1,721,895 research outputs found
The spike hypothesis in vaccine-induced adverse effects: questions and answers
No full textTrougakos and colleagues recently discussed the role of coronavirus disease 2019 (COVID-19) mRNA vaccine-induced spike (S) protein in adverse effects following vaccination [1]. We would like hereafter to answer one of their outstanding questions requiring response to improve efficacy and safety of COVID-19 vaccines, and to propose an additional question along with its possible answer
In response to Detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool 6 months after maternal COVID-19 vaccination
No full textEtica pubblica e amministrazione tra senso e consenso. Il destino incerto dei valori.
No full textObiettivo del volume è ricondurre l'agire amministrativo, a contatto con le sue fonti, al problema dei valori che ne devono sorreggere autorità e responsabilità, fino al tentativo di codificare l'etica
Evaluation of internal actions in tunnel lining applying genetic algorithms to monitoring data
Full text linkThis article presents an algorithm that can be applied to an innovative diagnostic systems for tunnels based on small and low-cost sensors that can be placed inside the tunnel lining and are able to provide the user with real-time information on the state of health of the structure. The aim of the system is measuring the internal actions (axial force, bending moment and shear) and the ovalization of the lining because of the actions exchanged between the ground and the lining itself. The algorithm presented in this paper aims to calculate the forces acting on tunnel lining starting only from the quantities measured by a set of clinometers and pressure sensors placed inside the casting, without any other knowledge of geotechnical or geological parameters. This method can therefore be applied in parallel with other traditional geotechnical investigation tools such as borehole inclinometers and radar interferometry when unexpected actions as landslides are interesting a tunnel
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The pathologies of the industrialized systems: 1.023 flats realized in Avellino (Italy) in the years ’80
No full textThe pathologies of the industrialized systems: 1.023 flats realized in Avellino in the ‘80s. Francesco Paolo R. Marino University of Study of Basilicata, Potenza, Italy (email: [email protected]) Abstract It is particularly interesting the case of the 1.023 flats of subsidized buildings realized in Avellino after the 1980 earthquake, for the most part in the years between the 1982 or 1983 and the 1986, and the others until the 1991 and 1992. This report pays particular attention to the case of Avellino, not only because of the constructive system (buildings with structure in steel, floors made by “prédalle”, carrying out staircase, and precast one layer infill panels, insulated on the inner side) but also because, thanks to a financing by the Region Campania in March 2001 and in February 2002 (just 15 years after the realization of the buildings), 604 flats of 7 districts are object of a program of building substitution. In other words, more than half of the flats completed in 1986 are going to be demolished; only the ones (other 192 flats) of the district Quattrograna West are object of building recovery; while 2 districts, Picarelli and Quattrograna East, are expecting the necessary financings to complete the recovering or the demolition. It has been found that the decision of demolishing the buildings was taken without deeply analysing the extension and nature of the pathologies. Actually, the absence of an appropriate relationship between the size of the buildings and the dimension of the families inhabiting them is a problem bigger than the technical pathologies affecting the buildings. This case-study shows the structural lack of quality control processes both on the project and the realization, which is typical of the administrative instruments used for these works, especially the Italian systems of awarding of contract “concessione di sola costruzione” and “appalto concorso”
WING FLUTTER SUPPRESSION ENHANCEMENT USING A WELL-SUITED ACTIVE CONTROL MODEL
No full textState-space theory is employed here to model a new active wing flutter suppression control. In this paper, the design of a flutter suppression control law, for the NASA Benchmark Active Control Technology wing, is proposed through a single input-single output controller and unsteady aerodynamics is modelled using the Theodorsen''s theory. Wing dynamic model is obtained by combining the aeroelastic equations of motion with the actuator model presented. Open-loop dynamic behaviour is examined for a single feedback variable that combines pitch and plunge accelerations. Here, a new formulation of control law, based on classical control techniques and featuring two feedback closed-loops, is successfully employed to reach superior stability robustness with respect to other control laws designed with classical flutter suppression schemes having only one feedback closed-loop. The process allows the stability of the aeroelastic system for flight speeds that exceed the open-loop flutter velocity
Understanding the Pharmacology of COVID-19 mRNA Vaccines: Playing Dice with the Spike?
No full textCoronavirus disease-19 (COVID-19) mRNA vaccines are the mainstays of mass vaccination campaigns in most Western countries. However, the emergency conditions in which their development took place made it impossible to fully characterize their effects and mechanism of action. Here, we summarize and discuss available evidence indicating that COVID-19 mRNA vaccines better reflect pharmaceutical drugs than conventional vaccines, as they do not contain antigens but an active SARS-CoV-2 S protein mRNA, representing at the same time an active principle and a prodrug, which upon intracellular translation results in the endogenous production of the SARS-CoV-2 S protein. Both vaccine-derived SARS-CoV-2 S protein mRNA and the resulting S protein exhibit a complex pharmacology and undergo systemic disposition. Defining COVID-19 mRNA vaccines as pharmaceutical drugs has straightforward implications for their pharmacodynamic, pharmacokinetic, clinical and post-marketing safety assessment. Only an accurate characterization of COVID-19 mRNA vaccines as pharmaceutical drugs will guarantee a safe, rational and individualized use of these products
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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