1,721,129 research outputs found
Insights into the Larderello Geothermal Field: structural setting and distribution of thermal and 3He anomalies
No full textTargeting and understanding hiv latency: The crispr system against the provirus
Full text linkThe presence of latently infected cells and reservoirs in HIV-1 infected patients constitutes a significant obstacle to achieve a definitive cure. Despite the efforts dedicated to solve these issues, the mechanisms underlying viral latency are still under study. Thus, on the one hand, new strategies are needed to elucidate which factors are involved in latency establishment and maintenance. On the other hand, innovative therapeutic approaches aimed at eradicating HIV infection are explored. In this context, advances of the versatile CRISPR-Cas gene editing technology are extremely promising, by providing, among other advantages, the possibility to target the HIV-1 genome once integrated into cellular DNA (provirus) and/or host-specific genes involved in virus infection/latency. This system, up to now, has been employed with success in numerous in vitro and in vivo studies, highlighting its increasing significance in the field. In this review, we focus on the progresses made in the use of different CRISPR-Cas strategies to target the HIV-1 provirus, and we then discuss recent advancements in the use of CRISPR screens to elucidate the role of host-specific factors in viral latency
Guidelines and management tools: a case study
Full text linkAs it is well known land use in dense populated area is often characterized by competing and fast evolving industrial and agricultural activities introducing various elements of environmental stress that must be taken into account in every planning and management phase.
In this work we discuss the application of a whole new integrated approach to the analysis of a quite strategic district in the Italy’s Pianura Padana, showing as the land use constraints and the related conflicts between the involved communities at different space-time scales, can be driven to solution and finally managed thanks to an increased diffuse knowledge and the implementation of innovative perception tools of the various stress elements, making possible the setup of a new guideline system, already implemented, and a higher environmental awareness
1st case of extra-gastrointestinal anisakiasis in a human diagnosed in Italy
No full textA case of extra-gastrointestinal infection by Anisakis in a woman living in Catania (Sicily, Southern Italy) is described. The patient complained of severe pain in the ileocecal region, and a diagnosis of acute appendicitis led to an appendectomy. During the intervention, a laparoscopic exploration showed a nodule on the large omentum that was surgically removed. Parasitological diagnosis was achieved on the basis of morphological observations carried out on the histological sections of the nodule
Palisaded myofibroblastoma of the breast: a tumor closely mimicking schwannoma: report of 2 cases.
No full textMyofibroblastoma is a relatively rare, benign mesenchymal tumor that typically occurs in the breast parenchyma. Unlike mammary-type myofibroblastoma, myofibroblastoma that primarily arises in the lymph nodes exhibits nuclear palisading, and the term palisaded myofibroblastoma has been proposed, accordingly. We report 2 unusual cases of myofibroblastoma of the male breast, which showed a predominant (>90% of the entire tumor) nuclear palisading and Verocay-like bodies. The present cases represent a hitherto unreported variant of mammary-type myofibroblastoma closely mimicking schwannoma. The diagnosis of myofibroblastoma was supported by immunohistochemical analyses showing a diffuse staining for desmin and CD34. In addition, the diagnosis of myofibroblastoma was confirmed in 1 case cytogenetically by the demonstration of the monoallelic loss of the FOXO1/13q14 locus by fluorescence in situ hybridization. Pathologists should be aware of this unusual variant of mammary myofibroblastoma to assure a correct diagnosis
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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