88,972 research outputs found
F-MACHOP IN ADVANCED AGGRESSIVE LYMPHOMA
No full textThe results of our ten years experience indicate that F-MACHOP, conceptually designed to exploit cell kinetic and synergistic principles, is an effective regimen with acceptable toxicity in a large proportion of adults with advanced stages of diffuse large cell or small non-cleaved cell lymphoma. More than 60% of all treated patients all expected to achieve long-term EFS. Patients achieving CR within 3 courses have a very high chance of being cured of their disease and do not require, in our opinion, intensification with other regimens. On the other hand the identification of a group of patients with poorer outcome (i.e. those failing to achieve an early CR) enabled testing of the potential efficacy of superintensive salvage regimens. Together with other 6 Italian hematologic institutions, we have recently participated in a prospective comparative randomized trial in which F-MACHOP was compared to MACOP-B in adults with advanced stages of diffuse large cell or small non-cleaved cell lymphoma. The preliminary results of this trial appear to confirm that F-MACHOP is an effective and tolerable regimen in such patients and there is a suggestion that its efficacy is superior to that of MACOP-B. This trial was closed to accrual in September 1991 and we look forward to the first complete analysis in March 1992
Le entrate signorili dei Mandelli a Maccagno: fine XIII-inizi XIV secolo
No full textIl saggio esamina la signoria esercitata dalla famiglia milanese dei Mandelli sul villaggio di Maccagno Inferiore, sul Lago Maggiore, a cavallo fra XIII e XIV secolo. Ne emerge il limitato rientro economico di questo territorio periferico, compensato però dal valore simbolico del potere ivi esercitato.The essay examines the lordship exercised by the Milanese Mandelli family over the village of Maccagno Inferiore, on the Lake Maggiore, between 13th and 14th centuries. This peripheral territory provided little wealth to the family, but this was compensated by the symbolic value of the power exercised
The F-MACHOP sequential combination chemotherapy regimen in advanced diffuse aggressive lymphomas: long-term results.
No full textThe present study reports the long-term results of the F-MACHOP sequential combination chemotherapy regimen in 113 adult patients with advanced stages of diffuse large-cell or undifferentiated lymphoma who were consecutively treated with this regimen from January 1980 to December 1986 at a single institution. The CR rate was 78% and 17 relapses were observed, so that 80% of CR patients are expected to be free of relapse at 5 and 10 years after a median follow-up off-therapy of 5.7 years (range 3.2-10.1). Projected survival and event-free survival at 8 years are 68% and 62%, respectively. Prognostic factor analysis indicates that the CR rate was influenced by systemic symptoms and number of extranodal sites, disease-free survival by tumor burden and number of courses to achievement of CR, event-free survival and survival by tumor mass diameter, systemic symptoms and number of extranodal sites. Toxicity was mainly hematological, and 3 patients (3%) died while severely neutropenic. The rapidity of response appears to have prognostic value, particularly in patients presenting with high tumor burden, in whom achievement of a CR within 3 courses indicates a group of patients with a very high chance of cure with this regimen
Sulla via di casa: strategie di un migrante senegalese
No full textIl ritorno di un emigrato nel Paese natio può essere definitivo o temporaneo e la decisione può essere volontaria o obbligata. Il migrante senegalese qui descritto è un attore territoriale che sta progettando e attuando il suo rientro in patria. Questo articolo vuole proporre una riflessione sul tema del progetto migratorio dei senegalesi con particolare riferimento alle sue implicazioni socioterritoriali.
The return of migrants in their native country may be permanent or temporary and the decision may be voluntary or forced. The Senegalese migrant, described in this paper, is a territorial-actor who is implementing and planning his return home. This article aims to introduce a reflection on the theme of the migration project of the senegaleses, with a particular reference to the social-territorial implications
La comunità di Pecetto contro i Mandelli feudatari (1444): linguaggi politici a confronto
No full textNel caso dei Mandelli e di Pecetto la signoria feudale, fallito il proprio ruolo di mediazione tra principe e comunità, si rivela una «struttura artificiale», sovrapposta per volontà del duca ad una comunità che, non sentendosi abbastanza tutelata nei propri interessi dai feudatari, fa appello al duca.In Pecetto the feudal lordship fails in its role of mediation between the prince and the community. So it reveals itself as an 'artificial structure', enforced by the duke to a community that, feeling itself not enough defended from feudal lords,appelas itself to the Duke
Pattern ventrale identificativo degli esemplari di Triturus carnifex della popolazione di via Mandelli, Rivolta d'Adda (CR)
No full textAlbum fotografico contenente le immagini dei pattern ventrali degli esemplari di Triturus carnifex apparenenti alla popolazione di via Mandelli in Rivolta d'Adda (CR). Gli esemplari sono identificati tramite codici indicanti sesso ed età (F = adult female, M = adult male, J = juvenile) seguiti da un numero progressivo.</p
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