1,721,200 research outputs found
The Xenopus laevis beta TrCP gene: genomic organization, alternative splicing, 5' and 3' region characterization and comparison of its structure with that of human beta TrCP genes.
No full texthTrCP plays a relevant role in the control of stability of several key protein factors. In Xenopus, hTrCP acts as an inhibitor of Wnt
signaling and dorsal axis formation. We determined the primary structure of the frog hTrCP gene, which consists of 14 exons and 13 introns,
spanning over 34 kb. Isoforms of x-hTrCP have been found, which show differences in the NH2 and COOH regions. NH2 isoforms differ for
the presence or absence of a 30 aa sequence, coded by exon III. In COOH isoforms, 19 C-terminal amino acids are replaced by three different
amino acids. Occurrence of two 5V splice donor sites for splicing of intron XIII provides an explanation for these isoforms, based on
alternative splicing. The DNA region of the putative hTrCP promoter contains several TATA elements, one GCCAAT box, and putative
binding sites for Ets, Tcf/Lef and NF-nB transcription factors. Two transcription initiation sites have been mapped downstream of TATA
boxes proximal to ATG for start of translation. Comparison of the Xenopus and human hTrCP genes indicates high conservation of exon
nucleotide and amino acid sequences, size and organization; differences are limited to exons coding for N- and C-terminal regions
T-LYMPHOCYTOSIS IN BRONCHOALVEOLAR LAVAGE FLUID OF HYPERSENSITIVITY PNEUMONITIS - ADDITIONAL COMMENTARY
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Sottopopolazioni T-linfocitarie nel liquido di lavaggio broncoalveolare di pazienti affetti da granulomatosi polmonare
No full textDispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Clinical physiological data on the bronchodilator effect of Duovent versus salbutamol in chronic obstructive lung disease.
No full text- …
