196,400 research outputs found
Erratum: Patients with Severe Obesity during the COVID- 19 Pandemic: How to Maintain an Adequate Multidisciplinary Nutritional Rehabilitation Program? (Obes Facts. (2021) DOI: 10.1159/000513283)
No full textIn the article by De Amicis et al. entitled "Patients with Severe Obesity during the COVID- 19 Pandemic: How to Maintain an Adequate Multidisciplinary Nutritional Rehabilitation Program?" [Obes Facts. 2021, DOI: 10.1159/000513283], the author list is incorrect. The correct author list is: De Amicis R. Cancello R. Capodaglio P. Gobbi M. Brunani A. Gilardini L. Castelnuovo G. Molinari E. Barbieri V. Mambrini S.P. Battezzati A. Bertoli S
Codice Diplomatico Aretino, 1: Le carte della Canonica di Arezzo (649-998)
No full textIl volume apre l’edizione delle carte della Canonica di Arezzo, il principale fondo archivistico conservato presso l’Archivio Capitolare di Arezzo nel quale è raccolto materiale documentario dalla metà del secolo VII sino al 1750. Costituiscono l’oggetto del presente volume le prime 45 pergamene, relative ai secoli VII-X, con l’inserimento di documenti non presenti nel tabularium. Si tratta complessivamente di 51 atti per gli anni 649-998. La quasi totalità del corpus documentario riguarda la secolare “contesa per le pievi” tra le diocesi di Arezzo e di Siena, il patrimonio della canonica di San Donato e della Chiesa aretina. La progressione temporale degli atti e delle notizie emerse dalla documentazione è ricostruita nel repertorio cronologico. Il lavoro è corredato dagli indici dei nomi di persona, di luogo e delle cose notevoli
CHANGES IN MEMBRANE IONIC CONDUCTANCES AND EXCITABILITY CHARACTERISTICS OF RAT SKELETAL MUSCLE DURING AGING
No full textMembrane electrical properties, component ionic conductances and excitability characteristics of extensor digitorum longus muscle from 3-4, 16 and 29 months old rats were measured "in vitro". Fiber diameter, membrane resistance (Rm) and membrane capacitance, increased with aging, and the increase was significant at 29 months. The increase of Rm was mostly due to a decrease of chloride conductance (GC1), whereas potassium conductance (GK) increased only slightly, at 16 and 29 months. Due to the lowered GC1, the latency of action potential increased at both ages with a consequent prolongation of the duration of action potential. Nevertheless, a decrease in the firing capability was recorded in the aged fibers. Our results indicate, that during aging, the most affected parameter of skeletal muscle fibers is GC1, although changes of this passive conductance alone cannot entirely account for the changes in the excitability characteristics recorded
The effect of diphenylamine-2-carboxylate on C1- channel conductance and on excitability characteristics of rat skeletal muscle
No full textThe effect of diphenylamine-2-carboxylate (DPC), a blocker of the Cl- conductance pathway in Cl- transporting epithelia, has been evaluated in-vitro on the electrophysiological variables of rat extensor digitorum longus muscle fibres. DPC (5-240 μM) caused a dose-related increase of membrane resistance which was attributed entirely to a fall in Cl- channel conductance (IC50, 120 μM), since potassium conductance was not affected by the treatment. DPC also modified fibre excitability. A significant dose-dependent increase was observed in the latency of the action potential and in the excitability of the membrane. DPC was less potent on striated fibres than anthracene-9-carboxylic acid, another specific blocker of C1- channel conductance. Moreover DPC was less potent on skeletal muscle than on C1- transporting epithelia. Morphological differences in the Cl- channels or of the drug binding sites may account for the differences between tissues
Subtle Cerebral Damage after Shunting vs Non Shunting during Carotid Endarterectomy
No full textObjectiveTo compare the extent of subtle cerebral damage (SCD) in patients undergoing carotid endarterectomy with or without shunt placement.DesignProspective, randomised study.Patients and methodsWe assessed a consecutive series of 96 patients undergoing endarterectomy for severe unilateral left carotid stenosis who had been randomly assigned to receive a shunt (48) or not (48). Eligibility criteria included age up to 80 years and Mini-Mental State Examination score >24 points. Patients underwent neuropsychological testing before surgery. Serum concentrations of S100 protein, neuron-specific enolase (NSE) and interleukin-6 (IL-6) were measured intraoperatively before and after carotid clamping. Finally, each patient underwent neuropsychological testing 3 weeks after surgery.ResultsPatients with and without shunt had similar serum concentrations of S100 protein, NSE and IL-6 as well as similar neuropsychological test scores, all p>0.05.ConclusionsThere was no difference in subtle cerebral damage between patients randomized to receive a shunt or not
Generalized Hardcore Dimer Models approach to low-energy Heisenberg frustrated antiferromagnets: general properties and application to the kagome antiferromagnet
No full text26 pages, 4 figures, EPAPS inlined, manuscript revised, corrected minor typos (notably figure 2).International audienceWe propose a general non-perturbative scheme that quantitatively maps the low-energy sector of spin-1/2 frustrated Heisenberg antiferromagnets to effective Generalized Quantum Dimer Models. We develop the formal lattice independent frame and establish some important results on (i) the locality of the generated Hamiltonians (ii) how full resummations can be performed in this renormalization scheme. The method is then applied to the much debated kagome antiferromagnet for which a fully resummed effective Hamiltonian - shown to capture the essential properties and provide deep insights on the microscopic model [D. Poilblanc, M. Mambrini and D. Schwandt, arXiv:0912.0724] - is derived
Membrane ionic conductances in normal and denervated skeletal muscle of the rat during development
No full textThe development of membrane ionic conductances of rat extensor digitorum longus (EDL) muscle fibers was studied in vitro using intracellular recordings. At 7-8 days after birth, the potassium conductance (GK) dominated the total membrane conductance while the chloride conductance (GCl) was very low. A rapid increase of GCl towards adult values was observed after few days (12-14 day old rats), whereas GK did not decrease up to day 23. Denervation at 7-8 days after birth suppressed the maturation of the electrical parameters measured, and 15 days after the nerve crush, GCl was just detectable. These results suggest that the maturation of the electrical properties, and in particular that of the resting chloride conductance in mammalian striated muscle fibers, occurs during the first weeks of postnatal life and is dependent on innervation
THE INFLUENCE OF INACTIVITY ON MEMBRANE RESTING CONDUCTANCES OF RAT SKELETAL MUSCLE FIBERS UNDERGOING REINNERVATION.
No full textThe role of activity in the maintenance of the normal component resting conductances of skeletal muscle fibres has been evaluated in vitro in rat extensor digitorum longus muscle during reinnervation from 2 to 40 days (a) after crushing of the peroneus nerve and (b) after local application of tetrodotoxin (TTX) to the crushed nerve. Whereas membrane conductances were regained after crushing alone, they were not completely restored when impulse propagation was blocked with TTX. It is concluded that nerve trophic factors are of primary importance in the control of muscular membrane conductances, and that transmission at the endplate and the muscle usage triggered by it have a minor but significant effec
EFFECTS OF CHLORIDE CHANNEL STEREOSPECIFIC ACTIVATOR AND INHIBITOR ON MYOTONIC MOUSE SKELETAL-MUSCLE FIBERS
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