1,721,132 research outputs found
Commentary: IL-17 in Chronic Inflammation: From Discovery to Targeting
No full textA recent article titled “IL-17 in chronic inflammation: From discovery to targeting,” by Beringer et al. (2016), greatly reviewed the biology of interleukin-17 (IL-17) family members highlighting the contributions of IL-17 cytokines toward diseases and IL-17-based treatment options. Authors attractively reported how preclinical and clinical studies have provided a solid scientific justification for targeting IL-17 and/or IL-17 receptor (IL-17RA) in human diseases such as inflammatory and autoimmune disorders. Here, I wish to implement the description of the biological properties of IL-17A on the cardiovascular system, the novel underlying mechanisms on platelets aggregation, and thrombus formation, and to report the contribution of IL-17A/IL-17RA axis in the association of autoimmune diseases with cardiovascular risk
Modeling equal and unequal mass binary neutron star mergers using public codes
No full textWe present three-dimensional simulations of the dynamics of binary neutron star mergers from the late stage of the inspiral process up to ∼20 ms after the system has merged, either to form a hypermassive neutron star or a rotating black hole. We investigate five equal mass models of total gravitational mass 2.207, 2.373, 2.537, 2.697, and 2.854M, respectively, and four unequal mass models with MADM≃2.53 M and q≃0.94, 0.88, 0.83, and 0.77 (where q=M(1)/M(2) is the mass ratio). We use a semirealistic equation of state, namely, the seven-segment piecewise polytropic SLyPP with a thermal component given by Γth=1.8. We have also compared the resulting dynamics (for one model) using both the BSSN-NOK and CCZ4 methods for the evolution of the gravitational sector and also different reconstruction methods for the matter sector, namely, PPM, WENO, and MP5. Our results show agreement at high resolution, but superiority of BSSN-NOK supplemented by WENO reconstruction at lower resolutions. One of the important characteristics of the present investigation is that for the first time it has been done using only publicly available open source software: the Einstein Toolkit code, deployed for the dynamical evolution, and the LORENE code, for the generation of the initial models. All of the source code and parameters used for the simulations have been made publicly available. This not only makes it possible to rerun and reanalyze our data but also enables others to directly build upon this work for future research
Binary neutron star merger simulations with different initial orbital frequency and equation of state
No full textWe present results from three-dimensional general relativistic simulations of binary neutron star coalescences and mergers using public codes. We considered equal mass models where the baryon mass of the two neutron stars. is 1.4M(circle dot), described by four different equations of state (EOS) for the cold nuclear matter (APR4, SLy, H4, and MS1; all parametrized as piecewise polytropes). We started the simulations from four different initial interbinary distances (40, 44.3, 50, and 60 km), including up to the last 16 orbits before merger. That allows us to show the effects on the gravitational wave (GW) phase evolution, radiated energy and angular momentum due to: the use of different EOS, the orbital eccentricity present in the initial data and the initial separation (in the simulation) between the two stars. Our results show that eccentricity has a major role in the discrepancy between numerical and analytical waveforms until the very last few orbits, where 'tidal' effects and missing high-order post-Newtonian coefficients also play a significant role. We test different methods for extrapolating the GW signal extracted at finite radii to null infinity. We show that an effective procedure for integrating the Newman-Penrose psi(4) signal to obtain the GW strain h is to apply a simple high-pass digital filter to h after a time domain integration, where only the two physical motivated integration constants are introduced. That should be preferred to the more common procedures of introducing additional integration constants, integrating in the frequency domain or filtering psi(4) before integration
Modeling mergers of known galactic systems of binary neutron stars
Full text linkWe present a study of the merger of six different known galactic systems of binary neutron stars (BNS) of unequal mass with a mass ratio between 0.75 and 0.99. Specifically, these systems are J1756-2251, J0737-3039A, J1906 + 0746, B1534 + 12, J0453 + 1559 and B1913 + 16. We follow the dynamics of the merger from the late stage of the inspiral process up to ∼20ms after the system has merged, either to form a hyper-massive neutron star (NS) or a rotating black hole (BH), using a semi-realistic equation of state (EOS), namely the seven-segment piece-wise polytropic SLy with a thermal component. For the most extreme of these systems (q = 0.75, J0453 + 1559), we also investigate the effects of different EOSs: APR4, H4, and MS1. Our numerical simulations are performed using only publicly available open source code such as, the Einstein toolkit code deployed for the dynamical evolution and the LORENE code for the generation of the initial models. We show results on the gravitational wave signals, spectrogram and frequencies of the BNS after the merger and the BH properties in the two cases in which the system collapses within the simulated time
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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