1,721,109 research outputs found
The Wadi Natrun evaporite deposits, Western Desert, Buhayra Governorate, Egypt
No full textWadi Natrun is a depression in Northern Egypt that hosts important evaporitic deposits. Mining of sodium minerals here started in Pharaonic times, probably as much as about 6000 years ago.
We studied the mineralogy of this area for about a decade, through extensive analytical work and field campaigns that allowed discovering excellent specimens of sodium minerals
I minerali di Wadi Natrun (Deserto occidentale, Egitto)
No full textLa depressione di Wadi Natrun è una delle località minerarie più antiche al mondo, coltivata per i suoi sali di sodio in epoca faraonica, e anche in tempi più remoti, probabilmente 6000 anni fa. La mineralogia di questo giacimento, mai approfondita prima, è stata studiata nel corso di una recente campagna di ricerca che ha consentito di recuperare interessanti ed anche vistosi esemplari di minerali salini
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
RNA processing: A new player of genomic instability in multiple myeloma
No full textGenomic instability, a hallmark of almost all cancers, originates from the combined effects of a deregulated DNA damage response, DNA repair defects, and a failure of cell-cycle checkpoints before the damaged DNA is propagated to daughter cells [1]. Alterations in this network of genomic integrity-preserving pathways lead to the accumulation of mutations, aneuploidy, and chromosomal alterations, the main causes of cancer. Multiple myeloma (MM) is a clonal malignancy of terminally differentiated plasma cells that reside and expand in the bone marrow. MM cells are characterized by a high aneuploidy incidence and recurrent structural chromosomal alterations, features that reflect these cells' underlying genomic instability [2]
Dallo scavo alla mostra. Le indagini sul sito altomedievale di S. Agata Bolognese
No full textNel 1994 durante gli scavi per l'allestimento di un settore della discarica intecomunale Nuova Geovis S.p.A. in loc. Crocetta a Sant'Agata Bolognese (Bo), sono venuti alla luce i resti di un villaggio altomedievale databile al X-XI secolo d.C., costituito da un nucleo abitato con strutture insediative e aree di produzione (focolari, officina per la lavorazione dei metalli, ecc.) circondato da un ampio fossato e da un terrapieno interno. Il presente volume, oltre a poter essere un utile quaderno didattico, illustra e riassume quanto svolto durante l'intervento archeologico di scavo e le metodologie adottate (gli operatori, il cantiere, le campagne di scavo, lo scavo stratigrafico, i rilievi, la strumentazione, la documentazione di scavo), le discipline utilizzate per la datazione (termoluminescenza, C14, dendrocronologia) e l'archeobiologia per la ricostruzione del contesto vegetale (attraverso l'archeopalinologia, archeocarpologia, archeoxilo-antracologia) ed animale (archeozoologia). L'ultima sezione è invece dedicata al restauro e alle relative tecniche per il recupero di ceramica, vetri e metalli, legni
Con l'odore dell'inchiostro sulle mani. Racconti in testa: Letture e scritture fuori dagli steccati
No full textTargeting oncogenic Notch signaling with SERCA inhibitors
Full text linkP-type ATPase inhibitors are among the most successful and widely prescribed therapeutics in modern pharmacology. Clinical transition has been safely achieved for H+/K+ ATPase inhibitors such as omeprazole and Na+/K+-ATPase inhibitors like digoxin. However, this is more challenging for Ca2+-ATPase modulators due to the physiological role of Ca2+ in cardiac dynamics. Over the past two decades, sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) modulators have been studied as potential chemotherapy agents because of their Ca2+-mediated pan-cancer lethal effects. Instead, recent evidence suggests that SERCA inhibition suppresses oncogenic Notch1 signaling emerging as an alternative to γ-secretase modulators that showed limited clinical activity due to severe side effects. In this review, we focus on how SERCA inhibitors alter Notch1 signaling and show that Notch on-target-mediated antileukemia properties of these molecules can be achieved without causing overt Ca2+ cellular overload
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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