1,721,292 research outputs found
Sistema di classificazione dei documenti di interesse ambientale
No full textLo schema di classificazione, oggetto dello studio e proposto in questo rapporto, è strutturato su 3 livelli gerarchici. Il primo livello copre 5 grandi settori: Risorse naturali, Produzione e servizi, Energia, Gestione del territorio, Ricerche interdisciplinari. Ciascuno di questi è illustrato da una breve nota esplicativa. Il secondo livello è costituito da 18 classi distribuite all'interno di ciascun settore. Il terzo livello comprende complessivamente 57 sottoclassi. Come per i grandi settori, anche le classi e le sottoclassi sono corredate da note esplicative che ne indicano l'estensione, illustrando in dettaglio lo specifico argomento trattato. Lo schema è accompagnato da un indice dei soggetti
The role of menin inhibitors in acute myeloid leukemia
No full textPurpose of reviewAcute myeloid leukemia (AML) characterized by NPM1 mutations or KMT2A rearrangements depends on abnormal epigenetic programs mediated by menin, a critical scaffold protein for sustaining the expression of oncogenic HOX/MEIS1 genes. Therefore, menin inhibitors have become a promising class of AML treatments.Recent findingsEarly-phase trials have shown that agents such as revumenib, ziftomenib, bleximenib, and enzomenib are active, particularly in relapsed/refractory disease, with 23-48% of patients achieving composite complete remission. However, the durability of single-agent treatment remains limited, and resistance mechanisms, such as MEN1 mutations or transcriptional reprogramming, have been identified. Consequently, combination approaches involving venetoclax, hypomethylating agents, or chemotherapy are being investigated to improve response depth and duration. Recent SAVE, KOMET-007, and cAMeLot-2 trials have demonstrated high overall response rates (68%-100%) and encouraging MRD-negative complete remissions when combining menin inhibitors with venetoclax-based regimens. This has been observed even in patients who have previously received venetoclax. Combinations with intensive chemotherapy (e.g., 7 + 3) in the frontline setting have also yielded high CRc rates (up to 94% in NPM1-mutated AML) without exacerbating toxicity.SummaryThese findings justify the integration of menin inhibitors into the AML therapeutic landscape, and support ongoing randomized trials to confirm their benefit in both frontline and relapse or refractory settings
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Hypomethylating Agent-Based Combination Therapies to Treat Post-Hematopoietic Stem Cell Transplant Relapse of Acute Myeloid Leukemia
Full text linkAllogeneic stem cell transplantation still represents the best curative option for most patients with acute myeloid leukemia, but relapse is still dramatically high. Due to their immunologic activity and safety profile, hypomethylating agents (HMAs) represent an interesting backbone for combination therapies. This review reports mechanism of action, safety, and efficacy data on combination strategies based on HMAs in the setting of post-allogeneic stem cell transplant relapse. Several studies highlighted how HMAs and donor lymphocyte infusion (DLI) combination may be advantageous. The combination strategy of HMA with venetoclax, possibly in association with DLI, is showing excellent results in terms of response rate, including molecular responses. Lenalidomide, despite its well-known high rates of severe graft-versus-host disease in post-transplant settings, is showing an acceptable safety profile in association with HMAs with a competitive response rate. Regarding FLT3 internal tandem duplication (ITD) mutant AML, tyrosine kinase inhibitors and particularly sorafenib have promising results as monotherapy and in combination with HMAs. Conversely, combination strategies with gemtuzumab ozogamicin or immune checkpoint inhibitors did not show competitive response rates and seem to be currently less attractive strategies. Associations with histone deacetylase inhibitors and isocitrate dehydrogenase 1 and 2 (IDH1/2) inhibitors represent new possible strategies that need to be better investigated
NGC 2849 and NGC 6134: two more BOCCE open clusters
Full text linkWe present CCD photometry of two southern open clusters. As part of the Bologna Open Cluster Chemical Evolution project we obtained BVI and UBVI imaging for NGC 2849 and NGC 6134, respectively. By means of the synthetic colour-magnitude diagram method and using various evolutionary sets of stellar evolution tracks with various metallicities, we determined at the same time age, distance and reddening. We also determined an approximate metallicity for NGC 2849, for which the information is not available from sounder methods like high-resolution spectroscopy. NGC 2849 turned to be 0.85-1.0 Gyr old with a solar metallicity. The foreground reddening is E(B - V) = 0.28 - 0.32, and the true distance modulus (m - M) 0 = 13.8-13.9. For NGC 6134 we did not obtain fully consistent answers from the V, B - V and V, V - I photometry, an unexpected problem, since both the metallicity and the reddening are known (from high-resolution spectroscopy and the U - B, B - V two colours diagram, respectively). This may either indicate a difficulty of current models (evolutionary tracks and/or models of atmosphere) to accurately reproduce colours, or be related to differences in the metal mixture assumed by the models and those of the clusters. Assuming the spectroscopic abundance and the colour excess [E(B - V) = 0.35] from the U - B, B - V plot, we derived a best age between 0.82 and 0.95 Gyr and a distance modulus 10.5. In agreement with previous studies, the NGC 6134 colour-magnitude diagram shows also a clear main sequence gap at V ˜ 15 and B-V ˜ 0.9-1.0 that is unexplained by canonical stellar evolution models.Fil: Ahumada, Andrea Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Observatorio Astronomico de Cordoba. Departamento de Astrofisica Estelar; ArgentinaFil: Cignoni, M.. Universitá di Bologna. Dipartimento di Astronomia; Italia;Fil: Bragaglia, A.. INAF-Osservatorio Astronomico di Bologna; Italia;Fil: Donati, P.. Universitá di Bologna. Dipartimento di Astronomia; Italia;Fil: Tosi, M.. INAF-Osservatorio Astronomico di Bologna; Italia;Fil: Marconi, G.. European Southern Observatory (ESO); Chile
Damasus and the Papal 'scrinium'
No full textThis chapter analyzes sources and problems concerning the origin of the papal archive with a focus on the role of the papacy of Damasus
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