESULTS: In the obese children mean HOMA-IR increased progressively across Tanner
stages, and was significantly higher in all groups (pre-pubertal and Tanner
stages 2-3, 4, and 5) of obese than in control children. HOMA-IR was
significantly correlated with BMI.
CONCLUSIONS: HOMA-IR in obese children increases at puberty more than in
normal-weight children and does not return to pre-pubertal values at the end of
puberty.
PMID: 19794287 [PubMed - indexed for MEDLINE
Metastasi cutanee di tipo teleangectasico-angiomatoide di carcinoma adenoido-cistico della parotide.
No full text
Low-grade fibromatosis-like spindle cell metaplastic carcinoma of the breast: a case report and literature review
No full text● Low grade fibromatosis-like spindle cell metaplastic carcinoma (FLSpCC) of the breast is a very rare variant of breast neoplasia presenting characteristic clinical and biological features: atypical clinical and radiologic presentation amd high risk of local recurrence but low risk of lymph node and distant metastases.
● Differentiation from other malignant tumors can be obtained only by histologic and immunohistochemical evaluation. These particulars may render the diagnosis and surgical management of such tumors challenging.
● Given the small amount of data published, every clinical case reported may be important to improve our knowledge on the argument. Therefore we describe in detail the clinical, diagnostic, histopathologic, and therapeutic information observed in our patient and compare them with those acquired by a review of the literature.
● Of particular interest is the comprehension of the role of the surgical resection margins for the reduction or elimination of local recurrences, which represent the most fearful aspect in the management of such tumors.
● Another interesting aspect is the assessment of the appropriate follow-up strategy for the early detection of local recurrences or distant metastases. The latter is rare but it must always be considered in patients with FLSpCC
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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